Research

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Peter E. Hammer, PhD

Peter Hammer, PhD
Department:
Cardiac Surgery Research
Hospital Title:
Staff Scientist
Academic Title:
Instructor in Surgery
Research Focus Area:
Cardiac Surgery
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Research Overview

Peter E. Hammer's primary research interests include mathematical modeling of cardiac biomechanics and electrophysiology as well as biomedical signal and image processing. Some applications of his work include heart valve simulation for surgical planning, analysis of new methods for mapping cardiac arrhythmias, and the study of heart rate variability. 

About Peter E. Hammer

Peter received his BS in mechanical engineering from the University of New Hampshire, his MS in biomedical engineering from Boston University, and his PhD in Biomedical Engineering from Tufts University. He has been engaged in research at Children's Hospital Boston since 1995.

Publications

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  1. Pacak CA, Hammer PE, MacKay AA, Dowd RP, Wang KR, Masuzawa A, Sill B, McCully JD, Cowan DB. Superparamagnetic iron oxide nanoparticles function as a long-term, multi-modal imaging label for non-invasive tracking of implanted progenitor cells. PLoS One. 2014; 9(9):e108695.
  2. Karamanos E, Teixeira PG, Sivrikoz E, Varga S, Chouliaras K, Okoye O, Hammer P. Intracranial pressure versus cerebral perfusion pressure as a marker of outcomes in severe head injury: a prospective evaluation. Am J Surg. 2014 Sep; 208(3):363-71.
  3. Hammer PE, Pacak CA, Howe RD, del Nido PJ. Straightening of curved pattern of collagen fibers under load controls aortic valve shape. J Biomech. 2014 Jan 22; 47(2):341-6.
  4. Hammer PE, del Nido PJ. Guidelines for sizing pericardium for aortic valve leaflet grafts. Ann Thorac Surg. 2013 Jul; 96(1):e25-7.
  5. Tenenholtz NA, Hammer PE, Schneider RJ, Vasilyev NV, Howe RD. On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair. Rep U S. 2011 Dec 31; 2011:1327-1332.
  6. Branco DM, Wolf CM, Sherwood M, Hammer PE, Kang PB, Berul CI. Cardiac electrophysiological characteristics of the mdx ( 5cv ) mouse model of Duchenne muscular dystrophy. J Interv Card Electrophysiol. 2007 Nov; 20(1-2):1-7.
  7. Soul JS, Hammer PE, Tsuji M, Saul JP, Bassan H, Limperopoulos C, Disalvo DN, Moore M, Akins P, Ringer S, Volpe JJ, Trachtenberg F, du Plessis AJ. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007 Apr; 61(4):467-73.
  8. Hammer PE, Saul JP. Resonance in a mathematical model of baroreflex control: arterial blood pressure waves accompanying postural stress. Am J Physiol Regul Integr Comp Physiol. 2005 Jun; 288(6):R1637-48.
  9. Maguire CT, Wakimoto H, Patel VV, Hammer PE, Gauvreau K, Berul CI. Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies. Physiol Genomics. 2003 Sep 29; 15(1):84-91.
  10. Moran AM, Friehs I, Takeuchi K, Stamm C, Hammer PE, McGowan FX, del Nido PJ, Colan SD. Noninvasive serial evaluation of myocardial mechanics in pressure overload hypertrophy of rabbit myocardium. Herz. 2003 Feb; 28(1):52-62.
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  12. Hammer PE, Brooks DH, Triedman JK. Estimation of entrainment response using electrograms from remote sites: validation in animal and computer models of reentrant tachycardia. J Cardiovasc Electrophysiol. 2003 Jan; 14(1):52-61.
  13. Gehrmann J, Meister M, Maguire CT, Martins DC, Hammer PE, Neer EJ, Berul CI, Mende U. Impaired parasympathetic heart rate control in mice with a reduction of functional G protein betagamma-subunits. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H445-56.
  14. Wakimoto H, Maguire CT, Kovoor P, Hammer PE, Gehrmann J, Triedman JK, Berul CI. Induction of atrial tachycardia and fibrillation in the mouse heart. Cardiovasc Res. 2001 Jun; 50(3):463-73.
  15. Gehrmann J, Hammer PE, Maguire CT, Wakimoto H, Triedman JK, Berul CI. Phenotypic screening for heart rate variability in the mouse. Am J Physiol Heart Circ Physiol. 2000 Aug; 279(2):H733-40.
  16. Hammer P, Litvack D, Saul JP. Interpreting open- and closed-loop transfer relations between cardiorespiratory parameters: lessons learned from a computer model of beat-to-beat cardiovascular regulation. Methods Inf Med. 1997 Dec; 36(4-5):237-40.
  17. Sill B, Hammer PE, Cowan DB. Optical mapping of Langendorff-perfused rat hearts. J Vis Exp. 2009 Aug 11; (30).
  18. Hammer PE, Sacks MS, del Nido PJ, Howe RD. Mass-spring model for simulation of heart valve tissue mechanical behavior. Ann Biomed Eng. 2011 Jun; 39(6):1668-79.
  19. Wilbring M, Alexiou K, Tugtekin SM, Sill B, Hammer P, Schmidt T, Simonis G, Matschke K, Kappert U. Transapical transcatheter valve-in-valve implantation for deteriorated mitral valve bioprostheses. Ann Thorac Surg. 2013 Jan; 95(1):111-7.
  20. Choi YH, Stamm C, Hammer PE, Kwaku KF, Marler JJ, Friehs I, Jones M, Rader CM, Roy N, Eddy MT, Triedman JK, Walsh EP, McGowan FX, del Nido PJ, Cowan DB. Cardiac conduction through engineered tissue. Am J Pathol. 2006 Jul; 169(1):72-85.
  21. Sill B, Roy N, Hammer PE, Triedman JK, Sigg DC, Kelly MF, Nedder A, Dunning PS, Cowan DB. Development of an ovine model of pediatric complete heart block. J Surg Res. 2011 Apr; 166(2):e103-8.
  22. Tansey EE, Kwaku KF, Hammer PE, Cowan DB, Federman M, Levitsky S, McCully JD. Reduction and redistribution of gap and adherens junction proteins after ischemia and reperfusion. Ann Thorac Surg. 2006 Oct; 82(4):1472-9.
  23. Hammer PE, Chen PC, del Nido PJ, Howe RD. Computational model of aortic valve surgical repair using grafted pericardium. J Biomech. 2012 Apr 30; 45(7):1199-204.
  24. Hammer PE, Berra I, del Nido PJ. Surgical repair of congenital aortic regurgitation by aortic root reduction: A finite element study. J Biomech. 2015 Nov 05; 48(14):3883-9.
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