Michael Agus

Michael Agus, MD

Division Chief, Division of Medicine Critical Care; Endowed Chair in Critical Care; Medical Director, Medicine Intensive Care Unit and Intermediate Care Program; Co-Medical Director, Biocontainment Unit

Associate Professor in Pediatrics, Harvard Medical School

    Contact: 617-355-5849

Medical Services

Specialties

  • Critical Care
  • Hormonal Abnormalities in Critical Illness

Departments

  • Medicine Critical Care
  • Endocrinology

Programs

  • Medicine Intensive Care Unit
  • Intermediate Care Program
To schedule an appointment: Call 617-355-5849

Experience and Education

Education

Medical School, MD

University of Pennsylvania, School of Medicine, 1995

Philadelphia, PA

Undergraduate, BA

University of Pennsylvania, College of Arts and Sciences, 1990

Philadelphia, PA

Internship, Pediatrics

Boston Children's Hospital, 1996

Boston, MA

Residency, Pediatric

Boston Children's Hospital, 1998

Boston, MA

Pediatric Critical Care Fellowship

Massachusetts General Hospital, 2002

Boston, MA

Pediatric Endocrinology Fellowship

Boston Children's Hospital, 2002

Boston, MA

Certifications

  • Pediatrics, Pediatric Critical Care, Pediatric Endocrinology

Publications

Publications powered by Harvard Catalyst Profiles
  1. Blinder JJ, Asaro LA, Wypij D, Selewski DT, Agus MSD, Gaies M, Ferguson MA. Acute Kidney Injury After Pediatric Cardiac Surgery: A Secondary Analysis of the Safe Pediatric Euglycemia After Cardiac Surgery Trial. Pediatr Crit Care Med. 2017 Jul; 18(7):638-646.
  2. Agus MSD, Wypij D, Nadkarni, VM. Tight Glycemic Control in Critically Ill Children. N Engl J Med. 2017 06 08; 376(23):e48.
  3. Geneslaw AS, Jia H, Lucas AR, Agus MSD, Edwards JD. Pediatric intermediate care and pediatric intensive care units: PICU metrics and an analysis of patients that use both. J Crit Care. 2017 May 26; 41:268-274.
  4. Menon K, McNally JD, Zimmerman JJ, Agus MS, O'Hearn K, Watson RS, Wong HR, Duffett M, Wypij D, Choong K. Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review. Pediatr Crit Care Med. 2017 Mar; 18(3):e146-e154.
  5. Soto-Rivera CL, Asaro LA, Agus MS, DeCourcey DD. Suspected Cerebral Edema in Diabetic Ketoacidosis: Is There Still a Role for Head CT in Treatment Decisions? Pediatr Crit Care Med. 2017 Mar; 18(3):207-212.
  6. Doctor A, Zimmerman J, Agus M, Rajasekaran S, Bubeck Wardenburg J, Fortenberry J, Zajicek A, Mairson E, Typpo K. Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies. Pediatr Crit Care Med. 2017 Mar; 18(3_suppl Suppl 1):S67-S82.
  7. Agus MS, Wypij D, Hirshberg EL, Srinivasan V, Faustino EV, Luckett PM, Alexander JL, Asaro LA, Curley MA, Steil GM, Nadkarni VM. Tight Glycemic Control in Critically Ill Children. N Engl J Med. 2017 02 23; 376(8):729-741.
  8. Wong J, Agus MS, Graham DA, Melendez E. A Critical Asthma Standardized Clinical and Management Plan Reduces Duration of Critical Asthma Therapy. Hosp Pediatr. 2017 02; 7(2):79-87.
  9. Agus MS, Hirshberg E, Srinivasan V, Faustino EV, Luckett PM, Curley MA, Alexander J, Asaro LA, Coughlin-Wells K, Duva D, French J, Hasbani N, Sisko MT, Soto-Rivera CL, Steil G, Wypij D, Nadkarni VM. Design and rationale of Heart and Lung Failure - Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children. Contemp Clin Trials. 2017 Feb; 53:178-187.
