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Michael L. McManus, MD, MPH

Michael McManus MD MPH
Department of Anesthesiology, Perioperative and Pain Medicine Research
Critical Care Medicine Research
Hospital Title:
Senior Associate in Critical Care Medicine, Boston Children’s Chair in Critical Care Anesthesiology
Academic Title:
Associate Professor of Anaesthesia, Harvard Medical School
Research Focus Area:
Public Health SystemsAccess to careAccess to critical hospital services

Research Overview

The fundamental goal of pediatric critical care is to effectively meet life-threatening emergencies with knowledge and technology. We function, however, in an imperfect system where timely access to care is frequently prevented by organizational, political, financial, geographical, and technical barriers. Our work aims to identify, understand, and overcome these barriers. 

We use large datasets, simulation modeling, and systems research tools to solve complex problems in emergency departments, operating rooms, and intensive care units. Our Robert Wood Johnson-funded research provided solutions for the ambulance diversion crisis in Massachusetts and our studies of surgical scheduling have improved access to critical care services. Current work focuses on hospital capabilities, networks of care, and the differential impacts of health system change on children.



Publications powered by Harvard Catalyst Profiles
  1. França UL, McManus ML. Frequency, trends, and antecedents of severe maternal depression after three million U.S. births. PLoS One. 2018; 13(2):e0192854.
  2. Graham RJ, McManus ML, Rodday AM, Weidner RA, Parsons SK. Pediatric Specialty Care Model for Management of Chronic Respiratory Failure: Cost and Savings Implications and Misalignment With Payment Models. Pediatr Crit Care Med. 2018 Feb 03.
  3. França UL, McManus ML. Trends in Regionalization of Hospital Care for Common Pediatric Conditions. Pediatrics. 2018 Jan; 141(1).
  4. França UL, McManus ML. Availability of Definitive Hospital Care for Children. JAMA Pediatr. 2017 Sep 05; 171(9):e171096.
  5. França UL, McManus ML. Transfer Frequency as a Measure of Hospital Capability and Regionalization. Health Serv Res. 2017 12; 52(6):2237-2255.
  6. Graham RJ, McManus ML, Rodday AM, Weidner RA, Parsons SK. Chronic respiratory failure: Utilization of a pediatric specialty integrated care program. Healthc (Amst). 2017 Mar; 5(1-2):23-28.
  7. McManus ML. Shifting Goals in Operating Room Management. A A Case Rep. 2016 Mar 15; 6(6):181-2.
  8. França UL, Mustafa S, McManus ML. The Growing Burden of Neonatal Opiate Exposure on Children and Family Services in Massachusetts. Child Maltreat. 2016 Feb; 21(1):80-4.
  9. Bravo F, Levi R, Ferrari LR, McManus ML. The nature and sources of variability in pediatric surgical case duration. Paediatr Anaesth. 2015 Oct; 25(10):999-1006.
  10. Casavant DW, McManus ML, Parsons SK, Zurakowski D, Graham RJ. Trial of telemedicine for patients on home ventilator support: feasibility, confidence in clinical management and use in medical decision-making. J Telemed Telecare. 2014 Dec; 20(8):441-9.
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  12. Mir-Kasimov M, Sturrock A, McManus M, Paine R. Effect of alveolar epithelial cell plasticity on the regulation of GM-CSF expression. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L504-11.
  13. Sturrock A, Seedahmed E, Mir-Kasimov M, Boltax J, McManus ML, Paine R. GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injury. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 01; 302(3):L343-51.
  14. Solter LF, Pilarska DK, McManus ML, Zúbrik M, Patocka J, Huang WF, Novotný J. Host specificity of microsporidia pathogenic to the gypsy moth, Lymantria dispar (L.): field studies in Slovakia. J Invertebr Pathol. 2010 Sep; 105(1):1-10.
  15. Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatr Dev Pathol. 2010 Sep-Oct; 13(5):397-403.
  16. Sturrock A, Vollbrecht T, Mir-Kasimov M, McManus M, Wilcoxen SE, Paine R. Mechanisms of suppression of alveolar epithelial cell GM-CSF expression in the setting of hyperoxic stress. Am J Physiol Lung Cell Mol Physiol. 2010 Mar; 298(3):L446-53.
  17. Hoch G, D'Amico V, Solter LF, Zubrik M, McManus ML. Quantifying horizontal transmission of Nosema lymantriae, a microsporidian pathogen of the gypsy moth, Lymantria dispar (Lep., Lymantriidae) in field cage studies. J Invertebr Pathol. 2008 Oct; 99(2):146-50.
  18. Vinecore K, Aboy M, McNames J, Phillips C, Agbeko R, Peters M, Ellenby M, McManus ML, Goldstein B. Design and implementation of a portable physiologic data acquisition system. Pediatr Crit Care Med. 2007 Nov; 8(6):563-9.
  19. Wolf GK, McClain CD, Zurakowski D, Dodson B, McManus ML. Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. Pediatr Crit Care Med. 2006 Sep; 7(5):434-9; quiz 440.
