EDUCATION

Medical School

  • Istanbul School of Medicine , 1986 , Istanbul , Turkey

Residency

  • Monmouth Medical Center , 1999 , Long Branch , NJ

Fellowship

  • Boston Children's Hospital , 2003 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Rheumatology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. JCI Insight. 2021 Aug 17. View abstract
  2. Microbiome is not linked to clinical disease severity of familial Mediterranean fever in an international cohort of children. Clin Exp Rheumatol. 2021 Jul 05. View abstract
  3. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review. World J Otorhinolaryngol Head Neck Surg. 2021 Jul; 7(3):166-173. View abstract
  4. Establishing core domain sets for Chronic Nonbacterial Osteomyelitis (CNO) and Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO): A report from the OMERACT 2020 special interest group. Semin Arthritis Rheum. 2021 Aug; 51(4):957-961. View abstract
  5. Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach. J Allergy Clin Immunol. 2021 May 15. View abstract
  6. Multiple Emergency Department Visits for a Diagnosis of Kawasaki Disease: An Examination of Risk Factors and Outcomes. J Pediatr. 2021 05; 232:127-132.e3. View abstract
  7. Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children. J Clin Invest. 2020 11 02; 130(11):5942-5950. View abstract
  8. Burden of illness in hereditary periodic fevers: a multinational observational patient diary study. Clin Exp Rheumatol. 2020 Sep-Oct; 38 Suppl 127(5):26-34. View abstract
  9. Safety Protocols for Adolescent Substance Use Research in Clinical Settings. J Adolesc Health. 2021 05; 68(5):999-1005. View abstract
  10. Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14405-14411. View abstract
  11. Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group. Pediatr Rheumatol Online J. 2020 Apr 15; 18(1):31. View abstract
  12. Inflammatory manifestations in patients with Shwachman-Diamond syndrome: A novel phenotype. Am J Med Genet A. 2020 07; 182(7):1754-1760. View abstract
  13. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020 03 26; 5(6). View abstract
  14. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2020 02; 79(2):225-231. View abstract
  15. Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma. J Rheumatol. 2020 08 01; 47(8):1242-1252. View abstract
  16. Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study. Pediatr Rheumatol Online J. 2019 Jul 15; 17(1):43. View abstract
  17. Risk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population. J Am Heart Assoc. 2019 06 04; 8(11):e011319. View abstract
  18. Screening and Counseling for Alcohol Use in Adolescents With Chronic Medical Conditions in the Ambulatory Setting. J Adolesc Health. 2019 06; 64(6):804-806. View abstract
  19. Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis. 2019 08; 78(8):1025-1032. View abstract
  20. Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Pediatr Rheumatol Online J. 2019 Feb 14; 17(1):7. View abstract
  21. Vasculitis in Systemic Autoinflammatory Diseases. Front Pediatr. 2018; 6:377. View abstract
  22. Using Smartphone Crowdsourcing to Redefine Normal and Febrile Temperatures in Adults: Results from the Feverprints Study. J Gen Intern Med. 2018 12; 33(12):2046-2047. View abstract
  23. Impact of biologics on disease course in systemic onset juvenile idiopathic arthritis. Clin Rheumatol. 2018 Dec; 37(12):3263-3273. View abstract
  24. In silico validation of the Autoinflammatory Disease Damage Index. Ann Rheum Dis. 2018 11; 77(11):1599-1605. View abstract
  25. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions. Arthritis Care Res (Hoboken). 2018 08; 70(8):1228-1237. View abstract
  26. De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. Mol Genet Metab Rep. 2018 Sep; 16:23-29. View abstract
  27. An international delphi survey for the definition of the variables for the development of new classification criteria for periodic fever aphtous stomatitis pharingitis cervical adenitis (PFAPA). Pediatr Rheumatol Online J. 2018 Apr 18; 16(1):27. View abstract
  28. The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey. Pediatr Rheumatol Online J. 2018 Mar 21; 16(1):19. View abstract
  29. Adding patient-reported outcomes to a multisite registry to quantify quality of life and experiences of disease and treatment for youth with juvenile idiopathic arthritis. J Patient Rep Outcomes. 2018; 2. View abstract
  30. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03; 214(7):1937-1947. View abstract
  31. Predicting Coronary Artery Aneurysms in Kawasaki Disease at a North American Center: An Assessment of Baseline z Scores. J Am Heart Assoc. 2017 May 31; 6(6). View abstract
  32. Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Rheumatol Int. 2017 Jun; 37(6):883-889. View abstract
  33. Physicians' Perspectives on the Diagnosis and Treatment of Chronic Nonbacterial Osteomyelitis. Int J Rheumatol. 2017; 2017:7694942. View abstract
  34. Periodic Fever, Aphthosis, Pharyngitis, and Adenitis Syndrome: Analysis of Patients From Two Geographic Areas. Arthritis Care Res (Hoboken). 2016 12; 68(12):1859-1865. View abstract
  35. Development of the autoinflammatory disease damage index (ADDI). Ann Rheum Dis. 2017 May; 76(5):821-830. View abstract
  36. Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS). Ann Rheum Dis. 2017 Jun; 76(6):942-947. View abstract
  37. Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution. Clin Exp Rheumatol. 2016 Sep-Oct; 34(5):946-952. View abstract