  10. Soto-Rivera CL, Schwartz SM, Sawyer JE, Macrae DJ, Agus MS. Endocrinologic Diseases in Pediatric Cardiac Intensive Care. Pediatr Crit Care Med. 2016 Aug; 17(8 Suppl 1):S296-301.
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  11. Sadhwani A, Asaro LA, Goldberg C, Ware J, Butcher J, Gaies M, Smith C, Alexander JL, Wypij D, Agus MS. Impact of Tight Glycemic Control on Neurodevelopmental Outcomes at 1 Year of Age for Children with Congenital Heart Disease: A Randomized Controlled Trial. J Pediatr. 2016 Jul; 174:193-198.e2.
  12. Soto-Rivera CL, Agus MS, Sawyer JE, Macrae DJ. Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Hormone Replacement Therapy. Pediatr Crit Care Med. 2016 Mar; 17(3 Suppl 1):S59-68.
  13. Russ CM, Agus M. Triage of Intermediate-Care Patients in Pediatric Hospitals. Hosp Pediatr. 2015 Oct; 5(10):542-7.
  14. Radabaugh CL, Ruch-Ross HS, Riley CL, Stockwell JA, Conway EE, Mink RB, Agus MS, Poss WB, Salerno RA, Vernon DD. Practice Patterns in Pediatric Critical Care Medicine: Results of a Workforce Survey. Pediatr Crit Care Med. 2015 Oct; 16(8):e308-12.
  15. Fisher JG, Sparks EA, Khan FA, Alexander JL, Asaro LA, Wypij D, Gaies M, Modi BP, Duggan C, Agus MS, Yu YM, Jaksic T. Tight Glycemic Control With Insulin Does Not Affect Skeletal Muscle Degradation During the Early Postoperative Period Following Pediatric Cardiac Surgery. Pediatr Crit Care Med. 2015 Jul; 16(6):515-21.
  16. Korzeniewski SJ, Soto-Rivera CL, Fichorova RN, Allred EN, Kuban KC, O'Shea TM, Paneth N, Agus M, Dammann O, Leviton A. Are preterm newborns who have relative hyperthyrotropinemia at increased risk of brain damage? J Pediatr Endocrinol Metab. 2014 Nov; 27(11-12):1077-88.
  17. Soto-Rivera CL, Fichorova RN, Allred EN, Van Marter LJ, Shah B, Martin CR, Agus MS, Leviton A. The relationship between TSH and systemic inflammation in extremely preterm newborns. Endocrine. 2015 Mar; 48(2):595-602.
  18. Steil GM, Agus MS. Tight glycemic control in the ICU - is the earth flat? Crit Care. 2014 Jun 27; 18(3):159.
  19. Agus MS, Asaro LA, Steil GM, Alexander JL, Silverman M, Wypij D, Gaies MG. Tight glycemic control after pediatric cardiac surgery in high-risk patient populations: a secondary analysis of the safe pediatric euglycemia after cardiac surgery trial. Circulation. 2014 Jun 03; 129(22):2297-304.
  20. Decourcey DD, Steil G, Wypij D, Agus M. The authors reply. Pediatr Crit Care Med. 2014 Mar; 15(3):285-6.
  21. Srinivasan V, Agus MS. Tight glucose control in critically ill children--a systematic review and meta-analysis. Pediatr Diabetes. 2014 Mar; 15(2):75-83.
  22. Agus MS. Tight glycemic control in children--is the target in sight? N Engl J Med. 2014 Jan 09; 370(2):168-9.
  23. Nathan M, Sadhwani A, Gauvreau K, Agus M, Ware J, Newburger JW, Pigula F. Association between Technical Performance Scores and neurodevelopmental outcomes after congenital cardiac surgery. J Thorac Cardiovasc Surg. 2014 Jul; 148(1):232-237.e3.
  24. Decourcey DD, Steil GM, Wypij D, Agus MS. Increasing use of hypertonic saline over mannitol in the treatment of symptomatic cerebral edema in pediatric diabetic ketoacidosis: an 11-year retrospective analysis of mortality*. Pediatr Crit Care Med. 2013 Sep; 14(7):694-700.
  25. Soto-Rivera CL, Agus MS. Measuring and reporting glycemic control in clinical trials: building a path to consensus. Crit Care. 2013 Jun 14; 17(3):155.
