MEDICAL SERVICES
Specialties
- Immune Thrombocytopenia (ITP)
- Hemolytic Anemia
- Anemia
- Pyruvate Kinase Deficiency (PK)
- Sickle Cell Disease
- Thrombosis
Departments
Programs
- Blood Disorders (Hematology) Center
- Platelet Function Disorders Program
- Rare Anemias and Iron Disorders Program
- Sickle Cell Disease Program
- Thrombosis and Anticoagulation Program
Languages
-
English
EDUCATION
Graduate Degree
MMSc
- Harvard Medical School , Boston , MA
Medical School
- Brown University , 2003 , Providence , RI
Internship
Pediatrics
- Boston Children's Hospital/Boston Medical Center , 2004 , Boston , MA
Residency
Pediatrics
- Boston Combined Residency Program (BCRP) , 2006 , Boston , MA
Fellowship
Pediatric Hematology-Oncology
- Boston Children's Hospital/ Dana-Farber Cancer Institute , 2010 , Boston , MA
PROFESSIONAL HISTORY
Rachael Grace, MD, MMSc, is a pediatric hematologist and clinical researcher at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. She is the medical director of both the Hematology Ambulatory Program and the Hematology Clinical Research Program. Dr. Grace enjoys clinical care of pediatric patients and her research interests are focused on improving outcomes in the care and treatment of individuals with immune cytopenias.
Dr. Grace is the lead investigator for the Pyruvate Kinase Deficiency Natural History Study, a global registry for patients with PK deficiency. She is a site investigator for the DRIVE-PK and ACTIVATE mitapivat (AG-348) clinical trials and the PEAK registry. She is also involved in multiple clinical research studies in immune cytopenias and is the director of the coordinating center for the ITP Consortium of North America (ICON), a research network of pediatric idiopathic thrombocytopenic purpura investigators from over 50 institutions in the U.S. and Canada.
Dr. Grace is an Associate Professor of Pediatrics at Harvard Medical School. She received her MD at Brown University and received her master’s degree in clinical research at Harvard Medical School. Dr. Grace completed her residency at Boston Children’s Hospital and completed her pediatric hematology/oncology fellowship at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center.
CERTIFICATIONS
- American Board of Pediatrics, General Pediatrics
- American Board of Pediatrics, Pediatric Hematology and Oncology
PUBLICATIONS
Publications powered by Harvard Catalyst Profiles
- Refractory autoimmune cytopenias in pediatric evans syndrome with underlying systemic immune dysregulation. Eur J Haematol. 2021 Feb 11. View abstract
- International survey on Helicobacter pylori testing in patients with immune thrombocytopenia: Communication of the platelet immunology scientific and standardization committee. J Thromb Haemost. 2021 01; 19(1):287-296. View abstract
- Comorbidities and complications in adults with pyruvate kinase deficiency. Eur J Haematol. 2020 Dec 28. View abstract
- Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method. Res Pract Thromb Haemost. 2021 Jan; 5(1):69-80. View abstract
- Management of pyruvate kinase deficiency in children and adults. Blood. 2020 Sep 10; 136(11):1241-1249. View abstract
- The variable manifestations of disease in pyruvate kinase deficiency and their management. Haematologica. 2020 09 01; 105(9):2229-2239. View abstract
- Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020 11; 146(5):1194-1200.e1. View abstract
- Pyruvate kinase deficiency in a newborn with extramedullary hematopoiesis in the skin. Blood. 2020 08 06; 136(6):770. View abstract
- Characterization of the severe phenotype of pyruvate kinase deficiency. Am J Hematol. 2020 Jul 03. View abstract
- Fatigue in children and adolescents with immune thrombocytopenia. Br J Haematol. 2020 Oct; 191(1):98-106. View abstract
- COVID-19 presenting with autoimmune hemolytic anemia in the setting of underlying immune dysregulation. Pediatr Blood Cancer. 2020 09; 67(9):e28382. View abstract
- The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency. Br J Haematol. 2020 May 28. View abstract
- The role of romiplostim for pediatric patients with immune thrombocytopenia. Ther Adv Hematol. 2020; 11:2040620720912992. View abstract
- The variable manifestations of disease in pyruvate kinase deficiency and their management. Haematologica. 2020 Mar 12. View abstract
- Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency. Am J Hematol. 2020 05; 95(5):472-482. View abstract
- Development of the pyruvate kinase deficiency diary and pyruvate kinase deficiency impact assessment: Disease-specific assessments. Eur J Haematol. 2020 May; 104(5):427-434. View abstract
- Genetic variants in toll-like receptor 4 are associated with lack of steroid-responsiveness in pediatric ITP patients. Am J Hematol. 2020 Jan 05. View abstract
- American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019 12 10; 3(23):3829-3866. View abstract
- Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency. N Engl J Med. 2019 09 05; 381(10):933-944. View abstract
- Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes. Am J Hematol. 2019 07; 94(7):741-750. View abstract
- Pediatric Hematology. Hematol Oncol Clin North Am. 2019 06; 33(3):xiii-xiv. View abstract
- Association of a positive direct antiglobulin test with chronic immune thrombocytopenia and use of second line therapies in children: A multi-institutional review. Am J Hematol. 2019 04; 94(4):461-466. View abstract
- How we manage patients with pyruvate kinase deficiency. Br J Haematol. 2019 03; 184(5):721-734. View abstract
