Soft Tissue Sarcomas

What is soft tissue sarcoma?

Soft tissue sarcomas are cancerous tumors that begin in the tissues that connect, support or surround the body's organs and structures, known as soft tissues. These tissues include muscle, tendon, synovial tissue (around joints), fat, blood vessels, lymph vessels, and nerves. Soft tissue sarcomas can develop almost anywhere in the body, but in children they are most common in the arms, legs, chest, and abdomen. These sarcomas are rare, comprising less than 1 percent of all new cancer cases per year and just 3 percent of all childhood tumors. In the United States, about 900 children and adolescents are diagnosed with soft tissue sarcomas each year.

Doctors are not sure what causes soft tissue sarcomas to emerge, but a genetic link is suspected. Some inherited diseases, such as Li Fraumeni syndrome and neurofibromatosis type 1, increase the risk of developing a soft tissue sarcoma.

Soft tissue sarcomas affect tissue that is elastic and easily moved, which means that a tumor may exist for a long time before being discovered, growing larger and pushing aside surrounding tissue.

How we care for soft tissue sarcoma

Children with soft tissue sarcoma are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through our Bone and Soft Tissue Tumors Program. Our integrated pediatric oncology program offers the combined expertise of a leading cancer center and a world-renown children’s hospital. We provide the full set of options that can be used to treat bone and soft tissue tumors, and our solid tumor treatment team can help you determine which option is best for your child.

Our pediatric oncologists have access to, and often lead, some of the most innovative clinical trials for soft tissue sarcomas. Our surgeons have specialized expertise in complex surgeries, and our radiation oncologists have access to the newest radiation therapy techniques that may also be used in the care of a child with soft tissue sarcoma

What is the latest research for soft tissue sarcoma?

At Dana-Farber/Boston Children's, your child will have access to cutting-edge therapies being tested by the nation's top researchers in pediatric cancer. Our scientists are conducting numerous research studies to help doctors better understand and treat soft tissue sarcomas.

These include:

  • genomic assessment of soft tissue sarcomas
  • angiogenesis inhibitors, which are substances that might be able to prevent the growth of tumors
  • biological therapies that harness the body's immune system to fight cancer

We are also the New England Phase I Center for the Children's Oncology Group, a group of cancer researchers from around the world dedicated to finding new treatments for pediatric cancer.

For many children with rare, recurrent, or hard-to-treat conditions, clinical trials provide new options.