Research

LIke ThisLIke ThisLIke This

Thomas Kulik, MD

Thomas Kulik MD
Department:
Cardiology Research
Hospital Title:
Senior Associate in Cardiology
Academic Title:
Associate Professor of Pediatrics, Harvard Medical School

Publications

Publications powered by Harvard Catalyst Profiles
  1. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99.
  2. Pogoriler JE, Kulik TJ, Casey AM, Baird CW, Mullen MP, Jenkins KJ, Vargas SO. Lung Pathology in Pediatric Pulmonary Vein Stenosis. Pediatr Dev Pathol. 2016 May-Jun; 19(3):219-29.
  3. Marr CR, McSweeney JE, Mullen MP, Kulik TJ. Central venous line complications with chronic ambulatory infusion of prostacyclin analogues in pediatric patients with pulmonary arterial hypertension. Pulm Circ. 2015 Jun; 5(2):322-6.
  4. Webber SA, Hsu DT, Ivy DD, Kulik TJ, Pahl E, Rosenthal DN, Morrow WR, Feinstein JA. Task Force 7: Pediatric Cardiology Fellowship Training in Pulmonary Hypertension, Advanced Heart Failure, and Transplantation. J Am Coll Cardiol. 2015 Aug 11; 66(6):732-9.
  5. Webber SA, Hsu DT, Ivy DD, Kulik TJ, Pahl E, Rosenthal DN, Morrow WR, Feinstein JA. Task Force 7: Pediatric Cardiology Fellowship Training in Pulmonary Hypertension, Advanced Heart Failure, and Transplantation. SPCTPD/ACC/AAP/AHA. Circulation. 2015 Aug 11; 132(6):e99-e106.
  6. Kulik TJ. Pulmonary hypertension caused by pulmonary venous hypertension. Pulm Circ. 2014 Dec; 4(4):581-95.
  7. Opotowsky AR, Halpern D, Kulik TJ, Systrom DM, Wu F. Inadequate venous return as a primary cause for Fontan circulatory limitation. J Heart Lung Transplant. 2014 Nov; 33(11):1194-6.
  8. Blume ED, Balkin EM, Aiyagari R, Ziniel S, Beke DM, Thiagarajan R, Taylor L, Kulik T, Pituch K, Wolfe J. Parental perspectives on suffering and quality of life at end-of-life in children with advanced heart disease: an exploratory study*. Pediatr Crit Care Med. 2014 May; 15(4):336-42.
  9. Mullen MP, Andrus J, Labella MH, Forbes PW, Rao S, McSweeney JE, Kulik TJ, DeMaso DR. Quality of life and parental adjustment in pediatric pulmonary hypertension. Chest. 2014 Feb; 145(2):237-44.
  10. Izzo A, McSweeney J, Kulik T, Khatwa U, Kothare SV. "Nocturnal seizures" in idiopathic pulmonary arterial hypertension. J Clin Sleep Med. 2013 Oct 15; 9(10):1091-2.
  11. Show all
  12. Abman SH, Kinsella JP, Rosenzweig EB, Krishnan U, Kulik T, Mullen M, Wessel DL, Steinhorn R, Adatia I, Hanna B, Feinstein J, Fineman J, Raj U, Humpl T. Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):572-5.
  13. Kulik TJ. Pulmonary blood flow and pulmonary hypertension: Is the pulmonary circulation flowophobic or flowophilic? Pulm Circ. 2012 Jul; 2(3):327-39.
  14. Farias M, Friedman KG, Powell AJ, de Ferranti SD, Marshall AC, Brown DW, Kulik TJ. Dynamic evolution of practice guidelines: analysis of deviations from assessment and management plans. Pediatrics. 2012 Jul; 130(1):93-8.
  15. Kulik TJ, Harris JE, McElhinney DB. The impact of pulmonary venous hypertension on the pulmonary circulation in the young. Congenit Heart Dis. 2011 Nov-Dec; 6(6):603-7.