  26. Hirshberg EL, Sward KA, Faustino EV, Nadkarni VM, Agus MS, Morris AH, Lacroix J. Clinical equipoise regarding glycemic control: a survey of pediatric intensivist perceptions. Pediatr Crit Care Med. 2013 Feb; 14(2):123-9.
  27. Gaies MG, Langer M, Alexander J, Steil GM, Ware J, Wypij D, Laussen PC, Newburger JW, Goldberg CS, Pigula FA, Shukla AC, Duggan CP, Agus MS. Design and rationale of safe pediatric euglycemia after cardiac surgery: a randomized controlled trial of tight glycemic control after pediatric cardiac surgery. Pediatr Crit Care Med. 2013 Feb; 14(2):148-56.
  28. Jacobi J, Bircher N, Krinsley J, Agus M, Braithwaite SS, Deutschman C, Freire AX, Geehan D, Kohl B, Nasraway SA, Rigby M, Sands K, Schallom L, Taylor B, Umpierrez G, Mazuski J, Schunemann H. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012 Dec; 40(12):3251-76.
  29. Wong J, Agus MS, Steil GM. Cardiac parameters in children recovered from acute illness as measured by electrical cardiometry and comparisons to the literature. J Clin Monit Comput. 2013 Feb; 27(1):81-91.
  30. Dauber A, Corcia L, Safer J, Agus MS, Einis S, Steil GM. Closed-loop insulin therapy improves glycemic control in children aged &lt7 years: a randomized controlled trial. Diabetes Care. 2013 Feb; 36(2):222-7.
  31. Agus MS, Steil GM, Wypij D, Costello JM, Laussen PC, Langer M, Alexander JL, Scoppettuolo LA, Pigula FA, Charpie JR, Ohye RG, Gaies MG. Tight glycemic control versus standard care after pediatric cardiac surgery. N Engl J Med. 2012 Sep 27; 367(13):1208-19.
  32. Steil GM, Langer M, Jaeger K, Alexander J, Gaies M, Agus MS. Value of continuous glucose monitoring for minimizing severe hypoglycemia during tight glycemic control. Pediatr Crit Care Med. 2011 Nov; 12(6):643-8.
  33. Steil GM, Eckstein OS, Caplow J, Agus MS, Walsh BK, Wong J. Non-invasive cardiac output and oxygen delivery measurement in an infant with critical anemia. J Clin Monit Comput. 2011 Apr; 25(2):113-9.
  34. Yu HY, Agus M, Kellogg MD. Clinical utility of Abbott Precision Xceed Pro® ketone meter in diabetic patients. Pediatr Diabetes. 2011 Nov; 12(7):649-55.
  35. Steil GM, Alexander J, Papas A, Monica L, Modi BP, Piper H, Jaksic T, Gottlieb R, Agus MS. Use of a continuous glucose sensor in an extracorporeal life support circuit. J Diabetes Sci Technol. 2011 Jan 01; 5(1):93-8.
  36. Agus MS, Alexander JL, Wolfsdorf JI. Utility of immediate hemoglobin A1c in children with type I diabetes mellitus. Pediatr Diabetes. 2010 Nov; 11(7):450-4.
  37. Weiss SL, Alexander J, Agus MS. Extreme stress hyperglycemia during acute illness in a pediatric emergency department. Pediatr Emerg Care. 2010 Sep; 26(9):626-32.
  38. Agus MSD. Endocrine emergencies. Fleisher GR, Ludwig S, editors. Textbook of Pediatric Emergency Medicine. 2009.
  39. Shih JL, Agus MS. Thyroid function in the critically ill newborn and child. Curr Opin Pediatr. 2009 Aug; 21(4):536-40.
  40. Mallory LA, Shaw JG, Burgess SL, Estrella E, Nurko S, Burpee TM, Agus MS, Darras BT, Kunkel LM, Kang PB. Congenital myasthenic syndrome with episodic apnea. Pediatr Neurol. 2009 Jul; 41(1):42-5.
  41. Agus MS, Hirshberg EL. Pediatrics: Intensive insulin therapy in critically ill children. Nat Rev Endocrinol. 2009 Jul; 5(7):360-2.
  42. Mallory LA, Shaw JG, Burgess SL,Estrella E, Nurko S, Burpee TM, Agus MS, Darras BT, Kunkel LM, Kang PB. Choline acetyltransferase deficiency causing congenital myasthenic syndrome with episodic apnea. Pediatr Neurol. 2009; 41:42-45.
