Caregiver Profile

Caregiver Profile

Meet Dr. Richard S. Lee


Undergraduate Degree

  • Princeton University , 1998 , Princeton , NJ

Medical School

  • Jefferson Medical College, Thomas Jefferson University , 1998 , Philadelphia , PA


  • University of Washington , 1999 , Seattle , WA


  • University of Washington , 2000 , Seattle , WA


  • University of Washington , 2003 , Seattle , WA


Chief Urology Resident
  • University of Washington , 2004 , Seattle , WA


Pediatric Urology
  • Boston Children's Hospital , 2007 , Boston , MA


Richard S. Lee, MD is the Vice Chair, Research, Director of Pediatric Urologic Oncology, Director of Pediatric Urologic Transplantation, and the Co-Director of the Bladder Exstrophy Program. He is a board-certified pediatric urologist specializing in complex genitourinary reconstruction, including bladder exstrophy and other complex pelvic malformations, pediatric urologic oncology, pediatric renal transplantation and reconstruction, and robotic surgery. Dr. Lee received his undergraduate degree in Chemical Engineering at Princeton University and his medical degree at Jefferson Medical College. He completed his 6-year Urologic Surgery residency at the University of Washington and then trained in a 3-year pediatric urology fellowship at Boston Children’s Hospital, Harvard Medical School.

Dr. Lee has multiple research interests each with a strong focus on preservation of kidney function. His laboratory focuses on identifying urinary biomarkers of kidney injury, kidney obstruction and infection. He has received numerous research grants for his work and has been continuously federally funded by the National Institutes of Health (NIH) since 2007.


