MEDICAL SERVICES

Languages

  • English

  • Romanian

EDUCATION

Medical School

  • The Victor Babes University of Medicine , 2004 , Timisoara , Romania

Residency

Anatomic and Clinical Pathology
  • University of Texas , 2012 , Houston , TX

Fellowship

Pediatric Pathology
  • Boston Children's Hospital , 2013 , Boston , MA

Fellowship

Neuropathology
  • University of California, San Francisco , 2015 , San Francisco , CA

CERTIFICATIONS

  • American Board of Pathology, Anatomic and Clinical Pathology
  • American Board of Pathology, Anatomic Neuropathology
  • American Board of Pathology, Pediatric Clinical Anatomic Pathology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Medullary Serotonergic Binding Deficits and Hippocampal Abnormalities in Sudden Infant Death Syndrome: One or Two Entities? Front Pediatr. 2021; 9:762017. View abstract
  2. Intracranial mesenchymal tumors with FET-CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas. Brain Pathol. 2021 Nov 25; e13037. View abstract
  3. Immunohistochemical surrogates for molecular alterations for the classification and grading of gliomas. Semin Diagn Pathol. 2022 Jan; 39(1):78-83. View abstract
  4. ALK+ histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. Blood. 2021 Nov 02. View abstract
  5. Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels. Arterioscler Thromb Vasc Biol. 2022 01; 42(1):e27-e43. View abstract
  6. Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. J Neuropathol Exp Neurol. 2021 Sep 27. View abstract
  7. Assessment of BCOR Internal Tandem Duplications in Pediatric Cancers by Targeted RNA Sequencing. J Mol Diagn. 2021 10; 23(10):1269-1278. View abstract
  8. IDH-mutant gliomas with additional class-defining molecular events. Mod Pathol. 2021 07; 34(7):1236-1244. View abstract
  9. Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion. Brain Res. 2021 07 01; 1762:147348. View abstract
  10. Outcomes after first relapse of childhood intracranial ependymoma. Pediatr Blood Cancer. 2021 08; 68(8):e28930. View abstract
  11. Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms. Brain Pathol. 2021 07; 31(4):e12918. View abstract
  12. Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant. Histopathology. 2021 Jan; 78(2):265-275. View abstract
  13. Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile. Mod Pathol. 2021 02; 34(2):264-279. View abstract
  14. Making the most of small samples: Optimization of tissue allocation of pediatric solid tumors for clinical and research use. Pediatr Blood Cancer. 2020 09; 67(9):e28326. View abstract
  15. Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathologica Communications. 2020; (8). View abstract
  16. Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathol Commun. 2020 07 14; 8(1):107. View abstract
  17. Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell. 2020 07 13; 38(1):44-59.e9. View abstract
  18. A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood. Eur J Med Genet. 2020. View abstract
  19. A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood. Eur J Med Genet. 2020 Sep; 63(9):104002. View abstract
  20. Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience. J Neurooncol. 2020 Aug; 149(1):113-122. View abstract
  21. An Update on Pediatric Gliomas. Surg Pathol Clin. 2020 Jun; 13(2):217-233. View abstract
  22. Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. View abstract
  23. Embryonal Tumors of the Central Nervous System: An Update. Surg Pathol Clin. 2020 Jun; 13(2):235-247. View abstract
  24. Somatic mutations in intracranial arteriovenous malformations. PLoS One. 2019; 14(12):e0226852. View abstract
  25. The molecular landscape of ETMR at diagnosis and relapse. Nature. 2019 12; 576(7786):274-280. View abstract
  26. Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10. View abstract
  27. Increasing value of autopsies in patients with brain tumors in the molecular era. J Neurooncol. 2019 Nov; 145(2):349-355. View abstract
  28. Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. Neuro Oncol. 2019 09 06; 21(9):1164-1174. View abstract
  29. Characterization of molecular signatures of supratentorial ependymomas. Mod Pathol. 2020 01; 33(1):47-56. View abstract
  30. Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. Neurol Neuroimmunol Neuroinflamm. 2019 05; 6(3):e560. View abstract
