MEDICAL SERVICES

Specialties

Departments

Programs

Languages

  • German

  • French

  • English

EDUCATION

Medical School

  • Westfalische Wilhelms-Universitat , 1999 , Munster , Germany

Internship

Pediatrics
  • Cleveland Clinic , 2004 , Cleveland , OH

Residency

Neurology
  • Westfalische Wilhelms-Universitat , 2000 , Munster , Germany

Residency

Pediatrics
  • Cleveland Clinic , 2005 , Cleveland , OH

Residency

Child Neurology
  • Cleveland Clinic , 2008 , Cleveland , OH

Fellowship

Epilepsy & Clinical Neurophysiology
  • Cleveland Clinic , 2003 , Cleveland , OH

Philosophy of Care

Within my Area of Excellence in Investigation I have an outstanding record of successful and productive research in areas of high relevance for our pediatric epilepsy population.  My expertise and experience as an innovator and teacher place me in an excellent position to continue to make important contributions to the field directly, as well as to exert future influence in the field through the researchers I train.

PROFESSIONAL HISTORY

As a pediatrician, pediatric neurologist, and clinical neurophysiologist, with specific training in seizure monitoring and treatment, I spend approximately 40% of my time in investigation, 20% in direct clinical care, 10% in teaching activities, and 30% in significant supporting activities. My early research experience as a resident and fellow included observational and interventional studies on clinical seizure manifestations and treatment. Following my 2008 appointment as Assistant in Neurology at Boston Children’s Hospital, I expanded my research to include circadian variation of seizures and used this information to develop a patient-oriented medication treatment schedule. My research is focused on identifying the factors that determine epileptic encephalopathies and status epilepticus as well as functional outcome later in life. Repetitive seizures and epileptic encephalopathy can impair development, plasticity and cognitive function of eloquent areas including language and memory. Seizure frequency reduction and seizure freedom, in particular after epilepsy surgery, have been shown to improve neurocognitive and developmental outcome. By identifying biomarkers that indicate predictors of cerebral damage and developmental outcome in epileptic encephalopathies and status epilepticus, we intend to reduce the occurrence of brain damage and later developmental disabilities and aim to identify novel therapeutic approaches.

What are we doing?

- Comparative effectiveness and interventional clinical trials in pediatric status epilepticus and epileptic encephalopathies

 

How do we do it?

Inventing, evaluating and implementing clinically relevant biomarkers and treatment paradigms to assess and benchmark these based on clinical data, neurophysiology, imaging, pharmacogenomics and genetics, in collaboration with basic researcher locally, nationally, and internationally.

Developing and evaluating monitoring tools for clinical biomarkers to further clinical epilepsy outcome measures including seizure characterization, neuropsychological outcome assessment, and quality of life assessment by means of seizure sensors and electronic tools including ICISS, the RENCI seizure tracking and outcome prediction modeling software, and novel in- and outpatient monitoring devices and algorithms, and neurophysiological, biochemical and genetic periodicity markers and implement these techniques into clinical workflow.

Research networks and collaborations are essential for our work, like the pediatric status epilepticus research group (www.pserg.org), the Pediatric Epilepsy Research Consortium , the pediatric critical care epilepsy research group, the Critical Care EEG consortium, the pediatric neurocritical care research group and other consortia.

CERTIFICATIONS

  • American Board of Psychiatry and Neurology, Child and Adolescent Neurology
  • American Board of Psychiatry and Neurology, Epilepsy

