EDUCATION

Medical School

  • Case Western Reserve University , 1981 , Cleveland , OH

Internship

  • University of Minnesota Hospital & Clinics , 1982 , Minneapolis , MN

Residency

  • Boston Children's Hospital , 1984 , Boston , MA

Residency

  • Beth Israel Deaconess Medical Center , 1985 , Boston , MA

Fellowship

  • Boston Children's Hospital / Massachusetts General Hospital , 1988 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Gastroenterology

PUBLICATIONS

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  1. mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion. Hum Mol Genet. 2021 Jun 26; 30(14):1273-1282. View abstract
  2. The synergistic effect of dexmedetomidine on propofol for paediatric deep sedation: A randomised trial. Eur J Anaesthesiol. 2021 05 01; 38(5):541-547. View abstract
  3. Response to Letter to the Editor on "Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up". J Pediatr Gastroenterol Nutr. 2020 10; 71(4):e136-e137. View abstract
  4. Barrett Esophagus and Intestinal Metaplasia of the Gastroesophageal Junction in Children: A Clinicopathologic Study. J Pediatr Gastroenterol Nutr. 2020 05; 70(5):562-567. View abstract
  5. Endoscopic cyst gastrostomy for traumatic pancreatic pseudocysts in children: a case series. Trauma Surg Acute Care Open. 2020; 5(1):e000456. View abstract
  6. Esophageal Capsule Endoscopy in Children and Young Adults With Portal Hypertension. J Pediatr Gastroenterol Nutr. 2019 12; 69(6):641-647. View abstract
  7. Successful Treatment of Juvenile Polyposis of Infancy With Sirolimus. Pediatrics. 2019 08; 144(2). View abstract
  8. Thoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study. J Pediatr Surg. 2019 Mar; 54(3):572-576. View abstract
  9. Acute Pancreatitis in a Patient with Maple Syrup Urine Disease: A Management Paradox. J Pediatr. 2018 07; 198:313-316. View abstract
  10. Metastatic rhabdomyosarcoma mimicking autoimmune pancreatitis diagnosed by EUS-guided fine-needle biopsy. Gastrointest Endosc. 2018 Sep; 88(3):562-563. View abstract
  11. New therapies for vascular anomalies of the gastrointestinal tract. Minerva Pediatr. 2018 Jun; 70(3):303-307. View abstract
  12. Initial Pain Management in Pediatric Acute Pancreatitis: Opioid Versus Non-opioid. J Pediatr Gastroenterol Nutr. 2018 02; 66(2):295-298. View abstract
  13. Gastrointestinal Bleeding and Management. Pediatr Clin North Am. 2017 06; 64(3):543-561. View abstract
  14. Specialized Imaging and Procedures in Pediatric Pancreatology: A North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Clinical Report. J Pediatr Gastroenterol Nutr. 2017 03; 64(3):472-484. View abstract
  15. Specialized Imaging and Procedures in Pediatric Pancreatology: A NASPGHAN Clinical Report. J Pediatr Gastroenterol Nutr. 2016 Aug 06. View abstract
  16. Gastrointestinal Infantile Hemangioma: Presentation and Management. J Pediatr Gastroenterol Nutr. 2015 Oct; 61(4):415-20. View abstract
  17. PTEN hamartoma tumour syndrome: early tumour development in children. Arch Dis Child. 2015 Jan; 100(1):34-7. View abstract
  18. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol. 2014 Jan; 16(1):108-17. View abstract
  19. Synthetic niches for differentiation of human embryonic stem cells bypassing embryoid body formation. . 2014 Jul; 102(5):1101-12. View abstract
  20. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol. 2011 Nov 27; 29(12):1132-44. View abstract
  21. A Pilot Study of Ketamine versus Midazolam/Fentanyl Sedation in Children Undergoing GI Endoscopy. Int J Pediatr. 2011; 2011:623710. View abstract
