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Clinical trials

Medical office intervention for adolescent drug use

Mark Flemming
John R. Knight, MD

Brief motivational interventions have been effective in reducing alcohol use among adults, but haven't been studied extensively in adolescents. Adolescent participants in this study will first receive an evaluation through the Adolescent Substance Abuse Program (ASAP) and then be randomly placed into one of two groups. The first group will receive "enhanced standard care" through ASAP. The second group will meet with an ASAP provider for three "motivational interviewing" sessions over four to six weeks. All participants will complete questionnaires at study entry, and again six and nine months later. We will compare the effectiveness of the two treatment approaches on rates of substance use and participation in other treatments.

Eligibility: Adolescents at risk or who have potentially serious levels of drug and alcohol use may be eligible.

More information: Contact: 617-355-5433 or ceasar@childrens.harvard.edu


Exercise-induced asthma

Mark Flemming
Wanda Phipatankakul, MD, MS

This study will evaluate whether Symbicort® (budesonide/formoterol), a new combination asthma medication, is more effective than budesonide alone in controlling exercise-induced asthma. If enrolled, participants will be asked to run on a treadmill and perform breathing tests at the baseline and each of four follow-up visits. During the eight-week study, participants will switch from their usual inhaled steroid medication to the study medications. Compensation of $50 and parking/MBTA reimbursement are given.

Eligibility: Children and adults between 12 and 50 with a history of persistent asthma and symptoms of exercise-induced asthma may be eligible.

More information:Jon Gaffin at 857-218-4803 or jonathan.gafffin@childrens.harvard.edu


Cerebral visual impairment in children born prematurely

Janet S. Soul, MD

The purpose of this study is to better understand vision problems that occur in children born prematurely. Standard vision test, a visual evoked potential test and a visual behavior test will be completed during the one-to three-study visits. Parking voucher and compensation of $20 will be provided.

Eligibility: Children born between 2000 and 2004 who have healthy eyesight and who were born full-term may be eligible.

More information: Jessica Landers at 617-355-0578 or Jessica.landers@childrens.harvard.edu


 
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