Microvillus Inclusion Disease (MVID) | Diagnosis & Treatments

How is microvillus inclusion disease diagnosed?

Diagnosing microvillus inclusion disease (MVID) involves a number of steps. First doctors will test to determine the kind of diarrhea involved and which nutrients cannot be absorbed.

If they suspect a congenital diarrhea, they will need to look at a sample of the tissue in the small intestine. To do this they will need to perform a procedure called an endoscopy, which uses a small flexible viewing tube to look at the intestine and obtain tiny tissue samples (biopsies).

Once they have a sample they will look at it under a microscope as well as with a special microscope (electron microscope). Using electron microscopy, doctors can detect the main features of microvillus inclusion disease, which are tiny but distinct differences in the cells of the small intestine.

In addition to these tests, doctors will perform genetic testing to see whether there are any differences in the genes known to cause MVID and other congenital diarrheas.

How is microvillus inclusion disease treated?

There are currently no drug treatments for MVID. Treatment is supportive and involves long-term maintenance of nutrition and hydration with parenteral nutrition.