MEDICAL SERVICES
Departments
Programs
Languages
-
English
EDUCATION
Medical School
- University of Witwatersrand , Johannesburg , South Africa
Internship
Internal Medicine and General Surgery
- Baragwanath Hospital , Johannesburg , South Africa
Residency
Neurology
- Boston City Hospital , Boston , MA
Fellowship
Research - Medicine and Neuroendocrinology
- Brigham and Women's Hospital , Boston , MA
Fellowship
Neurology
- Massachusetts General Hospital , Boston , MA
CERTIFICATIONS
- American Board of Psychiatry and Neurology, Neurology
PUBLICATIONS
Publications powered by Harvard Catalyst Profiles
- Todd N, Zhang Y, Power C, Becerra L, Borsook D, Livingstone M, McDannold N. Modulation of brain function by targeted delivery of GABA through the disrupted blood-brain barrier. Neuroimage. 2019 Jan 16; 189:267-275. View abstract
- Hansen MS, Becerra L, Dahl JB, Borsook D, Mårtensson J, Christensen A, Nybing JD, Havsteen I, Boesen M, Asghar MS. Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men. Brain Struct Funct. 2019 Jan 10. View abstract
- Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Schumacher M, Conley YP, Hammer M, Cheung S, Borsook D, Levine JD. Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients. Clin J Pain. 2019 Jan; 35(1):37-42. View abstract
- Borsook D, Youssef AM, Simons L, Elman I, Eccleston C. When pain gets stuck: the evolution of pain chronification and treatment resistance. Pain. 2018 Dec; 159(12):2421-2436. View abstract
- Bernstein CA, Nir RR, Noseda R, Fulton AB, Huntington S, Lee AJ, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory. Pain. 2018 Nov 19. View abstract
- Elman I, Upadhyay J, Langleben DD, Albanese M, Becerra L, Borsook D. Reward and aversion processing in patients with post-traumatic stress disorder: functional neuroimaging with visual and thermal stimuli. Transl Psychiatry. 2018 Nov 02; 8(1):240. View abstract
- Vanderhoof TS, Gurvits TV, Baker-Nolan JE, Borsook D, Elman I. Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking. Front Psychiatry. 2018; 9:473. View abstract
- Peng K, Yücel MA, Steele SC, Bittner EA, Aasted CM, Hoeft MA, Lee A, George EE, Boas DA, Becerra L, Borsook D. Morphine Attenuates fNIRS Signal Associated With Painful Stimuli in the Medial Frontopolar Cortex (medial BA 10). Front Hum Neurosci. 2018; 12:394. View abstract
- Nir RR, Lee AJ, Huntington S, Noseda R, Bernstein CA, Fulton AB, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls. Pain. 2018 Oct; 159(10):2030-2034. View abstract
- Hubbard CS, Becerra L, Heinz N, Ludwick A, Rasooly T, Yendiki A, Wu R, Schechter NL, Nurko S, Borsook D. Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS. eNeuro. 2018 Jul-Aug; 5(4). View abstract
- Todd N, Zhang Y, Arcaro M, Becerra L, Borsook D, Livingstone M, McDannold N. Focused ultrasound induced opening of the blood-brain barrier disrupts inter-hemispheric resting state functional connectivity in the rat brain. Neuroimage. 2018 09; 178:414-422. View abstract
- Solstrand Dahlberg L, Becerra L, Borsook D, Linnman C. Brain changes after spinal cord injury, a quantitative meta-analysis and review. Neurosci Biobehav Rev. 2018 07; 90:272-293. View abstract
- Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Ann Neurol. 2018 Mar; 83(3):508-521. View abstract
- Basch MC, Chow ET, Logan DE, Borsook D, Schechter NL, Simons LE. Cumulative effects of multiple pain sites in youth with chronic pain. Eur J Pain. 2018 07; 22(6):1134-1141. View abstract
- Borsook D, Youssef AM, Barakat N, Sieberg CB, Elman I. Subliminal (latent) processing of pain and its evolution to conscious awareness. Neurosci Biobehav Rev. 2018 05; 88:1-15. View abstract
- Elman I, Borsook D. Threat Response System: Parallel Brain Processes in Pain vis-à-vis Fear and Anxiety. Front Psychiatry. 2018; 9:29. View abstract
- Solstrand Dahlberg L, Linnman CN, Lee D, Burstein R, Becerra L, Borsook D. Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine. Front Neurol. 2018; 9:61. View abstract
- Bajic D, Craig MM, Mongerson CRL, Borsook D, Becerra L. Identifying Rodent Resting-State Brain Networks with Independent Component Analysis. Front Neurosci. 2017; 11:685. View abstract
- Simons LE, Sieberg CB, Conroy C, Randall ET, Shulman J, Borsook D, Berde C, Sethna NF, Logan DE. Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment. J Pain. 2018 Feb; 19(2):207-218. View abstract
- Peng K, Steele SC, Becerra L, Borsook D. Brodmann area 10: Collating, integrating and high level processing of nociception and pain. Prog Neurobiol. 2018 02; 161:1-22. View abstract
- Nyholt DR, Borsook D, Griffiths LR. Migrainomics - identifying brain and genetic markers of migraine. Nat Rev Neurol. 2017 Dec; 13(12):725-741. View abstract
- Linnman C, Catana C, Petkov MP, Chonde DB, Becerra L, Hooker J, Borsook D. Molecular and functional PET-fMRI measures of placebo analgesia in episodic migraine: Preliminary findings. Neuroimage Clin. 2018; 17:680-690. View abstract
- Peng K, Yücel MA, Aasted CM, Steele SC, Boas DA, Borsook D, Becerra L. Using prerecorded hemodynamic response functions in detecting prefrontal pain response: a functional near-infrared spectroscopy study. Neurophotonics. 2018 Jan; 5(1):011018. View abstract
- Borsook D, Bernat JL. Headache Professional Societies: Ethical Challenges and Suggested Solutions. Headache. 2017 Sep; 57(8):1273-1283. View abstract
- Mongerson CRL, Jennings RW, Borsook D, Becerra L, Bajic D. Resting-State Functional Connectivity in the Infant Brain: Methods, Pitfalls, and Potentiality. Front Pediatr. 2017; 5:159. View abstract
- Upadhyay J, Geber C, Hargreaves R, Birklein F, Borsook D. A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process. Neurosci Biobehav Rev. 2018 Jan; 84:407-423. View abstract
