MEDICAL SERVICES

Departments

Programs

Languages

  • English

EDUCATION

Medical School

  • University of Witwatersrand , Johannesburg , South Africa

Internship

Internal Medicine and General Surgery
  • Baragwanath Hospital , Johannesburg , South Africa

Residency

Neurology
  • Boston City Hospital , Boston , MA

Fellowship

Research - Medicine and Neuroendocrinology
  • Brigham and Women's Hospital , Boston , MA

Fellowship

Neurology
  • Massachusetts General Hospital , Boston , MA

CERTIFICATIONS

  • American Board of Psychiatry and Neurology, Neurology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Thalamocortical Connectivity in Experimentally-Induced Migraine Attacks: A Pilot Study. Brain Sci. 2021 Jan 27; 11(2). View abstract
  2. Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth. J Neurotrauma. 2021 Jan 08. View abstract
  3. Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia. PLoS One. 2021; 16(1):e0244320. View abstract
  4. Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as "No Losses" vs. "No Gains". Front Neurosci. 2020; 14:604867. View abstract
  5. The brain and behavioral correlates of motor-related analgesia (MRA). Neurobiol Dis. 2021 Jan; 148:105158. View abstract
  6. NIRS measures in pain and analgesia: Fundamentals, features, and function. Neurosci Biobehav Rev. 2021 Jan; 120:335-353. View abstract
  7. Commentary: Novel Use of Offset Analgesia to Assess Adolescents and Adults with Treatment Resistant Endometriosis-Associated Pain. J Pain Res. 2020; 13:2775-2782. View abstract
  8. The cornucopia of central disinhibition pain - An evaluation of past and novel concepts. Neurobiol Dis. 2020 11; 145:105041. View abstract
  9. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nat Rev Neurol. 2020 Jul; 16(7):381-400. View abstract
  10. Targeted manipulation of pain neural networks: The potential of focused ultrasound for treatment of chronic pain. Neurosci Biobehav Rev. 2020 08; 115:238-250. View abstract
  11. Secondary effects on brain physiology caused by focused ultrasound-mediated disruption of the blood-brain barrier. J Control Release. 2020 08 10; 324:450-459. View abstract
  12. Author Correction: Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone. Sci Rep. 2020 May 01; 10(1):7680. View abstract
  13. Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone. Sci Rep. 2020 03 27; 10(1):5617. View abstract
  14. Implications of the putamen in pain and motor deficits in complex regional pain syndrome. Pain. 2020 03; 161(3):595-608. View abstract
  15. Brain signatures of threat-safety discrimination in adolescent chronic pain. Pain. 2020 03; 161(3):630-640. View abstract
  16. Enhancing Choice and Outcomes for Therapeutic Trials in Chronic Pain: N-of-1 + Imaging (+ i). Trends Pharmacol Sci. 2020 02; 41(2):85-98. View abstract
  17. Clinical features and sex differences in pediatric post-traumatic headache: A retrospective chart review at a Boston area concussion clinic. Cephalalgia. 2020 06; 40(7):701-711. View abstract
  18. Endometriosis and pain in the adolescent- striking early to limit suffering: A narrative review. Neurosci Biobehav Rev. 2020 01; 108:866-876. View abstract
  19. Biological and behavioral markers of pain following nerve injury in humans. Neurobiol Pain. 2020 Jan-Jul; 7:100038. View abstract
  20. Blue light activates pulvinar nuclei in longstanding idiopathic photophobia: A case report. Neuroimage Clin. 2019; 24:102096. View abstract
  21. C-Fiber Assays in the Cornea vs. Skin. Brain Sci. 2019 Nov 12; 9(11). View abstract
  22. Scale-free amplitude modulation of low-frequency fluctuations in episodic migraine. Pain. 2019 10; 160(10):2298-2304. View abstract
  23. Modulation of brain networks by sumatriptan-naproxen in the inflammatory soup migraine model. Pain. 2019 09; 160(9):2161-2171. View abstract
  24. Delineating conditions and subtypes in chronic pain using neuroimaging. Pain Rep. 2019 Jul-Aug; 4(4):e768. View abstract
  25. Shifting brain circuits in pain chronicity. Hum Brain Mapp. 2019 10 15; 40(15):4381-4396. View abstract
  26. The neurovascular response is attenuated by focused ultrasound-mediated disruption of the blood-brain barrier. Neuroimage. 2019 11 01; 201:116010. View abstract
  27. Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report. Gut. 2019 09; 68(9):1701-1715. View abstract
  28. The failing cascade: Comorbid post traumatic stress- and opioid use disorders. Neurosci Biobehav Rev. 2019 08; 103:374-383. View abstract
  29. Migraine in the Young Brain: Adolescents vs. Young Adults. Front Hum Neurosci. 2019; 13:87. View abstract