  38. Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 07; 68(7):1758-68. View abstract
  39. A Screening Tool for Assessing Alcohol Use Risk among Medically Vulnerable Youth. PLoS One. 2016; 11(5):e0156240. View abstract
  40. A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S158. View abstract
  41. A119: deep sequencing analysis of the T regulatory and T effector repertoire in juvenile idiopathic arthritis. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S156. View abstract
  42. A81: spectrum of mevalonate kinase deficiency: is colitis more common than we think? Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S114. View abstract
  43. Autoinflammatory diseases in pediatrics. Dermatol Clin. 2013 Jul; 31(3):481-94. View abstract
  44. Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease. EMBO Mol Med. 2013 Feb; 5(2):210-20. View abstract
  45. Pediatric chronic nonbacterial osteomyelitis. Pediatrics. 2012 Nov; 130(5):e1190-7. View abstract
  46. Long-term surgical outcomes of adenotonsillectomy for PFAPA syndrome. Arch Otolaryngol Head Neck Surg. 2012 Oct; 138(10):902-6. View abstract
  47. Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33. View abstract
  48. Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken). 2012 Aug; 64(8):1175-85. View abstract
  49. A novel missense mutation in MVK associated with MK deficiency and dyserythropoietic anemia. Pediatrics. 2010 Apr; 125(4):e964-8. View abstract
  50. Drug-induced autoimmunity. Curr Opin Rheumatol. 2009 Sep; 21(5):547-51. View abstract
  51. Complete and sustained remission of juvenile dermatomyositis resulting from aggressive treatment. Arthritis Rheum. 2009 Jun; 60(6):1825-1830. View abstract
  52. NOD2-associated diseases: Bridging innate immunity and autoinflammation. Clin Immunol. 2010 Mar; 134(3):251-61. View abstract
  53. Chronic minocycline-induced autoimmunity in children. J Pediatr. 2008 Sep; 153(3):314-9. View abstract
  54. B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol. 2008 Jan; 121(1):191-196.e2. View abstract
  55. Vasculitis in children. Rheum Dis Clin North Am. 2007 Aug; 33(3):555-83. View abstract
  56. Update on pediatric vasculitis. Curr Opin Pediatr. 2005 Dec; 17(6):695-702. View abstract
  57. Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. Pediatrics. 2005 Jul; 116(1):e89-93. View abstract
  58. Vasculitis in children. Pediatr Clin North Am. 2005 Apr; 52(2):547-75, vii. View abstract
  59. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med. 2005 Jan 03; 201(1):35-9. View abstract
  60. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. View abstract
  61. Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3903-8. View abstract
  62. Emergency Department management of Lyme disease. Clinical Pediatric Emergency Medicine. 2004; 5(1):54-62. View abstract
  63. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200. View abstract
  64. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002 Sep; 17(3):265-76. View abstract
  65. Successful treatment of retroperitoneal fibrosis with tamoxifen in a child. J Rheumatol. 2001 Jul; 28(7):1693-5. View abstract
  66. “ Periodic Fever Disorders.”. International Seminars in Pediatric Gastroenterology and Nutrition. 2000; 9(3):9-15. View abstract
  67. Cross-reactions of anti-immunoglobulin sera with synthetic T-cell receptor beta peptides: mapping on a 3-dimension model. Adv Exp Med Biol. 1994; 347:93-8. View abstract
  68. Light and heavy chains specifying a human IgM kappa autoantibody to a T-cell receptor V beta-antigen. Immunol Lett. 1993 Nov; 38(3):223-7. View abstract
  69. Reactions of anti-immunoglobulin sera with synthetic T cell receptor peptides: implications for the three-dimensional structure and function of the TCR beta chain. Int Immunol. 1993 May; 5(5):491-502. View abstract
  70. Lack of preferential V beta usage in synovial T cells of rheumatoid arthritis patients. Immunol Res. 1993; 12(1):12-20. View abstract
  71. Human autoantibodies reactive with synthetic autoantigens from T-cell receptor beta chain. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3325-9. View abstract
  72. Antigenic mapping of a human lambda light chain: correlation with three dimensional structure. J Protein Chem. 1992 Apr; 11(2):129-37. View abstract
  73. T-cell receptors of man and mouse studied with antibodies against synthetic peptides. Exp Clin Immunogenet. 1992; 9(2):95-108. View abstract
  74. Antigenic mapping of light chains and T cell receptor beta chains. Adv Exp Med Biol. 1991; 303:235-42. View abstract
  75. "Cross-reactions of anti immunoglobulin sera with T cell receptor-beta peptides: mapping on a 3- dimensional model. Proceedings of the Seventh International Symposium on Immunobiology of Proteins and Peptides. 1991. View abstract
  76. "Antigenic mapping of light chains and Tcell receptor b chain". Proceedings of the Sixth International Symposium on Immunobiology of Proteins and Peptides. 1991; 235-242. View abstract
  77. "Corynebacterium Group D2 infection: A case report". Turkish J. of Infection. 1989; 3(4):450-463. View abstract
  78. "Cases of urinary tract infections caused by Salmonella thyphymurium". Turkish J. of Infection. 1989; 3(2):201-208. View abstract
  79. "Urinary tract infection caused by Corynebacterium jeikeium ( Corynebacterium Group JK) " . Turkish J. of Infection. 1989; 3(4):465-472. View abstract
  80. Leptospirosis: A case report". Turkish J. of Infection. 1989; 3(3):373-380. View abstract