Nephrotic Syndrome (Kidney Disease) Pediatric Research and Clinical Trials

Boston Children's Division of Nephrology is dedicated to better understanding and developing lasting treatments for the most serious kidney diseases affecting children. Some of our initiatives have focused on focal segmental glomerulosclerosis (FSGS).

Reducing the recurrence of FSGS after transplant

FSGS tends to return in 50% of kidney transplants, often recurring in the immediate post-transplant period and causing transplant loss. Using apheresis as part of a pre-transplant conditioning protocol, the Boston Children's Hospital Nephrology team led by Michael Somers, MD, has reduced the typical FSGS recurrence rate by more than half and has successfully reversed most FSGS in children who did recur.

Gene for FSGS discovered

Researchers from Boston Children's and Brigham and Women's Hospital have identified an important genetic cause of a devastating kidney disease that is the second leading cause of kidney failure in children. The study may provide clues to developing treatments for the disease, focal segmental glomerulosclerosis (FSGS), which currently forces children and young adults onto dialysis and often requires a kidney transplant. No effective treatments are known, and years of research have failed to uncover the underlying disease mechanism. Learn more.