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Robert Graham, MD

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Department of Anesthesiology, Perioperative and Pain Medicine Research
Critical Care Medicine Research
Hospital Title:
Associate in Critical Care Medicine
Research Focus Area:
Chronic Respiratory FailureTracheostomy biomeSpinal muscular atrophy

Research Overview

Dr. Robert Graham's research in health services focuses on clinical outcomes, resource utilization and health-related quality of life for children with chronic respiratory failure (CRF).  Additional clinical investigations include tracheostomy biome studies, nutritional assessment in CRF, and intervention trials in spinal muscular atrophy.


Publications powered by Harvard Catalyst Profiles
  1. Burgart AM, Magnus D, Tabor HK, Paquette ED, Frader J, Glover JJ, Jackson BM, Harrison CH, Urion DK, Graham RJ, Brandsema JF, Feudtner C. Ethical Challenges Confronted When Providing Nusinersen Treatment for Spinal Muscular Atrophy. JAMA Pediatr. 2017 Dec 11.
  2. Mercuri E, Finkel RS, Muntoni F, Wirth B, Montes J, Main M, Mazzone ES, Vitale M, Snyder B, Quijano-Roy S, Bertini E, Davis RH, Meyer OH, Simonds AK, Schroth MK, Graham RJ, Kirschner J, Iannaccone ST, Crawford TO, Woods S, Qian Y, Sejersen T. Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care. Neuromuscul Disord. 2017 Nov 23.
  3. Pérez-Losada M, Graham RJ, Coquillette M, Jafarey A, Castro-Nallar E, Aira M, Freishtat RJ, Mansbach JM. The temporal dynamics of the tracheal microbiome in tracheostomised patients with and without lower respiratory infections. PLoS One. 2017; 12(8):e0182520.
  4. Rodday AM, Terrin N, Leslie LK, Graham RJ, Parsons SK. Understanding the Relationship Between Child Health-Related Quality of Life and Parent Emotional Functioning in Pediatric Hematopoietic Stem Cell Transplant. J Pediatr Psychol. 2017 Aug 01; 42(7):804-814.
  5. Rodday AM, Graham RJ, Weidner RA, Terrin N, Leslie LK, Parsons SK. Predicting Health Care Utilization for Children With Respiratory Insufficiency Using Parent-Proxy Ratings of Children's Health-Related Quality of Life. J Pediatr Health Care. 2017 Nov - Dec; 31(6):654-662.
  6. Graham RJ, Rodday AM, Weidner RA, Parsons SK. The Impact on Family of Pediatric Chronic Respiratory Failure in the Home. J Pediatr. 2016 Aug; 175:40-6.
  7. Graham RJ, McManus ML, Rodday AM, Weidner RA, Parsons SK. Chronic respiratory failure: Utilization of a pediatric specialty integrated care program. Healthc (Amst). 2017 Mar; 5(1-2):23-28.
  8. Watters K, O'Neill M, Zhu H, Graham RJ, Hall M, Berry J. Two-year mortality, complications, and healthcare use in children with medicaid following tracheostomy. Laryngoscope. 2016 11; 126(11):2611-2617.
  9. Mehta NM, Newman H, Tarrant S, Graham RJ. Nutritional Status and Nutrient Intake Challenges in Children With Spinal Muscular Atrophy. Pediatr Neurol. 2016 Apr; 57:80-3.
  10. Haliloglu G, Topaloglu H. Evidence-based guideline summary: Evaluation, diagnosis, and management of congenital muscular dystrophy: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine. Neurology. 2015 Oct 20; 85(16):1432.
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  12. Kang PB, Morrison L, Iannaccone ST, Graham RJ, Bönnemann CG, Rutkowski A, Hornyak J, Wang CH, Christi C, North K. Author response. Neurology. 2015 Oct 20; 85(16):1432-3.
  13. Martinez EE, Bechard LJ, Smallwood CD, Duggan CP, Graham RJ, Mehta NM. Impact of Individualized Diet Intervention on Body Composition and Respiratory Variables in Children With Respiratory Insufficiency: A Pilot Intervention Study. Pediatr Crit Care Med. 2015 Jul; 16(6):e157-64.
