X-Linked Agammaglobulinemia | Symptoms & Causes

What causes X-linked agammaglobulinemia?

Women may carry the gene, but are unlikely to develop the disorder. However, an affected mother has a 50/50 chance of passing the gene to her child. Your child may be the first in your family to be diagnosed with X-linked agammaglobulinemia; this could be because the disease is a result of a new genetic mutation.

What are the symptoms of X-linked agammaglobulinemia?

Symptoms are likely to become apparent when your child is between 6 and 9 months old. Each child may experience symptoms differently, but common symptoms include:

An unusual susceptibility to numerous illnesses such as:

  • Nasal infections
  • Skin infections
  • Bone infections
  • Eye infections (including Pink Eye)
  • Meningitis
  • Bronchitis
  • Sepsis, or infection of the blood stream
  • Pneumonia
  • Diarrhea (from gastrointestinal infections)
  • Viral infections like hepatitis and polio
  • Failure to grow
  • Absence of tonsils and adenoids
  • Joint disease, primarily in the knees, similar to juvenile rheumatoid arthritis
  • Kidney inflammation
  • Red blood cell breakdown
  • Skin and muscle inflammation

The symptoms of X-linked agammaglobulinemia may resemble other problems or medical conditions. Always consult your child's physician for a diagnosis.