  43. Steil GM, Agus MS. Critical illness hyperglycemia: is failure of the beta-cell to meet extreme insulin demand indicative of dysfunction? Crit Care. 2009; 13(2):129.
  44. Steil GM, Agus MSD. Critical illness hyperglycemia: is failure of the beta-cell to meet extreme insulin demand indicative of dysfunction?. Critical Care. 2009; 13:129.
  45. Moses JM, Alexander JL, Agus MS. The correlation and level of agreement between end-tidal and blood gas pCO2 in children with respiratory distress: a retrospective analysis. BMC Pediatr. 2009 Mar 12; 9:20.
  46. Steil GM, Deiss D, Shih J, Buckingham B, Weinzimer S, Agus MSD. ICU Insulin delivery algorithms: Why so many? How to choose?. J Diab Sci Tech. 2009; 3(1):125-140.
  47. Steil GM, Deiss D, Shih J, Buckingham B, Weinzimer S, Agus MS. Intensive Care Unit Insulin Delivery Algorithms: Why So Many? How to Choose? J Diabetes Sci Technol. 2009 Jan; 3(1):125-140.
  48. Polito A, Thiagarajan RR, Laussen PC, Gauvreau K, Agus MS, Scheurer MA, Pigula FA, Costello JM. Association between intraoperative and early postoperative glucose levels and adverse outcomes after complex congenital heart surgery. Circulation. 2008 Nov 25; 118(22):2235-42.
  49. Agus MS, Javid PJ, Piper HG, Wypij D, Duggan CP, Ryan DP, Jaksic T. The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life support. Ann Surg. 2006 Oct; 244(4):536-44.
  50. Langer M, Modi, BP, Alexander JA, Jaksic T, Agus M. Continuous Glucose Monitoring in Pediatric Patients on Extracorporeal Life Support. American Academy of Pediatrics. 2006.
  51. Piper HG, Alexander JL, Shukla A, Pigula F, Costello JM, Laussen PC, Jaksic T, Agus MS. Real-time continuous glucose monitoring in pediatric patients during and after cardiac surgery. Pediatrics. 2006 Sep; 118(3):1176-84.
  52. Langer M, Modi BP, Agus M. Adrenal insufficiency in the critically ill neonate and child. Curr Opin Pediatr. 2006 Aug; 18(4):448-53.
  53. Agus MS, Alexander JL, Mantell PA. Continuous non-invasive end-tidal CO2 monitoring in pediatric inpatients with diabetic ketoacidosis. Pediatr Diabetes. 2006 Aug; 7(4):196-200.
  54. Agus, MSD, Jaksic, T. Nutritional Support of the Critically Ill Child. Wheeler DS, Wong HR, Shanley TP, editors. Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. 2005.
  55. Agus MSD, Piper HG, Alexander JA, Shukla A, Costello J, Pigula F, Jaksic T, Laussen P. Continuous glucose monitoring in pediatric cardiac surgery patients. European Society of Pediatric Endocrinology and Lawson Wilkins Pediatric Endocrine Society. 2005.
  56. Agus MSD, Alexander JA, Wolfsdorf JI. Benefits of immediate hemoglobin A1c results in pediatric type 1 diabetes patients. European Society of Pediatric Endocrinology and Lawson Wilkins Pediatric Endocrine Society. 2005.
  57. Agus MSD, Alexander JA, Wolfsdorf JI. Benefits of immediate hemoglobin A1c results in pediatric type 1 diabetes patients. Hormone Research. 2005; 64(S1).
  58. Agus MS, Wolfsdorf JI. Diabetic ketoacidosis in children. Pediatr Clin North Am. 2005 Aug; 52(4):1147-63, ix.
  59. Agus MSD, Piper HG, Javid PJ, Ryan DR, Duggan CP, Jaksic T. The effects of insulin on protein metabolism in critically ill neonates. Endocrine Society. 2005.
  60. Javid PJ, Halwick DR, Betit P, Thompson JE, Long K, Zhang Y, Jaksic T, Agus MS. The first use of live continuous glucose monitoring in patients on extracorporeal life support. Diabetes Technol Ther. 2005 Jun; 7(3):431-9.
