EDUCATION

Undergraduate Degree

  • University of Pennsylvania , 1984 , Philadelphia , PA

Medical School

  • Cornell University Medical College , 1988 , New York , NY

Internship

Pediatrics
  • Yale-New Haven Hospital , 1989 , New Haven , CT

Residency

Pediatrics
  • Yale-New Haven Hospital , 1991 , New Haven , CT

Fellowship

Pediatric Endocrinology
  • Boston Children's Hospital , 1994 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Endocrinology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Pituitary Tumors in Children. Adv Pediatr. 2021 08; 68:211-225. View abstract
  2. Juvenile Granulosa Cell Tumor as the Presenting Feature of McCune-Albright Syndrome. J Endocr Soc. 2021 Sep 01; 5(9):bvab098. View abstract
  3. Undernutrition and Pubertal Timing in Female Survivors of Medulloblastoma and Other Embryonal Tumors. J Clin Endocrinol Metab. 2020 10 01; 105(10). View abstract
  4. Novel predictive scoring system for morbid hypothalamic obesity in patients with pediatric craniopharyngioma. Childs Nerv Syst. 2021 02; 37(2):403-410. View abstract
  5. Clinical Course of Nonfunctional Pituitary Microadenoma in Children: A Single-Center Experience. J Clin Endocrinol Metab. 2019 12 01; 104(12):5906-5912. View abstract
  6. Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective. Horm Res Paediatr. 2019; 92(1):1-14. View abstract
  7. GH Therapy in Childhood Cancer Survivors: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2018 08 01; 103(8):2794-2801. View abstract
  8. Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018 08 01; 103(8):2761-2784. View abstract
  9. Diagnosis of GH Deficiency as a Late Effect of Radiotherapy in Survivors of Childhood Cancers. J Clin Endocrinol Metab. 2018 08 01; 103(8):2785-2793. View abstract
  10. Endocrine Late Effects in Childhood Cancer Survivors. J Clin Oncol. 2018 07 20; 36(21):2153-2159. View abstract
  11. DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments. Eur J Endocrinol. 2017 04; 176(4):R183-R203. View abstract
  12. Fertility and sexual function: a gap in training in pediatric endocrinology. J Pediatr Endocrinol Metab. 2017 Jan 01; 30(1):3-10. View abstract
  13. Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency. Horm Res Paediatr. 2016; 86(6):361-397. View abstract
  14. Update on childhood craniopharyngiomas. Curr Opin Endocrinol Diabetes Obes. 2016 08; 23(4):339-44. View abstract
  15. Klinefelter syndrome: fertility considerations and gaps in knowledge. Transl Pediatr. 2016 Jul; 5(3):183-184. View abstract
  16. Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016 Jun; 174(6):C1-8. View abstract
  17. Sperm Retrieval in Adolescents and Young Adults with Klinefelter Syndrome: A Prospective, Pilot Study. J Pediatr. 2016 Mar; 170:260-5.e1-2. View abstract
  18. Management of testosterone therapy in adolescents and young men with hypogonadism: are we following adult clinical practice guidelines? J Pediatr Endocrinol Metab. 2015 May; 28(5-6):635-40. View abstract
  19. Idiopathic short stature: a clinical review. JAMA. 2014 May 07; 311(17):1787-96. View abstract
  20. JAMA patient page. Short stature. JAMA. 2014 May 07; 311(17):1822. View abstract
  21. Potential role of IGF-1 z score to predict permanent linear growth impairment in children with IBD. J Pediatr Gastroenterol Nutr. 2014 Apr; 58(4):472-6. View abstract
  22. Klinefelter syndrome: are we missing opportunities for early detection? Clin Pediatr (Phila). 2013 Oct; 52(10):936-41. View abstract
  23. Predictors of neoplastic disease in children with isolated pituitary stalk thickening. Pediatr Blood Cancer. 2013 Oct; 60(10):1630-5. View abstract
  24. Isolated central hypothyroidism in young siblings as a manifestation of PROP1 deficiency: clinical impact of whole exome sequencing. Horm Res Paediatr. 2013; 79(6):379-86. View abstract
  25. GLI2 mutations as a cause of hypopituitarism. Pediatr Endocrinol Rev. 2012 Aug; 9(4):706-9. View abstract
  26. Male reproductive health after childhood, adolescent, and young adult cancers: a report from the Children's Oncology Group. J Clin Oncol. 2012 Sep 20; 30(27):3408-16. View abstract
  27. Semen analysis in adolescent cancer patients prior to bone marrow transplantation: when is it too late for fertility preservation? Pediatr Blood Cancer. 2013 Jan; 60(1):129-32. View abstract
  28. Barriers to fertility preservation in male adolescents with cancer: it's time for a multidisciplinary approach that includes urologists. Urology. 2012 Jun; 79(6):1206-9. View abstract
  29. Sleep dysfunction in long term survivors of craniopharyngioma. J Neurooncol. 2012 Jul; 108(3):543-9. View abstract
  30. Genetic disorders of the pituitary. Curr Opin Endocrinol Diabetes Obes. 2012 Feb; 19(1):33-9. View abstract
  31. Late adolescent linear growth pattern in pediatric-onset inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011 Sep; 53(3):246-9. View abstract
  32. Bone density in post-pubertal adolescent survivors of childhood brain tumors. Pediatr Blood Cancer. 2012 Jun; 58(6):959-63. View abstract
  33. Long-term clinical outcomes following treatment of childhood craniopharyngioma. Pediatr Blood Cancer. 2011 Jul 01; 56(7):1120-6. View abstract
  34. Variation in methods of predicting adult height for children with idiopathic short stature. Pediatrics. 2010 Nov; 126(5):938-44. View abstract