  • American Board of Urology, Pediatric Urology


Publications powered by Harvard Catalyst Profiles

  1. Malignancy Yield of Testis Pathology in Older Boys and Adolescents with Cryptorchidism. J Urol. 2021 Nov 18; 101097JU0000000000002345. View abstract
  2. The Urinary Proteomic Profile Implicates Key Regulators for Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Research Network Study. Mol Cell Proteomics. 2021 Nov 11; 21(1):100176. View abstract
  3. Urinary Tract Infections in Children with Vesicoureteral Reflux Are Accompanied by Alterations in Urinary Microbiota and Metabolome Profiles. Eur Urol. 2021 Sep 17. View abstract
  4. Uromodulin Isolation and Its N-Glycosylation Analysis by NanoLC-MS/MS. J Proteome Res. 2021 05 07; 20(5):2662-2672. View abstract
  5. Characterizing Patients with Recurrent Urinary Tract Infections in Vesicoureteral Reflux: A Pilot Study of the Urinary Proteome. Mol Cell Proteomics. 2020 Mar; 19(3):456-466. View abstract
  6. Modeling dynamic radial contrast enhanced MRI with linear time invariant systems for motion correction in quantitative assessment of kidney function. Med Image Anal. 2021 01; 67:101880. View abstract
  7. An in-depth Comparison of the Pediatric and Adult Urinary N-glycomes. Mol Cell Proteomics. 2020 11; 19(11):1767-1776. View abstract
  8. Correction to: Prospective pediatric study comparing glomerular filtration rate estimates based on motion-robust dynamic contrast-enhanced magnetic resonance imaging and serum creatinine (eGFR) to 99mTc DTPA. Pediatr Radiol. 2020 May; 50(5):755-756. View abstract
  9. Accuracy of Ultrasound in Identifying Renal Scarring as Compared to DMSA Scan. Urology. 2020 04; 138:134-137. View abstract
  10. Prospective pediatric study comparing glomerular filtration rate estimates based on motion-robust dynamic contrast-enhanced magnetic resonance imaging and serum creatinine (eGFR) to 99mTc DTPA. Pediatr Radiol. 2020 05; 50(5):698-705. View abstract
  11. Characterizing Patients with Recurrent Urinary Tract Infections in Vesicoureteral Reflux: A Pilot Study of the Urinary Proteome. Mol Cell Proteomics. 2020 03; 19(3):456-466. View abstract
  12. Feed and wrap magnetic resonance urography provides anatomic and functional imaging in infants without anesthesia. J Pediatr Urol. 2020 Feb; 16(1):116-120. View abstract
  13. CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations. Am J Hum Genet. 2019 12 05; 105(6):1286-1293. View abstract
  14. Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience. J Perinatol. 2020 01; 40(1):112-117. View abstract
  15. Interobserver and Intra-Observer Reliability of the Urinary Tract Dilation Classification System in Neonates: A Multicenter Study. J Urol. 2019 06; 201(6):1186-1192. View abstract
  16. Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract. J Am Soc Nephrol. 2018 09; 29(9):2348-2361. View abstract
  17. Collaborating with our adult colleagues: A case series of robotic surgery for suspicious and cancerous lesions in children and young adults performed in a free-standing children's hospital. J Pediatr Urol. 2018 04; 14(2):182.e1-182.e8. View abstract
  18. Has the robot caught up? National trends in utilization, perioperative outcomes, and cost for open, laparoscopic, and robotic pediatric pyeloplasty in the United States from 2003 to 2015. J Pediatr Urol. 2018 08; 14(4):336.e1-336.e8. View abstract
  19. Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int. 2017 07; 120(1):130-142. View abstract
  20. Urinary NGAL deficiency in recurrent urinary tract infections. Pediatr Nephrol. 2017 06; 32(6):1077-1080. View abstract
  21. Biomarkers for Wilms Tumor: A Brave New World. J Urol. 2016 11; 196(5):1337-1338. View abstract
  22. Urinary Proteomics Yield Pathological Insights for Ureteropelvic Junction Obstruction. Mol Cell Proteomics. 2016 08; 15(8):2607-15. View abstract
  23. Universal Solid-Phase Reversible Sample-Prep for Concurrent Proteome and N-Glycome Characterization. J Proteome Res. 2016 Mar 04; 15(3):891-9. View abstract
  24. Targeted sequencing of 96 renal developmental microRNAs in 1213 individuals from 980 families with congenital anomalies of the kidney and urinary tract. Nephrol Dial Transplant. 2016 08; 31(8):1280-3. View abstract
  25. Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases. Am J Surg Pathol. 2015 Aug; 39(8):1121-31. View abstract
  26. Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development. Am J Hum Genet. 2015 Aug 06; 97(2):291-301. View abstract
  27. Dual modifications strategy to quantify neutral and sialylated N-glycans simultaneously by MALDI-MS. Anal Chem. 2014 Jul 01; 86(13):6277-84. View abstract