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Video-based Detection of Generalized Tonic-clonic Seizures Using Deep Learning. IEEE J Biomed Health Inform. 2021 Jan 06; PP. View abstract
  2. Efficacy and Tolerability of Rufinamide in Epileptic Children Younger Than 4 Years. J Child Neurol. 2021 Mar; 36(4):281-287. View abstract
  3. Status Epilepticus-Work-Up and Management in Children. Semin Neurol. 2020 12; 40(6):661-674. View abstract
  4. Machine learning from wristband sensor data for wearable, noninvasive seizure forecasting. Epilepsia. 2020 12; 61(12):2653-2666. View abstract
  5. The burden of decisional uncertainty in the treatment of status epilepticus. Epilepsia. 2020 10; 61(10):2150-2162. View abstract
  6. First-line medication dosing in pediatric refractory status epilepticus. Neurology. 2020 11 10; 95(19):e2683-e2696. View abstract
  7. Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee. Epilepsy Curr. 2020 Sep; 20(5):245-264. View abstract
  8. Photoplethysmography: A measure for the function of the autonomic nervous system in focal impaired awareness seizures. Epilepsia. 2020 08; 61(8):1617-1626. View abstract
  9. Retrospective observational study on hospital readmission for status epilepticus in the United States over 2016. Epilepsia. 2020 07; 61(7):1386-1396. View abstract
  10. Autonomic nervous system changes detected with peripheral sensors in the setting of epileptic seizures. Sci Rep. 2020 07 14; 10(1):11560. View abstract
  11. Photoplethysmographic evaluation of generalized tonic-clonic seizures. Epilepsia. 2020 08; 61(8):1606-1616. View abstract
  12. EEG features of brain injury during extracorporeal membrane oxygenation in children. Neurology. 2020 09 08; 95(10):e1372-e1380. View abstract
  13. Slow wave activity during NREM sleep in patients with electrical status epilepticus in sleep. Seizure. 2020 08; 80:257-258. View abstract
  14. Association of guideline publication and delays to treatment in pediatric status epilepticus. Neurology. 2020 09 01; 95(9):e1222-e1235. View abstract
  15. Nonlinear Analysis of Visually Normal EEGs to Differentiate Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS). Sci Rep. 2020 05 21; 10(1):8419. View abstract
  16. Mortality in infantile spasms: A hospital-based study. Epilepsia. 2020 04; 61(4):702-713. View abstract
  17. Electrocardiographic changes associated with epilepsy beyond heart rate and their utilization in future seizure detection and forecasting methods. Clin Neurophysiol. 2020 04; 131(4):866-879. View abstract
  18. Pharmacotherapy for Pediatric Convulsive Status Epilepticus. CNS Drugs. 2020 01; 34(1):47-63. View abstract
  19. Seizure prediction and intervention. Neuropharmacology. 2020 08 01; 172:107898. View abstract
  20. Novel treatment approaches and pediatric research networks in status epilepticus. Epilepsy Behav. 2019 12; 101(Pt B):106564. View abstract
  21. Estimating the cost of status epilepticus admissions in the United States of America using ICD-10 codes. Seizure. 2019 Oct; 71:295-303. View abstract
  22. Electroencephalographic Reporting for Refractory Status Epilepticus. J Clin Neurophysiol. 2019 Sep; 36(5):365-370. View abstract
  23. Bone Health Screening Practices Among Neurologists in Patients on Antiepileptic Drugs: A Quality Improvement Project. Pediatr Neurol. 2020 01; 102:49-55. View abstract
  24. The onset of pediatric refractory status epilepticus is not distributed uniformly during the day. Seizure. 2019 Aug; 70:90-96. View abstract
  25. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav. 2019 08; 97:44-50. View abstract
  26. Encephalopathy related to Status Epilepticus during slow Sleep: from concepts to terminology. Epileptic Disord. 2019 Jun 01; 21(S1):5-12. View abstract
  27. Encephalopathy with continuous spike-waves during slow-wave sleep: evolution and prognosis. Epileptic Disord. 2019 Jun 01; 21(S1):15-21. View abstract
  28. Automated detection of sudden unexpected death in epilepsy risk factors in electronic medical records using natural language processing. Epilepsia. 2019 06; 60(6):1209-1220. View abstract
  29. Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. Neurology. 2019 05 14; 92(20):e2339-e2348. View abstract
  30. Peripheral multimodal monitoring of ANS changes related to epilepsy. Epilepsy Behav. 2019 07; 96:69-79. View abstract
  31. Seizure Prediction Models in the Neonatal Intensive Care Unit. J Clin Neurophysiol. 2019 May; 36(3):186-194. View abstract
  32. Characteristics of Future Models of Integrated Outpatient Care. Healthcare (Basel). 2019 Apr 27; 7(2). View abstract
  33. New onset refractory status epilepticus research: What is on the horizon? Neurology. 2019 04 23; 92(17):802-810. View abstract
