Research

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Susan M. Goobie, MD, FRCPC

Susan Goobie MD
Department:
Department of Anesthesiology, Perioperative and Pain Medicine Research
Research Focus Area:
Blood conservations strategiesMajor Surgery involving significant Blood LossCraniofacial surgeryAntifibrinolytic Treatment

Research Overview

Dr Goobie has an interest in management of pediatric patients undergoing major surgery such as neurosurgery, craniofacial surgery and orthopedic surgery with particular emphasis on blood conservation methods, coagulation disorders, thromboelastography and pharmacological research. She is currently investigating the PK/PD profile of the antifibrinolytic, tranexamic acid (TXA) and its role in reducing blood loss in non-cardiac surgery. She and her colleagues showed that TXA significantly reduced blood loss and blood transfusion peri-operatively in children undergoing craniofacial surgery. She published a manuscript entitled, 'Population Pharmacokinetics of TXA in Pediatric Patients Undergoing Craniosynostosis Surgery' in which she predicts the safest dose of TXA for this population. She has a double-blind placebo-controlled study in progress investigating TXA and the reduction in blood transfusion in children undergoing idiopathic scoliosis surgery. She also is recruiting for a multicenter international study entitled 'The Efficacy and Population Pharmacokinetics and Pharmacogenetics of a Reduced Dose of TXA for Craniosynostosis Surgery'. This trial will hopefully answer many questions regarding the appropriate dose of TXA, safety, the PK characteristics and unique patient factors which influence peri-operative bleeding.

Publications

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  1. Davidson A, Goobie SM. The translational value of chart reviews and the need for trials. Paediatr Anaesth. 2016 Sep; 26(9):864-5.
  2. Goobie SM, Faraoni D, Zurakowski D, DiNardo JA. Association of Preoperative Anemia With Postoperative Mortality in Neonates. JAMA Pediatr. 2016 Sep 1; 170(9):855-62.
  3. Meier PM, Zurakowski D, Goobie SM, Proctor MR, Meara JG, Young VJ, Rogers GF, DiNardo JA. Multivariable predictors of substantial blood loss in children undergoing craniosynostosis repair: implications for risk stratification. Paediatr Anaesth. 2016 Oct; 26(10):960-9.
  4. Goobie SM, DiNardo JA, Faraoni D. Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery. Transfusion. 2016 Oct; 56(10):2487-2494.
  5. Goobie SM, Haas T. Perioperative bleeding management in pediatric patients. Curr Opin Anaesthesiol. 2016 Jun; 29(3):352-8.
  6. Nishijima DK, Monuteaux MC, Faraoni D, Goobie SM, Lee L, Galante J, Holmes JF, Kuppermann N. Tranexamic Acid Use in United States Children's Hospitals. J Emerg Med. 2016 Jun; 50(6):868-874.e1.
  7. Faraoni D, Zurakowski D, Vo D, Goobie SM, Yuki K, Brown ML, DiNardo JA. Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Feb 23; 67(7):793-801.
  8. Goobie SM. A blood transfusion can save a child's life or threaten it. Paediatr Anaesth. 2015 Dec; 25(12):1182-3.
  9. Faraoni D, Van der Linden P, Ducloy-Bouthors AS, Goobie SM, DiNardo JA, Nielsen VG. Quantification of Fibrinolysis Using Velocity Curves Measured with Thromboelastometry in Children with Congenital Heart Disease. Anesth Analg. 2015 Aug; 121(2):486-91.
  10. Goobie SM, Zurakowski D, Proctor MR, Meara JG, Meier PM, Young VJ, Rogers GF. Predictors of clinically significant postoperative events after open craniosynostosis surgery. Anesthesiology. 2015 May; 122(5):1021-32.
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  12. Rogers GF, Greene AK, Proctor MR, Mulliken JB, Goobie SM, Stoler JM. Progressive Postnatal Pansynostosis. Cleft Palate Craniofac J. 2015 Nov; 52(6):751-7.
  13. Phi JH, Goobie SM, Hong KH, Dholakia A, Smith ER. Use of tranexamic acid in infants undergoing choroid plexus papilloma surgery: a report of two cases. Paediatr Anaesth. 2014 Jul; 24(7):791-3.
  14. Goobie SM, Haas T. Bleeding management for pediatric craniotomies and craniofacial surgery. Paediatr Anaesth. 2014 Jul; 24(7):678-89.
  15. Faraoni D, Goobie SM. The efficacy of antifibrinolytic drugs in children undergoing noncardiac surgery: a systematic review of the literature. Anesth Analg. 2014 Mar; 118(3):628-36.
  16. Goobie S. Should aprotinin be reconsidered for use in pediatric surgery? Paediatr Anaesth. 2014 Feb; 24(2):137-40.
  17. Haas T, Goobie S, Spielmann N, Weiss M, Schmugge M. Improvements in patient blood management for pediatric craniosynostosis surgery using a ROTEM(®) -assisted strategy - feasibility and costs. Paediatr Anaesth. 2014 Jul; 24(7):774-80.
  18. Faraoni D, Goobie SM. New insights about the use of tranexamic acid in children undergoing cardiac surgery: from pharmacokinetics to pharmacodynamics. Anesth Analg. 2013 Oct; 117(4):760-2.
  19. Goobie SM, Meier PM, Sethna NF, Soriano SG, Zurakowski D, Samant S, Pereira LM. Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. Clin Pharmacokinet. 2013 Apr; 52(4):267-76.
  20. Pietrini D. Intraoperative management of blood loss during craniosynostosis surgery. Paediatr Anaesth. 2013 Mar; 23(3):278-80.
  21. Goobie S. The case for the use of tranexamic acid. Paediatr Anaesth. 2013 Mar; 23(3):281-4.
  22. Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011 Apr; 114(4):862-71.
  23. Meier PM, Goobie SM, DiNardo JA, Proctor MR, Zurakowski D, Soriano SG. Endoscopic strip craniectomy in early infancy: the initial five years of anesthesia experience. Anesth Analg. 2011 Feb; 112(2):407-14.
  24. Dingeman RS, Goumnerova LC, Goobie SM. The use of a laryngeal mask airway for emergent airway management in a prone child. Anesth Analg. 2005 Mar; 100(3):670-1, table of contents.
  25. Goobie SM, Montgomery CJ, Basu R, McFadzean J, O'Connor GJ, Poskitt K, Tsui BC. Confirmation of direct epidural catheter placement using nerve stimulation in pediatric anesthesia. Anesth Analg. 2003 Oct; 97(4):984-8, table of contents.
  26. Pollard RC, Makky S, McFadzean J, Ainsworth L, Goobie SM, Montgomery CJ. An admixture of 3 mg x kg(-1) of propofol and 3 mg x kg(-1) of thiopentone reduces pain on injection in pediatric anesthesia. Can J Anaesth. 2002 Dec; 49(10):1064-9.
  27. Goobie SM, Soriano SG, Zurakowski D, McGowan FX, Rockoff MA. Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph. Anesth Analg. 2001 Oct; 93(4):887-92.
  28. Ginzberg H, Shin J, Ellis L, Goobie S, Morrison J, Corey M, Durie PR, Rommens JM. Segregation analysis in Shwachman-Diamond syndrome: evidence for recessive inheritance. Am J Hum Genet. 2000 Apr; 66(4):1413-6.
  29. Faraoni D, DiNardo JA, Goobie SM. Relationship Between Preoperative Anemia and In-Hospital Mortality in Children Undergoing Noncardiac Surgery. Anesth Analg. 2016 Dec; 123(6):1582-1587.
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