  31. An update on the central nervous system manifestations of DICER1 syndrome. Acta Neuropathol. 2020 04; 139(4):689-701. View abstract
  32. Recurrent EP300-BCOR Fusions in Pediatric Gliomas With Distinct Clinicopathologic Features. J Neuropathol Exp Neurol. 2019 04 01; 78(4):305-314. View abstract
  33. Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. Blood Adv. 2019 02 26; 3(4):503-507. View abstract
  34. Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. JAMA Ophthalmol. 2019 01 01; 137(1):91-95. View abstract
  35. Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System. J Neuropathol Exp Neurol. 2018 12 01; 77(12):1079-1084. View abstract
  36. Expanding the spectrum of pediatric NTRK-rearranged fibroblastic tumors to the central nervous system: A case report with RBPMS-NTRK3 fusion. Neuropathology. 2018 Dec; 38(6):624-630. View abstract
  37. PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours. Histopathology. 2018 Sep; 73(3):483-491. View abstract
  38. Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol. 2018 06; 188(6):1334-1344. View abstract
  39. Pediatric low-grade gliomas: next biologically driven steps. Neuro Oncol. 2018 01 22; 20(2):160-173. View abstract
  40. Mycoplasma hominis Empyema in an 18-Year-old Stem Cell and Lung Transplant Recipient: Case Report and Review of the Literature. J Pediatric Infect Dis Soc. 2017 Nov 24; 6(4):e173-e176. View abstract
  41. A novel GIT2-BRAF fusion in pilocytic astrocytoma. Diagn Pathol. 2017 Nov 15; 12(1):82. View abstract
  42. Neurenteric cyst at the dorsal craniocervical junction in a child: Case report. J Clin Neurosci. 2018 Feb; 48:86-89. View abstract
  43. Focal cerebral ß-amyloid angiopathy: A distinct clinicopathologic presentation. Neurol Clin Pract. 2017 Oct; 7(5):444-448. View abstract
  44. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017 Dec 01; 123(23):4631-4639. View abstract
  45. Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996. View abstract
  46. Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity? Brain Pathol. 2018 03; 28(2):183-191. View abstract
  47. Focal cerebral beta-amyloid angiopathy. A distinct clinicopathologic presentation. Neurology Clinical Practice. 2017. View abstract
  48. Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation. Pediatr Dev Pathol. 2017 Mar-Apr; 20(2):105-111. View abstract
  49. Diagnostic Histopathology. A review of molecular alterations with clinical impact in adult and paediatric gliomas. 2016; 22(11):439-446. View abstract
  50. Diagnostic Histopathology. Updates and review of neoplastic paediatric neuropathology. 2016; 22(11):431–438. View abstract
  51. Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. Pediatr Neurol. 2017 02; 67:59-63. View abstract
  52. Clinical, pathologic, and genetic features of Wilms tumors with WTX gene mutation. Pediatr Dev Pathol. 2016 Jan 04. View abstract
  53. Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas--Same Entity or First Cousins? Brain Pathol. 2016 Mar; 26(2):215-23. View abstract
  54. CNS intravascular large cell lymphoma in a patient with autoimmune hemolytic anemia. Neuropathology. 2015 Apr; 35(2):170-4. View abstract
  55. Sirolimus therapy in infants with severe hyperinsulinemic hypoglycemia. N Engl J Med. 2014 Mar 20; 370(12):1131-7. View abstract
  56. Role of calretinin immunohistochemical stain in evaluation of Hirschsprung disease: an institutional experience. Int J Clin Exp Pathol. 2013; 6(12):2955-61. View abstract
  57. Morphoproteomics provides support for TGF-ß pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis. Int J Clin Exp Pathol. 2012; 5(6):503-11. View abstract
  58. Intrahepatic cholangiocarcinoma--a rare indication for liver transplantation. Case report and review of the literature. Chirurgia (Bucur). 2012 Mar-Apr; 107(2):237-42. View abstract
  59. Neuron precursor features of spindle cell oncocytoma of adenohypophysis. Ann Clin Lab Sci. 2012; 42(2):123-9. View abstract
  60. Acute promyelocytic leukemia as a cause of intracoronary drug-eluting-stent thrombosis. Tex Heart Inst J. 2012; 39(3):416-9. View abstract
  61. Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications. Int J Clin Exp Pathol. 2010 Aug 08; 3(7):691-705. View abstract
  62. Renin-angiotensin system blockade is renoprotective in immune complex-mediated glomerulonephritis. J Am Soc Nephrol. 2008 Jun; 19(6):1168-76. View abstract