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Ming Hui Chen, MD, MSc

Ming Hui Chen, MD, MSc
Department:
Cardiology Research
Hospital Title:
Attending Cardiologist; Director
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
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About Ming Hui Chen, MD, MSc

Dr. Chen, a graduate of Princeton University and Harvard Medical School, trained as an internist and cardiologist at Massachusetts General Hospital. She also has a master’s degree in clinical investigation from Harvard Medical School. She now serves as an attending cardiologist at Boston Children’s Hospital. Dr. Chen has been on-staff at the Harvard Teaching Hospital for more than 25 years.

Research Overview

Dr. Chen has focused much of her clinical research efforts on the diagnosis and amelioration of late cardiac effects in cancer survivors—attempting to understand treatment-related cardiac effects in patients currently undergoing cancer treatment. As an expert in cardiac noninvasive imaging, Dr. Chen’s approach is preventative and one of non-invasive screening to detect cardiovascular issue earlier in its course. 

Twenty years ago, Dr. Chen began investigating the genetics and clinical cardiovascular ramifications of periventricular nodular heterotopia (PVNH), as well as the filamin A mutation that has been implicated as a causal factor in this multi-system disorder. She has helped analyze mechanisms of congenital heart disease in this population along with describing its clinical association with Ehlers-Danlos Syndrome. To improve the lives of patients with PVNH and cardiovascular disease, she is the founder and leader of the C-BrDG (pronounced C-Bridge) (Cardiology of Brain Development in Genetics Program).

Selected publications in Dr. Chen’s areas of expertise can be found below:  