  30. The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory. Pain. 2019 Mar; 160(3):569-578. View abstract
  31. Longitudinal Evaluation of Pain, Flare-Up, and Emotional Health in Fibrodysplasia Ossificans Progressiva: Analyses of the International FOP Registry. JBMR Plus. 2019 Aug; 3(8):e10181. View abstract
  32. Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Prog Neurobiol. 2019 06; 177:15-32. View abstract
  33. Modulation of brain function by targeted delivery of GABA through the disrupted blood-brain barrier. Neuroimage. 2019 04 01; 189:267-275. View abstract
  34. Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men. Brain Struct Funct. 2019 Apr; 224(3):1119-1139. View abstract
  35. Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients. Clin J Pain. 2019 01; 35(1):37-42. View abstract
  36. When pain gets stuck: the evolution of pain chronification and treatment resistance. Pain. 2018 Dec; 159(12):2421-2436. View abstract
  37. Reward and aversion processing in patients with post-traumatic stress disorder: functional neuroimaging with visual and thermal stimuli. Transl Psychiatry. 2018 11 02; 8(1):240. View abstract
  38. Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking. Front Psychiatry. 2018; 9:473. View abstract
  39. Morphine Attenuates fNIRS Signal Associated With Painful Stimuli in the Medial Frontopolar Cortex (medial BA 10). Front Hum Neurosci. 2018; 12:394. View abstract
  40. Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls. Pain. 2018 Oct; 159(10):2030-2034. View abstract
  41. Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS. eNeuro. 2018 Jul-Aug; 5(4). View abstract
  42. Focused ultrasound induced opening of the blood-brain barrier disrupts inter-hemispheric resting state functional connectivity in the rat brain. Neuroimage. 2018 09; 178:414-422. View abstract
  43. Brain changes after spinal cord injury, a quantitative meta-analysis and review. Neurosci Biobehav Rev. 2018 07; 90:272-293. View abstract
  44. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Ann Neurol. 2018 03; 83(3):508-521. View abstract
  45. Cumulative effects of multiple pain sites in youth with chronic pain. Eur J Pain. 2018 07; 22(6):1134-1141. View abstract
  46. Subliminal (latent) processing of pain and its evolution to conscious awareness. Neurosci Biobehav Rev. 2018 05; 88:1-15. View abstract
  47. Threat Response System: Parallel Brain Processes in Pain vis-à-vis Fear and Anxiety. Front Psychiatry. 2018; 9:29. View abstract
  48. Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine. Front Neurol. 2018; 9:61. View abstract
  49. Identifying Rodent Resting-State Brain Networks with Independent Component Analysis. Front Neurosci. 2017; 11:685. View abstract
  50. Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment. J Pain. 2018 02; 19(2):207-218. View abstract
  51. Brodmann area 10: Collating, integrating and high level processing of nociception and pain. Prog Neurobiol. 2018 02; 161:1-22. View abstract
  52. Migrainomics - identifying brain and genetic markers of migraine. Nat Rev Neurol. 2017 Dec; 13(12):725-741. View abstract
  53. Molecular and functional PET-fMRI measures of placebo analgesia in episodic migraine: Preliminary findings. Neuroimage Clin. 2018; 17:680-690. View abstract
  54. Using prerecorded hemodynamic response functions in detecting prefrontal pain response: a functional near-infrared spectroscopy study. Neurophotonics. 2018 Jan; 5(1):011018. View abstract
  55. Headache Professional Societies: Ethical Challenges and Suggested Solutions. Headache. 2017 Sep; 57(8):1273-1283. View abstract
  56. Resting-State Functional Connectivity in the Infant Brain: Methods, Pitfalls, and Potentiality. Front Pediatr. 2017; 5:159. View abstract
  57. A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process. Neurosci Biobehav Rev. 2018 Jan; 84:407-423. View abstract
  58. Age- and sex-related differences in the presentation of paediatric migraine: A retrospective cohort study. Cephalalgia. 2018 05; 38(6):1107-1118. View abstract
  59. Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5683-E5692. View abstract
  60. In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp. 2017 08; 38(8):4078-4087. View abstract
  61. Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache. 2017 May; 57 Suppl 2:97-111. View abstract
  62. The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations. J Pain. 2017 07; 18(7):757-777. View abstract
  63. Anesthesia, brain changes, and behavior: Insights from neural systems biology. Prog Neurobiol. 2017 06; 153:121-160. View abstract
