EDUCATION

Medical School

  • Colombian School of Medicine , 1991 , Bogota , Colombia

Internship

Surgical
  • Boston University , 1997 , Boston , MA

Residency

Anesthesia
  • Brigham and Women's Hospital , 2000 , Boston , MA

Fellowship

Pediatric Anesthesia and Critical Care
  • Boston Children's Hospital , 2001 , Boston , MA

Fellowship

Research
  • Boston Children's Hospital , 2002 , Boston , MA

CERTIFICATIONS

  • American Board of Anesthesiology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus. Thromb Haemost. 2020 Dec; 120(12):1668-1679. View abstract
  2. In silico features of ADAMTS13 contributing to plasmatic ADAMTS13 levels in neonates with congenital heart disease. Thromb Res. 2020 09; 193:66-76. View abstract
  3. TissueCoCoPUTs: Novel Human Tissue-Specific Codon and Codon-Pair Usage Tables Based on Differential Tissue Gene Expression. J Mol Biol. 2020 05 15; 432(11):3369-3378. View abstract
  4. Magnetic Resonance-Based Diagnostics for Bleeding Assessment in Neonatal Cardiac Surgery. Ann Thorac Surg. 2020 06; 109(6):1931-1936. View abstract
  5. Transition from Hemochron Response to Hemochron Signature Elite Activated Clotting Time Devices in a Congenital Cardiac Surgery Practice. J Extra Corpor Technol. 2019 Dec; 51(4):221-226. View abstract
  6. A Single Synonymous Variant (c.354G>A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity. Int J Mol Sci. 2019 Nov 15; 20(22). View abstract
  7. Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery. Br J Anaesth. 2019 12; 123(6):839-852. View abstract
  8. Translational and transcriptional responses in human primary hepatocytes under hypoxia. Am J Physiol Gastrointest Liver Physiol. 2019 06 01; 316(6):G720-G734. View abstract
  9. von Willebrand factor/ADAMTS-13 interactions at birth: implications for thrombosis in the neonatal period. J Thromb Haemost. 2019 Mar; 17(3):429-440. View abstract
  10. Thromboelastography Is Associated With Surrogates for Bleeding After Pediatric Cardiac Operations. Ann Thorac Surg. 2018 09; 106(3):799-806. View abstract
  11. A red cell preservation strategy reduces postoperative transfusions in pediatric heart surgery patients. Paediatr Anaesth. 2018 05; 28(5):450-457. View abstract
  12. Preoperative Thromboelastographic Profile of Patients with Congenital Heart Disease: Association of Hypercoagulability and Decreased Heparin Response. J Cardiothorac Vasc Anesth. 2018 08; 32(4):1657-1663. View abstract
  13. Elevated preoperative von Willebrand factor is associated with perioperative thrombosis in infants and neonates with congenital heart disease. J Thromb Haemost. 2017 12; 15(12):2306-2316. View abstract
  14. Compounding variants rescue the effect of a deleterious ADAMTS13 mutation in a child with severe congenital heart disease. Thromb Res. 2017 10; 158:98-101. View abstract
  15. Relationship Between Transfusion of Blood Products and the Incidence of Thrombotic Complications in Neonates and Infants Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2017 Dec; 31(6):1943-1948. View abstract
  16. Hypoxic preconditioning decreases nuclear factor ?B activity via Disrupted in Schizophrenia-1. Int J Biochem Cell Biol. 2016 Jan; 70:140-8. View abstract
  17. Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. Exp Mol Pathol. 2013 Dec; 95(3):350-56. View abstract
  18. Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. Exp Mol Pathol. 2013 Oct 25. View abstract
  19. ß-Ionone arrests cell cycle of gastric carcinoma cancer cells by a MAPK pathway. Arch Toxicol. 2013 Oct; 87(10):1797-808. View abstract
  20. Methods to assess tissue permeability. Methods Mol Biol. 2013; 1066:81-8. View abstract
  21. Apoptosis initiation of ß-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway. Arch Toxicol. 2013 Mar; 87(3):481-90. View abstract
  22. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63. View abstract
  23. Disrupted in Schizophrenia-1 (DISC1)Regulates ATM-mediated NFkappaB Activation during Hypoxia and Re-oxygenation. FASEB meeting. 2010. View abstract
  24. Dexmedetomidine is less pro-apoptotic than ketamine in the neonatal rat brain. ASA. 2009. View abstract
  25. Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. J Biol Chem. 2009 May 15; 284(20):13686-95. View abstract
  26. Adenosine signaling mediates small ubiquitin-like protein (sumo-1) modification of IKappaBalpha during hypoxia and re-oxygenation. In press, Journal of Biological Chemistry. 2009. View abstract
  27. Anesthesia for Pediatric Thoracic Surgery. Springer Science and Business Media ( Phillip Hartigan). 2009. View abstract
  28. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. 2009; 4(1):11-16. View abstract
  29. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6. View abstract
  30. Noxious Stimulation Attenuates Ketamine and Isoflurane-Induced Neuroapoptosis in the P7 Rat Brain. ASA, 2008. 2008. View abstract
  31. Ketamine Activates Cell Cycle Events and Apoptosis in the Neonatal Rat Brain. ASA, 2008. 2008. View abstract