  14. Kang PB, Morrison L, Iannaccone ST, Graham RJ, Bönnemann CG, Rutkowski A, Hornyak J, Wang CH, North K, Oskoui M, Getchius TS, Cox JA, Hagen EE, Gronseth G, Griggs RC. Evidence-based guideline summary: evaluation, diagnosis, and management of congenital muscular dystrophy: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine. Neurology. 2015 Mar 31; 84(13):1369-78.
  15. Martinez EE, Smallwood CD, Bechard LJ, Graham RJ, Mehta NM. Metabolic assessment and individualized nutrition in children dependent on mechanical ventilation at home. J Pediatr. 2015 Feb; 166(2):350-7.
  16. Casavant DW, McManus ML, Parsons SK, Zurakowski D, Graham RJ. Trial of telemedicine for patients on home ventilator support: feasibility, confidence in clinical management and use in medical decision-making. J Telemed Telecare. 2014 Dec; 20(8):441-9.
  17. Mehta NM, Smallwood CD, Graham RJ. Current applications of metabolic monitoring in the pediatric intensive care unit. Nutr Clin Pract. 2014 Jun; 29(3):338-47.
  18. Graham RJ, Rodday AM, Parsons SK. Family-centered assessment and function for children with chronic mechanical respiratory support. J Pediatr Health Care. 2014 Jul-Aug; 28(4):295-304.
  19. Graham RJ. Long-term ventilation: charting a pathway home. Arch Dis Child. 2013 Sep; 98(9):653.
  20. LaRovere KL, Graham RJ, Tasker RC. Pediatric neurocritical care: a neurology consultation model and implication for education and training. Pediatr Neurol. 2013 Mar; 48(3):206-11.
  21. Edwards JD, Houtrow AJ, Vasilevskis EE, Rehm RS, Markovitz BP, Graham RJ, Dudley RA. Chronic conditions among children admitted to U.S. pediatric intensive care units: their prevalence and impact on risk for mortality and prolonged length of stay*. Crit Care Med. 2012 Jul; 40(7):2196-203.
  22. Edwards JD, Kun SS, Graham RJ, Keens TG. End-of-life discussions and advance care planning for children on long-term assisted ventilation with life-limiting conditions. J Palliat Care. 2012; 28(1):21-7.
  23. Puri AS, Rahbar R, Dearden J, Graham RJ, Lillehei C, Orbach DB. Stretched and sheared microcatheter retained after onyx embolization of infantile myofibromatosis. Interv Neuroradiol. 2011 Jun; 17(2):261-6.
  24. Edwards JD, Davidson EJ, Houtrow AJ, Graham RJ. Pediatric resident attitudes toward caring for children with severe disabilities. Am J Phys Med Rehabil. 2010 Sep; 89(9):765-71.
  25. Berry JG, Graham RJ, Roberson DW, Rhein L, Graham DA, Zhou J, O'Brien J, Putney H, Goldmann DA. Patient characteristics associated with in-hospital mortality in children following tracheotomy. Arch Dis Child. 2010 Sep; 95(9):703-10.
  26. Berry JG, Graham DA, Graham RJ, Zhou J, Putney HL, O'Brien JE, Roberson DW, Goldmann DA. Predictors of clinical outcomes and hospital resource use of children after tracheotomy. Pediatrics. 2009 Aug; 124(2):563-72.
  27. Graham RJ, Athiraman U, Laubach AE, Sethna NF. Anesthesia and perioperative medical management of children with spinal muscular atrophy. Paediatr Anaesth. 2009 Nov; 19(11):1054-63.
  28. Graham RJ, Pemstein DM, Curley MA. Experiencing the pediatric intensive care unit: perspective from parents of children with severe antecedent disabilities. Crit Care Med. 2009 Jun; 37(6):2064-70.
  29. Graham RJ, Wachendorf MT, Burns JP, Mancuso TJ. Successful and safe delivery of anesthesia and perioperative care for children with complex special health care needs. J Clin Anesth. 2009 May; 21(3):165-72.
  30. Graham RJ. Medicine and children with special health care needs: conflict with the cult of cure. J Dev Behav Pediatr. 2008 Aug; 29(4):309-10.
  31. Jay Berry Robert Graham Dionne Graham. Clinical Outcomes and Hospital Use of Children Following Tracheostomy. Pediatric Academic Societies. 2008.