Publications

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  1. Kuebler JD, Chen MH, Alexander ME, Rhodes J. Exercise Performance in Patients with D-Loop Transposition of the Great Arteries After Arterial Switch Operation: Long-Term Outcomes and Longitudinal Assessment. Pediatr Cardiol. 2016 Feb; 37(2):283-9.
  2. Barac A, Murtagh G, Carver JR, Chen MH, Freeman AM, Herrmann J, Iliescu C, Ky B, Mayer EL, Okwuosa TM, Plana JC, Ryan TD, Rzeszut AK, Douglas PS. Cardiovascular Health of Patients With Cancer and Cancer Survivors: A Roadmap to the Next Level. J Am Coll Cardiol. 2015 Jun 30; 65(25):2739-46.
  3. Armenian SH, Hudson MM, Mulder RL, Chen MH, Constine LS, Dwyer M, Nathan PC, Tissing WJ, Shankar S, Sieswerda E, Skinner R, Steinberger J, van Dalen EC, van der Pal H, Wallace WH, Levitt G, Kremer LC. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015 Mar; 16(3):e123-36.
  4. Hasan BS, Lunze FI, Chen MH, Brown DW, Boudreau MJ, Rhodes J, McElhinney DB. Effects of transcatheter pulmonary valve replacement on the hemodynamic and ventricular response to exercise in patients with obstructed right ventricle-to-pulmonary artery conduits. JACC Cardiovasc Interv. 2014 May; 7(5):530-42.
  5. Chen MH, Blackington LH, Zhou J, Chu TF, Gauvreau K, Marcus KJ, Fisher DC, Diller LR, Ng AK. Blood pressure is associated with occult cardiovascular disease in prospectively studied Hodgkin lymphoma survivors after chest radiation. Leuk Lymphoma. 2014 Nov; 55(11):2477-83.
  6. Steingart RM, Bakris GL, Chen HX, Chen MH, Force T, Ivy SP, Leier CV, Liu G, Lenihan D, Lindenfeld J, Maitland ML, Remick SC, Tang WH. Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors. Am Heart J. 2012 Feb; 163(2):156-63.
  7. Chen MH, Colan SD, Diller L. Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res. 2011 Mar 4; 108(5):619-28.
  8. Daly KP, Colan SD, Blume ED, Margossian R, Gauvreau K, Duncan C, Lehmann LE, Chen MH. Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9.
  9. Galper SL, Yu JB, Mauch PM, Strasser JF, Silver B, Lacasce A, Marcus KJ, Stevenson MA, Chen MH, Ng AK. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood. 2011 Jan 13; 117(2):412-8.
  10. Demetri GD, Heinrich MC,Fletcher JA, Fletcher CD, Van den Abbeele AD,Corless C, Antonescu CR, George S, Morgan JA, Chen MH, Bello CL, Huang X, Cohen DP, Baum C, Maki RG. . Molecular Target Modulation, Imaging, and Clinical Evaluation of Gastrointestinal Stromal Tumor Patients Treated with Sunitinib Malate after Imatinib Failure Sunitinib mechanisms of efficacy. Clin Cancer Research. 2009; (in press).
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  12. Kerkela R, Woulfe K, Durand JB, Chu T, Chen MH, Force T. Sunitinib cardiotoxicity is mediated by off-target inhibition of AMPK-activated protein kinase. Clinical and Translation Science. 2009; 2(1):15-25.
  13. Chen MH, Rupnick MA, Chu T, Force T, Demetri GD. Cardiotoxicity of the tyrosine kinase inhibitor- sunitinib. Lancet. 2008.
  14. Shankar SM, Marina N, Hudson MM, Hodgson DC, Adams MJ, Landier W, Bhatia S, Meeske K, Chen MH, Kinahan KE, Steinberger J, Rosenthal D. Monitoring for cardiovascular disease in survivors of childhood cancer: report from the Cardiovascular Disease Task Force of the Children's Oncology Group. Pediatrics. 2008 Feb; 121(2):e387-96.
  15. Chen-Plotkin AS, Vossel KA, Samuels MA, Chen MH . Encephalopathy, stroke and myocardial infarction as complications of dimethyl sulfoxide use in stem cell transplantation. Neurology. 2007; 68:859-861..
  16. E. Bermudez and MH Chen. Stress Echocardiography: Indications and Protocols. Essential Echocardiography; a Practical Handbook with DVD (solomon and bulwer). 2007; 149-160.
  17. Feng Y, Chen MH, Moskowitz I, Lu Q, Liu H, Mendonza A, Yoshida Y, Vidali L, Nakamura F, Jessell T, Flanagan J, Kwiatkowski DJ, Walsh CA. Filamin A is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Nat Acad Sci. 2006; 103(52):19836-19841..
  18. Nguyen L, Chu T, Mauch P, Diller L, Ng A, Chen MH. . Cardiac irradiation during mediastinal radiation for Hodgkin’s Disease. NCI Conference for Cancer Survivors. 2006.
