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    Dana-Farber Cancer Institute450 Brookline AvenueBoston, Massachusetts 02215
    New Patients: 1-888-PEDI-ONC (733-4662); Existing Patients: 617-632-3270

Lindsay Frazier, MD

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Associate Professor of Epidemiology, Harvard School of Public Health; Associate Professor of Pediatrics, Harvard Medical School
Primary Office Location: Dana-Farber Cancer Institute450 Brookline AvenueBoston, Massachusetts 02215

Contact: 617-632-2273

Fax: 617-632-5710

Appointments:New Patients: 1-888-PEDI-ONC (733-4662); Existing Patients: 617-632-3270

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    • Departments/Divisions
    • Hematology / Oncology
    • Medicine
    • Services/Programs
    • Hematology / Oncology
    • Hematology / Oncology
    • Hematology / Oncology
  • Cancer Epidemiology

    Cancer Prevention in Children

    Germ Cell Tumors

    Hematology Oncology

  • Medical School

    Dartmouth Medical School, 1984

    Hanover, NH

    Graduate School, Masters in Science

    Harvard School of Public Health, 1993

    Fellowship, Pediatric Hematology/Oncology

    Boston Children's Hospital/Dana-Farber Cancer Institute, 07/87 to 06/89

    Boston, MA

    Internship, Pediatrics

    Boston Children's Hospital, 07/84 to 06/85

    Boston, MA

    Residency, Pediatric

    Boston Children's Hospital, 07/85 to 06/87

    Boston, MA

  • Pediatrics, Pediatric Hematology/Oncology

  • Dr. A. Lindsay Frazier’s clinical focus within pediatric oncology is germ cell tumors (GCT). Her involvement in germ cell tumors ranges from clinical trials, to biology and to epidemiology. She has served on the steering committee of the Childrens’ Oncology Group’s (COG) germ cell committee since 1996 and assumed leadership of the committee in 2007 which entails oversight of all current protocols and development of the strategic initiatives for future protocols across the spectrum of disease from low risk to high risk to salvage therapies.. She has served as the Chair of the COG protocol for low/intermediate risk germ cell tumors protocol (AGCT0132), Vice-Chair of the COG protocol for relapsed germ cell tumors and for high risk germ cell tumors. She has authored numerous papers and chapters on pediatric germ cell tumors and is currently editing a book for Springer of Pediatric Germ Cell Tumors. Dr. Frazier led the formation of an international group of germ cell tumor specialists from the United States and United Kingdom, “MaGIC—the Malignant Germ Cell International Collaboration”  that has merged their clinical trial data from the past 25 years to create a more comprehensive risk classification system now serving as the basis for next generation of international clinical trials currently under review. MaGIC has recently been expanded to include the clinical trial data of the Gynecologic Oncology Group (ovarian GCT) and the Medical Research Council (testicular cancer) so that this risk classification can be developed spanning the adolescent-young adult boundaries. The clinical data can also now be linked to banked biologic specimens. Drs. Frazier and Amatruda have already successfully collaborated on several translational projects utilizing these datasets. Dr. Frazier also holds an appointment in epidemiology at the Harvard School of Public Health and until 2011 served as the co-director of the Growing Up Today Study, a national cohort study of 27,000 offspring of the women in the Nurses Health Study. Her epidemiologic expertise is of use in the design of the design and interpretation of the data generated by this trial.

  • Cancer Screening, Cancer Prevention, Risk Behaviors in Adolescents, Outcomes, Germ Cell Tumors Cost-effectiveness of cancer screening (JAMA 284:1954, 2000) Diet and weight control in adolescents (Pediatrics 104:918, 1999; Am J Epidemiol 152:446, 2000; JAMA 285:2461, 2001; Cancer Causes Control 15: 73, 2004) Impact of cancer prevention behaviors in children and adolescents on causes of adult malignancies: tobacco use, infection with human papilloma virus, sun skin damage, and diet (Pediatrics 109:1009, 2002; Breast Cancer Res 5:R59, 2003; Pediatrics 117:e688, 2006) Germ cell tumors (J Clin Oncol 24:2544, 2006)

The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”
- Sandra L. Fenwick, President and CEO