MEDICAL SERVICES

EDUCATION

Medical School

  • University of Pennsylvania School of Medicine , 2004 , Philadelphia , PA

Internship

  • Children’s Hospital of Philadelphia , 2005 , Philadelphia , PA

Residency

Pediatrics
  • Children’s Hospital of Philadelphia , 2006 , Philadelphia , PA

Fellowship

Pediatric Infectious Diseases
  • Boston Children's Hospital , 2010 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, General Pediatrics
  • American Board of Pediatrics, Infectious Diseases

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. The Ringleaders: Understanding the Apicomplexan Basal Complex Through Comparison to Established Contractile Ring Systems. Front Cell Infect Microbiol. 2021; 11:656976. View abstract
  2. ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nat Immunol. 2021 03; 22(3):347-357. View abstract
  3. Depletion of the mini-chromosome maintenance complex binding protein allows the progression of cytokinesis despite abnormal karyokinesis during the asexual development of Plasmodium falciparum. Cell Microbiol. 2021 03; 23(3):e13284. View abstract
  4. Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25722-25731. View abstract
  5. Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis. PLoS Pathog. 2020 06; 16(6):e1008587. View abstract
  6. Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria. Nature. 2020 06; 582(7810):104-108. View abstract
  7. A Novel Antiparasitic Compound Kills Ring-Stage Plasmodium falciparum and Retains Activity Against Artemisinin-Resistant Parasites. J Infect Dis. 2020 03 02; 221(6):956-962. View abstract
  8. Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome. mSphere. 2020 01 08; 5(1). View abstract
  9. An essential contractile ring protein controls cell division in Plasmodium falciparum. Nat Commun. 2019 05 16; 10(1):2181. View abstract
  10. Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum. mBio. 2018 02 27; 9(1). View abstract
  11. Getting Your Head around Cerebral Malaria. . 2017 11 08; 22(5):586-588. View abstract
  12. Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen. J Infect Dis. 2017 07 15; 216(2):267-275. View abstract
  13. PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum. Nat Commun. 2017 07 05; 8(1):63. View abstract
  14. The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum. mBio. 2017 06 13; 8(3). View abstract
  15. Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Mar 06; 2:17038. View abstract
  16. Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Feb 17; 2:17017. View abstract
  17. Receptor for Activated C-Kinase 1 (PfRACK1) is required for Plasmodium falciparum intra-erythrocytic proliferation. Mol Biochem Parasitol. 2017 01; 211:62-66. View abstract
  18. An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites. Nat Commun. 2016 04 28; 7:11449. View abstract
  19. Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res. 2015 Dec 02; 43(21):10515-24. View abstract
  20. Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. Science. 2014 May 23; 344(6186):871-7. View abstract
  21. Inside scoop on outside proteins. Infect Immun. 2014 Mar; 82(3):921-3. View abstract
  22. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 2012 Jan 13; 335(6065):218-21. View abstract
  23. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10. View abstract
  24. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010 May 14; 328(5980):910-2. View abstract
  25. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 Feb; 75(4):990-1006. View abstract
  26. Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010 Feb; 9(2):228-41. View abstract
  27. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):972-5. View abstract
  28. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85. View abstract
  29. Emergence of community-associated methicillin resistant Staphylococcus aureus in Hawaii, 2001-2003. J Infect. 2007 Apr; 54(4):349-57. View abstract
  30. Intracellular trafficking of HIV-1 cores: journey to the center of the cell. Curr Top Microbiol Immunol. 2003; 281:179-208. View abstract
  31. Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import. J Virol. 2002 Dec; 76(23):12087-96. View abstract
  32. HIV-1 infection requires a functional integrase NLS. Mol Cell. 2001 May; 7(5):1025-35. View abstract
  33. In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail. J Virol. 2001 Jan; 75(1):278-91. View abstract