- Wilcox SL, Ludwick AM, Lebel A, Borsook D. Age- and sex-related differences in the presentation of paediatric migraine: A retrospective cohort study. Cephalalgia. 2018 05; 38(6):1107-1118. View abstract
- Noseda R, Lee AJ, Nir RR, Bernstein CA, Kainz VM, Bertisch SM, Buettner C, Borsook D, Burstein R. Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5683-E5692. View abstract
- Youssef AM, Ludwick A, Wilcox SL, Lebel A, Peng K, Colon E, Danehy A, Burstein R, Becerra L, Borsook D. In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp. 2017 08; 38(8):4078-4087. View abstract
- Noseda R, Borsook D, Burstein R. Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache. 2017 May; 57 Suppl 2:97-111. View abstract
- Smith SM, Dworkin RH, Turk DC, Baron R, Polydefkis M, Tracey I, Borsook D, Edwards RR, Harris RE, Wager TD, Arendt-Nielsen L, Burke LB, Carr DB, Chappell A, Farrar JT, Freeman R, Gilron I, Goli V, Haeussler J, Jensen T, Katz NP, Kent J, Kopecky EA, Lee DA, Maixner W, Markman JD, McArthur JC, McDermott MP, Parvathenani L, Raja SN, Rappaport BA, Rice ASC, Rowbotham MC, Tobias JK, Wasan AD, Witter J. The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations. J Pain. 2017 07; 18(7):757-777. View abstract
- Colon E, Bittner EA, Kussman B, McCann ME, Soriano S, Borsook D. Anesthesia, brain changes, and behavior: Insights from neural systems biology. Prog Neurobiol. 2017 06; 153:121-160. View abstract
- Becerra L, Bishop J, Barmettler G, Kainz V, Burstein R, Borsook D. Brain network alterations in the inflammatory soup animal model of migraine. Brain Res. 2017 04 01; 1660:36-46. View abstract
- Borsook D. Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors. Pain. 2017 02; 158(2):185-186. View abstract
- Hodkinson DJ, Veggeberg R, Kucyi A, van Dijk KR, Wilcox SL, Scrivani SJ, Burstein R, Becerra L, Borsook D. Cortico-Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine. eNeuro. 2016 Nov-Dec; 3(6). View abstract
- Faria V, Kossowsky J, Petkov MP, Kaptchuk TJ, Kirsch I, Lebel A, Borsook D. Parental Attitudes About Placebo Use in Children. J Pediatr. 2017 02; 181:272-278.e10. View abstract
- Azqueta-Gavaldon M, Schulte-Göcking H, Storz C, Azad S, Reiners A, Borsook D, Becerra L, Kraft E. Basal ganglia dysfunction in complex regional pain syndrome - A valid hypothesis? Eur J Pain. 2017 03; 21(3):415-424. View abstract
- Aasted CM, Yücel MA, Steele SC, Peng K, Boas DA, Becerra L, Borsook D. Frontal Lobe Hemodynamic Responses to Painful Stimulation: A Potential Brain Marker of Nociception. PLoS One. 2016; 11(11):e0165226. View abstract
- Bajic D, Craig MM, Borsook D, Becerra L. Probing Intrinsic Resting-State Networks in the Infant Rat Brain. Front Behav Neurosci. 2016; 10:192. View abstract
- Hubbard CS, Becerra L, Smith JH, DeLange JM, Smith RM, Black DF, Welker KM, Burstein R, Cutrer FM, Borsook D. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016; 10:497. View abstract
- Rosenthal P, Borsook D, Moulton EA. Oculofacial Pain: Corneal Nerve Damage Leading to Pain Beyond the Eye. Invest Ophthalmol Vis Sci. 2016 Oct 01; 57(13):5285-5287. View abstract
- Linnman C, Catana C, Svärdsudd K, Appel L, Engler H, Långström B, Sörensen J, Furmark T, Fredrikson M, Borsook D, Peterson M. Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow. PLoS One. 2016; 11(9):e0161563. View abstract
- Hodkinson DJ, Wilcox SL, Veggeberg R, Noseda R, Burstein R, Borsook D, Becerra L. Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci. 2016 07 27; 36(30):8026-36. View abstract
- Wilcox SL, Veggeberg R, Lemme J, Hodkinson DJ, Scrivani S, Burstein R, Becerra L, Borsook D. Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine. Front Hum Neurosci. 2016; 10:366. View abstract
- Yücel MA, Selb J, Aasted CM, Lin PY, Borsook D, Becerra L, Boas DA. Mayer waves reduce the accuracy of estimated hemodynamic response functions in functional near-infrared spectroscopy. Biomed Opt Express. 2016 Aug 01; 7(8):3078-88. View abstract
- Kussman BD, Aasted CM, Yücel MA, Steele SC, Alexander ME, Boas DA, Borsook D, Becerra L. Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias. PLoS One. 2016; 11(7):e0158975. View abstract
- Simons LE, Goubert L, Vervoort T, Borsook D. Circles of engagement: Childhood pain and parent brain. Neurosci Biobehav Rev. 2016 09; 68:537-546. View abstract
- Hubbard CS, Becerra L, Heinz N, Ludwick A, Rasooly T, Wu R, Johnson A, Schechter NL, Borsook D, Nurko S. Abdominal Pain, the Adolescent and Altered Brain Structure and Function. PLoS One. 2016; 11(5):e0156545. View abstract
- Borsook D, Linnman C, Faria V, Strassman AM, Becerra L, Elman I. Reward deficiency and anti-reward in pain chronification. Neurosci Biobehav Rev. 2016 09; 68:282-297. View abstract
- Noseda R, Bernstein CA, Nir RR, Lee AJ, Fulton AB, Bertisch SM, Hovaguimian A, Cestari DM, Saavedra-Walker R, Borsook D, Doran BL, Buettner C, Burstein R. Migraine photophobia originating in cone-driven retinal pathways. Brain. 2016 07; 139(Pt 7):1971-86. View abstract
- George E, Elman I, Becerra L, Berg S, Borsook D. Pain in an era of armed conflicts: Prevention and treatment for warfighters and civilian casualties. Prog Neurobiol. 2016 06; 141:25-44. View abstract
- Becerra L, Aasted CM, Boas DA, George E, Yücel MA, Kussman BD, Kelsey P, Borsook D. Brain measures of nociception using near-infrared spectroscopy in patients undergoing routine screening colonoscopy. Pain. 2016 Apr; 157(4):840-848. View abstract
- Becerra L, Veggeberg R, Prescot A, Jensen JE, Renshaw P, Scrivani S, Spierings ELH, Burstein R, Borsook D. A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 2016; 11:588-594. View abstract