  28. Can we do better? J Urol. 2014 Apr; 191(4):893-4. View abstract
  29. Multi-planar dynamic contrast-enhanced ultrasound assessment of blood flow in a rabbit model of testicular torsion. Ultrasound Med Biol. 2014 Feb; 40(2):361-70. View abstract
  30. The GlycoFilter: a simple and comprehensive sample preparation platform for proteomics, N-glycomics and glycosylation site assignment. Mol Cell Proteomics. 2013 Oct; 12(10):2981-91. View abstract
  31. An in-depth comparison of the male pediatric and adult urinary proteomes. Biochim Biophys Acta. 2014 May; 1844(5):1044-50. View abstract
  32. SweetSEQer, simple de novo filtering and annotation of glycoconjugate mass spectra. Mol Cell Proteomics. 2013 Jun; 12(6):1735-40. View abstract
  33. A classifier based on accurate mass measurements to aid large scale, unbiased glycoproteomics. Mol Cell Proteomics. 2013 Apr; 12(4):1017-25. View abstract
  34. PNGase F catalyzes de-N-glycosylation in a domestic microwave. Anal Biochem. 2012 Aug 01; 427(1):33-5. View abstract
  35. Economic and radiation costs of initial imaging approaches after a child's first febrile urinary tract infection. Clin Pediatr (Phila). 2012 Jan; 51(1):23-30. View abstract
  36. Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis. Pediatrics. 2010 Nov; 126(5):865-71. View abstract
  37. One-step sample concentration, purification, and albumin depletion method for urinary proteomics. J Proteome Res. 2010 Nov 05; 9(11):6082-9. View abstract
  38. The predictive value of the first postnatal ultrasound in children with antenatal hydronephrosis. J Pediatr Urol. 2011 Apr; 7(2):128-36. View abstract
  39. Sonourethrogram to manage adolescent anterior urethral stricture. J Urol. 2010 Oct; 184(4 Suppl):1699-702. View abstract
  40. Radiation dose and screening for vesicoureteral reflux. AJR Am J Roentgenol. 2010 Feb; 194(2):W243. View abstract
  41. Robot-assisted laparoscopic nephrectomy and contralateral ureteral reimplantation in children. J Endourol. 2010 Jan; 24(1):123-8. View abstract
  42. Biofeedback training for lower urinary tract symptoms: factors affecting efficacy. J Urol. 2009 Oct; 182(4 Suppl):2050-5. View abstract
  43. Ultrasound versus computerized tomography for evaluating urolithiasis. J Urol. 2009 Oct; 182(4 Suppl):1829-34. View abstract
  44. Nomograms for predicting annual resolution rate of primary vesicoureteral reflux: results from 2,462 children. J Urol. 2009 Oct; 182(4):1535-41. View abstract
  45. Proteomics and opportunities for clinical translation in urological disease. J Urol. 2009 Sep; 182(3):835-43. View abstract
  46. Biomarkers for pediatric urological disease. Curr Opin Urol. 2009 Jul; 19(4):397-401. View abstract
  47. Perinatal Urology. Pediatric Nephrology Ellis Avner and William Harmon, editors. 2009. View abstract
  48. Pediatric Laparoscopic Nephrectomy / Partial Nephrectomy. Glenn’s Urologic Surgery Sam Graham and Thomas Keane, editors . 2009. View abstract
  49. Robot assisted laparoscopic partial nephrectomy: a viable and safe option in children. J Urol. 2009 Feb; 181(2):823-8; discussion 828-9. View abstract
  50. Optimizing sample handling for urinary proteomics. J Proteome Res. 2008 Sep; 7(9):4022-30. View abstract
  51. Does the Deflux procedure reduce the incidence of urinary tract infections in children with vesicoureteral reflux? Nat Clin Pract Urol. 2008 Apr; 5(4):182-3. View abstract
  52. Temporal variations of the postnatal rat urinary proteome as a reflection of systemic maturation. Proteomics. 2008 Mar; 8(5):1097-112. View abstract
  53. Robot-assisted laparoscopic ileal bladder augmentation: defining techniques and potential pitfalls. J Endourol. 2008 Feb; 22(2):355-60. View abstract
  54. Obstruction of the Urinary Tract, including Hydronephrosis. Hansen AR, Puder M, editors. Manual of Neonatal Surgical Intensive Care. 2008. View abstract
  55. Laparoscopic reoperative pediatric pyeloplasty with robotic assistance. J Endourol. 2007 Oct; 21(10):1137-40. View abstract
  56. Early results of robot assisted laparoscopic lithotomy in adolescents. J Urol. 2007 Jun; 177(6):2306-9; discussion 2309-10. View abstract
  57. Ureteral complications in renal transplantation: a comparison of the Lich-Gregoir versus the Taguchi technique. Transplant Proc. 2007 Jun; 39(5):1461-4. View abstract
  58. Determining the optimal method of extracting proteins from urine for proteomic biomarker discovery. American Society of Mass Spectrometry. 2007. View abstract
  59. Health A to Z: Male Infertility. 2007. View abstract
  60. Health A to Z: Phimosis and Paraphimosis. 2007. View abstract
