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The purpose of this trial is to investigate if the study drug affects learning skills in individuals diagnosed with TSC. The participant will be asked to take by mouth either the study drug or a placebo, which is determined by chance. The study involves about nine visits to Children's over six months with each visit including blood draws, laboratory tests and other screening evaluations such as neuropsychological, seizure and sleep assessments. The study drug will be provided at no charge, and a voucher for parking will be provided at each study visit.
Eligibility: Individuals diagnosed with TSC between the ages of 6 and 21 years and with an IQ greater than or equal to 60.
Contact: Melanie Jacobs at 617-919-3499 or
melanie.jacobs@childrens.harvard.edu
This trial will evaluate the role of azithromycin (antibiotic) and oral steroids in preventing and treating asthma and wheeze in children. The study may last up to 12 months, with visits that include education and monitoring in the clinic and on the phone. Participants will receive asthma supplies and medication, physical exams and asthma education. Families will receive compensation for transportation, parking and their time.
Eligibility: Toddlers and preschoolers age 12 to 71 months (1 to 5 years 11 months old) who wheeze.
Contact: Wendy Gordon at 857-218-5336 or
asthma@childrens.harvard.edu
This study focuses on comparing the presence or absence of certain bacterial species in stool samples between IBD patients and healthy patients, as well as how the intestinal bacteria change over time with respect to patient medication and treatment. The goal of the study is to develop better treatment and less invasive diagnostic tests for patients with IBD.
Eligibility: Both patients with and without diagnosed IBD are eligible to participate. Patients must be over the age of 3 months and must not have had a bowel preparation in the last week.
Contact: Jay Ingram at 617-355-2962 or
jay.ingram@childrens.harvard.edu
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