  32. Graham RJ, Pemstein DM, Palfrey JS. Included but isolated: early intervention programmes provision for children and families with chronic respiratory support needs. Child Care Health Dev. 2008 May; 34(3):373-9.
  33. Graham RJ. Specialty services for children with special health care needs: supplement not supplant the medical home. Arch Dis Child. 2008 Jan; 93(1):2-4.
  34. Graham RJ, Fleegler EW, Robinson WM. Chronic ventilator need in the community: a 2005 pediatric census of Massachusetts. Pediatrics. 2007 Jun; 119(6):e1280-7.
  35. Graham RJ, Stein P. Gastric outlet obstruction in an infant: lactobezoar. Am J Emerg Med. 2007 Jan; 25(1):98-9.
  36. O'Brien JE, Birnkrant DJ, Dumas HM, Haley SM, Burke SA, Graham RJ, Kharasch VS. Weaning children from mechanical ventilation in a post-acute care setting. Pediatr Rehabil. 2006 Oct-Dec; 9(4):365-72.
  37. The informed patient (column - Laura Landro): Pediatric hospitals teach doctors ways to convey tragic news. Cited in article. Wall Street Journal. 2006.
  38. Jeff Edwards, MD, MA, Emily J. Davidson, MD, MPH, Robert J. Graham, MD. Resident Attitudes Toward Caring for Children with Severe Disabilities. 2006.
  39. Graham RJ. Acute respiratory distress syndrome in children with severe motor and intellectual disabilities. Brain Dev. 2006 Jun; 28(5):342.
  40. Graham R Dussel V Wolfe J. Research. Oxford Textbook of Palliative Care for Children, Goldman A, Hain R, Liben S (eds). 2006; 615-647.
  41. Graham RJ, Robinson WM. Integrating palliative care into chronic care for children with severe neurodevelopmental disabilities. J Dev Behav Pediatr. 2005 Oct; 26(5):361-5.
  42. Graham RJ. An opportunity: critical care beyond the intensive care unit. Pediatr Crit Care Med. 2005 May; 6(3):327-8.
  43. Graham RJ. Jading. Pediatr Crit Care Med. 2005 Jan; 6(1):93; author reply 93.
  44. O'Brien JE, Graham RJ, Dumas HM, and Kjarasch VS. Inpatient pediatric pulmonary rehabilitation: development of a minimum data set. Advance for Directors in Rehabilitation. 2005; 14(2):57-68.
  45. Graham RJ, Dumas HM, O'Brien JE, Burns JP. Congenital neurodevelopmental diagnoses and an intensive care unit: defining a population. Pediatr Crit Care Med. 2004 Jul; 5(4):321-8.
  46. Haley SM, Graham RJ, Dumas HM. Outcome rating scales for pediatric head injury. J Intensive Care Med. 2004 Jul-Aug; 19(4):205-19.
  47. Tracy Magee PhD, CPNP, RN, Robert J. Graham MD, Jane E O'Brien MD, Stephen M. Haley PhD, Helene M. Dumas MS, Virginia S. Kharasch MD. Developing a pediatric pulmonary multidisciplinary data set: meeting everyone's needs, clinician, patient, and researcher. 2004.
  48. Graham R. Evidence-based medicine, predictive model review of Robertson CMT, Joffe AR, Moore AJ, Watt JM. Neurodevelopmental outcome of young pediatric intensive care survivors of serious brain injury. (Pediatric Critical Care Medicine 2002; 3(4):345-350) 2003.
  49. Randolph AG and Graham R. Measuring the health status of pediatric ICU survivors. Surviving Intensive Care. 2003; 107-115.
  50. Graham R. Evidence-based medicine, predictive models review of Hatherill M, McIntyre AG, Wattie M, Murdoch IA. Early hyperlactatemia in critically ill children. (Intensive Care Medicine 2000; 26:314-318) 2001.
  51. Graham R. Evidence-based medicine, quality of life review of Sheridan RL et al. Longterm outcomes of children surviving massive burns (JAMA 2000; 283:69-73) 2001.
  52. Babl, FE and Graham R. A pain in the heel: sneaker puncture wounds. Infectious Diseases in Children. 1999; 12(2):32.
  53. Peacock WJ and Graham R. Advances in pediatric neurosurgery - surgical management of epileptic surgery. Headlines. 1993; 12-14.
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