  61. Health A to Z: Priapism. 2007. View abstract
  62. Ask the Expert: Cystoscopy. 2007. View abstract
  63. Can a complete primary repair approach be applied to cloacal exstrophy? J Urol. 2006 Dec; 176(6 Pt 1):2643-8. View abstract
  64. Global methods for protein glycosylation analysis by mass spectrometry. Biochim Biophys Acta. 2006 Dec; 1764(12):1870-80. View abstract
  65. Applying the ALARA concept to the evaluation of vesicoureteric reflux. Pediatr Radiol. 2006 Sep; 36 Suppl 2:185-91. View abstract
  66. Antenatal hydronephrosis as a predictor of postnatal outcome: a meta-analysis. Pediatrics. 2006 Aug; 118(2):586-93. View abstract
  67. Robotic surgery for ureteropelvic junction obstruction. Curr Opin Urol. 2006 Jul; 16(4):291-4. View abstract
  68. Health A to Z: Peyronies Disease. 2006. View abstract
  69. Ask the Expert: Radiation treatment and the bladder. 2006. View abstract
  70. The SeqR – a software tool for the analysis of high accuracy mass spectral data. American Society of Mass Spectrometry,. 2006. View abstract
  71. A proteomics platform based on spectrum alignment for de novo sequencing by LTQ FT MS. American Society of Mass Spectrometry. 2006. View abstract
  72. Health A to Z: Impotence. 2006. View abstract
  73. Health A to Z: Retrograde Ejaculation. 2006. View abstract
  74. Pediatric robot assisted laparoscopic dismembered pyeloplasty: comparison with a cohort of open surgery. J Urol. 2006 Feb; 175(2):683-7; discussion 687. View abstract
  75. Pediatric retroperitoneal laparoscopic partial nephrectomy: comparison with an age matched cohort of open surgery. J Urol. 2005 Aug; 174(2):708-11; discussion 712. View abstract
  76. Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine. Am J Transplant. 2005 Jul; 5(7):1626-34. View abstract
  77. Health A to Z: Epididymitis and Orchitis. 2005. View abstract
  78. Symptomatic refluxing distal ureteral stumps after nephroureterectomy and heminephroureterectomy. What should we do? J Urol. 2005 Jan; 173(1):204-6; discussion 206. View abstract
  79. Commentary on: Timing of Follow-up Voiding Cystourethrogram in Children with Primary Vesicoureteral Reflux: Development and Application of a Clinical Algorithm. American Journal of Urology Review. 2005; 3(11):481-3. View abstract
  80. Molecular cloning and characterization of canine ICOS. Genomics. 2004 Oct; 84(4):730-6. View abstract
  81. Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs. Blood. 2004 Dec 15; 104(13):4311-8. View abstract
  82. Intracorporeal laparoscopic appendicovesicostomy: a case report of a novel approach. J Urol. 2004 May; 171(5):1899. View abstract
  83. Vasoepididymostomy. Graham SD, editor. Glenn's Urology Surgery. 2004; 455-461. View abstract
  84. Traumatic renal artery pseudoaneurysm: diagnosis and management techniques. J Trauma. 2003 Nov; 55(5):972-8. View abstract
  85. FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model. Transplantation. 2003 Oct 27; 76(8):1155-8. View abstract
  86. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population. Transplantation. 2003 Aug 27; 76(4):625-31. View abstract
  87. Postgrafting immunosuppression with sirolimus and cyclosporine facilitates stable mixed hematopoietic chimerism in dogs given sublethal total body irradiation before marrow transplantation from DLA-identical littermates. Biol Blood Marrow Transplant. 2003 Aug; 9(8):489-95. View abstract
  88. Intermediate outcomes of dual renal allografts. Transplant Proc. 2003 Mar; 35(2):854-5. View abstract
  89. Intermediate outcomes of dual renal allografts: the University of Washington experience. J Urol. 2003 Mar; 169(3):855-8. View abstract
  90. Survival of small bowel transplants in canine mixed hematopoietic chimeras: preliminary results. Transplant Proc. 2002 Dec; 34(8):3366-7. View abstract
  91. Percutaneous central dual-lumen catheter for apheresis in the canine. J Invest Surg. 2002 Nov-Dec; 15(6):337-41. View abstract
  92. A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res. 2002 Apr; 12(4):543-54. View abstract
  93. Treatment outcomes in localized prostate cancer: a patient-oriented approach. Semin Urol Oncol. 2002 Feb; 20(1):63-73. View abstract
  94. Salvage anterior C1-C2 screw fixation and arthrodesis through the lateral approach in a patient with a symptomatic pseudoarthrosis. Am J Orthop (Belle Mead NJ). 1997 May; 26(5):349-53. View abstract
  95. Cervical Orthoses: A biomechanical and functional review. Jefferson Orthopaedic J. 1995; 24:29-36. View abstract
  96. An Examination of the Application of a Proton Exchange Membrane Fuel Cell for Cogeneration in a Hospital. 1994. View abstract