  16. Kulik TJ, Rhein LM, Mullen MP. Pulmonary arterial hypertension in infants with chronic lung disease: will we ever understand it? J Pediatr. 2010 Aug; 157(2):186-90.
  17. Kulik TJ. Pathophysiology of acute pulmonary vasoconstriction. Pediatr Crit Care Med. 2010 Mar; 11(2 Suppl):S10-4.
  18. Graham TP, Beekman RH, Allen HD, Bricker JT, Freed MD, Hurwitz RA, McQuinn TC, Schieken RM, Strong WB, Zahka KG, Sanders SP, Colan SD, Cordes TM, Donofrio MT, Ensing GJ, Geva T, Kimball TR, Sahn DJ, Silverman NH, Sklansky MS, Weinberg PM, Hellenbrand WE, Lloyd TR, Lock JE, Mullins CE, Romes JJ, Teitel DF, Vetter VL, Silka MJ, Van Hare GF, Walsh EP, Kulik T, Giglia TM, Kocis KC, Mahoney LT, Schwartz SM, Wernovsky G, Wessel DL, Murphy D, Foster E, Benson DW, Baldwin HS, Hirshfeld JW, Kugler JD, Moskowitz WB, Creager MA, Lorell BH, Merli G, Rodgers GP, Rutherford JD, Tracy CM, Weitz HH. ACCF/AHA/AAP recommendations for training in pediatric cardiology. A report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence (ACC/AHA/AAP Writing Committee to Develop Training Recommendations for Pediatric Cardiology). Circulation. 2005 Oct 18; 112(16):2555-80.
  19. Allen HD, Bricker JT, Freed MD, Hurwitz RA, McQuinn TC, Schieken RM, Strong WB, Zahka KG, Sanders SP, Colan SD, Cordes TM, Donofrio MT, Ensing GJ, Geva T, Kimball TR, Sahn DJ, Silverman NH, Sklansky MS, Weinberg PM, Beekman RH, Hellenbrand WE, Lloyd TR, Lock JE, Mullins CE, Rome JJ, Teitel DF, Vetter VL, Silka MJ, Van Hare GF, Walsh EP, Kulik T, Giglia TM, Kocis KC, Mahoney LT, Schwartz SM, Wernovsky G, Wessel DL, Murphy DJ, Foster E, Benson DW, Baldwin HS, Mahoney LT, McQuinn TC. ACC/AHA/AAP recommendations for training in pediatric cardiology. Pediatrics. 2005 Dec; 116(6):1574-96.
  20. Kulik T, Giglia TM, Kocis KC, Mahoney LT, Schwartz SM, Wernovsky G, Wessel DL. ACCF/AHA/AAP recommendations for training in pediatric cardiology. Task force 5: requirements for pediatric cardiac critical care. J Am Coll Cardiol. 2005 Oct 4; 46(7):1396-9.
  21. Bailey JM, Hoffman TM, Wessel DL, Nelson DP, Atz AM, Chang AC, Kulik TJ, Spray TL, Akbary A, Miller RP, Wernovsky G. A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery. J Pharmacokinet Pharmacodyn. 2004 Feb; 31(1):43-59.
  22. Somjen D, Kohen F, Gayer B, Kulik T, Knoll E, Stern N. Role of putative membrane receptors in the effect of androgens on human vascular cell growth. J Endocrinol. 2004 Jan; 180(1):97-106.
  23. Wright GE, Crowley DC, Charpie JR, Ohye RG, Bove EL, Kulik TJ. High systemic vascular resistance and sudden cardiovascular collapse in recovering Norwood patients. Ann Thorac Surg. 2004 Jan; 77(1):48-52.
  24. Kolovos NS, Bratton SL, Moler FW, Bove EL, Ohye RG, Bartlett RH, Kulik TJ. Outcome of pediatric patients treated with extracorporeal life support after cardiac surgery. Ann Thorac Surg. 2003 Nov; 76(5):1435-41; discussion 1441-2.
