Auditory Brainstem Response Evaluation Research

Research study involving ABRE

The aim of a study taking place in the Division of Developmental Medicine is to determine the long-term effects of iron deficiency in infancy. Specifically, 1200 10-year-old Chilean children who participated in a previous study as infants and preschoolers are receiving broad-based evaluations of the effects of a long-term preventive trial. One exciting aspect of this large project involves the assessment of long-term neuromaturational effects in a subset of 200 children.

Some neurophysiologic aspects that are being examined include auditory brainstem response, visual evoked potentials, spontaneous motor activity (using Actigraphic recordings), sleep-wake cycle (using polysomnographic recordings), heart rate variability, neuroendocrine patterns, and the evaluation of neurocognitive functioning using ERPs. Children’s role in this involves the implementation of ERPs to assess recognition memory and response inhibition. ERPs are being used in this context in order to examine the long-lasting impairment of specific cognitive processes in early iron deficiency.