  35. Relationship between blood-spot insulin-like growth factor 1 levels and hand-wrist assessment of skeletal maturity. Am J Orthod Dentofacial Orthop. 2009 Jul; 136(1):59-64. View abstract
  36. Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. Horm Res. 2009; 71(2):100-10. View abstract
  37. Assessing skeletal maturity by using blood spot insulin-like growth factor I (IGF-I) testing. Am J Orthod Dentofacial Orthop. 2008 Aug; 134(2):209-16. View abstract
  38. Short stature in a phenotypic male caused by mixed gonadal dysgenesis. Nat Clin Pract Endocrinol Metab. 2008 Sep; 4(9):524-8. View abstract
  39. Cancer treatment and the ovary: the effects of chemotherapy and radiation. Ann N Y Acad Sci. 2008; 1135:123-5. View abstract
  40. Assessment of adrenal suppression in children with asthma treated with inhaled corticosteroids: use of dehydroepiandrosterone sulfate as a screening test. Ann Allergy Asthma Immunol. 2006 Aug; 97(2):182-6. View abstract
  41. Endocrine late effects of cancer treatment. Endocrinol Metab Clin North Am. 2005 Sep; 34(3):769-89, xi. View abstract
  42. Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance. Pediatrics. 2005 Jun; 115(6):e742-8. View abstract
  43. Endocrine Sequelae of Therapy for Cancer in Children. Endo Metab Clin NA. 2005. View abstract
  44. “Endocrine Sequelae in Cancer Survivors”. Syllabus for A Current Review of Endocrinology, Serono Symposium, San Diego, CA. 2005. View abstract
  45. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab. 2003 Oct; 88(10):4832-9. View abstract
  46. Height and weight in children treated for acute lymphoblastic leukemia: relationship to CNS treatment. J Clin Oncol. 2003 Aug 01; 21(15):2953-60. View abstract
  47. A novel nonsense mutation in the Pit-1 gene: evidence for a gene dosage effect. J Clin Endocrinol Metab. 2003 Mar; 88(3):1241-7. View abstract
  48. Endocrine late effects of cancer treatment. Curr Opin Pediatr. 2003 Feb; 15(1):3-9. View abstract
  49. Hypopituitarism . Clinical Management of Pediatric Endocrine Disorders.Radovick S and MacGillivray M, editors. 2003; 3-36. View abstract
  50. “Molecular Basis of Hypopituitarism”. Syllabus for A Current Review of Endocrinology, Serono Symposium, Seattle, WA. 2003. View abstract
  51. Other transcription factors and hypopituitarism. Rev Endocr Metab Disord. 2002 Dec; 3(4):301-11. View abstract
  52. Molecular basis of combined pituitary hormone deficiencies. Endocr Rev. 2002 Aug; 23(4):431-42. View abstract
  53. Eating Dysfunction Following Endoscopic Third Ventriculostomy. American Association of Neurological Surgery. 2002. View abstract
  54. Memory deficits among children with craniopharyngiomas. Neurosurgery. 2001 Nov; 49(5):1053-7; discussion 1057-8. View abstract
  55. Understanding Growth Patterns. Contemporary Pediatrics. 2001; 18:94-122. View abstract
  56. Constitutional Short Stature: Timmy and the “Big Kids”. In: Knight JR and Emans SJ, editors. Bright Futures Case Studies for Primary Care Clinicians, A Guide to the Case Teaching Method; and Growth in Children and Adolescents. U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau. 2001. View abstract
  57. Understanding Growth: Normal vs. Abnormal Patterns. In: Knight JR and Emans SJ, editors. Bright Futures Case Studies for Primary Care Clinicians, A Guide to the Case Teaching Method; and Growth in Children and Adolescents. U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau. 2001. View abstract
  58. cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes. J Biol Chem. 2000 Oct 27; 275(43):33365-72. View abstract
  59. Genetic regulation of the embryology of the pituitary gland and somatotrophs. Endocrine. 2000 Apr; 12(2):99-106. View abstract
  60. CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression. J Clin Invest. 1999 Oct; 104(8):1123-30. View abstract
  61. Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency. Mol Endocrinol. 1999 Mar; 13(3):476-84. View abstract
  62. A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein. Mol Endocrinol. 1999 Feb; 13(2):268-75. View abstract
  63. Transcription Factors and Hypopituitarism. TEM. 1999; 10:326-332. View abstract
  64. “Anterior Pituitary Hormone Deficiencies”. Syllabus for A Current Review of Endocrinology, Serono Symposium, New Orleans, LA. 1999. View abstract
  65. The molecular basis of hypopituitarism. Horm Res. 1998; 49 Suppl 1:30-6. View abstract
  66. Familial Growth Hormone Deficiency Associated with MRI Abnormalities. Amer J Human Genetics. 1998; 80:128-132. View abstract
  67. Optic chiasm astrocytomas of childhood. 1. Long-term follow-up. Pediatr Neurosurg. 1997 Sep; 27(3):121-8. View abstract
  68. Molecular Aspects of Hormone Deficiency Caused by Pit-1 Gene Mutations. Advances in Molecular and Cellular Endocrinology. LeRoith D, editor. 1997; 1:31-50. View abstract
  69. Diencephalic syndrome: Clinical Features and Imaging Findings. Amer J of Neuroradiology. 1997; 18:1499-1505. View abstract
  70. Role of Pit-1 on the Expression of Growth Hormone, Prolactin, and Thyrotropin. Endo Metab Clin NA. 1996; 25:523-540. View abstract
  71. Controversies in Clinical and Surgical Endocrinology. Short Stature. In: Herrera MF, Lerman I, editors. 1996. View abstract
  72. A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates. J Clin Endocrinol Metab. 1995 Feb; 80(2):679-84. View abstract