  25. Hoffman TM, Wernovsky G, Atz AM, Kulik TJ, Nelson DP, Chang AC, Bailey JM, Akbary A, Kocsis JF, Kaczmarek R, Spray TL, Wessel DL. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation. 2003 Feb 25; 107(7):996-1002.
  26. Gajarski RJ, Mosca RS, Ohye RG, Bove EL, Crowley DC, Custer JR, Moler FW, Valentini A, Kulik TJ. Use of extracorporeal life support as a bridge to pediatric cardiac transplantation. J Heart Lung Transplant. 2003 Jan; 22(1):28-34.
  27. Riegger LQ, Voepel-Lewis T, Kulik TJ, Malviya S, Tait AR, Mosca RS, Bove EL. Albumin versus crystalloid prime solution for cardiopulmonary bypass in young children. Crit Care Med. 2002 Dec; 30(12):2649-54.
  28. Maher KO, VanDerElzen K, Bove EL, Mosca RS, Chenoweth CE, Kulik TJ. A retrospective review of three antibiotic prophylaxis regimens for pediatric cardiac surgical patients. Ann Thorac Surg. 2002 Oct; 74(4):1195-200.
  29. Somjen D, Amir-Zaltsman Y, Gayer B, Kulik T, Knoll E, Stern N, Lu LJ, Toldo L, Kohen F. 6-Carboxymethyl genistein: a novel selective oestrogen receptor modulator (SERM) with unique, differential effects on the vasculature, bone and uterus. J Endocrinol. 2002 Jun; 173(3):415-27.
  30. Hoffman TM, Wernovsky G, Atz AM, Bailey JM, Akbary A, Kocsis JF, Nelson DP, Chang AC, Kulik TJ, Spray TL, Wessel DL. Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Prophylactic Intravenous Use of Milrinone After Cardiac Operation in Pediatrics. Am Heart J. 2002 Jan; 143(1):15-21.
  31. Kocis KC, Dekeon MK, Rosen HK, Bandy KP, Crowley DC, Bove EL, Kulik T. Pressure-regulated volume control vs volume control ventilation in infants after surgery for congenital heart disease. Pediatr Cardiol. 2001 May-Jun; 22(3):233-7.
  32. Charpie JR, Dekeon MK, Goldberg CS, Mosca RS, Bove EL, Kulik TJ. Postoperative hemodynamics after Norwood palliation for hypoplastic left heart syndrome. Am J Cardiol. 2001 Jan 15; 87(2):198-202.
  33. Goldberg CS, Schwartz EM, Brunberg JA, Mosca RS, Bove EL, Schork MA, Stetz SP, Cheatham JP, Kulik TJ. Neurodevelopmental outcome of patients after the fontan operation: A comparison between children with hypoplastic left heart syndrome and other functional single ventricle lesions. J Pediatr. 2000 Nov; 137(5):646-52.
  34. Charpie JR, Dekeon MK, Goldberg CS, Mosca RS, Bove EL, Kulik TJ. Serial blood lactate measurements predict early outcome after neonatal repair or palliation for complex congenital heart disease. J Thorac Cardiovasc Surg. 2000 Jul; 120(1):73-80.
  35. Mosca RS, Kulik TJ, Goldberg CS, Vermilion RP, Charpie JR, Crowley DC, Bove EL. Early results of the fontan procedure in one hundred consecutive patients with hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2000 Jun; 119(6):1110-8.
  36. Mosca RS, Kulik TJ, Marshall K, Hernandez R, Fletcher SE. Mycotic pseudoaneurysm associated with aortic coarctation. J Cardiovasc Magn Reson. 2000; 2(3):209-12.
  37. Kim BS, Putnam AJ, Kulik TJ, Mooney DJ. Optimizing seeding and culture methods to engineer smooth muscle tissue on biodegradable polymer matrices. Biotechnol Bioeng. 1998 Jan 5; 57(1):46-54.