  19. Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan J, Dychter SS, Larsen PR, Demetri GD, Alexander EK . Primary hypothyroidism is a common complication of sunitinib therapy in patients with gastrointestinal stromal tumors. Ann Int Med. 2006; 145(9):660-664..
  20. Sheen Vl, Janset AN, Chen MH, Parrini E, Morgan T, Ravenscroft R et al. FLNA mutations cause a variant Ehlers-Danlos syndrome associated with periventricular heterotopia. Neurology 2005;64(2)254-62. Neurology. 2005; 64(2):254-262.
  21. Chen MH, Cooper M. Echoquest. 2003.
  22. Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D. Incidence and prognosis of syncope. N Engl J Med. 2002 Sep 19; 347(12):878-85.
  23. Chen MH, Cash EP, Danias PG, Kissinger KV, Bornstein BA, Rhodes LM, Harris JR, Gelman R, Manning WJ. Respiratory maneuvers decrease irradiated cardiac volume in patients with left-sided breast cancer. J Mag Reson Imag. 2002; 4(2):265-271.
  24. Bermudez E, Chen MH. Cardiac effects of propofol for transesophageal-guided cardioversion. Heart Dis. 2002; 4(6):355-7.
  25. Alvarez Ginzo A, Chen MH. Post-surgical left ventricular pseudoaneurysm. Texas Heart Institute Journal. 2002; 29(3):220-21.
  26. Chen, MH. Cardiac Ultrasound Curriculum for First Year Cardiac Fellows (Brigham and Women's Hospital). 2001.
  27. Chen L, Chen MH, Larson MG, Evans J, Benjamin EJ, Levy D. Risk factors for syncope in a community-based sample (the Framingham Heart Study). Am J Cardiol. 2000 May 15; 85(10):1189-93.
  28. Chen MH. Integration of Managed Care into Clinical Practice. 2000.
  29. Chen MH, Chuang ML, Bornstein BA, Gelman R, Harris JR, Manning WJ. Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals. Circulation. 1997 Nov 18; 96(10):3269-72.
  30. Haider AW, Chen L, Larson MG, Evans JC, Chen MH, Levy D. Antecedent hypertension confers increased risk for adverse outcomes after initial myocardial infarction. Hypertension. 1997 Nov; 30(5):1020-4.
  31. McConnell MV, Khasgiwala VC, Savord BJ, Chen MH, Chuang ML, Edelman RR, Manning WJ. Prospective adaptive navigator correction for breath-hold MR coronary angiography. Magn Reson Med. 1997 Jan; 37(1):148-52.
  32. Chuang ML, Chen MH, Khasgiwala VC, McConnell MV, Edelman RR, Manning WJ. Adaptive correction of imaging plane position in segmented K-space cine cardiac MR imaging. J Mag Reson Imag. 1997; Magn Res Med 37:811-814.
  33. McConnell MV, Khasgiwala VC, Savord BJ, Chen MH, Chuang ML, Edelman RR, Manning WJ. Magnetic resonance coronary angiography during free breathing: comparison of navigator locations and respiratory suppression methods. Am J Roentgenol. 1997; 168:1369-1375.
  34. Chen C, Li L, Chen LL, Prada JV, Chen MH, Fallon JT, Weyman AE, Waters D, Gillam L. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation. 1995 Aug 15; 92(4):756-66.
  35. Padial LR, Chen MH, Vuille C, Guerrero JL, Weyman AE, Picard MH. Pulsatile pressure affects the velocity of decay of echocardiographic contrast agents. J Am Soc Echocardiogr. 1995; 8:285-292..
  36. Hendel RC, Chen MH, L'Italien G, Newell JB, Eagle KA. Gender differences in clinical markers and dipyridimole-thallium imaging in the prediction of perioperative and long-term cardiac events after vascular surgery. Circulation. 1994; 91:1044-1051..
  37. Chen MH, Weyman AE. Echo-doppler assessment of prosthetic heart valves: what is the meaning for the clinician?. ACC Curr. Jour. Rev. 1994; (Nov-Dec).
  38. Saul JP, Berger RD, Albrecht P, Stein SP, Chen MH, Cohen RJ. Transfer function analysis of the circulation: unique insights into cardiovascular regulation. Am J Physiol. 1991 Oct; 261(4 Pt 2):H1231-45.
  39. Chen MH, Berger RD, Saul JP, Stevenson K, Cohen K, Cohen RJ. Transfer function analysis of the autonomic response to respiratory activity druing random interval breathing: II. Respiratory sinus arrhythmia. Am. J. Physiol. 1989; 25:H153-H161..
  40. Chen MH, Berger RD, Saul JP, Stevenson K, Cohen RJ. Transfer function analysis of the autonomic response to respiratory activity during random interval breathing. Comput Cardiol. 1987; 13:149-52.