  22. Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases. Mol Ther. 2011 May; 19(5):942-50. View abstract
  23. Culture of human pluripotent stem cells on glass slides for high-resolution imaging. Methods Mol Biol. 2011; 767:161-73. View abstract
  24. Portomesenteric venous thrombosis associated with rectal venous malformations. J Pediatr Surg. 2010 Jun; 45(6):1221-7. View abstract
  25. Juvenile polyps: recurrence in patients with multiple and solitary polyps. Clin Gastroenterol Hepatol. 2010 Sep; 8(9):795-9. View abstract
  26. Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells. In Vitro Cell Dev Biol Anim. 2010 Apr; 46(3-4):247-58. View abstract
  27. Macrocystic lymphatic malformation in the pulmonary parenchyma. Ann Thorac Surg. 2009 May; 87(5):1607-9. View abstract
  28. Matrix metalloproteinases in the urine and tissue of patients with juvenile polyps: potential biomarkers for the presence of polyps. J Pediatr Gastroenterol Nutr. 2009 Apr; 48(4):405-11. View abstract
  29. Atypical manifestation of patent ductus venosus in a child: intervening against a paradoxical presentation. J Vasc Interv Radiol. 2009 Apr; 20(4):537-42. View abstract
  30. Increased incidence of urinary matrix metalloproteinases as predictors of disease in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2008 Aug; 14(8):1091-6. View abstract
  31. Efficiency of propofol versus midazolam and fentanyl sedation at a pediatric teaching hospital: a prospective study. Gastrointest Endosc. 2008 Jun; 67(7):1067-75. View abstract
  32. Eosinophilic esophagitis: endoscopic findings. Gastrointest Endosc Clin N Am. 2008 Jan; 18(1):45-57; viii. View abstract
  33. Cell-cell signaling through NOTCH regulates human embryonic stem cell proliferation. Stem Cells. 2008 Mar; 26(3):715-23. View abstract
  34. Gastrointestinal tract involvement in Langerhans cell histiocytosis: case report and literature review. Pediatrics. 2006 Nov; 118(5):e1593-9. View abstract
  35. Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia. Am J Gastroenterol. 2006 Jul; 101(7):1666-70. View abstract
  36. Microstream capnography improves patient monitoring during moderate sedation: a randomized, controlled trial. Pediatrics. 2006 Jun; 117(6):e1170-8. View abstract
  37. Complex pancreatic vascular anomalies in children. J Pediatr Surg. 2006 Mar; 41(3):473-8. View abstract
  38. Combined endoscopic cautery and clip closure of chronic gastrocutaneous fistulas. Gastrointest Endosc. 2005 Sep; 62(3):432-5. View abstract
  39. Cutaneovisceral angiomatosis with thrombocytopenia. Pediatr Dev Pathol. 2005 Jul-Aug; 8(4):407-19. View abstract
  40. Air embolism during intraoperative endoscopic localization and surgical resection for blue rubber bleb nevus syndrome. Anesthesiology. 2005 Jun; 102(6):1279-80. View abstract
  41. Blue rubber bleb nevus syndrome: surgical eradication of gastrointestinal bleeding. Ann Surg. 2005 Mar; 241(3):523-8. View abstract
  42. Endoscopic placement of the capsule endoscope in children. Gastrointest Endosc. 2004 Nov; 60(5):818-21. View abstract
  43. Randomized pilot study of a new atrial-based minimal ventricular pacing mode in dual-chamber implantable cardioverter-defibrillators. Heart Rhythm. 2004 Jul; 1(2):160-7. View abstract
  44. Association of Schatzki ring with eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2004 Apr; 38(4):436-41. View abstract
  45. Human embryonic stem cells: multilineage differentiation and mechanisms of self-renewal. Arch Med Res. 2003 Nov-Dec; 34(6):558-64. View abstract
  46. Imaging characteristics of blue rubber bleb nevus syndrome. AJR Am J Roentgenol. 2003 Oct; 181(4):1041-8. View abstract
