Research

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Peter Nigrovic, MD

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Hospital Title:
Attending Physician in Rheumatology; Director, Center for Adults with Pediatric Rheumatic Illness (CAPRI), Brigham and Women’s Hospital
Academic Title:
Associate Professor of Medicine, Harvard Medical School

Research Overview

The Nigrovic laboratory studies basic mechanisms of inflammatory arthritis, with a long-range goal of identifying new ways to target the disease in clinic. Ongoing studies use both human samples and mouse models, and investigate the biology of multiple immune cells including neutrophils, T cells, monocytes and megakaryocytes. We also study the role of antibodies and associated glycosylation, as well as new approaches to the genetics of arthritis. With respect to translational research specific to juvenile idiopathic arthritis, Dr. Nigrovic chairs translational research for the 114-center US and Canadian pediatric rheumatology research collaborative CARRA, is co-principal investigator of the First-line Options in Systemic JIA Treatment (FROST) study, and directs the NIAMS-funded Joint Biology Consortium to accelerate arthritis research at Boston Children’s Hospital, the Brigham and Women’s Hospital, and beyond.

Publications

Stoll ML, Zurakowski D, Nigrovic LE, Nichols DP, Sundel RP, Nigrovic PA. Patients with juvenile psoriatic arthritis comprise two distinct populations. Arthritis Rheum. 2006 Nov; 54(11):3564-72.

Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt, Massarotti EM, Remold-O’Donnell E, Farndale RW, Ware J, Lee DM. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science. 2010 Jan 29; 327(5965):580-3. PMC2927861

Nigrovic PA, Mannion M, Prince FHM, Zeft A, Rabinovich CE, van Rossum, MAJ, Cortis E, Pardeo M, Miettunen PM, Janow G, Birmingham J, Eggebeen E, Janssen E, Shulman AI, Son MB, Hong S, Jones K, Ilowite NT, Cron RQ, Higgins GC. Anakinra as first-line disease modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum. 2011 Feb; 63(2):545-55.

Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33. PMC3429730

Dewitt EM, Kimura Y, Beukelman T, Nigrovic PA, Onel K, Prahalad S, Schneider R, Stoll ML, Angeles-Han S, Milojevic D, Schikler KN, Vehe RK, Weiss JE, Weiss P, Ilowite NT, Wallace CA. Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2012 Jul; 64(7):1001-10. PMC3368104

Ringold S, Beukelman T, Nigrovic PA, Kimura Y; CARRA Registry Site Principal Investigators. Race, ethnicity, and disease outcomes in juvenile idiopathic arthritis: a cross-sectional analysis of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. J Rheumatol. 2013 Jun;40(6):936-42.

Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rosé CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P; Boston Children's JIA Registry*; British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group; Childhood Arthritis Prospective Study (CAPS); Childhood Arthritis Response to Medication Study (CHARMS); German Society for Pediatric Rheumatology (GKJR); JIA Gene Expression Study; NIAMS JIA Genetic Registry; TREAT Study; United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC), Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet. 2013 Jun; 45(6):664-9. PMC3673707 *Boston Children’s JIA Registry: Peter A. Nigrovic (director), Fatma Dedeoglu, Robert C. Fuhlbrigge, Melissa M. Hazen, Lauren A. Henderson, Erin Janssen, Susan Kim, Mindy S. Lo, Mary Beth F. Son, Robert P. Sundel, Irit Tirosh, Heather O. Tory.)

Nigrovic PA, Muscal E, Riebschleger M, Moorthy LN, Brunner HI, Eberhard BA, Klein-Gitelman M, Prahalad S, Schneider R. AMIGO: a novel approach to the mentorship gap in pediatric rheumatology. J Pediatr. 2014 Feb;164(2):226-7.e1-3.

Tuttle KSL, Vargas SO, Callahan M, Bae D, Nigrovic PA. Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity. Pediatric Rheum 2015;13:7.

Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Son MB, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Lee YN, Nigrovic PA, Notarangelo LD. Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 Jul;68(7):1758-68.

Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.

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