  64. Brain network alterations in the inflammatory soup animal model of migraine. Brain Res. 2017 04 01; 1660:36-46. View abstract
  65. Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors. Pain. 2017 02; 158(2):185-186. View abstract
  66. Cortico-Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine. eNeuro. 2016 Nov-Dec; 3(6). View abstract
  67. Parental Attitudes About Placebo Use in Children. J Pediatr. 2017 02; 181:272-278.e10. View abstract
  68. Basal ganglia dysfunction in complex regional pain syndrome - A valid hypothesis? Eur J Pain. 2017 03; 21(3):415-424. View abstract
  69. Frontal Lobe Hemodynamic Responses to Painful Stimulation: A Potential Brain Marker of Nociception. PLoS One. 2016; 11(11):e0165226. View abstract
  70. Probing Intrinsic Resting-State Networks in the Infant Rat Brain. Front Behav Neurosci. 2016; 10:192. View abstract
  71. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016; 10:497. View abstract
  72. Oculofacial Pain: Corneal Nerve Damage Leading to Pain Beyond the Eye. Invest Ophthalmol Vis Sci. 2016 Oct 01; 57(13):5285-5287. View abstract
  73. Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow. PLoS One. 2016; 11(9):e0161563. View abstract
  74. Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci. 2016 07 27; 36(30):8026-36. View abstract
  75. Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine. Front Hum Neurosci. 2016; 10:366. View abstract
  76. Mayer waves reduce the accuracy of estimated hemodynamic response functions in functional near-infrared spectroscopy. Biomed Opt Express. 2016 Aug 01; 7(8):3078-88. View abstract
  77. Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias. PLoS One. 2016; 11(7):e0158975. View abstract
  78. Circles of engagement: Childhood pain and parent brain. Neurosci Biobehav Rev. 2016 Sep; 68:537-546. View abstract
  79. Abdominal Pain, the Adolescent and Altered Brain Structure and Function. PLoS One. 2016; 11(5):e0156545. View abstract
  80. Reward deficiency and anti-reward in pain chronification. Neurosci Biobehav Rev. 2016 Sep; 68:282-297. View abstract
  81. Migraine photophobia originating in cone-driven retinal pathways. Brain. 2016 07; 139(Pt 7):1971-86. View abstract
  82. Pain in an era of armed conflicts: Prevention and treatment for warfighters and civilian casualties. Prog Neurobiol. 2016 06; 141:25-44. View abstract
  83. Brain measures of nociception using near-infrared spectroscopy in patients undergoing routine screening colonoscopy. Pain. 2016 Apr; 157(4):840-848. View abstract
  84. A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 2016; 11:588-594. View abstract
  85. (219) Regional brain structure differences in learning, motivation, and emotion between treatment responders and non-responders in pediatric CRPS. J Pain. 2016 Apr; 17(4S):S30. View abstract
  86. Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers. PLoS One. 2016; 11(3):e0150334. View abstract
  87. Random Forest Segregation of Drug Responses May Define Regions of Biological Significance. Front Comput Neurosci. 2016; 10:21. View abstract
  88. Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703. View abstract
  89. Common Brain Mechanisms of Chronic Pain and Addiction. Neuron. 2016 Jan 06; 89(1):11-36. View abstract
  90. CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. Pain Med. 2015 Dec; 16(12):2368-85. View abstract
  91. The migraine brain in transition: girls vs boys. Pain. 2015 Nov; 156(11):2212-2221. View abstract
  92. Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas. J Neurophysiol. 2016 Jan 01; 115(1):208-17. View abstract
  93. Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine. PLoS One. 2015; 10(9):e0137971. View abstract
  94. Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses. Neurophotonics. 2015 Jul; 2(3):035005. View abstract
  95. Pain and spinal cord imaging measures in children with demyelinating disease. Neuroimage Clin. 2015; 9:338-47. View abstract
  96. The Insula: A "Hub of Activity" in Migraine. Neuroscientist. 2016 12; 22(6):632-652. View abstract
  97. Pediatric Pain Screening Tool: rapid identification of risk in youth with pain complaints. Pain. 2015 Aug; 156(8):1511-1518. View abstract
  98. Taking the headache out of migraine. Neurol Clin Pract. 2015 Aug; 5(4):317-325. View abstract
  99. The Promise of Effective Pain Treatment Outcomes: Rallying Academic Centers to Lead the Charge. Pain Med. 2015 Aug; 16(8):1457-66. View abstract
  100. Female migraineurs show lack of insular thinning with age. Pain. 2015 Jul; 156(7):1232-1239. View abstract