  32. Pulmonary anti-inflammatory adaptation to hypoxia through adenosine-mediated Cullin-1 Deneddylation. ASA, San Francisco CA. 2007. View abstract
  33. Central Venous Access in the Neonate. 2007. View abstract
  34. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol. 2007 Jun 15; 178(12):8127-37. View abstract
  35. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. FASEB meeting, 2007. Washington DC. 2007. View abstract
  36. Identification of ecto-nucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol, In press. 2007. View abstract
  37. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest. 2007 Mar; 117(3):703-11. View abstract
  38. Mechanical Ventilation of the Neonate. Cambridge Press. 2007. View abstract
  39. Early tracheal extubation after liver or multivisceral transplantation in infant and toddler recipients: Is it safe?. ASA. 2006. View abstract
  40. Transcriptional Repression of Na-K-2Cl-cotransporter NKCC1 by Hypoxia Inducible Factor-1. AJP. Cell Physiol. 2006; 291:C282-C289. View abstract
  41. Identification of Molecular Anti-inflammatory Mechanisms of Adenosine: Cullin-1 Denedddylation during Hypoxic Preconditioning. 8th International Symposium on Adenosine and Adenine Nucleotides. 2006. View abstract
  42. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood. 2006 Sep 01; 108(5):1602-10. View abstract
  43. Endothelial Catabolism of Extracellular Adenosine during Hypoxia: Role of Surface Adenosine Deaminase and CD26. Blood. Epub ahead of print. 2006. View abstract
  44. HIF-dependent Repression of Na-K-2Clcotransporter (NKCC1) in Hypoxia. FASEB meeting 2006. San Francisco CA. 2006. View abstract
  45. Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. . 2006 Aug; 291(2):C282-9. View abstract
  46. Anesthetic Management of a Patient with Hepatopulmonary Syndrome, Prolonged QTc Interval and Panhypopituitarism for Liver Transplantation. Society of Pediatric Anesthesia meeting. 2006. View abstract
  47. Methods to assess tissue permeability. Methods Mol Biol. 2006; 341:111-7. View abstract
  48. Transcriptional Repression of Na-K-2Cl-cotransporter (NKCC1) by Hypoxia Inducible Factor 1. Keystone Symposia. 2005. View abstract
  49. Anesthesia for Emergent non-cardiac Surgery in neonates with Unpalliated Hypoplastic Left Heart Syndrome. SPA/AAP. 2005. View abstract
  50. Methods in Molecular Biology. Methods to Assess Tissue Permeability. Cell-Cell Interactions. 2005; 341:111-117. View abstract
  51. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 06; 200(11):1395-405. View abstract
  52. Critical Role for ecto-5'nucleotidase in pulmonary vascular permeability during hypoxia. ASA. 2004. View abstract
  53. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004 Dec 15; 104(13):3986-92. View abstract
  54. The dynamic influences of hypoxia on extracellular nucleotide metabolism and nucleoside signalling. Purines 2004. 2004. View abstract
  55. Prolonged Ketamine Administration increases brain derived neurotrophic factor in developing rat brains. 2003. View abstract
  56. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med. 2003 Sep 01; 198(5):783-96. View abstract
  57. Implications of hypoxia on mucosal barrier function. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):77-87. View abstract
  58. Lung growth after reduced size transplantation in a sheep model. Transplantation. 1999 Jan 27; 67(2):233-40. View abstract
  59. Insulin-like growth factor-I gene expression in three models of accelerated lung growth. J Pediatr Surg. 1998 Jul; 33(7):1057-60; discussion 1061. View abstract
  60. The use of expandable metallic stents for acute tracheal stenosis in the growing lamb. J Pediatr Surg. 1998 Jul; 33(7):1038-41; discussion 1041-2. View abstract
  61. Lung growth following reduced-size lung transplantation in a sheep model. 1998. View abstract
  62. Pulmonary blood flow distribution during partial liquid ventilation. J Appl Physiol (1985). 1998 May; 84(5):1540-50. View abstract
  63. Insulin like growth factor I gene expression in three models of accelerated lung growth. 1997. View abstract
  64. The use of expandable metallic stents for acute tracheal stenosis in the growing lamb. 1997. View abstract
  65. Effects of nitric oxide on hyperinflation-induced pulmonary hypertension in the isolated-perfused lung. Crit Care Med. 1996 Aug; 24(8):1388-95. View abstract
  66. Continuos intrapulmonary distention with perfluorocarbon does not result in postnatal lung growth in adult sheep. 1996. View abstract
  67. Redistribution of pulmonary blood flow during partial liquid ventilation. 1996. View abstract
  68. University of Wisconsin cerebroplegia in a piglet survival model of circulatory arrest. Ann Thorac Surg. 1995 Dec; 60(6 Suppl):S494-500. View abstract
  69. The effect of nitric oxide on overdistention pulmonary hypertension in the isolated sheep lung model. 1995. View abstract
  70. Limb fractures associated with craneoencephalic trauma. 1991. View abstract