- Kim P, Hinkle C, Zhang R, Becerra L, Borsook D, Simons L. (219) Regional brain structure differences in learning, motivation, and emotion between treatment responders and non-responders in pediatric CRPS. J Pain. 2016 Apr; 17(4S):S30. View abstract
- Asghar MS, Becerra L, Larsson HB, Borsook D, Ashina M. Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers. PLoS One. 2016; 11(3):e0150334. View abstract
- Bukhari Q, Borsook D, Rudin M, Becerra L. Random Forest Segregation of Drug Responses May Define Regions of Biological Significance. Front Comput Neurosci. 2016; 10:21. View abstract
- Simons LE, Erpelding N, Hernandez JM, Serrano P, Zhang K, Lebel AA, Sethna NF, Berde CB, Prabhu SP, Becerra L, Borsook D. Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703. View abstract
- Elman I, Borsook D. Common Brain Mechanisms of Chronic Pain and Addiction. Neuron. 2016 Jan 06; 89(1):11-36. View abstract
- Becerra L, Schwartzman RJ, Kiefer RT, Rohr P, Moulton EA, Wallin D, Pendse G, Morris S, Borsook D. CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. Pain Med. 2015 Dec; 16(12):2368-85. View abstract
- Faria V, Erpelding N, Lebel A, Johnson A, Wolff R, Fair D, Burstein R, Becerra L, Borsook D. The migraine brain in transition: girls vs boys. Pain. 2015 Nov; 156(11):2212-21. View abstract
- Becerra L, Bishop J, Barmettler G, Xie Y, Navratilova E, Porreca F, Borsook D. Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas. J Neurophysiol. 2016 Jan 01; 115(1):208-17. View abstract
- Hodkinson DJ, Veggeberg R, Wilcox SL, Scrivani S, Burstein R, Becerra L, Borsook D. Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine. PLoS One. 2015; 10(9):e0137971. View abstract
- Yücel MA, Selb J, Aasted CM, Petkov MP, Becerra L, Borsook D, Boas DA. Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses. Neurophotonics. 2015 Jul; 2(3):035005. View abstract
- Barakat N, Gorman MP, Benson L, Becerra L, Borsook D. Pain and spinal cord imaging measures in children with demyelinating disease. Neuroimage Clin. 2015; 9:338-47. View abstract
- Borsook D, Veggeberg R, Erpelding N, Borra R, Linnman C, Burstein R, Becerra L. The Insula: A "Hub of Activity" in Migraine. Neuroscientist. 2016 12; 22(6):632-652. View abstract
- Simons LE, Smith A, Ibagon C, Coakley R, Logan DE, Schechter N, Borsook D, Hill JC. Pediatric Pain Screening Tool: rapid identification of risk in youth with pain complaints. Pain. 2015 Aug; 156(8):1511-8. View abstract
- Borsook D, Dodick DW. Taking the headache out of migraine. Neurol Clin Pract. 2015 Aug; 5(4):317-325. View abstract
- Gilligan CJ, Borsook D. The Promise of Effective Pain Treatment Outcomes: Rallying Academic Centers to Lead the Charge. Pain Med. 2015 Aug; 16(8):1457-66. View abstract
- Maleki N, Barmettler G, Moulton EA, Scrivani S, Veggeberg R, Spierings EL, Burstein R, Becerra L, Borsook D. Female migraineurs show lack of insular thinning with age. Pain. 2015 Jul; 156(7):1232-9. View abstract
- Upadhyay J, Lemme J, Anderson J, Bleakman D, Large T, Evelhoch JL, Hargreaves R, Borsook D, Becerra L. Test-retest reliability of evoked heat stimulation BOLD fMRI. J Neurosci Methods. 2015 Sep 30; 253:38-46. View abstract
- Borsook D, Kussman B, George E, Becerra L, Burke D. Reply to Letter: "Surgically Induced Neuropathic Pain: Understanding the Perioperative Process". Ann Surg. 2015 Jun; 261(6):e162-3. View abstract
- Aasted CM, Yücel MA, Cooper RJ, Dubb J, Tsuzuki D, Becerra L, Petkov MP, Borsook D, Dan I, Boas DA. Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial. Neurophotonics. 2015 Apr; 2(2):020801. View abstract
- Rosenthal P, Borsook D. Ocular neuropathic pain. Br J Ophthalmol. 2016 Jan; 100(1):128-34. View abstract
- Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. J Neurosci. 2015 Apr 29; 35(17):6619-29. View abstract
- Yücel MA, Aasted CM, Petkov MP, Borsook D, Boas DA, Becerra L. Specificity of hemodynamic brain responses to painful stimuli: a functional near-infrared spectroscopy study. Sci Rep. 2015 Mar 30; 5:9469. View abstract
- Aggarwal S, Kheirkhah A, Cavalcanti BM, Cruzat A, Colon C, Brown E, Borsook D, Prüss H, Hamrah P. Autologous Serum Tears for Treatment of Photoallodynia in Patients with Corneal Neuropathy: Efficacy and Evaluation with In Vivo Confocal Microscopy. Ocul Surf. 2015 Jul; 13(3):250-62. View abstract
- Erpelding N, Simons L, Lebel A, Serrano P, Pielech M, Prabhu S, Becerra L, Borsook D. Rapid treatment-induced brain changes in pediatric CRPS. Brain Struct Funct. 2016 Mar; 221(2):1095-111. View abstract
- Schreiber KL, Campbell C, Martel MO, Greenbaum S, Wasan AD, Borsook D, Jamison RN, Edwards RR. Distraction analgesia in chronic pain patients: the impact of catastrophizing. Anesthesiology. 2014 Dec; 121(6):1292-301. View abstract
- Rojas-Mirquez JC, Rodriguez-Zuñiga MJ, Bonilla-Escobar FJ, Garcia-Perdomo HA, Petkov M, Becerra L, Borsook D, Linnman C. Nocebo effect in randomized clinical trials of antidepressants in children and adolescents: systematic review and meta-analysis. Front Behav Neurosci. 2014; 8:375. View abstract
- Borsook D. The role of imaging. J Peripher Nerv Syst. 2014 Oct; 19 Suppl 2:S26-7. View abstract
- Barmettler G, Brawn J, Maleki N, Scrivani S, Burstein R, Becerra L, Borsook D. A new electronic diary tool for mapping and tracking spatial and temporal head pain patterns in migraine. Cephalalgia. 2015 Apr; 35(5):417-25. View abstract
- Borsook D, Hargreaves R, Bountra C, Porreca F. Lost but making progress--Where will new analgesic drugs come from? Sci Transl Med. 2014 Aug 13; 6(249):249sr3. View abstract
- Becerra L, Sava S, Simons LE, Drosos AM, Sethna N, Berde C, Lebel AA, Borsook D. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69. View abstract
- Noseda R, Kainz V, Borsook D, Burstein R. Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One. 2014; 9(8):e103929. View abstract