  61. Agus M. One step forward: an advance in understanding of adrenal insufficiency in the pediatric critically ill. Crit Care Med. 2005 Apr; 33(4):911-2.
  62. Agus MSD. Endocrine emergencies. Fleisher GR, Ludwig S, editors. Textbook of Pediatric Emergency Medicine. 2004.
  63. Agus MSD, Lindheim J. Clowning in the pediatric intensive care unit. Lindheim J, editor. The Art and Joy of Hospital Clowning: The Jeannie Lindheim Hospital Clown Training Process. 2004.
  64. Agus MS, Javid PJ, Ryan DP, Jaksic T. Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation. J Pediatr Surg. 2004 Jun; 39(6):839-44; discussion 839-44.
  65. Javid PJ, Haight R, Long K, Zhang Y, Jaksic T, Agus MSD. The first use of live continuous glucose monitoring in critically ill neonates. American Diabetes Association. 2004.
  66. Agus MSD, Alexander JA, Mantell P. Continuous non-invasive CO2 monitoring in pediatric inpatients with diabetic ketoacidosis. American Diabetes Association. 2004.
  67. Agus MS, Jaksic T. Critically low hormone and catecholamine concentrations in the primed extracorporeal life support circuit. ASAIO J. 2004 Jan-Feb; 50(1):65-7.
  68. Warren HS, Jr, Gonzalez RG, Tian D. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 38-2003. A 12-year-old girl with fever and coma. New England Journal of Medicine. 2003; 349(24):2341-9.
  69. Javid PJ, Agus MSD, Ryan DP, Jaksic T. Intravenous Insulin Improves Protein Breakdown in Infants on Extracorporeal Membrane Oxygenation. Journal of the American College of Surgeons. 2003; 197(3):S48.
  70. Halwick DR, Betit P, Thompson JE, Javid PJ, Long KJ, Zhang Y, Agus MSD. Technical evaluation of a glucose and oxygen sensor in an extracorporeal circuit. ECMO & Advanced Therapies for Respiratory Failure. 2003.
  71. Javid PJ, Halwick D, Jaksic T, Long K, Zhang Y, Agus MSD. Continuous glucose monitoring in an extracorporeal circuit. ECMO & Advanced Therapies for Respiratory Failure. 2003.
  72. Agus MSD. Continuous analyte monitor and method of using same. 2002.
  73. Agus MS, Jaksic T. Nutritional support of the critically ill child. Curr Opin Pediatr. 2002 Aug; 14(4):470-81.
  74. Agus MSD, Ryan DP, Jaksic T. Effect of hyperinsulinemic clamp on protein catabolism in critically ill neonates. Lawson Wilkins Pediatric Endocrine Society at Society for Pediatric Research. 2002.
  75. Agus MS, Agus ZS. Cardiovascular actions of magnesium. Crit Care Clin. 2001 Jan; 17(1):175-86.
  76. Agus, MSD. The hormonal response to critical illness. Radovick S, MacGillivray MH, editors. Trends in Pediatric Endocrinology. 2001.
  77. Agus MS, Swain JF, Larson CL, Eckert EA, Ludwig DS. Dietary composition and physiologic adaptations to energy restriction. Am J Clin Nutr. 2000 Apr; 71(4):901-7.
  78. Katz LE, Liu F, Baker B, Agus MS, Nunn SE, Hintz RL, Cohen P. The effect of growth hormone treatment on the insulin-like growth factor axis in a child with nonislet cell tumor hypoglycemia. J Clin Endocrinol Metab. 1996 Mar; 81(3):1141-6.
  79. Agus MS, Katz LE, Satin-Smith M, Meadows AT, Hintz RL, Cohen P. Non-islet-cell tumor associated with hypoglycemia in a child: successful long-term therapy with growth hormone. J Pediatr. 1995 Sep; 127(3):403-7.
To schedule an appointment: Call 617-355-5849

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