X-Linked Agammaglobulinemia

What is X-linked agammaglobulinemia?

The first immunodeficiency disease ever identified, X-linked agammaglobulinemia is caused by a gene, located on the X chromosome that makes your child unable to produce antibodies. Children with this disease are prone to infections in the middle ear, sinuses, and lungs, but the bloodstream and internal organs may also be affected.

Also known as Bruton's agammaglobulinemia or congenital agammaglobulinemia, X-Linked agammaglobulinemia is an inherited disorder, occurring mainly in boys, in which your child is unable to produce antibodies (the body's primary defense against bacteria and viruses).

This immunodeficiency disease makes it difficult for your child to fight off bacterial infections and certain viral infections. Approximately one in 10,000 children are born with this disease. Early diagnosis and treatment may allow your child to live a relatively normal, active life

How we care for X-linked agammaglobulinemia

The Immunology Program team at Boston Children’s Hospital evaluates and treats children with various types of immune system disorders. We are widely recognized as one of the world leaders in immunology treatment and research.