  34. Outcome of ambulatory video-EEG monitoring in a ˜10,000 patient nationwide cohort. Seizure. 2019 Mar; 66:104-111. View abstract
  35. Timely Interventions for Children with ADHD through Web-Based Monitoring Algorithms. Diseases. 2019 Feb 07; 7(1). View abstract
  36. Using EHRs to advance epilepsy care. Neurol Clin Pract. 2019 Feb; 9(1):83-88. View abstract
  37. Diagnostic yield of genetic tests in epilepsy: A meta-analysis and cost-effectiveness study. Neurology. 2019 Jan 04. View abstract
  38. Chronotherapeutic implications of cyclic seizure patterns. Nat Rev Neurol. 2018 Dec; 14(12):696-697. View abstract
  39. KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect. Ann Neurol. 2018 11; 84(5):766-780. View abstract
  40. Circadian rhythm and epilepsy. Lancet Neurol. 2018 12; 17(12):1098-1108. View abstract
  41. Status epilepticus prevention, ambulatory monitoring, early seizure detection and prediction in at-risk patients. Seizure. 2019 May; 68:31-37. View abstract
  42. Caring electronically for young outpatients who have epilepsy. Epilepsy Behav. 2018 10; 87:226-232. View abstract
  43. Long-term outcomes of status epilepticus: A critical assessment. Epilepsia. 2018 10; 59 Suppl 2:155-169. View abstract
  44. Estimating the cost of admissions related to convulsive status epilepticus in the United States of America. Seizure. 2018 Oct; 61:186-198. View abstract
  45. Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 09; 142(3). View abstract
  46. Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers. Pediatr Neurol. 2018 09; 86:33-41. View abstract
  47. Automating Interictal Spike Detection: Revisiting A Simple Threshold Rule. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:299-302. View abstract
  48. Timing in the treatment of status epilepticus: From basics to the clinic. Seizure. 2019 May; 68:22-30. View abstract
  49. Machine Learning for Outcome Prediction in Electroencephalograph (EEG)-Monitored Children in the Intensive Care Unit. J Child Neurol. 2018 07; 33(8):546-553. View abstract
  50. Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus. Epilepsy Res. 2018 08; 144:1-6. View abstract
  51. Different as night and day: Patterns of isolated seizures, clusters, and status epilepticus. Epilepsia. 2018 05; 59(5):e73-e77. View abstract
  52. Towards acute pediatric status epilepticus intervention teams: Do we need "Seizure Codes"? Seizure. 2018 May; 58:133-140. View abstract
  53. Factors associated with treatment delays in pediatric refractory convulsive status epilepticus. Neurology. 2018 05 08; 90(19):e1692-e1701. View abstract
  54. Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus. JAMA Neurol. 2018 04 01; 75(4):410-418. View abstract
  55. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 04 01; 172(4):352-360. View abstract
  56. Common data elements for epilepsy mobile health systems. Epilepsia. 2018 05; 59(5):1020-1026. View abstract
  57. Can a collaborative healthcare network improve the care of people with epilepsy? Epilepsy Behav. 2018 05; 82:189-193. View abstract
  58. Conscious control of breathing: A key to prevention of sudden unexpected death in epilepsy? Ann Neurol. 2018 03; 83(3):449-450. View abstract
  59. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PLoS One. 2018; 13(3):e0193599. View abstract
  60. New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES): State of the art and perspectives. Epilepsia. 2018 04; 59(4):745-752. View abstract
  61. Patterns of epileptic seizure occurrence. Brain Res. 2019 01 15; 1703:3-12. View abstract
  62. Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. Epilepsia. 2018 04; 59(4):739-744. View abstract
  63. Should patients with complex febrile seizure be admitted for further management? Am J Emerg Med. 2018 08; 36(8):1386-1390. View abstract
  64. Devices for Ambulatory Monitoring of Sleep-Associated Disorders in Children with Neurological Diseases. Children (Basel). 2017 Dec 25; 5(1). View abstract
  65. The Need for Antiepileptic Drug Chronotherapy to Treat Selected Childhood Epilepsy Syndromes and Avert the Harmful Consequences of Drug Resistance. J Cent Nerv Syst Dis. 2017; 9:1179573516685883. View abstract
  66. Sleep patterns predictive of daytime challenging behavior in individuals with low-functioning autism. Autism Res. 2018 02; 11(2):391-403. View abstract
  67. New-Onset Status Epilepticus in Pediatric Patients: Causes, Characteristics, and Outcomes. Pediatr Neurol. 2018 03; 80:61-69. View abstract
  68. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View abstract
  69. Time to continuous electroencephalogram in repeated admissions to the pediatric intensive care unit. Seizure. 2018 Jan; 54:19-26. View abstract
  70. The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia. 2017 12; 58(12):2098-2103. View abstract