  101. Test-retest reliability of evoked heat stimulation BOLD fMRI. J Neurosci Methods. 2015 Sep 30; 253:38-46. View abstract
  102. Reply to Letter: "Surgically Induced Neuropathic Pain: Understanding the Perioperative Process". Ann Surg. 2015 Jun; 261(6):e162-3. View abstract
  103. Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial. Neurophotonics. 2015 Apr; 2(2):020801. View abstract
  104. Ocular neuropathic pain. Br J Ophthalmol. 2016 Jan; 100(1):128-34. View abstract
  105. Migraine: multiple processes, complex pathophysiology. J Neurosci. 2015 Apr 29; 35(17):6619-29. View abstract
  106. Specificity of hemodynamic brain responses to painful stimuli: a functional near-infrared spectroscopy study. Sci Rep. 2015 Mar 30; 5:9469. View abstract
  107. Autologous Serum Tears for Treatment of Photoallodynia in Patients with Corneal Neuropathy: Efficacy and Evaluation with In Vivo Confocal Microscopy. Ocul Surf. 2015 Jul; 13(3):250-62. View abstract
  108. Rapid treatment-induced brain changes in pediatric CRPS. Brain Struct Funct. 2016 Mar; 221(2):1095-111. View abstract
  109. Distraction analgesia in chronic pain patients: the impact of catastrophizing. Anesthesiology. 2014 Dec; 121(6):1292-301. View abstract
  110. Nocebo effect in randomized clinical trials of antidepressants in children and adolescents: systematic review and meta-analysis. Front Behav Neurosci. 2014; 8:375. View abstract
  111. The role of imaging. J Peripher Nerv Syst. 2014 Oct; 19 Suppl 2:S26-7. View abstract
  112. A new electronic diary tool for mapping and tracking spatial and temporal head pain patterns in migraine. Cephalalgia. 2015 Apr; 35(5):417-25. View abstract
  113. Lost but making progress--Where will new analgesic drugs come from? Sci Transl Med. 2014 Aug 13; 6(249):249sr3. View abstract
  114. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69. View abstract
  115. Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One. 2014; 9(8):e103929. View abstract
  116. Harnessing the placebo effect in pediatric migraine clinic. J Pediatr. 2014 Oct; 165(4):659-65. View abstract
  117. Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy. Pain. 2014 Aug; 155(8):1659-1666. View abstract
  118. The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-1742. View abstract
  119. The cerebellum and addiction: insights gained from neuroimaging research. Addict Biol. 2014 May; 19(3):317-31. View abstract
  120. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One. 2014; 9(4):e95508. View abstract
  121. Sex and the migraine brain. Neurobiol Dis. 2014 Aug; 68:200-14. View abstract
  122. Insights and advances in post-traumatic headache: research considerations. Curr Neurol Neurosci Rep. 2014 Feb; 14(2):428. View abstract
  123. Psychological processing in chronic pain: a neural systems approach. Neurosci Biobehav Rev. 2014 Feb; 39:61-78. View abstract
  124. The effect of naltrexone on body fat mass in olanzapine-treated schizophrenic or schizoaffective patients: a randomized double-blind placebo-controlled pilot study. J Psychopharmacol. 2014 Apr; 28(4):395-400. View abstract
  125. Losses and gains: chronic pain and altered brain morphology. Expert Rev Neurother. 2013 Nov; 13(11):1221-34. View abstract
  126. Completing the Pain Circuit: Recent Advances in Imaging Pain and Inflammation beyond the Central Nervous System. Rambam Maimonides Med J. 2013; 4(4):e0026. View abstract
  127. Habenula functional resting-state connectivity in pediatric CRPS. J Neurophysiol. 2014 Jan; 111(2):239-47. View abstract
  128. Migraine Mistakes: Error Awareness. Neuroscientist. 2014 Jun; 20(3):291-304. View abstract
  129. Capturing brain metrics of neuropathic pain using nuclear magnetic resonance. Pain Manag. 2013 Sep; 3(5):395-409. View abstract
  130. Use of functional imaging across clinical phases in CNS drug development. Transl Psychiatry. 2013 Jul 16; 3:e282. View abstract
  131. Pain and suicidality: insights from reward and addiction neuroscience. Prog Neurobiol. 2013 Oct; 109:1-27. View abstract
  132. Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans. J Neurophysiol. 2013 Sep; 110(5):1221-6. View abstract
  133. Objectifying chronic pain: from the patient to diagnostic metrics. Virtual Mentor. 2013 May 01; 15(5):439-42. View abstract
  134. Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One. 2013; 8(3):e57205. View abstract
  135. Pain and analgesia: the value of salience circuits. Prog Neurobiol. 2013 May; 104:93-105. View abstract
  136. Transforming pain medicine: adapting to science and society. Eur J Pain. 2013 Sep; 17(8):1109-25. View abstract
