Research

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Yoshio Okada, PhD

Yoshio Okada, PhD
Research Center:
Fetal-Neonatal Neuroimaging and Developmental Science Center
Department:
Medicine Research
Division
Newborn Medicine Research
Hospital Title:
Associate Scientific Researcher
Academic Title:
Clinical Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Neuroimaging
Contact:
781-216-1128
Contact Via Email
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Research Overview

Web Site:  Fetal-Neonatal Neuroimaging and Developmental Science Center

Dr. Okada is currently engaged in several areas of research: 

Human brain development - Dr. Okada is the Director of the Magnetoencephalography (MEG) Program at Children's Hospital Boston. This program is part of the Fetal-Neonatal Neuroimaging and Developmental Science (FNNDSC) of the Newborn Medicine Research Center and the Division of Epilepsy of Department of Neurology at Children’s. It is dedicated to furthering our understanding of mechanisms of human brain development,  electrophysiological bases of information processing in the human brain and physiological bases of functional abnormality in children with various neurological and psychiatric disorders. Dr. Okada hopes that this MEG program will provide unique opportunities for scientists at Harvard University to discover the fundamental issues concerning human brain functions and development in health and disease.

Neural current MRI – Dr. Okada and his colleague, Dr. Padma Sundaram, Instructor of Radiology at Children’s recently succeeded in showing that Magnetic Resonance Imaging (MRI) can be used to directly measure neuronal currents from the brain of animals, specifically in an intact brain structure called cerebellum in turtle. Dr. Okada believes that this ncMRI can be developed to image neuronal activity directly with MRI in humans.

Electrophysiology of cortical neuronal networks and brain plasticity – Dr. Okada has designed a novel neuroimaging instrument to stimulate one or more focal regions of the cerebral cortex with magnetic pulses and measure functional coupling within various neural networks of interest.  He believes that this new instrument can be used to provide novel understanding of functional roles of various neuronal networks in human brain. He also believes the new technology can be used to help with rehabilitation of children and adults who suffer from various types of brain injury by accelerating reorganization of the brain to optimize the functions of surviving neurons.

About Yoshio Okada

Dr. Okada received his PhD from the Rockefeller University in New York City in the field of psychology and neuroscience. He is the pioneer in the study of the physiological basis of magnetoencephalography (MEG) and electroencephalography (EEG). He has established through his research carried out over a period of 25 years that these two noninvasive techniques provide direct measurements of the electrophysiological activity of synchronously active neurons. Dr. Okada has made contributions to the development of novel biomagnetic instruments that have opened new ways to study the electrophysiology of the brain and is an inventor of new instruments that are in the process of development. These instruments include a pediatric MEG system called “babySQUID”, the first of its kind optimized for studying the electrophysiological development of human brain, a second-generation pediatric MEG system called “babyMEG”, which is based on the babySQUID, but provides a whole-head coverage with sensitivities and spatial resolution that are higher than any existing MEG instruments, an inverted SQUID (superconducting quantum interference device ) microscope capable of simultaneously measuring biomagnetic fields, electrical potentials and optical images from biological preparations and a whole-head cryogenically cooled Transcranial Magnetic Stimulation (TMS) system that will provide unique novel methods for studying functional networks of the human brain. Dr. Okada is a founder of a center called “Biomedical Research and Integrative Neuroimaging Center” or BRaIN Imaging Center at the University of New Mexico prior to joining Harvard Medical School. This BRaIN Imaging Center is a state-of-the-art multimodal neuroimaging facility with many types of neuroimaging methods created to provide a research environment for neuroscientists at the University for carrying out competitive research and to provide a training and education environment for developing the careers of the junior faculty members of the University.