  71. Behaviorally-determined sleep phenotypes are robustly associated with adaptive functioning in individuals with low functioning autism. Sci Rep. 2017 10 27; 7(1):14228. View abstract
  72. Rescue Medications in Epilepsy Patients: A Family Perspective. Seizure. 2017 Nov; 52:188-194. View abstract
  73. Multicenter clinical assessment of improved wearable multimodal convulsive seizure detectors. Epilepsia. 2017 11; 58(11):1870-1879. View abstract
  74. Continuous EEG in Pediatric Critical Care: Yield and Efficiency of Seizure Detection. J Clin Neurophysiol. 2017 Sep; 34(5):421-426. View abstract
  75. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 09 01; 171(9):863-871. View abstract
  76. Novel clinical manifestations in patients with KCNA2 mutations. Seizure. 2017 Oct; 51:74-76. View abstract
  77. Disparities in epilepsy surgery in the United States of America. J Neurol. 2017 Aug; 264(8):1735-1745. View abstract
  78. Effect of vigabatrin on seizure control and safety profile in different subgroups of children with epilepsy. Epilepsia. 2017 09; 58(9):1575-1585. View abstract
  79. Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit. J Child Neurol. 2017 Sep; 32(10):880-885. View abstract
  80. A Question Worth Asking. J Clin Neurophysiol. 2017 Jul; 34(4):392. View abstract
  81. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct; 75:73-79. View abstract
  82. Nonintravenous rescue medications for pediatric status epilepticus: A cost-effectiveness analysis. Epilepsia. 2017 08; 58(8):1349-1359. View abstract
  83. Diagnostic and Therapeutic Management of a First Unprovoked Seizure in Children and Adolescents With a Focus on the Revised Diagnostic Criteria for Epilepsy. J Child Neurol. 2017 07; 32(8):774-788. View abstract
  84. Use of EEG in critically ill children and neonates in the United States of America. J Neurol. 2017 Jun; 264(6):1165-1173. View abstract
  85. Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders. Brain. 2017 May 01; 140(5):1316-1336. View abstract
  86. Increasing Ketamine Use for Refractory Status Epilepticus in US Pediatric Hospitals. J Child Neurol. 2017 06; 32(7):638-646. View abstract
  87. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar; 81(3):419-429. View abstract
  88. Understanding Death in Children With Epilepsy. Pediatr Neurol. 2017 05; 70:7-15. View abstract
  89. Time to electroencephalography is independently associated with outcome in critically ill neonates and children. Epilepsia. 2017 03; 58(3):420-428. View abstract
  90. Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep. Epilepsy Res. 2017 02; 130:74-80. View abstract
  91. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology. 2017 Jan 24; 88(4):386-394. View abstract
  92. Seizures caused by brain tumors in children. Seizure. 2017 Jan; 44:98-107. View abstract
  93. Texting Rhythm With Temporal Predominance. J Clin Neurophysiol. 2016 Dec; 33(6):570. View abstract
  94. Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. Pediatr Crit Care Med. 2016 10; 17(10):968-975. View abstract
  95. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 11; 57(11):1834-1842. View abstract
  96. Interictal epileptiform discharges and cognition. Dev Med Child Neurol. 2017 01; 59(1):13-14. View abstract
  97. HHV-6 and seizure: A systematic review and meta-analysis. J Med Virol. 2017 01; 89(1):161-169. View abstract
  98. The future of medicine will be dark without international collaboration [corrected]. Seizure. 2016 10; 41:42. View abstract
  99. Automated seizure detection systems and their effectiveness for each type of seizure. Seizure. 2016 Aug; 40:88-101. View abstract
  100. Real-time multi-channel monitoring of burst-suppression using neural network technology during pediatric status epilepticus treatment. Clin Neurophysiol. 2016 08; 127(8):2820-2831. View abstract
  101. Clobazam higher-evening differential dosing as an add-on therapy in refractory epilepsy. Seizure. 2016 Aug; 40:1-6. View abstract
  102. 2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects. Epilepsy Curr. 2016 May-Jun; 16(3):192-7. View abstract
  103. Effectiveness of once-daily high-dose ACTH for infantile spasms. Epilepsy Behav. 2016 06; 59:4-8. View abstract
  104. Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. J Clin Neurophysiol. 2016 Apr; 33(2):133-40. View abstract
  105. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar; 79(3):475-84. View abstract
  106. Effectiveness of antiepileptic therapy in patients with PCDH19 mutations. Seizure. 2016 Feb; 35:106-10. View abstract
  107. Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus. Seizure. 2016 Feb; 35:4-10. View abstract
