Research

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Thea Brennan-Krohn, MD

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Hospital Title:
Assistant in Medicine
Academic Title:
Instructor in Pediatrics, Harvard Medical School
Research Focus Area:
Antibiotic synergyAntimicrobial resistance

Research Overview

Dr. Brennan-Krohn’s research involves the evaluation of antimicrobial combinations for synergistic activity against multidrug-resistant Gram-negative bacteria, specifically carbapenem-resistant Enterobacteriaceae (CRE). These pathogens, which are increasing in frequency worldwide, are very challenging to treat and tend to affect patients critically ill patients, in whom antibiotic selection may be complicated by factors including underlying illness and drug-drug interactions. Combination therapy is frequently used to treat such infections, with the goal of achieving synergistic activity between two drugs, but much remains to be understood about the mechanisms of action of antimicrobial combinations and about how to determine which combinations, if any, are likely to be effective against which pathogens. Dr. Brennan-Krohn’s research aims to identify promising combination regimens and to improve diagnostic methods for synergy testing.

About Thea Brennan-Krohn

Dr. Brennan-Krohn earned her BA in Classics from Brown University and her MD from Stanford University School of Medicine, then completed a Pediatrics residency and pediatric Infectious Diseases fellowship at Boston Children’s Hospital. She also completed a medical microbiology fellowship at Beth Israel Deaconess Medical Center and is a diplomate of the American Board of Medical Microbiology. Dr. Brennan-Krohn joined the division of Infectious Diseases as faculty in 2017. Her research is performed in the laboratory of Dr. James Kirby at Beth Israel Deaconess Medical Center.


Publications

Publications powered by Harvard Catalyst Profiles
  1. Brennan-Krohn T, Truelson KA, Smith KP, Kirby JE. Screening for synergistic activity of antimicrobial combinations against carbapenem-resistant Enterobacteriaceae using inkjet printer-based technology. J Antimicrob Chemother. 2017 Oct 01; 72(10):2775-2781.
  2. Smith KP, Richmond DL, Brennan-Krohn T, Elliott HL, Kirby JE. Development of MAST: A Microscopy-Based Antimicrobial Susceptibility Testing Platform. SLAS Technol. 2017 Aug 01; 2472630317727721.
  3. Brennan-Krohn T, Yoon E, Nishino M, Kirby JE, Riedel S. Arthroconidia in Lung Tissue: An Unusual Histopathological Finding in Pulmonary Coccidioidomycosis. Hum Pathol. 2017 Aug 01.
  4. Brennan-Krohn T, Smith KP, Kirby JE. The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance. J Clin Microbiol. 2017 Aug; 55(8):2304-2308.
  5. Smith KP, Brennan-Krohn T, Weir S, Kirby JE. Improved Accuracy of Cefepime Susceptibility Testing for Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae with an On-Demand Digital Dispensing Method. J Clin Microbiol. 2017 Feb; 55(2):470-478.
  6. Brennan-Krohn T, Pica N, Sandora TJ, McAdam A. The Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. J Clin Microbiol. 2016 Jun; 54(6):1414-5.
  7. Brennan-Krohn T, Pica N, Sandora TJ, McAdam A. Closing the Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. J Clin Microbiol. 2016 Jun; 54(6):1672.
  8. Brennan-Krohn T, Salloway S, Correia S, Dong M, de la Monte SM. Glial vascular degeneration in CADASIL. J Alzheimers Dis. 2010; 21(4):1393-402.
  9. Grant JE, Correia S, Brennan-Krohn T, Malloy PF, Laidlaw DH, Schulz SC. Frontal white matter integrity in borderline personality disorder with self-injurious behavior. J Neuropsychiatry Clin Neurosci. 2007; 19(4):383-90.
  10. Grant JE, Correia S, Brennan-Krohn T. White matter integrity in kleptomania: a pilot study. Psychiatry Res. 2006 Oct 30; 147(2-3):233-7.
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