  137. Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg. 2013 Mar; 257(3):403-12. View abstract
  138. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 2013 Feb; 14(2):103-13. View abstract
  139. Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects. J Pharmacol Exp Ther. 2013 Apr; 345(1):41-51. View abstract
  140. Pain response measured with arterial spin labeling. NMR Biomed. 2013 Jun; 26(6):664-73. View abstract
  141. Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI. PLoS One. 2013; 8(1):e50169. View abstract
  142. Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain. J Neuroimmune Pharmacol. 2013 Jun; 8(3):547-63. View abstract
  143. Migraine tweets - what can online behavior tell us about disease? Cephalalgia. 2013 Jan; 33(1):68-9. View abstract
  144. The human amygdala and pain: evidence from neuroimaging. Hum Brain Mapp. 2014 Feb; 35(2):527-38. View abstract
  145. Migraine: maladaptive brain responses to stress. Headache. 2012 Oct; 52 Suppl 2:102-6. View abstract
  146. An approach to localizing corneal pain representation in human primary somatosensory cortex. PLoS One. 2012; 7(9):e44643. View abstract
  147. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012 Aug; 135(Pt 8):2546-59. View abstract
  148. The enigma of the dorsolateral pons as a migraine generator. Cephalalgia. 2012 Aug; 32(11):803-12. View abstract
  149. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013 Jul; 218(4):903-12. View abstract
  150. A future without chronic pain: neuroscience and clinical research. Cerebrum. 2012 May; 2012:7. View abstract
  151. Effects of naltrexone on food intake and body weight gain in olanzapine-treated rats. J Psychopharmacol. 2012 Sep; 26(9):1244-51. View abstract
  152. Migraine changes the brain: neuroimaging makes its mark. Curr Opin Neurol. 2012 Jun; 25(3):252-62. View abstract
  153. Concurrent functional and structural cortical alterations in migraine. Cephalalgia. 2012 Jun; 32(8):607-20. View abstract
  154. Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discov Today. 2012 Sep; 17(17-18):964-73. View abstract
  155. BOLD responses in somatosensory cortices better reflect heat sensation than pain. J Neurosci. 2012 Apr 25; 32(17):6024-31. View abstract
  156. The young brain and concussion: imaging as a biomarker for diagnosis and prognosis. Neurosci Biobehav Rev. 2012 Jul; 36(6):1510-31. View abstract
  157. 'Hot feet - hot brain': gene and brain dysfunction in erythromelalgia. Pain. 2012 May; 153(5):945-947. View abstract
  158. Mapping pain activation and connectivity of the human habenula. J Neurophysiol. 2012 May; 107(10):2633-48. View abstract
  159. Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. PLoS One. 2012; 7(2):e31118. View abstract
  160. Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load. Neuron. 2012 Jan 26; 73(2):219-34. View abstract
  161. Unmasking the mysteries of the habenula in pain and analgesia. Prog Neurobiol. 2012 Feb; 96(2):208-19. View abstract
  162. The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf. 2012 Jan; 10(1):2-14. View abstract
  163. Neuroimaging of the periaqueductal gray: state of the field. Neuroimage. 2012 Mar; 60(1):505-22. View abstract
  164. A simple and objective method for reproducible resting state network (RSN) detection in fMRI. PLoS One. 2011; 6(12):e27594. View abstract
  165. Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine. Neuroimage. 2012 Feb 15; 59(4):3762-73. View abstract
  166. Neurological diseases and pain. Brain. 2012 Feb; 135(Pt 2):320-44. View abstract
  167. Robust reproducible resting state networks in the awake rodent brain. PLoS One. 2011; 6(10):e25701. View abstract
  168. Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms. J Neurosci. 2011 Oct 05; 31(40):14204-17. View abstract
  169. Migraine attacks the Basal Ganglia. Mol Pain. 2011 Sep 21; 7:71. View abstract
  170. Imaging drugs with and without clinical analgesic efficacy. Neuropsychopharmacology. 2011 Dec; 36(13):2659-73. View abstract
  171. Chronic (neuropathic) corneal pain and blepharospasm: five case reports. Pain. 2011 Oct; 152(10):2427-2431. View abstract
  172. How close are we in utilizing functional neuroimaging in routine clinical diagnosis of neuropathic pain? Curr Pain Headache Rep. 2011 Jun; 15(3):223-9. View abstract
  173. Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery? Expert Opin Drug Discov. 2011 Jun 01; 6(6):597-617. View abstract
  174. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements. Drug Discov Today. 2011 Jul; 16(13-14):583-93. View abstract