  41. Berger RD, Chen MH, Saul JP. Method and Apparatus for the Assessment of Autonomic Response by Broad-band Excitation. 1986.
  42. Vazquez de Prada JA, Chen MH, Guerrero JL, Padial LR, Jiang L, Schwammenthal E, Sagie A, Weyman AE, Levine RA, Chen C. Intracardiac echocardiography: in vitro and in vivo validation for right ventricular volume and function. Am Heart J. 1996 Feb; 131(2):320-8.
  43. Douglas PS, Katz SE, Weinberg EO, Chen MH, Bishop SP, Lorell BH. Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload. J Am Coll Cardiol. 1998 Oct; 32(4):1118-25.
  44. Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, Woulfe K, Pravda E, Cassiola F, Desai J, George S, Morgan JA, Harris DM, Ismail NS, Chen JH, Schoen FJ, Van den Abbeele AD, Demetri GD, Force T, Chen MH. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007 Dec 15; 370(9604):2011-9.
  45. Chen L, Ma L, de Prada VA, Chen M, Feng YJ, Waters D, Gillam L, Chen C. Effects of beta-blockade and atropine on ischemic responses in left ventricular regions subtending coronary stenosis during dobutamine stress echocardiography. J Am Coll Cardiol. 1996 Dec; 28(7):1866-76.
  46. Gregory SA, Yepes CB, Byrne JG, D'Ambra MN, Chen MH. Atrial endocarditis--the importance of the regurgitant jet lesion. Echocardiography. 2005 May; 22(5):426-30.
  47. Chen MH, Kerkelä R, Force T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation. 2008 Jul 1; 118(1):84-95.
  48. Sagie A, Freitas N, Chen MH, Marshall JE, Weyman AE, Levine RA. Echocardiographic assessment of mitral stenosis and its associated valvular lesions in 205 patients and lack of association with mitral valve prolapse. J Am Soc Echocardiogr. 1997 Mar; 10(2):141-8.
  49. Chen C, Guerrero JL, Vazquez de Prada JA, Padial LR, Schwammenthal E, Chen MH, Jiang L, Svizzero T, Simon H, Thomas JD, et al. Intracardiac ultrasound measurement of volumes and ejection fraction in normal, infarcted, and aneurysmal left ventricles using a 10-MHz ultrasound catheter. Circulation. 1994 Sep; 90(3):1481-91.
  50. Vazquez de Prada JA, Jiang L, Chen MH, Padial LR, Guerrero JL, Schwammenthal E, King ME, Weyman AE, Chen C, Levine RA. Intracardiac ultrasonographic assessment of atrial septal defect area: in vitro validation and technical considerations. Am Heart J. 1995 Aug; 130(2):302-6.
  51. Lu HM, Cash E, Chen MH, Chin L, Manning WJ, Harris J, Bornstein B. Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: a CT study. Int J Radiat Oncol Biol Phys. 2000 Jul 1; 47(4):895-904.
  52. Lunze FI, Colan SD, Gauvreau K, Chen MH, Perez-Atayde AR, Blume ED, Singh TP. Cardiac allograft function during the first year after transplantation in rejection-free children and young adults. Circ Cardiovasc Imaging. 2012 Nov; 5(6):756-64.
  53. Chen MH, Abernathey E, Lunze F, Colan SD, O'Neill S, Bergersen L, Geva T, Blume ED. Utility of exercise stress echocardiography in pediatric cardiac transplant recipients: a single-center experience. J Heart Lung Transplant. 2012 May; 31(5):517-23.
  54. Hasan BS, Lunze FI, McElhinney DB, Stantcheva E, Brown DW, Rhodes J, Chen MH. Exercise stress echocardiographic assessment of outflow tract and ventricular function in patients with an obstructed right ventricular-to-pulmonary artery conduit after repair of conotruncal heart defects. Am J Cardiol. 2012 Nov 15; 110(10):1527-33.
  55. Chen MH. Cardiac dysfunction induced by novel targeted anticancer therapy: an emerging issue. Curr Cardiol Rep. 2009 May; 11(3):167-74.
  56. Kerkela R, Woulfe KC, Durand JB, Vagnozzi R, Kramer D, Chu TF, Beahm C, Chen MH, Force T. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci. 2009 Feb; 2(1):15-25.
  57. Demetri GD, Heinrich MC, Fletcher JA, Fletcher CD, Van den Abbeele AD, Corless CL, Antonescu CR, George S, Morgan JA, Chen MH, Bello CL, Huang X, Cohen DP, Baum CM, Maki RG. Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure. Clin Cancer Res. 2009 Sep 15; 15(18):5902-9.
  58. Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan JA, Dychter SS, Larsen PR, Demetri GD, Alexander EK. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med. 2006 Nov 7; 145(9):660-4.
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