  38. Reyes A, Bove EL, Mosca RS, Kulik TJ, Ludomirsky A. Tricuspid valve repair in children with hypoplastic left heart syndrome during staged surgical reconstruction. Circulation. 1997 Nov 4; 96(9 Suppl):II-341-3; discussion II-344-5.
  39. Mosca RS, Hennein HA, Kulik TJ, Crowley DC, Michelfelder EC, Ludomirsky A, Bove EL. Modified Norwood operation for single left ventricle and ventriculoarterial discordance: an improved surgical technique. Ann Thorac Surg. 1997 Oct; 64(4):1126-32.
  40. Kocis KC, Vermilion RP, Callow LB, Kulik TJ, Ludomirsky A, Bove EL. Complications of femoral artery cannulation for perioperative monitoring in children. J Thorac Cardiovasc Surg. 1996 Nov; 112(5):1399-400.
  41. Bradley SM, Mosca RS, Hennein HA, Crowley DC, Kulik TJ, Bove EL. Bidirectional superior cavopulmonary connection in young infants. Circulation. 1996 Nov 1; 94(9 Suppl):II5-11.
  42. Kulik TJ, Moler FW, Palmisano JM, Custer JR, Mosca RS, Bove EL, Bartlett RH. Outcome-associated factors in pediatric patients treated with extracorporeal membrane oxygenator after cardiac surgery. Circulation. 1996 Nov 1; 94(9 Suppl):II63-8.
  43. Schwartz SM, Gordon D, Mosca RS, Bove EL, Heidelberger KP, Kulik TJ. Collagen content in normal, pressure, and pressure-volume overloaded developing human hearts. Am J Cardiol. 1996 Apr 1; 77(9):734-8.
  44. Kulik TJ. Inhaled nitric oxide in the management of congenital heart disease. Curr Opin Cardiol. 1996 Jan; 11(1):75-80.
  45. Mosca RS, Bove EL, Crowley DC, Sandhu SK, Schork MA, Kulik TJ. Hemodynamic characteristics of neonates following first stage palliation for hypoplastic left heart syndrome. Circulation. 1995 Nov 1; 92(9 Suppl):II267-71.
  46. Kolpakov V, Rekhter MD, Gordon D, Wang WH, Kulik TJ. Effect of mechanical forces on growth and matrix protein synthesis in the in vitro pulmonary artery. Analysis of the role of individual cell types. Circ Res. 1995 Oct; 77(4):823-31.
  47. Kolpakov V, Gordon D, Kulik TJ. Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ Res. 1995 Feb; 76(2):305-9.
  48. Iannettoni MD, Bove EL, Mosca RS, Lupinetti FM, Dorostkar PC, Ludomirsky A, Crowley DC, Kulik TJ, Rosenthal A. Improving results with first-stage palliation for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 1994 Mar; 107(3):934-40.
  49. Kulik TJ, Alvarado SP. Effect of stretch on growth and collagen synthesis in cultured rat and lamb pulmonary arterial smooth muscle cells. J Cell Physiol. 1993 Dec; 157(3):615-24.
  50. Lupinetti FM, Kulik TJ, Beekman RH, Crowley DC, Bove EL. Correction of total anomalous pulmonary venous connection in infancy. J Thorac Cardiovasc Surg. 1993 Nov; 106(5):880-5.
  51. Wessel DL, Adatia I, Giglia TM, Thompson JE, Kulik TJ. Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Circulation. 1993 Nov; 88(5 Pt 1):2128-38.
  52. Chang AC, Kulik TJ, Hickey PR, Wessel DL. Real-time gas-exchange measurement of oxygen consumption in neonates and infants after cardiac surgery. Crit Care Med. 1993 Sep; 21(9):1369-75.
  53. Rothman A, Kulik TJ, Taubman MB, Berk BC, Smith CW, Nadal-Ginard B. Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures. Circulation. 1992 Dec; 86(6):1977-86.