- Faria V, Linnman C, Lebel A, Borsook D. Harnessing the placebo effect in pediatric migraine clinic. J Pediatr. 2014 Oct; 165(4):659-65. View abstract
- Xie JY, Qu C, Patwardhan A, Ossipov MH, Navratilova E, Becerra L, Borsook D, Porreca F. Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy. Pain. 2014 Aug; 155(8):1659-66. View abstract
- Simons LE, Pielech M, Erpelding N, Linnman C, Moulton E, Sava S, Lebel A, Serrano P, Sethna N, Berde C, Becerra L, Borsook D. The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-42. View abstract
- Moulton EA, Elman I, Becerra LR, Goldstein RZ, Borsook D. The cerebellum and addiction: insights gained from neuroimaging research. Addict Biol. 2014 May; 19(3):317-31. View abstract
- Moulton EA, Becerra L, Johnson A, Burstein R, Borsook D. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One. 2014; 9(4):e95508. View abstract
- Borsook D, Erpelding N, Lebel A, Linnman C, Veggeberg R, Grant PE, Buettner C, Becerra L, Burstein R. Sex and the migraine brain. Neurobiol Dis. 2014 Aug; 68:200-14. View abstract
- Monteith TS, Borsook D. Insights and advances in post-traumatic headache: research considerations. Curr Neurol Neurosci Rep. 2014 Feb; 14(2):428. View abstract
- Simons LE, Elman I, Borsook D. Psychological processing in chronic pain: a neural systems approach. Neurosci Biobehav Rev. 2014 Feb; 39:61-78. View abstract
- Taveira TH, Wu WC, Tschibelu E, Borsook D, Simonson DC, Yamamoto R, Langleben DD, Swift R, Elman I. The effect of naltrexone on body fat mass in olanzapine-treated schizophrenic or schizoaffective patients: a randomized double-blind placebo-controlled pilot study. J Psychopharmacol. 2014 Apr; 28(4):395-400. View abstract
- Borsook D, Erpelding N, Becerra L. Losses and gains: chronic pain and altered brain morphology. Expert Rev Neurother. 2013 Nov; 13(11):1221-34. View abstract
- Linnman C, Borsook D. Completing the Pain Circuit: Recent Advances in Imaging Pain and Inflammation beyond the Central Nervous System. Rambam Maimonides Med J. 2013; 4(4):e0026. View abstract
- Erpelding N, Sava S, Simons LE, Lebel A, Serrano P, Becerra L, Borsook D. Habenula functional resting-state connectivity in pediatric CRPS. J Neurophysiol. 2014 Jan; 111(2):239-47. View abstract
- Borsook D, Aasted CM, Burstein R, Becerra L. Migraine Mistakes: Error Awareness. Neuroscientist. 2014 Jun; 20(3):291-304. View abstract
- Erpelding N, Borsook D. Capturing brain metrics of neuropathic pain using nuclear magnetic resonance. Pain Manag. 2013 Sep; 3(5):395-409. View abstract
- Borsook D, Becerra L, Fava M. Use of functional imaging across clinical phases in CNS drug development. Transl Psychiatry. 2013 Jul 16; 3:e282. View abstract
- Elman I, Borsook D, Volkow ND. Pain and suicidality: insights from reward and addiction neuroscience. Prog Neurobiol. 2013 Oct; 109:1-27. View abstract
- Becerra L, Navratilova E, Porreca F, Borsook D. Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans. J Neurophysiol. 2013 Sep; 110(5):1221-6. View abstract
- Borsook D. Objectifying chronic pain: from the patient to diagnostic metrics. Virtual Mentor. 2013 May 01; 15(5):439-42. View abstract
- Linnman C, Becerra L, Lebel A, Berde C, Grant PE, Borsook D. Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One. 2013; 8(3):e57205. View abstract
- Borsook D, Edwards R, Elman I, Becerra L, Levine J. Pain and analgesia: the value of salience circuits. Prog Neurobiol. 2013 May; 104:93-105. View abstract
- Borsook D, Kalso E. Transforming pain medicine: adapting to science and society. Eur J Pain. 2013 Sep; 17(8):1109-25. View abstract
- Borsook D, Kussman BD, George E, Becerra LR, Burke DW. Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg. 2013 Mar; 257(3):403-12. View abstract
- Bruehl S, Apkarian AV, Ballantyne JC, Berger A, Borsook D, Chen WG, Farrar JT, Haythornthwaite JA, Horn SD, Iadarola MJ, Inturrisi CE, Lao L, Mackey S, Mao J, Sawczuk A, Uhl GR, Witter J, Woolf CJ, Zubieta JK, Lin Y. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 2013 Feb; 14(2):103-13. View abstract
- Becerra L, Upadhyay J, Chang PC, Bishop J, Anderson J, Baumgartner R, Schwarz AJ, Coimbra A, Wallin D, Nutile L, George E, Maier G, Sunkaraneni S, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Borsook D. Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects. J Pharmacol Exp Ther. 2013 Apr; 345(1):41-51. View abstract
- Maleki N, Brawn J, Barmettler G, Borsook D, Becerra L. Pain response measured with arterial spin labeling. NMR Biomed. 2013 Jun; 26(6):664-73. View abstract
- Gear R, Becerra L, Upadhyay J, Bishop J, Wallin D, Pendse G, Levine J, Borsook D. Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI. PLoS One. 2013; 8(1):e50169. View abstract
- Linnman C, Becerra L, Borsook D. Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain. J Neuroimmune Pharmacol. 2013 Jun; 8(3):547-63. View abstract
- Linnman C, Maleki N, Becerra L, Borsook D. Migraine tweets - what can online behavior tell us about disease? Cephalalgia. 2013 Jan; 33(1):68-9. View abstract
- Simons LE, Moulton EA, Linnman C, Carpino E, Becerra L, Borsook D. The human amygdala and pain: evidence from neuroimaging. Hum Brain Mapp. 2014 Feb; 35(2):527-38. View abstract
- Maleki N, Becerra L, Borsook D. Migraine: maladaptive brain responses to stress. Headache. 2012 Oct; 52 Suppl 2:102-6. View abstract
- Moulton EA, Becerra L, Rosenthal P, Borsook D. An approach to localizing corneal pain representation in human primary somatosensory cortex. PLoS One. 2012; 7(9):e44643. View abstract
- Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012 Aug; 135(Pt 8):2546-59. View abstract
- Borsook D, Burstein R. The enigma of the dorsolateral pons as a migraine generator. Cephalalgia. 2012 Aug; 32(11):803-12. View abstract
- Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013 Jul; 218(4):903-12. View abstract
- Borsook D. A future without chronic pain: neuroscience and clinical research. Cerebrum. 2012 May; 2012:7. View abstract
- Kurbanov DB, Currie PJ, Simonson DC, Borsook D, Elman I. Effects of naltrexone on food intake and body weight gain in olanzapine-treated rats. J Psychopharmacol. 2012 Sep; 26(9):1244-51. View abstract
- Sprenger T, Borsook D. Migraine changes the brain: neuroimaging makes its mark. Curr Opin Neurol. 2012 Jun; 25(3):252-62. View abstract
- Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in migraine. Cephalalgia. 2012 Jun; 32(8):607-20. View abstract
- Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ. Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discov Today. 2012 Sep; 17(17-18):964-73. View abstract
- Moulton EA, Pendse G, Becerra LR, Borsook D. BOLD responses in somatosensory cortices better reflect heat sensation than pain. J Neurosci. 2012 Apr 25; 32(17):6024-31. View abstract
- Toledo E, Lebel A, Becerra L, Minster A, Linnman C, Maleki N, Dodick DW, Borsook D. The young brain and concussion: imaging as a biomarker for diagnosis and prognosis. Neurosci Biobehav Rev. 2012 Jul; 36(6):1510-31. View abstract
- Borsook D. 'Hot feet - hot brain': gene and brain dysfunction in erythromelalgia. Pain. 2012 May; 153(5):945-7. View abstract
- Shelton L, Pendse G, Maleki N, Moulton EA, Lebel A, Becerra L, Borsook D. Mapping pain activation and connectivity of the human habenula. J Neurophysiol. 2012 May; 107(10):2633-48. View abstract
- Elman I, Becerra L, Tschibelu E, Yamamoto R, George E, Borsook D. Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. PLoS One. 2012; 7(2):e31118. View abstract
- Borsook D, Maleki N, Becerra L, McEwen B. Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load. Neuron. 2012 Jan 26; 73(2):219-34. View abstract
- Shelton L, Becerra L, Borsook D. Unmasking the mysteries of the habenula in pain and analgesia. Prog Neurobiol. 2012 Feb; 96(2):208-19. View abstract
- Rosenthal P, Borsook D. The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf. 2012 Jan; 10(1):2-14. View abstract
- Linnman C, Moulton EA, Barmettler G, Becerra L, Borsook D. Neuroimaging of the periaqueductal gray: state of the field. Neuroimage. 2012 Mar; 60(1):505-22. View abstract
- Pendse GV, Borsook D, Becerra L. A simple and objective method for reproducible resting state network (RSN) detection in fMRI. PLoS One. 2011; 6(12):e27594. View abstract
- Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Schwarz AJ, Pendse G, Wallin D, Nutile L, Bishop J, George E, Elman I, Sunkaraneni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine. Neuroimage. 2012 Feb 15; 59(4):3762-73. View abstract
- Borsook D. Neurological diseases and pain. Brain. 2012 Feb; 135(Pt 2):320-44. View abstract
- Becerra L, Pendse G, Chang PC, Bishop J, Borsook D. Robust reproducible resting state networks in the awake rodent brain. PLoS One. 2011; 6(10):e25701. View abstract
- Noseda R, Jakubowski M, Kainz V, Borsook D, Burstein R. Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms. J Neurosci. 2011 Oct 05; 31(40):14204-17. View abstract
- Maleki N, Becerra L, Nutile L, Pendse G, Brawn J, Bigal M, Burstein R, Borsook D. Migraine attacks the Basal Ganglia. Mol Pain. 2011 Sep 21; 7:71. View abstract
- Upadhyay J, Anderson J, Schwarz AJ, Coimbra A, Baumgartner R, Pendse G, George E, Nutile L, Wallin D, Bishop J, Neni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Imaging drugs with and without clinical analgesic efficacy. Neuropsychopharmacology. 2011 Dec; 36(13):2659-73. View abstract
- Borsook D, Rosenthal P. Chronic (neuropathic) corneal pain and blepharospasm: five case reports. Pain. 2011 Oct; 152(10):2427-31. View abstract
- Borsook D, Becerra L. How close are we in utilizing functional neuroimaging in routine clinical diagnosis of neuropathic pain? Curr Pain Headache Rep. 2011 Jun; 15(3):223-9. View abstract
- Borsook D, Hargreaves R, Becerra L. Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery? Expert Opin Drug Discov. 2011 Jun 01; 6(6):597-617. View abstract
- Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements. Drug Discov Today. 2011 Jul; 16(13-14):583-93. View abstract
- Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices. Drug Discov Today. 2011 Aug; 16(15-16):671-82. View abstract
- Moulton EA, Elman I, Pendse G, Schmahmann J, Becerra L, Borsook D. Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images. J Neurosci. 2011 Mar 09; 31(10):3795-804. View abstract
- Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging. Discov Med. 2011 Mar; 11(58):209-19. View abstract
- Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions. Discov Med. 2011 Mar; 11(58):197-207. View abstract
- Maleki N, Becerra L, Upadhyay J, Burstein R, Borsook D. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp. 2012 Jan; 33(1):75-88. View abstract
- Elman I, Zubieta JK, Borsook D. The missing p in psychiatric training: why it is important to teach pain to psychiatrists. Arch Gen Psychiatry. 2011 Jan; 68(1):12-20. View abstract
- Borsook D, Becerra L. CNS animal fMRI in pain and analgesia. Neurosci Biobehav Rev. 2011 Apr; 35(5):1125-43. View abstract
- Borsook D, Hargreaves R. Brain imaging in migraine research. Headache. 2010 Oct; 50(9):1523-7. View abstract
- Becerra L, Chang PC, Bishop J, Borsook D. CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw. Neuroimage. 2011 Jan 15; 54(2):1355-66. View abstract
- Borsook D, George E, Kussman B, Becerra L. Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010 Dec; 92(4):601-12. View abstract
- Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91. View abstract
