Stylopoulos Laboratory

Our laboratory was established in May 2011 under the leadership of Dr. Nicholas Stylopoulos. We are part of the Center for Basic and Translational Obesity Research at Boston Children's Hospital. The Center for Basic and Translational Obesity Research is an exciting new research program in the Division of Endocrinology at Boston Children’s Hospital and Harvard Medical School. Our goal is to improve our understanding of how people develop obesity and other metabolic diseases, and to help translate research findings into better treatments. We are located on the 16th floor of the Center for Life Science Building in the Longwood Medical Area in Boston. We hope that this webpage will provide you with a comprehensive overview of our work and our current research activities. Please feel free to contact us for more information.


The goals of the current studies in our laboratory are:

To study weight loss surgery in order to develop new, less invasive treatments for obesity. If we can understand the mechanisms whereby weight loss surgery, especially the gastric bypass surgery, works to normalize blood glucose levels and improve metabolism, we could develop new, non-surgical therapies for diabetes, obesity and other metabolic diseases that take advantage of these mechanisms. We call this process “reverse engineering of gastric bypass surgery.”

To study weight loss surgery in order to gain insight into the physiological mechanisms of metabolic and weight regulation. Currently, the projects of our laboratory focus on specific targets that could lead to the development of novel treatments for obesity and its metabolic complications. These new treatments are based on specific pathways that are affected by RYGB.  We have identified these potential pathways and mechanisms using animal models of weight loss surgery. We hope that by developing a better understanding of these these mechanisms, we will develop drug candidates and drug combination treatments that could reproduce the effects of RYGB, without the invasiveness of surgery. Thus, we will eventually be able to "bypass the bypass."

Bypassing Diabetes

The fundamental question we try to answer is how gastric bypass improves glucose and lipid metabolism and cures diabetes and the metabolic syndrome. We have recently proposed a new mechanism, based on studies on rodent models. These studies and our hypothesis have been published recently in Science. Please click on the pictures below for additional information about this work.

 Our paper was also recently featured on NIH Director's blog:

Please click the picture below to read more about the story of our paper, as covered by Harvard Medical School: