Research

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Michelle Bosquet Enlow, PhD

Department:
Psychiatry
Division
Psychology Research
Hospital Title:
Associate in Psychology
Academic Title:
Assistant Professor of Psychology, Harvard Medical School
Research Focus Area:
AnxietyChild abuseChild abuse and neglectChild DevelopmentDevelopmental origins of health and diseaseFetal programmingTrauma
Contact:
617-919-4680

Research Overview

Dr. Bosquet Enlow’s current research program examines the diverse routes by which intergenerational effects influence mental health risk, integrating genetics and epigenetics, neuroscience, biological psychology, and socio-emotional processes. Her studies focus on the impact of maternal and child stress and trauma exposures and maternal psychopathology (depression, anxiety, posttraumatic stress disorder [PTSD]) on child development. She has conducted research examining the ways that mothers’ trauma histories may disrupt development in pregnancy, infancy, and the preschool period and the ways that such disruptions may increase vulnerability to mental health problems in later life. Dr. Bosquet Enlow has a particularly keen interest in understanding risk factors for anxiety disorders. She has also extended her research program to include how early processes may impact child physical health, including immune development and vulnerability to atopic disorders (e.g., allergies, asthma), and neurocognitive development. In addition, Dr. Bosquet Enlow has contributed to the development of clinical measures for assessing traumatic stress responses in children, including the Traumatic Events Screening Inventory-Parent Report Revised, the Child Stress Disorders Checklist-Short Form, and an acute stress disorder module adapted from the Diagnostic Interview for Children and Adolescents (DICA).

About Michelle Bosquet Enlow

Dr. Bosquet Enlow is a developmental and clinical psychologist with specialized training in infant mental health (birth to age 5), the assessment and treatment of traumatic stress in children and adults, and the development of child stress regulation. She received a B.A. in Psychology fromYale University (mentor Dr. Alice Carter) and a Ph.D. from the Developmental Psychopathology and Clinical Science program at the University of Minnesota (mentor Dr. Byron Egeland); she completed an internship in Clinical Psychology and a fellowship in Infant Mental Health at Louisiana State University Health Sciences Center (mentor Dr. Joy Osofsky) and an APA-accredited postdoctoral fellowship in Clinical Psychology through the Boston Consortium in Clinical Psychology (mentor Dr. Glenn Saxe).  Dr. Bosquet Enlow is particularly interested in understanding how risk for mental health difficulties throughout life are established in early development.  Ultimately, she aims to design interventions that support healthy development and prevent the occurrence of mental health problems, particularly in highly vulnerable populations.