- Borsook D, Becerra L. Using NMR approaches to drive the search for new CNS therapeutics. Curr Opin Investig Drugs. 2010 Jul; 11(7):771-8. View abstract
- Elman I, Tschibelu E, Borsook D. Psychosocial stress and its relationship to gambling urges in individuals with pathological gambling. Am J Addict. 2010 Jul-Aug; 19(4):332-9. View abstract
- Moulton EA, Becerra L, Maleki N, Pendse G, Tully S, Hargreaves R, Burstein R, Borsook D. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States. Cereb Cortex. 2011 Feb; 21(2):435-48. View abstract
- Upadhyay J, Maleki N, Potter J, Elman I, Rudrauf D, Knudsen J, Wallin D, Pendse G, McDonald L, Griffin M, Anderson J, Nutile L, Renshaw P, Weiss R, Becerra L, Borsook D. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain. 2010 Jul; 133(Pt 7):2098-114. View abstract
- Pendse GV, Schwarz AJ, Baumgartner R, Coimbra A, Upadhyay J, Borsook D, Becerra L. Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profile. J Magn Reson Imaging. 2010 Jun; 31(6):1445-57. View abstract
- Moulton EA, Schmahmann JD, Becerra L, Borsook D. The cerebellum and pain: passive integrator or active participator? Brain Res Rev. 2010 Oct 05; 65(1):14-27. View abstract
- George E, Becerra L, Upadhyay J, Schmidt U, Borsook D. Evaluation of novel drugs using fMRI in early-phase clinical trials: safety monitoring. Drug Discov Today. 2010 Aug; 15(15-16):684-9. View abstract
- Borsook D, Upadhyay J, Chudler EH, Becerra L. A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging. Mol Pain. 2010 May 13; 6:27. View abstract
- Scrivani S, Wallin D, Moulton EA, Cole S, Wasan AD, Lockerman L, Bajwa Z, Upadhyay J, Becerra L, Borsook D. A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study. Pain Med. 2010 Jun; 11(6):920-41. View abstract
- Borsook D, Sava S, Becerra L. The pain imaging revolution: advancing pain into the 21st century. Neuroscientist. 2010 Apr; 16(2):171-85. View abstract
- Pendse GV, Baumgartner R, Schwarz AJ, Coimbra A, Borsook D, Becerra L. A statistical framework for optimal design matrix generation with application to fMRI. IEEE Trans Med Imaging. 2010 Sep; 29(9):1573-611. View abstract
- Becerra L, Harris W, Grant M, George E, Boas D, Borsook D. Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli. PLoS One. 2009 Nov 24; 4(11):e8016. View abstract
- Upadhyay J, Pendse G, Anderson J, Schwarz AJ, Baumgartner R, Coimbra A, Bishop J, Knudsen J, George E, Grachev I, Iyengar S, Bleakman D, Hargreaves R, Borsook D, Becerra L. Improved characterization of BOLD responses for evoked sensory stimuli. Neuroimage. 2010 Feb 01; 49(3):2275-86. View abstract
- Moulton EA, Becerra L, Borsook D. An fMRI case report of photophobia: activation of the trigeminal nociceptive pathway. Pain. 2009 Oct; 145(3):358-63. View abstract
- Borsook D. Ketamine and chronic pain--going the distance. Pain. 2009 Oct; 145(3):271-2. View abstract
- Prescot A, Becerra L, Pendse G, Tully S, Jensen E, Hargreaves R, Renshaw P, Burstein R, Borsook D. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009 Jun 30; 5:34. View abstract
- Sava S, Lebel AA, Leslie DS, Drosos A, Berde C, Becerra L, Borsook D. Challenges of functional imaging research of pain in children. Mol Pain. 2009 Jun 16; 5:30. View abstract
- Borsook D, Sava S. Pain: Do ACE inhibitors exacerbate complex regional pain syndrome? Nat Rev Neurol. 2009 Jun; 5(6):306-8. View abstract
- Pendse G, Borsook D, Becerra L. Enhanced false discovery rate using Gaussian mixture models for thresholding fMRI statistical maps. Neuroimage. 2009 Aug 01; 47(1):231-61. View abstract
- Moulton EA, Pendse G, Morris S, Aiello-Lammens M, Becerra L, Borsook D. Segmentally arranged somatotopy within the face representation of human primary somatosensory cortex. Hum Brain Mapp. 2009 Mar; 30(3):757-65. View abstract
- Becerra L, Schwartzman RJ, Kiefer RT, Rohr P, Moulton EA, Wallin D, Pendse G, Morris S, Borsook D. CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. Pain Med. 2009 Feb 25. View abstract
- Borsook D, Becerra L. Emotional pain without sensory pain--dream on? Neuron. 2009 Jan 29; 61(2):153-5. View abstract
- Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799. View abstract
- Upadhyay J, Knudsen J, Anderson J, Becerra L, Borsook D. Noninvasive mapping of human trigeminal brainstem pathways. Magn Reson Med. 2008 Nov; 60(5):1037-46. View abstract
- DaSilva AF, Becerra L, Pendse G, Chizh B, Tully S, Borsook D. Colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain. PLoS One. 2008; 3(10):e3396. View abstract
- Bieber CM, Fernandez K, Borsook D, Brennan MJ, Butler SF, Jamison RN, Osgood E, Sharpe-Potter J, Thomson HN, Weiss RD, Katz NP. Retrospective accounts of initial subjective effects of opioids in patients treated for pain who do or do not develop opioid addiction: a pilot case-control study. Exp Clin Psychopharmacol. 2008 Oct; 16(5):429-34. View abstract
- Lebel A, Becerra L, Wallin D, Moulton EA, Morris S, Pendse G, Jasciewicz J, Stein M, Aiello-Lammens M, Grant E, Berde C, Borsook D. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008 Jul; 131(Pt 7):1854-79. View abstract
- Borsook D, Bleakman D, Hargreaves R, Upadhyay J, Schmidt KF, Becerra L. A 'BOLD' experiment in defining the utility of fMRI in drug development. Neuroimage. 2008 Aug 15; 42(2):461-6. View abstract
- Becerra L, Harris W, Joseph D, Huppert T, Boas DA, Borsook D. Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems. Neuroimage. 2008 Jun; 41(2):252-9. View abstract
- Becerra L, Borsook D. Signal valence in the nucleus accumbens to pain onset and offset. Eur J Pain. 2008 Oct; 12(7):866-9. View abstract
- Borsook D, Moulton EA, Tully S, Schmahmann JD, Becerra L. Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects. Cerebellum. 2008; 7(3):252-72. View abstract