  108. aEEG and cEEG: Two complementary techniques to assess seizures and encephalopathy in neonates: Editorial on "Amplitude-integrated EEG for detection of neonatal seizures: A systematic review" by Rakshasbhuvankar et al. Seizure. 2015 Dec; 33:88-9. View abstract
  109. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4. View abstract
  110. Treatment of electrical status epilepticus in sleep: A pooled analysis of 575 cases. Epilepsia. 2015 Nov; 56(11):1738-46. View abstract
  111. Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia. 2015 Oct; 56(10):1599-604. View abstract
  112. Should epileptiform discharges be treated? Epilepsia. 2015 Oct; 56(10):1492-504. View abstract
  113. Outcomes in pediatric patients with nonconvulsive status epilepticus. Epilepsy Behav. 2015 Aug; 49:98-103. View abstract
  114. Acute seizure suppression by transcranial direct current stimulation in rats. Ann Clin Transl Neurol. 2015 Aug; 2(8):843-56. View abstract
  115. Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. Epilepsy Res. 2015 Sep; 115:113-8. View abstract
  116. Seizures and brain regulatory systems: consciousness, sleep, and autonomic systems. J Clin Neurophysiol. 2015 Jun; 32(3):188-93. View abstract
  117. Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology. 2015 Jun 09; 84(23):2304-11. View abstract
  118. Therapeutic choices in convulsive status epilepticus. Expert Opin Pharmacother. 2015 Mar; 16(4):487-500. View abstract
  119. Pediatric refractory epilepsy: A decision analysis comparing medical versus surgical treatment. Epilepsia. 2015 Feb; 56(2):263-72. View abstract
  120. Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker? Clin EEG Neurosci. 2015 Jan; 46(1):16-25. View abstract
  121. Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31. View abstract
  122. Pediatric status epilepticus management. Curr Opin Pediatr. 2014 Dec; 26(6):668-74. View abstract
  123. Febrile status epilepticus: time is of the essence. Epilepsy Curr. 2014 Nov-Dec; 14(6):345-7. View abstract
  124. Development and validation of a seizure prediction model in critically ill children. Seizure. 2015 Feb; 25:104-11. View abstract
  125. Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER. Epilepsy Res. 2014 Dec; 108(10):1874-88. View abstract
  126. Subunit composition of neurotransmitter receptors in the immature and in the epileptic brain. Biomed Res Int. 2014; 2014:301950. View abstract
  127. Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy. Epilepsy Behav. 2014 Aug; 37:291-307. View abstract
  128. Localization of sleep spindles, k-complexes, and vertex waves with subdural electrodes in children. J Clin Neurophysiol. 2014 Aug; 31(4):367-74. View abstract
  129. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View abstract
  130. Management of pediatric status epilepticus. Curr Treat Options Neurol. 2014 Jul; 16(7):301. View abstract
  131. Comparison of pediatric patients with status epilepticus lasting 5-29 min versus =30 min. Epilepsy Behav. 2014 Aug; 37:1-6. View abstract
  132. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View abstract
  133. Treatment for continuous spikes and waves during sleep (CSWS): survey on treatment choices in North America. Epilepsia. 2014 Jul; 55(7):1099-108. View abstract
  134. Comparison of risk factors for pediatric convulsive status epilepticus when defined as seizures = 5 min versus seizures = 30 min. Seizure. 2014 Oct; 23(9):692-8. View abstract
  135. Pediatric status epilepticus: how common is cerebrospinal fluid pleocytosis in the absence of infection? Seizure. 2014 Aug; 23(7):573-5. View abstract
  136. Predicting diurnal and sleep/wake seizure patterns in paediatric patients of different ages. Epileptic Disord. 2014 Mar; 16(1):56-66. View abstract
  137. Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus. Epilepsy Res. 2014 May; 108(4):605-15. View abstract
  138. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View abstract
  139. Development and implementation of a quality improvement curriculum for child neurology residents: lessons learned. Pediatr Neurol. 2014 May; 50(5):452-7. View abstract
  140. Diagnostic delays in children with early onset epilepsy: impact, reasons, and opportunities to improve care. Epilepsia. 2014 Jan; 55(1):123-32. View abstract
  141. Electrocorticography for seizure foci mapping in epilepsy surgery. J Clin Neurophysiol. 2013 Dec; 30(6):554-70. View abstract
  142. Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study. J Pediatr. 2014 Feb; 164(2):339-46.e1-2. View abstract
  143. Outcomes of vagal nerve stimulation in a pediatric population: a single center experience. Seizure. 2014 Feb; 23(2):105-11. View abstract
  144. Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. 2014 Feb; 23(2):87-97. View abstract