Publications

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  1. Bosquet Enlow M, White MT, Hails K, Cabrera I, Wright RJ. The Infant Behavior Questionnaire-Revised: Factor structure in a culturally and sociodemographically diverse sample in the United States. Infant Behav Dev. 2016 May; 43:24-35.
  2. Bosquet Enlow M, Englund MM, Egeland B. Maternal Childhood Maltreatment History and Child Mental Health: Mechanisms in Intergenerational Effects. J Clin Child Adolesc Psychol. 2016 Apr 12; 1-16.
  3. Schreier HM, Enlow MB, Ritz T, Coull BA, Gennings C, Wright RO, Wright RJ. Lifetime exposure to traumatic and other stressful life events and hair cortisol in a multi-racial/ethnic sample of pregnant women. Stress. 2016; 19(1):45-52.
  4. Gonzalez-Heydrich J, Bosquet Enlow M, D'Angelo E, Seidman LJ, Gumlak S, Kim A, Woodberry KA, Rober A, Tembulkar S, Graber K, O'Donnell K, Hamoda HM, Kimball K, Rotenberg A, Oberman LM, Pascual-Leone A, Keshavan MS, Duffy FH. Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample. Schizophr Res. 2015 Dec; 169(1-3):340-5.
  5. Schreier HM, Enlow MB, Ritz T, Gennings C, Wright RJ. Childhood abuse is associated with increased hair cortisol levels among urban pregnant women. J Epidemiol Community Health. 2015 Dec; 69(12):1169-74.
  6. Bosquet Enlow M, King L, Schreier HM, Howard JM, Rosenfield D, Ritz T, Wright RJ. Maternal sensitivity and infant autonomic and endocrine stress responses. Early Hum Dev. 2014 Jul; 90(7):377-85.
  7. Brunst KJ, Enlow MB, Kannan S, Carroll KN, Coull BA, Wright RJ. Effects of Prenatal Social Stress and Maternal Dietary Fatty Acid Ratio on Infant Temperament: Does Race Matter? Epidemiology (Sunnyvale). 2014; 4(4).
  8. Brunst KJ, Wright RO, DiGioia K, Enlow MB, Fernandez H, Wright RJ, Kannan S. Racial/ethnic and sociodemographic factors associated with micronutrient intakes and inadequacies among pregnant women in an urban US population. Public Health Nutr. 2014 Sep; 17(9):1960-70.
  9. Enlow MB, Blood E, Egeland B. Sociodemographic risk, developmental competence, and PTSD symptoms in young children exposed to interpersonal trauma in early life. J Trauma Stress. 2013 Dec; 26(6):686-94.
  10. Bosquet Enlow M, Egeland B, Carlson E, Blood E, Wright RJ. Mother-infant attachment and the intergenerational transmission of posttraumatic stress disorder. Dev Psychopathol. 2014 Feb; 26(1):41-65.
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  12. Ritz T, Bosquet Enlow M, Schulz SM, Kitts R, Staudenmayer J, Wright RJ. Respiratory sinus arrhythmia as an index of vagal activity during stress in infants: respiratory influences and their control. PLoS One. 2012; 7(12):e52729.
  13. Enlow MB, Egeland B, Blood EA, Wright RO, Wright RJ. Interpersonal trauma exposure and cognitive development in children to age 8 years: a longitudinal study. J Epidemiol Community Health. 2012 Nov; 66(11):1005-10.
  14. Bosquet Enlow M, Kitts RL, Blood E, Bizarro A, Hofmeister M, Wright RJ. Maternal posttraumatic stress symptoms and infant emotional reactivity and emotion regulation. Infant Behav Dev. 2011 Dec; 34(4):487-503.
  15. Sternthal MJ, Enlow MB, Cohen S, Canner MJ, Staudenmayer J, Tsang K, Wright RJ. Maternal interpersonal trauma and cord blood IgE levels in an inner-city cohort: a life-course perspective. J Allergy Clin Immunol. 2009 Nov; 124(5):954-60.
  16. Rifkin-Graboi, A., Borelli, J.L., & Bosquet, M. Neurobiology of stress in infancy . C.H. Zeanah, Jr. (Ed.), Handbook of Infant Mental Health. 2008.
  17. Saxe G, Geary M, Bedard K, Bosquet M, Miller A, Koenen K, Stoddard F, Moulton S. Separation anxiety as a mediator between acute morphine administration and PTSD symptoms in injured children. Ann N Y Acad Sci. 2006 Jul; 1071:41-5.
