Cleft lip and/or palate and isolated cleft palate are common birth defects: 1 in 1,000, and 1 in 2,500, respectively. They are categorized as syndromic (an underlying cause) or nonsyndromic (no underlying cause).
This study aims to identify hereditary cases of nonsyndromic cleft lip and/or palate (NS CLP) based on subtle characteristics detected in NS CLP patients and families, and to identify genes and genetic variations that cause NS CLP. We would like to understand how variations in certain genes correlate with specific abnormalities.
Eligibility: Children over 2 years with NS CLP, with or without a family history of NS, may be eligible.
Contact: Kathleen Busa at 857-218-4876 or firstname.lastname@example.org
This study is currently recruiting participants and will evaluate the usefulness of adenotonsillectomy versus medical therapy in children with mild obstructive sleep apnea (OSA). Neurocognitive testing and a sleep study will be performed, and participants will receive $450 upon completion of the study.
Eligibility: Children between 5 and 9.99 years old with no significant medical problems who are candidates for adenotonsillectomy with mild OSA may be eligible.
Contact:Amanda Caplan at 617-355-5309 or email@example.com