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Rudolph Pienaar, PhD

Rudolph Pienaar, PhD
Radiology Research
Hospital Title:
Staff Scientist
Academic Title:
Instructor in Radiology, Harvard Medical School
Research Focus Area:
Brain surface feature analysisBrain ConnectivityWeb-based Computing
Contact Via Email
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Research Overview:

  • Developing web-based neuro-computational workflows for common radiological settings
  • Curvature/shape analysis on brain surfaces
  • Information processing/optimization in brain connectivity

About the Researcher:

I am currently faculty Staff Scientist at the Children's Hospital Boston, where I am the Technical Director of the Fetal-Neonatal Neuroimaging and Development Science Center (FNNDSC). The Center aims to play both a research and clinical role in the Boston’s Children's Hospital, and in my capacity at the Center I am engaged in both translational as well as applied research. The goal of the translational research component is to rapidly prototype and deploy complex research-based software within a clinical setting. To this end I head up a small team developing simple interfaces to creating, managing, and using a wide array of research software, as well as optimizing design and execution of the same. My applied research explores and models the basic processes underpinning human brain development, especially the shape of cortical surfaces and the role this can play in development and disease. Related interests are white matter tractography, specifically the propagation and flow of information through brain networks, as well as investigating relationships between cortical surface markers and internal fiber organization.


Publications powered by Harvard Catalyst Profiles
  1. Ou Y, Gollub RL, Retzepi K, Reynolds N, Pienaar R, Pieper S, Murphy SN, Grant PE, Zöllei L. Brain extraction in pediatric ADC maps, toward characterizing neuro-development in multi-platform and multi-institution clinical images. Neuroimage. 2015 Nov 15; 122:246-61.
  2. Baumer FM, Song JW, Mitchell PD, Pienaar R, Sahin M, Grant PE, Takahashi E. Longitudinal changes in diffusion properties in white matter pathways of children with tuberous sclerosis complex. Pediatr Neurol. 2015 Jun; 52(6):615-23.
  3. Pienaar R, Rannou N, Bernal J, Hahn D, Grant PE. ChRIS--A web-based neuroimaging and informatics system for collecting, organizing, processing, visualizing and sharing of medical data. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:206-9.
  4. Im K, Pienaar R, Paldino MJ, Gaab N, Galaburda AM, Grant PE. Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. Cereb Cortex. 2013 Dec; 23(12):3007-15.
  5. Pienaar R, Paldino MJ, Madan N, Krishnamoorthy KS, Alsop DC, Dehaes M, Grant PE. A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. Neuroimage. 2012 Nov 15; 63(3):1510-8.
  6. Vishwas MS, Healy BC, Pienaar R, Gorman MP, Grant PE, Chitnis T. Diffusion tensor analysis of pediatric multiple sclerosis and clinically isolated syndromes. AJNR Am J Neuroradiol. 2013 Feb; 34(2):417-23.
  7. Choe MS, Ortiz-Mantilla S, Makris N, Gregas M, Bacic J, Haehn D, Kennedy D, Pienaar R, Caviness VS, Benasich AA, Grant PE. Regional infant brain development: an MRI-based morphometric analysis in 3 to 13 month olds. Cereb Cortex. 2013 Sep; 23(9):2100-17.
  8. Ronan L, Pienaar R, Williams G, Bullmore E, Crow TJ, Roberts N, Jones PB, Suckling J, Fletcher PC. Intrinsic curvature: a marker of millimeter-scale tangential cortico-cortical connectivity? Int J Neural Syst. 2011 Oct; 21(5):351-66.
  9. Im K, Pienaar R, Lee JM, Seong JK, Choi YY, Lee KH, Grant PE. Quantitative comparison and analysis of sulcal patterns using sulcal graph matching: a twin study. Neuroimage. 2011 Aug 1; 57(3):1077-86.
  10. Dehaes M, Grant PE, Sliva DD, Roche-Labarbe N, Pienaar R, Boas DA, Franceschini MA, Selb J. Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. Biomed Opt Express. 2011; 2(3):552-67.
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  12. Hagmann P, Sporns O, Madan N, Cammoun L, Pienaar R, Wedeen VJ, Meuli R, Thiran JP, Grant PE. White matter maturation reshapes structural connectivity in the late developing human brain. Proc Natl Acad Sci U S A. 2010 Nov 2; 107(44):19067-72.
  13. Vishwas MS, Chitnis T, Pienaar R, Healy BC, Grant PE. Tract-based analysis of callosal, projection, and association pathways in pediatric patients with multiple sclerosis: a preliminary study. AJNR Am J Neuroradiol. 2010 Jan; 31(1):121-8.
  14. Pienaar R, Fischl B, Caviness V, Makris N, Grant PE. A METHODOLOGY FOR ANALYZING CURVATURE IN THE DEVELOPING BRAIN FROM PRETERM TO ADULT. Int J Imaging Syst Technol. 2008 Jun 1; 18(1):42-68.
  15. Yu P, Grant PE, Qi Y, Han X, Ségonne F, Pienaar R, Busa E, Pacheco J, Makris N, Buckner RL, Golland P, Fischl B. Cortical surface shape analysis based on spherical wavelets. IEEE Trans Med Imaging. 2007 Apr; 26(4):582-97.
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