  175. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices. Drug Discov Today. 2011 Aug; 16(15-16):671-82. View abstract
  176. Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images. J Neurosci. 2011 Mar 09; 31(10):3795-804. View abstract
  177. Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging. Discov Med. 2011 Mar; 11(58):209-19. View abstract
  178. Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions. Discov Med. 2011 Mar; 11(58):197-207. View abstract
  179. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp. 2012 Jan; 33(1):75-88. View abstract
  180. The missing p in psychiatric training: why it is important to teach pain to psychiatrists. Arch Gen Psychiatry. 2011 Jan; 68(1):12-20. View abstract
  181. CNS animal fMRI in pain and analgesia. Neurosci Biobehav Rev. 2011 Apr; 35(5):1125-43. View abstract
  182. Brain imaging in migraine research. Headache. 2010 Oct; 50(9):1523-7. View abstract
  183. CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw. Neuroimage. 2011 Jan 15; 54(2):1355-66. View abstract
  184. Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010 Dec; 92(4):601-12. View abstract
  185. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91. View abstract
  186. Using NMR approaches to drive the search for new CNS therapeutics. Curr Opin Investig Drugs. 2010 Jul; 11(7):771-8. View abstract
  187. Psychosocial stress and its relationship to gambling urges in individuals with pathological gambling. Am J Addict. 2010 Jul-Aug; 19(4):332-9. View abstract
  188. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States. Cereb Cortex. 2011 Feb; 21(2):435-48. View abstract
  189. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain. 2010 Jul; 133(Pt 7):2098-114. View abstract
  190. Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profile. J Magn Reson Imaging. 2010 Jun; 31(6):1445-57. View abstract
  191. The cerebellum and pain: passive integrator or active participator? Brain Res Rev. 2010 Oct 05; 65(1):14-27. View abstract
  192. Evaluation of novel drugs using fMRI in early-phase clinical trials: safety monitoring. Drug Discov Today. 2010 Aug; 15(15-16):684-9. View abstract
  193. A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging. Mol Pain. 2010 May 13; 6:27. View abstract
  194. A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study. Pain Med. 2010 Jun; 11(6):920-41. View abstract
  195. The pain imaging revolution: advancing pain into the 21st century. Neuroscientist. 2010 Apr; 16(2):171-85. View abstract
  196. A statistical framework for optimal design matrix generation with application to fMRI. IEEE Trans Med Imaging. 2010 Sep; 29(9):1573-611. View abstract
  197. Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli. PLoS One. 2009 Nov 24; 4(11):e8016. View abstract
  198. Improved characterization of BOLD responses for evoked sensory stimuli. Neuroimage. 2010 Feb 01; 49(3):2275-86. View abstract
  199. An fMRI case report of photophobia: activation of the trigeminal nociceptive pathway. Pain. 2009 Oct; 145(3):358-363. View abstract
  200. Ketamine and chronic pain--going the distance. Pain. 2009 Oct; 145(3):271-272. View abstract
  201. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009 Jun 30; 5:34. View abstract
  202. Challenges of functional imaging research of pain in children. Mol Pain. 2009 Jun 16; 5:30. View abstract
  203. Pain: Do ACE inhibitors exacerbate complex regional pain syndrome? Nat Rev Neurol. 2009 Jun; 5(6):306-8. View abstract
  204. Enhanced false discovery rate using Gaussian mixture models for thresholding fMRI statistical maps. Neuroimage. 2009 Aug 01; 47(1):231-61. View abstract
  205. Segmentally arranged somatotopy within the face representation of human primary somatosensory cortex. Hum Brain Mapp. 2009 Mar; 30(3):757-65. View abstract
  206. CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. Pain Med. 2009 Feb 25. View abstract
  207. Emotional pain without sensory pain--dream on? Neuron. 2009 Jan 29; 61(2):153-5. View abstract
  208. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799. View abstract
  209. Noninvasive mapping of human trigeminal brainstem pathways. Magn Reson Med. 2008 Nov; 60(5):1037-46. View abstract
  210. Colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain. PLoS One. 2008; 3(10):e3396. View abstract
  211. Retrospective accounts of initial subjective effects of opioids in patients treated for pain who do or do not develop opioid addiction: a pilot case-control study. Exp Clin Psychopharmacol. 2008 Oct; 16(5):429-34. View abstract
  212. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008 Jul; 131(Pt 7):1854-79. View abstract
