Juvenile Nasopharyngeal Angiofibroma Pediatric Research and Clinical Trials

Juvenile nasopharyngeal angiofibroma is an enigma to physicians and scientists. Nobody yet understands why this disease appears almost always in adolescent boys – or why it disappears when those patients reach their 20s and 30s.

To better understand JNA, the physician scientists in our programs are currently conducting a study involving whole exome sequencing of patients with JNA. Whole exome sequencing can help provide insights into complex diseases by finding common genetic variants (mutations) shared between the individuals with the disease. Once the specific mutations are discovered, it may then be possible to develop drugs that can counteract those mutations. Ultimately, someday we may be able to treat the disease without needing surgery.

The whole exome sequencing study is being performed primarily to increase scientific knowledge. However, if an individual’s test reveals information that could be of clinical benefit, those results will be returned to the referring physician for discussion with you and your child.