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Everolimus in pediatric patients with ALL
In this research study conducted by Boston Children's Hospital and Dana-Farber Cancer Institute, we are looking to learn how everolimus works in combination with four other drugs commonly used to treat relapsed acute lymphoblastic leukemia (ALL): prednisone, vincristine, PEG-asparaginase and doxorubicin. The main goal of the study is to evaluate the side effects of this treatment combination in order to determine a safe dose of everolimus that can be given with these other drugs.
Eligibility: Patients may be eligible for participation if they have ALL in first bone marrow relapse occurring more than 18 months from initial diagnosis, normal organ function and a maximum prior cumulative doxorubicin dose of </= 360 mg/m2 or equivalent. For complete eligibility requirements, visit the study site at on.chbos.org/pv0412-ALLtrial.
Contact: Boston Children's Hospital Pediatric Clinical Translation Investigation Program at ctip@partners.org
Study of the treatment for brachial plexus birth palsy
This study is designed to determine the natural history of brachial plexus birth palsy (BPBP) and establish the ideal timing for microsurgery, tendon transfer and osteotomies and ultimately develop a universal standard of care. Patients who meet the criteria for microsurgical repair of a rupture injury will undergo surgery at 5 to 6 months of age. Infants with an avulsion injury will have surgery at 3 months of age. As part of Boston Children's regular standard of care, the functional status of patients will be monitored and recorded on a regular basis for a follow-up period of five years. Patients will be asked to routinely complete the MODEMS Pediatric Outcomes questionnaire, which will track their recovery.
Eligibility: All infants/children diagnosed with BPBP will be eligible for participation in this study.
Contact: Emily Reiff at 617-355-0549 or emily.reiff@childrens.harvard.edu
Beverages and social health study
Researchers at Boston Children's are studying how different beverages affect body weight and heart disease risk factors. Participants will receive deliveries of study beverages to their home and parking vouchers or T fares for five study visits. Participants may also receive American Express gift cards worth up to $300.
Eligibility: Patients may be eligible if they are 18 to 35 years of age and will remain in the Boston area for the next year.
Contact: Abigail Lukens at 617-355-2500
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