  213. A 'BOLD' experiment in defining the utility of fMRI in drug development. Neuroimage. 2008 Aug 15; 42(2):461-6. View abstract
  214. Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems. Neuroimage. 2008 Jun; 41(2):252-9. View abstract
  215. Signal valence in the nucleus accumbens to pain onset and offset. Eur J Pain. 2008 Oct; 12(7):866-9. View abstract
  216. Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects. Cerebellum. 2008; 7(3):252-72. View abstract
  217. Adriamycin injection into the medial cord of the brachial plexus: computed tomography-guided targeted pain therapy. Pain Med. 2008 Jan-Feb; 9(1):83-7. View abstract
  218. Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux). Mol Pain. 2007 Nov 06; 3:34. View abstract
  219. Pain and motor system plasticity. Pain. 2007 Nov; 132(1-2):8-9. View abstract
  220. Neuroimaging revolutionizes therapeutic approaches to chronic pain. Mol Pain. 2007 Sep 11; 3:25. View abstract
  221. Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic. Curr Pain Headache Rep. 2007 Jun; 11(3):201-7. View abstract
  222. Cluster headache: a review of neuroimaging findings. Curr Pain Headache Rep. 2007 Apr; 11(2):131-6. View abstract
  223. Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study. Neuroimage. 2007 May 01; 35(4):1586-600. View abstract
  224. Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci. 2006 Oct 18; 26(42):10646-57. View abstract
  225. Breaking down the barriers: fMRI applications in pain, analgesia and analgesics. Mol Pain. 2006 Sep 18; 2:30. View abstract
  226. Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers. Anesth Analg. 2006 Jul; 103(1):208-16, table of contents. View abstract
  227. Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. J Pharmacol Exp Ther. 2006 Nov; 319(2):507-14. View abstract
  228. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache. 2006 Jun; 46 Suppl 1:S32-8. View abstract
  229. A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov. 2006 May; 5(5):411-24. View abstract
  230. Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents. Neuropsychopharmacology. 2006 Oct; 31(10):2091-120. View abstract
  231. Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders. Eur J Pain. 2007 Jan; 11(1):7-20. View abstract
  232. Is There Such Thing as a Schizophrenic Stomach? Neuropsychopharmacology. 2006; 31:2328. View abstract
  233. Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens. Neurosci Lett. 2006 Jan 16; 392(3):159-64. View abstract
  234. Functional imaging of pain and analgesia--a valid diagnostic tool? Pain. 2005 Oct; 117(3):247-250. View abstract
  235. The effect of antinociceptive drugs tested at different times after nerve injury in rats. Anesth Analg. 2005 Jul; 101(1):175-9, table of contents. View abstract
  236. Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat. Pharmacol Biochem Behav. 2005 May; 81(1):170-81. View abstract
  237. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J Neurobiol. 2004 Oct; 61(1):107-25. View abstract
  238. fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers. J Neurophysiol. 2004 Jun; 91(6):2723-33. View abstract
  239. Antineuropathic effects of the antibiotic derivative spicamycin KRN5500. Pain Med. 2004 Mar; 5(1):104-8. View abstract
  240. CNS activation by noxious heat to the hand or foot: site-dependent delay in sensory but not emotion circuitry. J Neurophysiol. 2004 Jan; 91(1):533-41. View abstract
  241. Pain imaging: future applications to integrative clinical and basic neurobiology. Adv Drug Deliv Rev. 2003 Aug 28; 55(8):967-86. View abstract
  242. Pain: the past, present and future. Adv Drug Deliv Rev. 2003 Aug 28; 55(8):931-4. View abstract
  243. Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat. J Neurosci. 2003 Aug 27; 23(21):7897-903. View abstract
  244. A single intravenous injection of KRN5500 (antibiotic spicamycin) produces long-term decreases in multiple sensory hypersensitivities in neuropathic pain. Anesth Analg. 2003 Jul; 97(1):174-82, table of contents. View abstract
  245. Neural circuitry underlying pain modulation: expectation, hypnosis, placebo. Trends Cogn Sci. 2003 May; 7(5):197-200. View abstract
  246. Somatotopic activation in the human trigeminal pain pathway. J Neurosci. 2002 Sep 15; 22(18):8183-92. View abstract
  247. A water-soluble synthetic spicamycin derivative (San-Gly) decreases mechanical allodynia in a rodent model of neuropathic pain. Neurosci Lett. 2002 Sep 13; 330(1):37-40. View abstract
  248. Utilizing brain imaging for analgesic drug development. Curr Opin Investig Drugs. 2002 Sep; 3(9):1342-7. View abstract
