Ureteropelvic Junction (UPJ) Obstruction | Research & Clinical Trials

Research & Innovation

Proteomics and biomarkers

  • Proteomics, the study of an organism's proteins, picks up where the Human Genome Project left off. Proteins are everywhere in the body, but not all proteins encoded in the genome are expressed—and each organ in the body expresses a different set of proteins.
  • In Boston Children’s Hospital’s Department of Urology, Rosalyn Adam, PhD, Keith Solomon, PhD, Richard Lee, MD, and colleagues are working to categorize the entire collection of urine proteins and understand what is different in children with in urologic diseases like congenital UPJ obstructions. They are also using proteomics to detect changes in bladder tissue that may be associated with disease progression. 

Managing pain after surgery

  • Boston Children’s has been a pioneer in anesthesia for children, and our urologists and anesthesia doctors have worked together to develop highly effective pain management techniques for children who have surgery.
  • Using these methods, most children recover quickly after surgery and their pain is kept to a minimum. Most children can go home one or two days after surgery. In addition, we have been leaders in development of less invasive methods of correcting UPJ obstructions. Our pioneering surgeons have used laparoscopic and robotic-assisted laparoscopic surgery to successfully correct UPJ obstructions in many children.