- Grant PE, Gallagher J, Gonzalez RG, Borsook D. Adriamycin injection into the medial cord of the brachial plexus: computed tomography-guided targeted pain therapy. Pain Med. 2008 Jan-Feb; 9(1):83-7. View abstract
- Borsook D, Moulton EA, Pendse G, Morris S, Cole SH, Aiello-Lammens M, Scrivani S, Becerra LR. Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux). Mol Pain. 2007 Nov 06; 3:34. View abstract
- Borsook D. Pain and motor system plasticity. Pain. 2007 Nov; 132(1-2):8-9. View abstract
- Borsook D, Moulton EA, Schmidt KF, Becerra LR. Neuroimaging revolutionizes therapeutic approaches to chronic pain. Mol Pain. 2007 Sep 11; 3:25. View abstract
- Borsook D, Becerra L. Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic. Curr Pain Headache Rep. 2007 Jun; 11(3):201-7. View abstract
- DaSilva AF, Goadsby PJ, Borsook D. Cluster headache: a review of neuroimaging findings. Curr Pain Headache Rep. 2007 Apr; 11(2):131-6. View abstract
- Moulton EA, Pendse G, Morris S, Strassman A, Aiello-Lammens M, Becerra L, Borsook D. Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study. Neuroimage. 2007 May 01; 35(4):1586-600. View abstract
- Becerra L, Morris S, Bazes S, Gostic R, Sherman S, Gostic J, Pendse G, Moulton E, Scrivani S, Keith D, Chizh B, Borsook D. Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci. 2006 Oct 18; 26(42):10646-57. View abstract
- Borsook D, Becerra LR. Breaking down the barriers: fMRI applications in pain, analgesia and analgesics. Mol Pain. 2006 Sep 18; 2:30. View abstract
- Becerra L, Harter K, Gonzalez RG, Borsook D. Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers. Anesth Analg. 2006 Jul; 103(1):208-16, table of contents. View abstract
- Negus SS, Vanderah TW, Brandt MR, Bilsky EJ, Becerra L, Borsook D. Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. J Pharmacol Exp Ther. 2006 Nov; 319(2):507-14. View abstract
- Borsook D, Burstein R, Moulton E, Becerra L. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache. 2006 Jun; 46 Suppl 1:S32-8. View abstract
- Borsook D, Becerra L, Hargreaves R. A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov. 2006 May; 5(5):411-24. View abstract
- Elman I, Borsook D, Lukas SE. Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents. Neuropsychopharmacology. 2006 Oct; 31(10):2091-120. View abstract
- Borsook D, Becerra L, Carlezon WA, Shaw M, Renshaw P, Elman I, Levine J. Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders. Eur J Pain. 2007 Jan; 11(1):7-20. View abstract
- Elman I, Borsook D, Lukas SE. Is There Such Thing as a Schizophrenic Stomach? Neuropsychopharmacology. 2006; 31:2328. View abstract
- Aharon I, Becerra L, Becerraa L, Chabris CF, Borsook D, Borsooka D. Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens. Neurosci Lett. 2006 Jan 16; 392(3):159-64. View abstract
- Borsook D, Becerra L. Functional imaging of pain and analgesia--a valid diagnostic tool? Pain. 2005 Oct; 117(3):247-50. View abstract
- Hama AT, Borsook D. The effect of antinociceptive drugs tested at different times after nerve injury in rats. Anesth Analg. 2005 Jul; 101(1):175-9, table of contents. View abstract
- Hama AT, Borsook D. Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat. Pharmacol Biochem Behav. 2005 May; 81(1):170-81. View abstract
- Borsook D, Burstein R, Becerra L. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J Neurobiol. 2004 Oct; 61(1):107-25. View abstract
- Borras MC, Becerra L, Ploghaus A, Gostic JM, DaSilva A, Gonzalez RG, Borsook D. fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers. J Neurophysiol. 2004 Jun; 91(6):2723-33. View abstract
- Borsook D, Edwards AD. Antineuropathic effects of the antibiotic derivative spicamycin KRN5500. Pain Med. 2004 Mar; 5(1):104-8. View abstract
- Becerra L, Iadarola M, Borsook D. CNS activation by noxious heat to the hand or foot: site-dependent delay in sensory but not emotion circuitry. J Neurophysiol. 2004 Jan; 91(1):533-41. View abstract
- Borsook D, Becerra L. Pain imaging: future applications to integrative clinical and basic neurobiology. Adv Drug Deliv Rev. 2003 Aug 28; 55(8):967-86. View abstract
- Borsook D. Pain: the past, present and future. Adv Drug Deliv Rev. 2003 Aug 28; 55(8):931-4. View abstract
- Borsook D, DaSilva AF, Ploghaus A, Becerra L. Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat. J Neurosci. 2003 Aug 27; 23(21):7897-903. View abstract
- Kobierski LA, Abdi S, DiLorenzo L, Feroz N, Borsook D. A single intravenous injection of KRN5500 (antibiotic spicamycin) produces long-term decreases in multiple sensory hypersensitivities in neuropathic pain. Anesth Analg. 2003 Jul; 97(1):174-82, table of contents. View abstract
- Ploghaus A, Becerra L, Borras C, Borsook D. Neural circuitry underlying pain modulation: expectation, hypnosis, placebo. Trends Cogn Sci. 2003 May; 7(5):197-200. View abstract
- DaSilva AF, Becerra L, Makris N, Strassman AM, Gonzalez RG, Geatrakis N, Borsook D. Somatotopic activation in the human trigeminal pain pathway. J Neurosci. 2002 Sep 15; 22(18):8183-92. View abstract
- DiLorenzo L, Kobierski L, Moore KA, Borsook D. A water-soluble synthetic spicamycin derivative (San-Gly) decreases mechanical allodynia in a rodent model of neuropathic pain. Neurosci Lett. 2002 Sep 13; 330(1):37-40. View abstract
- Borsook D, Ploghaus A, Becerra L. Utilizing brain imaging for analgesic drug development. Curr Opin Investig Drugs. 2002 Sep; 3(9):1342-7. View abstract
- Becerra L, Breiter HC, Wise R, Gonzalez RG, Borsook D. Reward circuitry activation by noxious thermal stimuli. Neuron. 2001 Dec 06; 32(5):927-46. View abstract
- Abdi S, Vilassova N, Decosterd I, Feroz N, Borsook D. The effects of KRN5500, a spicamycin derivative, on neuropathic and nociceptive pain models in rats. Anesth Analg. 2000 Oct; 91(4):955-9. View abstract