- The burden of disease in pyruvate kinase deficiency: Patients' perception of the impact on health-related quality of life. Eur J Haematol. 2018 Dec; 101(6):758-765. View abstract
- Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. Haematologica. 2019 02; 104(2):e51-e53. View abstract
- Ofatumumab for acute treatment and prophylaxis of a patient with multiple relapses of acquired thrombotic thrombocytopenic purpura. J Thromb Thrombolysis. 2018 Jul; 46(1):81-83. View abstract
- Red Blood Cell Enzyme Disorders. Pediatr Clin North Am. 2018 06; 65(3):579-595. View abstract
- Physician decision making in selection of second-line treatments in immune thrombocytopenia in children. Am J Hematol. 2018 07; 93(7):882-888. View abstract
- Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood. 2018 05 17; 131(20):2183-2192. View abstract
- The use of prophylactic anticoagulation during induction and consolidation chemotherapy in adults with acute lymphoblastic leukemia. J Thromb Thrombolysis. 2018 Feb; 45(2):306-314. View abstract
- Platelet Function in ITP, Independent of Platelet Count, Is Consistent Over Time and Is Associated with Both Current and Subsequent Bleeding Severity. Thromb Haemost. 2018 01; 118(1):143-151. View abstract
- Predictors of remission in children with newly diagnosed immune thrombocytopenia: Data from the Intercontinental Cooperative ITP Study Group Registry II participants. Pediatr Blood Cancer. 2018 Jan; 65(1). View abstract
- Second-line therapies in immune thrombocytopenia. Hematology Am Soc Hematol Educ Program. 2016 Dec 02; 2016(1):698-706. View abstract
- Increasing observation rates in low-risk pediatric immune thrombocytopenia using a standardized clinical assessment and management plan (SCAMP® ). Pediatr Blood Cancer. 2017 05; 64(5). View abstract
- Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia. Cold Spring Harb Mol Case Stud. 2016 Jul; 2(4):a000885. View abstract
- Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study. Pediatr Blood Cancer. 2016 08; 63(8):1407-13. View abstract
- Vitamin B12 Deficiency Presenting with Neurological Dysfunction in an Adolescent. Pediatr Neurol. 2016 09; 62:66-70. View abstract
- Erythrocyte pyruvate kinase deficiency: 2015 status report. Am J Hematol. 2015 Sep; 90(9):825-30. View abstract
- Thrombopoietin-receptor agonists in children with immune thrombocytopenia. Lancet. 2015 Oct 24; 386(10004):1606-9. View abstract
- Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood. 2015 Aug 13; 126(7):873-9. View abstract
- Image-guided core needle biopsy in the diagnosis of malignant lymphoma. Eur J Surg Oncol. 2015 Jul; 41(7):852-8. View abstract
- The utility of the DDAVP challenge test in children with low von Willebrand factor. Br J Haematol. 2015 Sep; 170(6):884-6. View abstract
- Treatment and outcomes of immune cytopenias following solid organ transplant in children. Pediatr Blood Cancer. 2015 02; 62(2):214-218. View abstract
- The use of erythropoietin-stimulating agents versus supportive care in newborns with hereditary spherocytosis: a single centre's experience. Eur J Haematol. 2014 Aug; 93(2):161-4. View abstract
- Standardized clinical assessment and management plans (SCAMPs): perspectives on a new method to understand treatment decisions and outcomes in immune thrombocytopenia. Semin Hematol. 2013 Jan; 50 Suppl 1:S31-8. View abstract
- A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload. Blood. 2012 Apr 05; 119(14):3263-8. View abstract
- Trends in anti-D immune globulin for childhood immune thrombocytopenia: usage, response rates, and adverse effects. Am J Hematol. 2012 Mar; 87(3):315-7. View abstract
- Applicability of 2009 international consensus terminology and criteria for immune thrombocytopenia to a clinical pediatric population. Pediatr Blood Cancer. 2012 Feb; 58(2):216-20. View abstract
- Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia. Pediatr Blood Cancer. 2012 Feb; 58(2):221-5. View abstract
- The frequency and management of asparaginase-related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute consortium protocols. Br J Haematol. 2011 Feb; 152(4):452-9. View abstract
- Unsuspected pulmonary emboli in pediatric oncology patients: detection with MDCT. AJR Am J Roentgenol. 2010 May; 194(5):1216-22. View abstract
- Genetic studies in pediatric ITP: outlook, feasibility, and requirements. Ann Hematol. 2010 Jul; 89 Suppl 1:S95-103. View abstract
- Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea. Am J Hematol. 2010 Feb; 85(2):135-7. View abstract
- Compliance with immunizations in splenectomized individuals with hereditary spherocytosis. Pediatr Blood Cancer. 2009 Jul; 52(7):865-7. View abstract
- Rituximab for adolescents with haemophilia and high titre inhibitors. Haemophilia. 2006 May; 12(3):218-22. View abstract
- Cardiac presentation of ALK positive anaplastic large cell lymphoma. Eur J Haematol. 2005 Dec; 75(6):511-4. View abstract
- Ivermectin is better than benzyl benzoate for childhood scabies in developing countries. J Paediatr Child Health. 2002 Aug; 38(4):401-4. View abstract
- Transmembrane versus soluble stem cell factor expression in human testis. J Androl. 2000 Jul-Aug; 21(4):579-85. View abstract
- Fludarabine, cytarabine, G-CSF and idarubicin (FLAG-IDA) for the treatment of poor-risk myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol. 1997 Dec; 99(4):939-44. View abstract
- Ligand linked assembly of Scapharca dimeric hemoglobin. J Biol Chem. 1997 Feb 28; 272(9):5689-94. View abstract