  249. Reward circuitry activation by noxious thermal stimuli. Neuron. 2001 Dec 06; 32(5):927-46. View abstract
  250. The effects of KRN5500, a spicamycin derivative, on neuropathic and nociceptive pain models in rats. Anesth Analg. 2000 Oct; 91(4):955-9. View abstract
  251. Adherence monitoring and drug surveillance in chronic opioid therapy. J Pain Symptom Manage. 2000 Oct; 20(4):293-307. View abstract
  252. Noxious hot and cold stimulation produce common patterns of brain activation in humans: a functional magnetic resonance imaging study. Neurosci Lett. 2000 Jul 14; 288(2):159-62. View abstract
  253. Systemic lipopolysaccharide and interleukin-1beta activate the interleukin 6: STAT intracellular signaling pathway in neurons of mouse trigeminal ganglion. Neurosci Lett. 2000 Mar 03; 281(1):61-4. View abstract
  254. Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase. J Neurochem. 1999 Jul; 73(1):129-38. View abstract
  255. The opioid contract in the management of chronic pain. J Pain Symptom Manage. 1999 Jul; 18(1):27-37. View abstract
  256. Human brain activation under controlled thermal stimulation and habituation to noxious heat: an fMRI study. Magn Reson Med. 1999 May; 41(5):1044-57. View abstract
  257. Proenkephalin transgene regulation in the paraventricular nucleus of the hypothalamus by lipopolysaccharide and interleukin-1beta. J Comp Neurol. 1999 Mar 08; 405(2):199-215. View abstract
  258. PhosphoCREB and CREM/ICER: positive and negative regulation of proenkephalin gene expression in the paraventricular nucleus of the hypothalamus. J Mol Neurosci. 1999 Feb; 12(1):35-51. View abstract
  259. Injection of the piriformis muscle by fluoroscopic and electromyographic guidance. Reg Anesth Pain Med. 1998 Nov-Dec; 23(6):554-9. View abstract
  260. Acute plasticity in the human somatosensory cortex following amputation. Neuroreport. 1998 Apr 20; 9(6):1013-7. View abstract
  261. Proenkephalin gene regulation in the paraventricular nucleus by GABA: interactions with opioid systems in a transgenic model. J Neurochem. 1998 Feb; 70(2):604-16. View abstract
  262. Intravenous lidocaine for treatment-resistant pruritus. Am J Med. 1997 Jun; 102(6):584-5. View abstract
  263. Estrogen and stress interact to regulate the hypothalamic expression of a human proenkephalin promoter-beta-galactosidase fusion gene in a site-specific and sex-specific manner. J Neuroendocrinol. 1997 Apr; 9(4):317-26. View abstract
  264. Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations. Pain. 1997 Mar; 70(1):99-101. View abstract
  265. Corticosteroid-induced mania after single regional application at the celiac plexus. Anesthesiology. 1996 Nov; 85(5):1194-6. View abstract
  266. Distinct lateral and medial projections of the spinohypothalamic tract of the rat. J Comp Neurol. 1996 Sep 30; 373(4):549-74. View abstract
  267. Mechanisms regulating proenkephalin gene expression: contributions of transgenic models. NIDA Res Monogr. 1996; 161:59-71. View abstract
  268. Proenkephalin gene regulation in the neuroendocrine hypothalamus: a model of gene regulation in the CNS. Am J Physiol. 1995 Sep; 269(3 Pt 1):E393-408. View abstract
  269. Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids. J Neurosci. 1994 Dec; 14(12):7261-71. View abstract
  270. Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol Endocrinol. 1994 Feb; 8(2):240-8. View abstract
  271. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25. View abstract
  272. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol. 1993 Nov; 70(5):1811-21. View abstract
  273. Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice. Mol Endocrinol. 1992 Sep; 6(9):1502-12. View abstract
  274. Regulation of opioid gene expression: a model to understand neural plasticity. NIDA Res Monogr. 1992; 126:98-112. View abstract
  275. GABA and circadian timekeeping: implications for manic-depression and sleep disorders. Med Hypotheses. 1986 Feb; 19(2):185-98. View abstract
  276. Daily rhythms of benzodiazepine receptor numbers in frontal lobe and cerebellum of the rat. Life Sci. 1985 Jun 17; 36(24):2333-7. View abstract
  277. Recurrent ulceration and hypergastrinaemia in the gastrectomized patient. An approach to diagnosis. S Afr J Surg. 1983 Mar; 21(1):35-42. View abstract
  278. The febrile responses in rabbits and rats to leucocyte pyrogens of different species. J Physiol. 1978 Jun; 279:113-20. View abstract
  279. A dissociation between temperature regulation and fever in the rabbit. J Physiol. 1977 Apr; 266(2):423-33. View abstract