  54. Bialecki RA, Kulik TJ, Colucci WS. Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells. Am J Physiol. 1992 Nov; 263(5 Pt 1):L602-6.
  55. Sadoshima J, Jahn L, Takahashi T, Kulik TJ, Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem. 1992 May 25; 267(15):10551-60.
  56. Chang AC, Wernovsky G, Kulik TJ, Jonas RA, Wessel DL. Management of the neonate with transposition of the great arteries and persistent pulmonary hypertension. Am J Cardiol. 1991 Nov 1; 68(11):1253-5.
  57. Kulik TJ, Bialecki RA, Colucci WS, Rothman A, Glennon ET, Underwood RH. Stretch increases inositol trisphosphate and inositol tetrakisphosphate in cultured pulmonary vascular smooth muscle cells. Biochem Biophys Res Commun. 1991 Oct 31; 180(2):982-7.
  58. Anderson WD, Kulik TJ, Mayer JE. Inhibition of contraction of isolated lymphatic ducts by atrial natriuretic peptide. Am J Physiol. 1991 Mar; 260(3 Pt 2):R610-4.
  59. Rothman A, Kulik TJ. Pulmonary hypertension and asthma in two patients with congenital heart disease. Am J Dis Child. 1989 Aug; 143(8):977-9.
  60. Kulik TJ, Evans JN, Gamble WJ. Stretch-induced contraction in pulmonary arteries. Am J Physiol. 1988 Dec; 255(6 Pt 2):H1391-8.
  61. Kulik TJ, Lock JE. Leukotrienes and the immature pulmonary circulation. Am Rev Respir Dis. 1987 Jul; 136(1):220-2.
  62. Helgason H, Keane JF, Fellows KE, Kulik TJ, Lock JE. Balloon dilation of the aortic valve: studies in normal lambs and in children with aortic stenosis. J Am Coll Cardiol. 1987 Apr; 9(4):816-22.
  63. Fuhrman BP, Smith-Wright DL, Kulik TJ, Lock JE. Effects of static and fluctuating airway pressure on intact pulmonary circulation. J Appl Physiol (1985). 1986 Jan; 60(1):114-22.
  64. Johnson DE, Kulik TJ, Lock JE, Elde RP, Thompson TR. Bombesin-, calcitonin-, and serotonin-immunoreactive pulmonary neuroendocrine cells in acute and chronic neonatal lung disease. Pediatr Pulmonol. 1985 May-Jun; 1(3 Suppl):S13-20.
  65. Kulik TJ, Johnson DE, Lock JE. Pulmonary vascular effects of Leu5-enkephalin in conscious newborn lambs. Peptides. 1985 Jan-Feb; 6(1):1-5.
  66. Ring JC, Kulik TJ, Burke BA, Lock JE. Morphologic changes induced by dilation of the pulmonary valve anulus with overlarge balloons in normal newborn lambs. Am J Cardiol. 1985 Jan 1; 55(1):210-4.
  67. Gatto C, Johnson MG, Seybold V, Kulik TJ, Lock JE, Johnson DE. Distribution and quantitative developmental changes in guinea pig pulmonary beta-receptors. J Appl Physiol Respir Environ Exerc Physiol. 1984 Dec; 57(6):1901-7.
  68. Kulik TJ, Lock JE. Pulmonary vasodilator therapy in persistent pulmonary hypertension of the newborn. Clin Perinatol. 1984 Oct; 11(3):693-701.
  69. Lock JE, Bass JL, Kulik TJ, Fuhrman BP. Chronic percutaneous pericardial drainage with modified pigtail catheters in children. Am J Cardiol. 1984 Apr 1; 53(8):1179-82.
  70. Kulik TJ, Lock JE. The assessment of pulmonary vascular tone: a review of experimental methodologies. Pediatr Pharmacol (New York). 1984; 4(2):73-83.
