EDUCATION

Undergraduate Degree

  • Pennsylvania State University , State College , PA

Graduate Degree

  • Case Western Reserve University School of Medicine , Cleveland , OH

Medical School

  • Case Western Reserve University School of Medicine , Cleveland , OH

Internship

  • Cincinnati Children's Hospital , Cincinnati , OH

Residency

  • Cincinnati Children's Hospital , Cincinnati , OH

Fellowship

Allergy and Immunology
  • Boston Children's Hospital , Boston , MA

PUBLICATIONS

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  1. Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020 11; 146(5):1194-1200.e1. View abstract
  2. Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! Clin Immunol. 2020 07; 216:108459. View abstract
  3. RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. J Allergy Clin Immunol. 2020 06; 145(6):1673-1680.e11. View abstract
  4. Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders. Clin Rev Allergy Immunol. 2019 Oct; 57(2):213-225. View abstract
  5. Oral viscous mometasone is an effective treatment for eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2020 Mar; 8(3):1107-1109. View abstract
  6. Defective TLR9-driven STAT3 activation in B cells of patients with CVID. Clin Immunol. 2018 12; 197:40-44. View abstract
  7. Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2016 09; 138(3):852-859.e3. View abstract
  8. Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. J Allergy Clin Immunol. 2014 Jun; 133(6):1753-5.e3. View abstract
  9. Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):221-3. View abstract
  10. Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. Spine J. 2012 Aug; 12(8):e1-6. View abstract
  11. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20. View abstract
  12. TH17 deficiency in human disease. J Allergy Clin Immunol. 2012 Jun; 129(6):1429-35; quiz 1436-7. View abstract
  13. Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1304-5.e3. View abstract
  14. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010 Nov; 89(6):403-425. View abstract
  15. Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. J Allergy Clin Immunol. 2010 Aug; 126(2):332-7, 337.e1-2. View abstract
  16. Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. J Allergy Clin Immunol. 2010 Jul; 126(1):127-32.e7. View abstract
  17. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51. View abstract
  18. Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. J Allergy Clin Immunol. 2007 Oct; 120(4):900-7. View abstract
  19. Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol. 2007 Dec; 120(6):1382-8. View abstract
  20. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007 Oct 01; 204(10):2407-22. View abstract
  21. Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. J Allergy Clin Immunol. 2006 Dec; 118(6):1357-62. View abstract
  22. Lessons learned from molecular defects in nuclear factor kappaB dependent signaling. Microbes Infect. 2006 Apr; 8(4):1151-6. View abstract
  23. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med. 2004 Aug 02; 200(3):399-404. View abstract
  24. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci. 2003 Apr 01; 23(7):2665-74. View abstract
  25. beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J Neurosci. 1998 Jun 15; 18(12):4451-60. View abstract
  26. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci. 1997 Apr 01; 17(7):2284-94. View abstract