Publications

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  1. Sundaram P, Nummenmaa A, Wells W, Orbach D, Orringer D, Mulkern R, Okada Y. Direct neural current imaging in an intact cerebellum with magnetic resonance imaging. Neuroimage. 2016 May 15; 132:477-90.
  2. Papadelis C, Grant PE, Okada Y, Preissl H. Editorial on emerging neuroimaging tools for studying normal and abnormal human brain development. Front Hum Neurosci. 2015; 9:127.
  3. Murakami S, Okada Y. Invariance in current dipole moment density across brain structures and species: physiological constraint for neuroimaging. Neuroimage. 2015 May 1; 111:49-58.
  4. Papadelis C, Ahtam B, Nazarova M, Nimec D, Snyder B, Grant PE, Okada Y. Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study. Front Hum Neurosci. 2014; 8:725.
  5. Hunold A, Haueisen J, Ahtam B, Doshi C, Harini C, Camposano S, Warfield SK, Grant PE, Okada Y, Papadelis C. Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report. Front Hum Neurosci. 2014; 8:175.
  6. Nummenmaa A, McNab JA, Savadjiev P, Okada Y, Hämäläinen MS, Wang R, Wald LL, Pascual-Leone A, Wedeen VJ, Raij T. Targeting of white matter tracts with transcranial magnetic stimulation. Brain Stimul. 2014 Jan-Feb; 7(1):80-4.
  7. Nummenmaa A, Stenroos M, Ilmoniemi RJ, Okada YC, Hämäläinen MS, Raij T. Comparison of spherical and realistically shaped boundary element head models for transcranial magnetic stimulation navigation. Clin Neurophysiol. 2013 Oct; 124(10):1995-2007.
  8. Lew S, Sliva DD, Choe MS, Grant PE, Okada Y, Wolters CH, Hämäläinen MS. Effects of sutures and fontanels on MEG and EEG source analysis in a realistic infant head model. Neuroimage. 2013 Aug 1; 76:282-93.
  9. Nevalainen P, Pihko E, Metsäranta M, Sambeth A, Wikström H, Okada Y, Autti T, Lauronen L. Evoked magnetic fields from primary and secondary somatosensory cortices: a reliable tool for assessment of cortical processing in the neonatal period. Clin Neurophysiol. 2012 Dec; 123(12):2377-83.
  10. Pihko E, Nevalainen P, Stephen J, Okada Y, Lauronen L. Maturation of somatosensory cortical processing from birth to adulthood revealed by magnetoencephalography. Clin Neurophysiol. 2009 Aug; 120(8):1552-61.
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  12. Nevalainen P, Lauronen L, Sambeth A, Wikström H, Okada Y, Pihko E. Somatosensory evoked magnetic fields from the primary and secondary somatosensory cortices in healthy newborns. Neuroimage. 2008 Apr 1; 40(2):738-45.
  13. Attal Y, Bhattacharjee M, Yelnik J, Cottereau B, Lefèvre J, Okada Y, Bardinet E, Chupin M, Baillet S. Modeling and detecting deep brain activity with MEG & EEG. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:4937-40.
  14. Lauronen L, Nevalainen P, Wikström H, Parkkonen L, Okada Y, Pihko E. Immaturity of somatosensory cortical processing in human newborns. Neuroimage. 2006 Oct 15; 33(1):195-203.
  15. Murakami S, Okada Y. Contributions of principal neocortical neurons to magnetoencephalography and electroencephalography signals. J Physiol. 2006 Sep 15; 575(Pt 3):925-36.
  16. Zhang T, Okada Y. Recursive artifact windowed-single tone extraction method (RAW-STEM) as periodic noise filter for electrophysiological signals with interfering transients. J Neurosci Methods. 2006 Sep 15; 155(2):308-18.
  17. Wang Y, Hosler G, Zhang T, Okada Y. Effects of temporary bilateral ligation of the internal carotid arteries on the low- and high-frequency somatic evoked potentials in the swine. Clin Neurophysiol. 2005 Oct; 116(10):2420-8.
  18. Flemming L, Wang Y, Caprihan A, Eiselt M, Haueisen J, Okada Y. Evaluation of the distortion of EEG signals caused by a hole in the skull mimicking the fontanel in the skull of human neonates. Clin Neurophysiol. 2005 May; 116(5):1141-52.
  19. Ikeda H, Wang Y, Okada YC. Origins of the somatic N20 and high-frequency oscillations evoked by trigeminal stimulation in the piglets. Clin Neurophysiol. 2005 Apr; 116(4):827-41.
  20. Pihko E, Lauronen L, Wikström H, Taulu S, Nurminen J, Kivitie-Kallio S, Okada Y. Somatosensory evoked potentials and magnetic fields elicited by tactile stimulation of the hand during active and quiet sleep in newborns. Clin Neurophysiol. 2004 Feb; 115(2):448-55.
  21. Murakami S, Hirose A, Okada YC. Contribution of ionic currents to magnetoencephalography (MEG) and electroencephalography (EEG) signals generated by guinea-pig CA3 slices. J Physiol. 2003 Dec 15; 553(Pt 3):975-85.
  22. Kato S, Papuashvili N, Okada YC. Identification and functional characterization of the trigeminal ventral cervical reflex pathway in the swine. Clin Neurophysiol. 2003 Feb; 114(2):263-71.
  23. Kato S, Wang Y, Papuashvili N, Okada YC. Stable synchronized high-frequency signals from the main sensory and spinal nuclei of the pig activated by Abeta fibers of the maxillary nerve innervating the snout. Brain Res. 2003 Jan 3; 959(1):1-10.
  24. Okada Y, Hämäläinen M, Pratt K, Mascarenas A, Miller P, Han M, Robles J, Cavallini A, Power B, Sieng K, Sun L, Lew S, Doshi C, Ahtam B, Dinh C, Esch L, Grant E, Nummenmaa A, Paulson D. BabyMEG: A whole-head pediatric magnetoencephalography system for human brain development research. Rev Sci Instrum. 2016 Sep; 87(9):094301.
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