  18. Bosquet M, Egeland B. The development and maintenance of anxiety symptoms from infancy through adolescence in a longitudinal sample. Dev Psychopathol. 2006; 18(2):517-50.
  19. Koenen KC, Saxe G, Purcell S, Smoller JW, Bartholomew D, Miller A, Hall E, Kaplow J, Bosquet M, Moulton S, Baldwin C. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol Psychiatry. 2005 Dec; 10(12):1058-9.
  20. Saxe GN, Miller A, Bartholomew D, Hall E, Lopez C, Kaplow J, Koenen KC, Bosquet M, Allee L, Erikson I, Moulton S. Incidence of and risk factors for acute stress disorder in children with injuries. J Trauma. 2005 Oct; 59(4):946-53.
  21. Bosquet, M., & Warren, S. L. (2005, April). Society for Research in Child Development, Atlanta, Georgia. . The parent-child relationship and child emotional reactivity: Mechanisms for the development of child anxiety. 2005.
  22. Saxe, G. S., Bosquet, M., Stoddard, F., & Kassam-Adams, N. Screening for PTSD in injured children. 2004.
  23. Hall, E., Saxe, G., Kaplow, J., Koenen, K.C., Miller, A., Bartholomew, D., Lopez, C., Bosquet, M., King, L., & King, D. Acute stress symptoms in parents of children with burns or injuries. 2004.
  24. Bosquet, M., Saxe, G., & Kassam-Adams, N. A 4-Item Screener for ASD and PTSD in Children. 2004.
  25. Miller, A., Saxe, G., Stoddard, F., Bartholomew, D., Hall, E., Lopez, C., Kaplow, J., Koenen, K.C., Bosquet, M., & Reich, W. . Reliability and validity of the DICA-ASD. 2004.
  26. Saxe, G., Miller, A., Bartholomew, D., Hall, E., Lopez, C., Kaplow, J., Koenen, K., Bosquet, M., Allee, L., Erikson, I., & Moulton, S. Prevalence of and risk factors for Acute Stress Disorder in children with injuries. 2004.
  27. Bosquet, M. How research informs clinical work with traumatized young children. J. D. Osofsky (Ed.), Young Children and Trauma: What do we know and what do we need to know? N. 2004.
  28. Saxe, G. N., & Bosquet, M. The PTSD Screen. 2004.
  29. Bosquet, M. . An examination of the development of anxiety symptoms from a developmental psychopathology perspective. 2003.
  30. Egeland, B., Bosquet, M., & Levy, A. K. Continuities and discontinuities in the intergenerational transmission of child maltreatment: Implications for breaking the cycle of abuse. Browne, K., Hanks, H., Stratton, P., & Hamilton, C. (Eds.), Early prediction and prevention of child abuse: A handbook. 2002; 217-232.
  31. Egeland, B., & Bosquet, M. Emotion regulation in early childhood: The role of attachment-oriented interventions. B. S. Zuckerman, A. F. Lieberman, & N. A. Fox (Eds.), Emotional regulation and developmental health: Infancy and early childhood. 2002; 101-124.
  32. Ghosh Ippen, C., Ford, J., Racusin, R., Acker, M., Bosquet, M., Rogers, K., Ellis, C., Schiffman, J., Ribbe, D., Cone, P., Lukovitz, M., Edwards, J., The Child Trauma Research Project of the Early Trauma Treatment Network, & The National Center for PTSD Dartmouth Child Trauma Research Group. . Traumatic Events Screening Inventory-Parent Report Revised. 2002.
  33. Michelle Bosquet. An examination of the development of anxiety symptoms from a developmental psychopathology perspective. 2001.
  34. Bosquet M, Egeland B. Associations among maternal depressive symptomatology, state of mind and parent and child behaviors: implications for attachment-based interventions. Attach Hum Dev. 2001 Sep; 3(2):173-99.
  35. Bosquet, M. Associations among maternal state of mind, depression, and parent and child behaviors: Implications for attachment interventions. 2001.
  36. Egeland, B., & Bosquet M. . Review of the book Cycles of maltreatment: Facts, fallacies, and interventions. Child Abuse and Neglect: The International Journal. 2001; 25:313-314.