  71. Lock JE, Kulik TJ, Green TP, Niemi T, Einzig S. Resting and exercise renal blood flows in immature ovine aortic coarctation. Impact of gradient relief. Circ Res. 1983 Nov; 53(5):644-54.
  72. Kulik TJ, Johnson DE, Elde RP, Lock JE. Pulmonary vascular effects of bombesin and gastrin-releasing peptide in conscious newborn lambs. J Appl Physiol Respir Environ Exerc Physiol. 1983 Oct; 55(4):1093-7.
  73. Benson DW, Benditt DG, Anderson RW, Dunnigan A, Pritzker MR, Kulik TJ, Zavoral JH. Cardiac arrest in young, ostensibly healthy patients: clinical, hemodynamic, and electrophysiologic findings. Am J Cardiol. 1983 Jul; 52(1):65-9.
  74. Kulik TJ, Bass JL, Fuhrman BP, Moller JH, Lock JE. Exercise induced pulmonary vasoconstriction. Br Heart J. 1983 Jul; 50(1):59-64.
  75. Kulik TJ, Foker JE, Lucas RV, Anderson RW, Lock JE. Postoperative hemodynamics in children with polytetrafluoroethylene shunts. Circulation. 1981 Aug; 64(2 Pt 2):II123-30.
  76. Archer SL, Kulik TJ, Chesler E, Weir EK. The effects of substance P on the preconstricted pulmonary vasculature of the anesthetized dog. Proc Soc Exp Biol Med. 1986 Oct; 183(1):19-27.
  77. Mandell VS, Lock JE, Mayer JE, Parness IA, Kulik TJ. The "laid-back" aortogram: an improved angiographic view for demonstration of coronary arteries in transposition of the great arteries. Am J Cardiol. 1990 Jun 1; 65(20):1379-83.
  78. Kulik TJ, Johnson DE, Elde RP, Lock JE. Pulmonary and systemic vascular effects of serotonin in conscious newborn lambs. Dev Pharmacol Ther. 1988; 11(3):135-41.
  79. Kulik TJ, Schutjer RK, Howland DF, Lock JE. Pulmonary and systemic vascular effects of SRS-A blockade in conscious lambs. Am J Physiol. 1985 Nov; 249(5 Pt 2):H968-73.
  80. Donnelly JP, Raffel DM, Shulkin BL, Corbett JR, Bove EL, Mosca RS, Kulik TJ. Resting coronary flow and coronary flow reserve in human infants after repair or palliation of congenital heart defects as measured by positron emission tomography. J Thorac Cardiovasc Surg. 1998 Jan; 115(1):103-10.
  81. Kulik TJ, Johnson DE, Elde RP, Lock JE. Pulmonary vascular effects of vasoactive intestinal peptide in conscious newborn lambs. Am J Physiol. 1984 May; 246(5 Pt 2):H716-9.
  82. Mammel MC, Einzig S, Kulik TJ, Thompson TR, Lock JE. Pulmonary vascular effects of amrinone in conscious lambs. Pediatr Res. 1983 Sep; 17(9):720-4.
  83. Ring JC, Bass JL, Marvin W, Fuhrman BP, Kulik TJ, Foker JE, Lock JE. Management of congenital stenosis of a branch pulmonary artery with balloon dilation angioplasty. Report of 52 procedures. J Thorac Cardiovasc Surg. 1985 Jul; 90(1):35-44.
  84. Lim DS, Kulik TJ, Kim DW, Charpie JR, Crowley DC, Maher KO. Aminophylline for the prevention of apnea during prostaglandin E1 infusion. Pediatrics. 2003 Jul; 112(1 Pt 1):e27-9.
  85. Kulik TJ, Clark RL, Hasan BS, Keane JF, Springmuller D, Mullen MP. Pulmonary arterial hypertension: what the large pulmonary arteries tell us. Pediatr Cardiol. 2011 Aug; 32(6):759-65.
LIke ThisLIke ThisLIke This
Close