  145. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View abstract
  146. Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. Epilepsia. 2013 Oct; 54(10):1753-60. View abstract
  147. The diagnostic yield of pediatric polysomnography based on the professional background of referring physicians. Clin Pediatr (Phila). 2013 Dec; 52(12):1154-60. View abstract
  148. Priorities in pediatric epilepsy research: improving children's futures today. Neurology. 2013 Sep 24; 81(13):1166-75. View abstract
  149. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013; 2013:583531. View abstract
  150. Electroencephalography monitoring in critically ill children: current practice and implications for future study design. Epilepsia. 2013 Aug; 54(8):1419-27. View abstract
  151. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View abstract
  152. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality. Neurology. 2013 Jul 23; 81(4):383-91. View abstract
  153. Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. Epilepsia. 2013 Aug; 54(8):1498-503. View abstract
  154. Visual aids to medical data and computational diagnostics: new frontiers in pediatric neurology. Epilepsy Behav. 2013 Aug; 28(2):258-60. View abstract
  155. Management of childhood epilepsy. Continuum (Minneap Minn). 2013 Jun; 19(3 Epilepsy):656-81. View abstract
  156. Predictors of seizure occurrence in children undergoing pre-surgical monitoring. Seizure. 2013 Oct; 22(8):640-6. View abstract
  157. Electroencephalography in the pediatric emergency department: when is it most useful? J Child Neurol. 2014 Apr; 29(4):475-82. View abstract
  158. Clinical practice guidelines and practice parameters for the child neurologist. J Child Neurol. 2013 Jul; 28(7):917-25. View abstract
  159. Cardiopulmonary complications during pediatric seizures: a prelude to understanding SUDEP. Epilepsia. 2013 Jun; 54(6):1083-91. View abstract
  160. Chronopharmacology of anti-convulsive therapy. Curr Neurol Neurosci Rep. 2013 Apr; 13(4):339. View abstract
  161. Pediatric ICU EEG monitoring: current resources and practice in the United States and Canada. J Clin Neurophysiol. 2013 Apr; 30(2):156-60. View abstract
  162. Should readmission within 30 days after discharge of children hospitalized for a neurologic disorder be considered a quality assurance failure? J Child Neurol. 2013 Jun; 28(6):758-61. View abstract
  163. Electroencephalographic monitoring in the pediatric intensive care unit. Curr Neurol Neurosci Rep. 2013 Mar; 13(3):330. View abstract
  164. Sturge-Weber syndrome: clinical and radiological correlates in 86 patients. Ideggyogy Sz. 2013 Jan 30; 66(1-2):53-7. View abstract
  165. Automated quantification of spikes. Epilepsy Behav. 2013 Feb; 26(2):143-52. View abstract
  166. Electrical status epilepticus in sleep: clinical presentation and pathophysiology. Pediatr Neurol. 2012 Dec; 47(6):390-410. View abstract
  167. The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2013 Apr; 54(4):741-50. View abstract
  168. Risk factors associated with death in in-hospital pediatric convulsive status epilepticus. PLoS One. 2012; 7(10):e47474. View abstract
  169. Clinical evolution of seizures: distribution across time of day and sleep/wakefulness cycle. J Neurol. 2013 Feb; 260(2):549-57. View abstract
  170. Pediatric focal epilepsy syndromes. J Clin Neurophysiol. 2012 Oct; 29(5):425-40. View abstract
  171. Dacrystic seizures: demographic, semiologic, and etiologic insights from a multicenter study in long-term video-EEG monitoring units. Epilepsia. 2012 Oct; 53(10):1810-9. View abstract
  172. Chrono-epileptology: time to reconsider seizure timing. Seizure. 2012 Jul; 21(6):411. View abstract
  173. Overcoming barriers to successful epilepsy management. Epilepsy Curr. 2012 Jul; 12(4):158-60. View abstract
  174. Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients. Seizure. 2012 Sep; 21(7):535-9. View abstract
  175. Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy. Pediatr Neurol. 2012 Jun; 46(6):359-62. View abstract
  176. Diurnal and sleep/wake patterns of epileptic spasms in different age groups. Epilepsia. 2012 Jul; 53(7):1170-7. View abstract
  177. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View abstract
  178. Outcomes of epileptic spasms in patients aged less than 3 years: single-center United States experience. Pediatr Neurol. 2012 May; 46(5):276-80. View abstract
  179. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View abstract
  180. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View abstract
  181. Autonomic changes with seizures correlate with postictal EEG suppression. Neurology. 2012 Jun 05; 78(23):1868-76. View abstract
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