  37. Bosquet M, Egeland B. Predicting parenting behaviors from Antisocial Practices content scale scores of the MMPI-2 administered during pregnancy. J Pers Assess. 2000 Feb; 74(1):146-62.
  38. Nelson, C. A., & Bosquet, M. . Neurobiology of fetal and infant development: Implications for infant mental health. C.H. Zeanah, Jr. (Ed.), Handbook of infant mental health. 2000; 37-59.
  39. Egeland, B., Weinfield, N. S., Bosquet, M., & Cheng, V. K. Remembering, repeating, and working through: Lessons from attachment-based interventions. J. D. Osofsky & H. E. Fitzgerald (Eds.), WAIMH Handbook of infant mental health: Vol. 4. Infant mental health in groups at high risk. 2000; 4:35-89.
  40. Bosquet, M. Associations between maternal personality and clinical symptomatology measured pre-partum and infant attachment. 1999.
  41. Bosquet, M. Associations between maternal antisocial attitudes measured pre-partum and parenting behaviors. 1999.
  42. Reznick, J. S., Fueser, J. J., & Bosquet, M. . Self-corrected reaching in a three-location delayed-response search task. Psychological Science. 1998; 9:66-70.
  43. Bosquet, M., & Warren, S. L. Could my child be at risk for developing an anxiety disorder? Special focus on anxiety disorders in children, adolescents, and young adults (2nd ed., pp. 25-27). 1998.
  44. Bosquet, M. . Predicting parent behavior from the Antisocial Practices Content Scores administered during pregnancy. . 1997.
  45. Schuder, M., Bosquet, M., & Erickson, M. F. The effects of a home visitation intervention on paternal involvement. 1997.
  46. Bosquet, M., Chazan, R., & Carter, A. S. . Associations between maternal depression and infant affect and behavior. 1996.
  47. Carter, A., Bosquet, M., & Chazan, R. The association of maternal depressive symptoms and infant behavioral inhibition at four months of age. 1994.
  48. Reznick, J. S., & Bosquet, M. . Reaching beyond infant forgetting. 1994.
  49. Suglia SF, Ryan L, Bellinger DC, Enlow MB, Wright RJ. Children's exposure to violence and distress symptoms: influence of caretakers' psychological functioning. Int J Behav Med. 2011 Mar; 18(1):35-43.
  50. Bosquet Enlow M, Kassam-Adams N, Saxe G. The Child Stress Disorders Checklist-Short Form: a four-item scale of traumatic stress symptoms in children. Gen Hosp Psychiatry. 2010 May-Jun; 32(3):321-7.
  51. Enlow MB, Kullowatz A, Staudenmayer J, Spasojevic J, Ritz T, Wright RJ. Associations of maternal lifetime trauma and perinatal traumatic stress symptoms with infant cardiorespiratory reactivity to psychological challenge. Psychosom Med. 2009 Jul; 71(6):607-14.
  52. Gonzalez-Heydrich J, Enlow MB, D'Angelo E, Seidman LJ, Gumlak S, Kim A, Woodberry KA, Rober A, Tembulkar S, O'Donnell K, Hamoda HM, Kimball K, Rotenberg A, Oberman LM, Pascual-Leone A, Keshavan MS, Duffy FH. N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth. Neural Plast. 2016; 2016:4209831.
  53. Suglia SF, Staudenmayer J, Cohen S, Enlow MB, Rich-Edwards JW, Wright RJ. Cumulative Stress and Cortisol Disruption among Black and Hispanic Pregnant Women in an Urban Cohort. Psychol Trauma. 2010 Dec 1; 2(4):326-334.
  54. Miller A, Enlow MB, Reich W, Saxe G. A diagnostic interview for acute stress disorder for children and adolescents. J Trauma Stress. 2009 Dec; 22(6):549-56.
  55. Suglia SF, Enlow MB, Kullowatz A, Wright RJ. Maternal intimate partner violence and increased asthma incidence in children: buffering effects of supportive caregiving. Arch Pediatr Adolesc Med. 2009 Mar; 163(3):244-50.
  56. Wright RJ, Enlow MB. Maternal stress and perinatal programming in the expression of atopy. Expert Rev Clin Immunol. 2008 Sep 1; 4(5):535-538.
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