  47. Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Biochim Biophys Acta. 2003 Jul 30; 1638(3):208-16. View abstract
  48. High-resolution EUS in children with eosinophilic "allergic" esophagitis. Gastrointest Endosc. 2003 Jan; 57(1):30-6. View abstract
  49. Diagnosis and management of MNGIE syndrome in children: case report and review of the literature. J Pediatr Gastroenterol Nutr. 2002 Sep; 35(3):377-83. View abstract
  50. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002 Aug; 56(2):260-70. View abstract
  51. Morphology of the cardia and significance of carditis in pediatric patients. Am J Surg Pathol. 2002 Aug; 26(8):1032-9. View abstract
  52. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002 May; 122(5):1216-25. View abstract
  53. Research agenda for pediatric gastroenterology, hepatology and nutrition: endoscopy. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S254-7. View abstract
  54. Visceral vascular anomalies. Gastrointest Endosc Clin N Am. 2001 Oct; 11(4):813-34, viii. View abstract
  55. Laparoscopic and thoracoscopic esophagomyotomy for children with achalasia. J Pediatr Gastroenterol Nutr. 2001 Oct; 33(4):466-71. View abstract
  56. Endorectal pull-through abates gastrointestinal hemorrhage from colorectal venous malformations. J Pediatr Surg. 2000 Jun; 35(6):982-4. View abstract
  57. Gastrointestinal bleeding in infancy and childhood. Gastroenterol Clin North Am. 2000 Mar; 29(1):37-66, v. View abstract
  58. Endoscopic retrograde cholangiopancreatography in children. Subcommittee on Endoscopy and Procedures of the Patient Care Committee of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2000 Mar; 30(3):335-42. View abstract
  59. Pediatric endoscopy. Gastrointest Endosc Clin N Am. 2000 Jan; 10(1):175-94, viii. View abstract
  60. Allergic esophagitis in children: a clinicopathological entity. Am J Surg Pathol. 1999 Apr; 23(4):390-6. View abstract
  61. Mitochondrial neurogastrointestinal encephalomyopathy: diagnosis by rectal biopsy. Am J Surg Pathol. 1998 Sep; 22(9):1141-7. View abstract
  62. Use of octreotide for the treatment of severe gastrointestinal bleeding in children. J Pediatr Gastroenterol Nutr. 1998 Mar; 26(3):356-9. View abstract
  63. Clinical competency in pediatric endoscopy. J Pediatr Gastroenterol Nutr. 1998 Feb; 26(2):200-4. View abstract
  64. Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. Hepatology. 1997 May; 25(5):1176-83. View abstract
  65. Complications following percutaneous endoscopic gastrostomy and subsequent catheter replacement in children and young adults. Gastrointest Endosc. 1997 Jan; 45(1):64-71. View abstract
  66. Outpatient liver biopsy in children: a medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1996 Oct; 23(3):213-6. View abstract
  67. Endoscopic band ligation of a Dieulafoy lesion in the small intestine of a child. Gastrointest Endosc. 1996 Sep; 44(3):336-9. View abstract
  68. Endoscopic ligation of esophageal varices in children. J Pediatr Gastroenterol Nutr. 1995 Feb; 20(2):202-8. View abstract
  69. Lymphocytes bearing the gamma delta T-cell receptor in normal human intestine and celiac disease. Hum Pathol. 1991 Jul; 22(7):690-4. View abstract
  70. Isolation and restriction map of the V-J interval of the human T cell receptor gamma chain locus. Genomics. 1989 Apr; 4(3):445-8. View abstract
  71. Gastrointestinal bleeding due to oral dicloxacillin therapy for osteomyelitis. Pediatrics. 1979 Apr; 63(4):676-7. View abstract
  72. Antigenic variation of rhinovirus type 22. . 1970 Jan; 133(1):329-33. View abstract