news banner
 

pediatric views

other publications

news room

giving

 
 

Research: New method to produce iPS cells reported

Derrick Rossi, PhD, a researcher at the Immune Disease Institute/Program in Cellular and Molecular Medicine at Children's, has developed an RNA-based technology to produce induced pluripotent stem (iPS) cells that is safer and faster than current virus-based methods, and could become a central enabling technology in regenerative medicine.
The study, published in Cell Stem Cell in early September, reports overcoming three major drawbacks in iPS cells produced using traditional approaches and techniques. Standard virus-based programming poses a risk of introducing mutations that could trigger cancers, and only a fraction of the cells treated actually turn into iPS cells. Dr. Rossi's technique, using modified RNA to encode and drive the reprogramming proteins, cut in half the time required to create iPS cells, was up to 100 times more efficient and did not integrate into the cells' DNA. It also efficiently redirected stem cells to form other tissue types.
Dr. Rossi has patented his findings and recently formed a company called ModeRNA Therapeutics to translate them to the clinic.



 
 
  Cell Stem Cell: Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

A Safer Method for Creating Pluripotent Stem Cells

 

 
  mouse  

Subscribe to our monthly
e-newsletter, eDose

   

Subscribe to our RSS feed

 

  Contact Us
 

Share

 

Share