- Fishman SM, Wilsey B, Yang J, Reisfield GM, Bandman TB, Borsook D. Adherence monitoring and drug surveillance in chronic opioid therapy. J Pain Symptom Manage. 2000 Oct; 20(4):293-307. View abstract
- Tracey I, Becerra L, Chang I, Breiter H, Jenkins L, Borsook D, González RG. Noxious hot and cold stimulation produce common patterns of brain activation in humans: a functional magnetic resonance imaging study. Neurosci Lett. 2000 Jul 14; 288(2):159-62. View abstract
- Kobierski LA, Srivastava S, Borsook D. Systemic lipopolysaccharide and interleukin-1beta activate the interleukin 6: STAT intracellular signaling pathway in neurons of mouse trigeminal ganglion. Neurosci Lett. 2000 Mar 03; 281(1):61-4. View abstract
- Kobierski LA, Wong AE, Srivastava S, Borsook D, Hyman SE. Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase. J Neurochem. 1999 Jul; 73(1):129-38. View abstract
- Fishman SM, Bandman TB, Edwards A, Borsook D. The opioid contract in the management of chronic pain. J Pain Symptom Manage. 1999 Jul; 18(1):27-37. View abstract
- Becerra LR, Breiter HC, Stojanovic M, Fishman S, Edwards A, Comite AR, Gonzalez RG, Borsook D. Human brain activation under controlled thermal stimulation and habituation to noxious heat: an fMRI study. Magn Reson Med. 1999 May; 41(5):1044-57. View abstract
- Van Koughnet K, Smirnova O, Hyman SE, Borsook D. Proenkephalin transgene regulation in the paraventricular nucleus of the hypothalamus by lipopolysaccharide and interleukin-1beta. J Comp Neurol. 1999 Mar 08; 405(2):199-215. View abstract
- Borsook D, Smirnova O, Behar O, Lewis S, Kobierski LA. PhosphoCREB and CREM/ICER: positive and negative regulation of proenkephalin gene expression in the paraventricular nucleus of the hypothalamus. J Mol Neurosci. 1999 Feb; 12(1):35-51. View abstract
- Fishman SM, Caneris OA, Bandman TB, Audette JF, Borsook D. Injection of the piriformis muscle by fluoroscopic and electromyographic guidance. Reg Anesth Pain Med. 1998 Nov-Dec; 23(6):554-9. View abstract
- Borsook D, Becerra L, Fishman S, Edwards A, Jennings CL, Stojanovic M, Papinicolas L, Ramachandran VS, Gonzalez RG, Breiter H. Acute plasticity in the human somatosensory cortex following amputation. Neuroreport. 1998 Apr 20; 9(6):1013-7. View abstract
- Borsook D, Falkowski O, Smirnova O. Proenkephalin gene regulation in the paraventricular nucleus by GABA: interactions with opioid systems in a transgenic model. J Neurochem. 1998 Feb; 70(2):604-16. View abstract
- Fishman SM, Caneris OA, Stojanovic MP, Borsook D. Intravenous lidocaine for treatment-resistant pruritus. Am J Med. 1997 Jun; 102(6):584-5. View abstract
- Priest CA, Borsook D, Pfaff DW. Estrogen and stress interact to regulate the hypothalamic expression of a human proenkephalin promoter-beta-galactosidase fusion gene in a site-specific and sex-specific manner. J Neuroendocrinol. 1997 Apr; 9(4):317-26. View abstract
- Manfredi PL, Borsook D, Chandler SW, Payne R. Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations. Pain. 1997 Mar; 70(1):99-101. View abstract
- Fishman SM, Catarau EM, Sachs G, Stojanovic M, Borsook D. Corticosteroid-induced mania after single regional application at the celiac plexus. Anesthesiology. 1996 Nov; 85(5):1194-6. View abstract
- Burstein R, Falkowsky O, Borsook D, Strassman A. Distinct lateral and medial projections of the spinohypothalamic tract of the rat. J Comp Neurol. 1996 Sep 30; 373(4):549-74. View abstract
- Hyman SE, Borsook D. Mechanisms regulating proenkephalin gene expression: contributions of transgenic models. NIDA Res Monogr. 1996; 161:59-71. View abstract
- Borsook D, Hyman SE. Proenkephalin gene regulation in the neuroendocrine hypothalamus: a model of gene regulation in the CNS. Am J Physiol. 1995 Sep; 269(3 Pt 1):E393-408. View abstract
- Borsook D, Falkowski O, Rosen H, Comb M, Hyman SE. Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids. J Neurosci. 1994 Dec; 14(12):7261-71. View abstract
- Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE. Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol Endocrinol. 1994 Feb; 8(2):240-8. View abstract
- Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25. View abstract
- Strassman AM, Vos BP, Mineta Y, Naderi S, Borsook D, Burstein R. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol. 1993 Nov; 70(5):1811-21. View abstract
- Borsook D, Rosen H, Collard M, Dressler H, Herrup K, Comb MJ, Hyman SE. Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice. Mol Endocrinol. 1992 Sep; 6(9):1502-12. View abstract
- Comb MJ, Kobierski L, Chu HM, Tan Y, Borsook D, Herrup K, Hyman SE. Regulation of opioid gene expression: a model to understand neural plasticity. NIDA Res Monogr. 1992; 126:98-112. View abstract
- Borsook D, Richardson GS, Moore-Ede MC, Brennan MJ. GABA and circadian timekeeping: implications for manic-depression and sleep disorders. Med Hypotheses. 1986 Feb; 19(2):185-98. View abstract
- Brennan MJ, Volicer L, Moore-Ede MC, Borsook D. Daily rhythms of benzodiazepine receptor numbers in frontal lobe and cerebellum of the rat. Life Sci. 1985 Jun 17; 36(24):2333-7. View abstract
- Mannell A, Borsook D, Diamantes T. Recurrent ulceration and hypergastrinaemia in the gastrectomized patient. An approach to diagnosis. S Afr J Surg. 1983 Mar; 21(1):35-42. View abstract
- Borsook D, Laburn H, Mitchell D. The febrile responses in rabbits and rats to leucocyte pyrogens of different species. J Physiol. 1978 Jun; 279:113-20. View abstract
- Borsook D, Laburn HP, Rosendorff C, Willies GH, Woolf CJ. A dissociation between temperature regulation and fever in the rabbit. J Physiol. 1977 Apr; 266(2):423-33. View abstract