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Rong Luo, PhD

Rong Luo, PhD
Medicine Research
Newborn Medicine Research
Hospital Title:
Associate Scientific Researcher
Academic Title:
Instructor in Pediatrics, Harvard Medical School
Research Focus Area:
GPR56 in brain development
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Research Overview

Rong Luo's research has been focused on elucidating the cellular and molecular mechanisms by which GPR56, a member of the adhesion G protein-coupled receptor family, regulates brain development. One of her projects was to define the function and signaling pathways of GPR56  in the developing mouse brain. Dr. Piao and Dr. Luo have successfully identified collagen III as the ligand of GPR56, which opens up many avenues for further studies. Dr. Luo's proposed studies cover several areas of research, including: 1) the role of GPR56 in CNS myelination; 2) GPR56 signaling in brain development and malformation; 3) identifying and characterizing the ligands of other adhesion G protein-coupled receptors, such as GPR126. Mouse genetics model and in vitro biochemistry, proteomics techniques are used to accomplish the research goals. 


Publications powered by Harvard Catalyst Profiles
  1. Zhao M, Luo R, Liu Y, Gao L, Fu Z, Fu Q, Luo X, Chen Y, Deng X, Liang Z, Li X, Cheng C, Liu Z, Fang W. miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR-p-PI3K/AKT-c-JUN. Nat Commun. 2016; 7:11309.
  2. Zhao M, Fang W, Wang Y, Guo S, Shu L, Wang L, Chen Y, Fu Q, Liu Y, Hua S, Fan Y, Liu Y, Deng X, Luo R, Mei Z, Jiang Q, Liu Z. Enolase-1 is a therapeutic target in endometrial carcinoma. Oncotarget. 2015 Jun 20; 6(17):15610-27.
  3. Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015; 6:6121.
  4. Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014; 9(6):e100043.
  5. Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Shimono C, Sekiguchi K, Piao X. GPR56 functions together with a3ß1 integrin in regulating cerebral cortical development. PLoS One. 2013; 8(7):e68781.
  6. Chen YF, Luo RZ, Li Y, Cui BK, Song M, Yang AK, Chen WK. High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2013 Mar; 270(3):1009-17.
  7. Singer K, Luo R, Jeong SJ, Piao X. GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration. Mol Neurobiol. 2013 Feb; 47(1):186-96.
  8. Jeong SJ, Luo R, Li S, Strokes N, Piao X. Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. J Comp Neurol. 2012 Sep 1; 520(13):2930-40.
  9. Luo R, Jin Z, Deng Y, Strokes N, Piao X. Disease-associated mutations prevent GPR56-collagen III interaction. PLoS One. 2012; 7(1):e29818.
  10. Jeong SJ, Li S, Luo R, Strokes N, Piao X. Loss of Col3a1, the gene for Ehlers-Danlos syndrome type IV, results in neocortical dyslamination. PLoS One. 2012; 7(1):e29767.
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  12. Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X. G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12925-30.
  13. Luo R, Yang HM, Jin Z, Halley DJ, Chang BS, MacPherson L, Brueton L, Piao X. A novel GPR56 mutation causes bilateral frontoparietal polymicrogyria. Pediatr Neurol. 2011 Jul; 45(1):49-53.
  14. Jin Z, Luo R, Piao X. GPR56 and its related diseases. Prog Mol Biol Transl Sci. 2009; 89:1-13.
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