MEDICAL SERVICES

EDUCATION

Undergraduate Degree

  • Trinity College , 1990 , Hartford , CT

Graduate Degree

PhD
  • University of Connecticut School of Medicine , 1997 , Farmington , CT

Medical School

  • University of Connecticut School of Medicine , 1997 , Farmington , CT

Internship

Pediatrics
  • Yale-New Haven Hospital , New Haven , CT

Residency

Pediatrics
  • Yale-New Haven Hospital , 2000 , New Haven , CT

Fellowship

Pediatric Endocrinology
  • Boston Children's Hospital , 2003 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Endocrinology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Coculture of primary human colon monolayer with human gut bacteria. Nat Protoc. 2021 Aug; 16(8):3874-3900. View abstract
  2. Rosette morphology in zona glomerulosa formation and function. Mol Cell Endocrinol. 2021 06 15; 530:111287. View abstract
  3. Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. Stem Cells. 2021 03; 39(3):296-305. View abstract
  4. False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency. J Pediatr Endocrinol Metab. 2021 Apr 27; 34(4):517-520. View abstract
  5. Organoid culture system for patient-derived lung metastatic osteosarcoma. Med Oncol. 2020 Oct 20; 37(11):105. View abstract
  6. Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. Med (N Y). 2021 Jan 15; 2(1):74-98.e9. View abstract
  7. Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-a Induced Injury. Cell Mol Bioeng. 2020 Oct; 13(5):487-505. View abstract
  8. Wnt/ß-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. Oncogene. 2020 07; 39(30):5282-5291. View abstract
  9. Rapid Prototyping of Multilayer Microphysiological Systems. ACS Biomater Sci Eng. 2021 07 12; 7(7):2949-2963. View abstract
  10. Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. Biomaterials. 2020 09; 254:120125. View abstract
  11. Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell Rep. 2020 04 21; 31(3):107524. View abstract
  12. ß-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nat Commun. 2020 04 03; 11(1):1680. View abstract
  13. Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun. 2020 04 03; 11(1):1679. View abstract
  14. Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. PLoS One. 2020; 15(4):e0230231. View abstract
  15. Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. J Clin Invest. 2020 01 02; 130(1):83-93. View abstract
  16. Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. Cell Mol Gastroenterol Hepatol. 2020; 9(3):507-526. View abstract
  17. Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice. Endocrinology. 2019 10 01; 160(10):2215-2229. View abstract
  18. Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 Jul; 3(7):583. View abstract
  19. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769. View abstract
  20. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 07; 3(7):520-531. View abstract
  21. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome. 2019 03 20; 7(1):43. View abstract
  22. Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. Hypertension. 2019 02; 73(2):407-414. View abstract
  23. A ZNRF3-dependent Wnt/ß-catenin signaling gradient is required for adrenal homeostasis. Genes Dev. 2019 02 01; 33(3-4):209-220. View abstract
  24. The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms. Endocrinology. 2018 12 01; 159(12):3950-3964. View abstract
  25. Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a Menses-Like Model. Stem Cells Dev. 2019 01 01; 28(1):1-12. View abstract
  26. Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab. 2018 10 01; 103(10):3585-3588. View abstract
  27. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal Immunol. 2018 11; 11(6):1684-1693. View abstract
  28. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. View abstract
  29. Adrenocortical development: Lessons from mouse models. Ann Endocrinol (Paris). 2018 Jun; 79(3):95-97. View abstract
  30. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol. 2018 06; 38(6):1283-1296. View abstract
  31. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018 03; 16(3):e2002417. View abstract
  32. Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip. Cell Mol Gastroenterol Hepatol. 2018; 5(4):634-635. View abstract
  33. Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. 2018 02 13; 8(1):2871. View abstract
  34. PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight. 2018 01 25; 3(2). View abstract
  35. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 01 09; 10(1):17-26. View abstract
  36. Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. Stem Cells. 2018 01; 36(1):91-102. View abstract
  37. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 07 06; 21(1):78-90.e6. View abstract
  38. A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila). 2018 01; 56(1):74-76. View abstract
  39. The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):95-114. View abstract
  40. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. View abstract
  41. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. View abstract
  42. Regulation of zonation and homeostasis in the adrenal cortex. Mol Cell Endocrinol. 2017 02 05; 441:146-155. View abstract
  43. An enduring role for quiescent stem cells. Dev Dyn. 2016 07; 245(7):718-26. View abstract
  44. Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. J Physiol. 2016 10 15; 594(20):5851-5860. View abstract
  45. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. View abstract
  46. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues. J Physiol. 2016 09 01; 594(17):4805-13. View abstract
  47. The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Mol Hum Reprod. 2016 Apr; 22(4):272-84. View abstract
  48. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22; 13(11):2403-2411. View abstract
  49. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. View abstract
  50. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. Cell Stem Cell. 2015 10 01; 17(4):486-498. View abstract
  51. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015 Jul; 15(1):165-71. View abstract
  52. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis. 2014 Oct; 236(2):312-20. View abstract
  53. Optimised protocols for the identification of the murine cardiac side population. Stem Cell Rev Rep. 2013 Oct; 9(5):731-9. View abstract
  54. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-673. View abstract
  55. Telomerase expression in the mammalian heart. FASEB J. 2012 Dec; 26(12):4832-40. View abstract
  56. International workshop: radiation effects on mutation in somatic and germline stem cells. Int J Radiat Biol. 2012 Jun; 88(6):501-6. View abstract
  57. Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell Stem Cell. 2012 Jan 06; 10(1):2-4. View abstract
  58. Characterization and fate of telomerase-expressing epithelia during kidney repair. J Am Soc Nephrol. 2011 Dec; 22(12):2256-65. View abstract
  59. Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. . 2011 Mar 01; 10(5):723-4. View abstract
  60. Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative. Int J Pediatr Endocrinol. 2010; 2010:275213. View abstract
  61. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):179-84. View abstract
  62. Regulation of gene expression in the intestinal epithelium. Prog Mol Biol Transl Sci. 2010; 96:207-29. View abstract
  63. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10420-5. View abstract
  64. Small intestinal stem cell markers. J Anat. 2008 Jul; 213(1):52-8. View abstract
  65. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 06; 2(3):230-40. View abstract
  66. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54. View abstract
  67. COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. J Biol Chem. 1997 Dec 12; 272(50):31241-50. View abstract
  68. Role of the first intron in the regulation of the COL 1A1 gene. Matrix Biol. 1996 Jul; 15(2):62-3; author reply 70. View abstract
  69. Novel use for BAL 31 nuclease-generated nested deletions: sequencing from the inside out. Biotechniques. 1995 Apr; 18(4):614-7. View abstract
  70. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. J Bone Miner Res. 1994 Dec; 9(12):1935-43. View abstract
  71. Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells. J Biol Chem. 1994 Feb 18; 269(7):4903-9. View abstract