  20. Vavra J, Hylis M, Vossbrinck CR, Pilarska DK, Linde A, Weiser J, McManus ML, Hoch G, Solter LF. Vairimorpha disparis n. comb. (Microsporidia: Burenellidae): a redescription and taxonomic revision of Thelohania disparis Timofejeva 1956, a microsporidian parasite of the gypsy moth Lymantria dispar (L.) (Lepidoptera: Lymantriidae). J Eukaryot Microbiol. 2006 Jul-Aug; 53(4):292-304.
  21. Fallon DJ, Solter LF, Bauer LS, Miller DL, Cate JR, McManus ML. Effect of entomopathogenic nematodes on Plectrodera scalator (Fabricius) (Coleoptera: Cerambycidae). J Invertebr Pathol. 2006 May; 92(1):55-7.
  22. Hylis M, Pilarska DK, Oborník M, Vávra J, Solter LF, Weiser J, Linde A, McManus ML. Nosema chrysorrhoeae n. sp. (Microsporidia), isolated from browntail moth (Euproctis chrysorrhoea L.) (Lepidoptera, Lymantriidae) in Bulgaria: characterization and phylogenetic relationships. J Invertebr Pathol. 2006 Feb; 91(2):105-14.
  23. Litvak E, Buerhaus PI, Davidoff F, Long MC, McManus ML, Berwick DM. Managing unnecessary variability in patient demand to reduce nursing stress and improve patient safety. Jt Comm J Qual Patient Saf. 2005 Jun; 31(6):330-8.
  24. Khwaja OS, Robson CD, McManus ML, Urion DK. Basilar meningitis associated with ethmoid and sphenoid cephaloceles. Pediatr Neurol. 2005 Jul; 33(1):57-60.
  25. Wise-Faberowski L, Soriano SG, Ferrari L, McManus ML, Wolfsdorf JI, Majzoub J, Scott RM, Truog R, Rockoff MA. Perioperative management of diabetes insipidus in children. J Neurosurg Anesthesiol. 2004 Jul; 16(3):220-5.
  26. McManus ML, Long MC, Cooper A, Litvak E. Queuing theory accurately models the need for critical care resources. Anesthesiology. 2004 May; 100(5):1271-6.
  27. Wise-Faberowski L, Soriano SG, Ferrari L, McManus ML, Wolfsdorf JI, Majzoub J, Scott RM, Truog R, Rockoff MA. Perioperative management of diabetes insipidus in children [corrected]. J Neurosurg Anesthesiol. 2004 Jan; 16(1):14-9.
  28. McManus ML, Long MC, Cooper A, Mandell J, Berwick DM, Pagano M, Litvak E. Variability in surgical caseload and access to intensive care services. Anesthesiology. 2003 Jun; 98(6):1491-6.
  29. Litvak E, Long MC, Cooper AB, McManus ML. Emergency department diversion: causes and solutions. Acad Emerg Med. 2001 Nov; 8(11):1108-10.
  30. D'Amico V, Elkinton JS, Podgwaite JD, Slavicek JM, McManus ML, Burand JP. A field release of genetically engineered gypsy moth (Lymantria dispar L.) nuclear polyhedrosis virus (LdNPV). J Invertebr Pathol. 1999 May; 73(3):260-8.
  31. Bauer LS, Miller DL, Maddox JV, McManus ML. Interactions between a Nosema sp. (Microspora: nosematidae) and nuclear polyhedrosis virus infecting the gypsy moth, Lymantria dispar (Lepidoptera: lymantriidae). J Invertebr Pathol. 1998 Sep; 72(2):147-53.
  32. McManus ML, Soriano SG. Rebound swelling of astroglial cells exposed to hypertonic mannitol. Anesthesiology. 1998 Jun; 88(6):1586-91.
  33. Emma F, McManus M, Strange K. Intracellular electrolytes regulate the volume set point of the organic osmolyte/anion channel VSOAC. Am J Physiol. 1997 Jun; 272(6 Pt 1):C1766-75.
  34. Soriano SG, McManus ML, Sullivan LJ, Rockoff MA, Black PM, Burrows FA. Cerebral blood flow velocity after mannitol infusion in children. Can J Anaesth. 1996 May; 43(5 Pt 1):461-6.
  35. McManus ML, Churchwell KB, Strange K. Regulation of cell volume in health and disease. N Engl J Med. 1995 Nov 09; 333(19):1260-6.
  36. McManus ML, Kevy SV, Bower LK, Hickey PR. Coagulation factor deficiencies during initiation of extracorporeal membrane oxygenation. J Pediatr. 1995 Jun; 126(6):900-4.
  37. Churchwell KB, McManus ML, Kent P, Gorlin J, Galacki D, Humphreys D, Kevy SV. Intensive blood and plasma exchange for treatment of coagulopathy in meningococcemia. J Clin Apher. 1995; 10(4):171-7.
  38. Soriano SG, McManus ML, Sullivan LJ, Scott RM, Rockoff MA. Doppler sensor placement during neurosurgical procedures for children in the prone position. J Neurosurg Anesthesiol. 1994 Jul; 6(3):153-5.
  39. McManus M, Serhan C, Jackson P, Strange K. Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. Am J Physiol. 1994 Jul; 267(1 Pt 1):C266-71.
  40. McManus M, Fischbarg J, Sun A, Hebert S, Strange K. Laser light-scattering system for studying cell volume regulation and membrane transport processes. Am J Physiol. 1993 Aug; 265(2 Pt 1):C562-70.
  41. McManus ML, Strange K. Acute volume regulation of brain cells in response to hypertonic challenge. Anesthesiology. 1993 Jun; 78(6):1132-7.
  42. McManus ML, Churchwell KB. Coagulopathy as a predictor of outcome in meningococcal sepsis and the systemic inflammatory response syndrome with purpura. Crit Care Med. 1993 May; 21(5):706-11.
  43. Paredes A, McManus M, Kwon HM, Strange K. Osmoregulation of Na(+)-inositol cotransporter activity and mRNA levels in brain glial cells. Am J Physiol. 1992 Dec; 263(6 Pt 1):C1282-8.
  44. Irazuzta J, McManus ML. Use of topically applied nitroglycerin in the treatment of purpura fulminans. J Pediatr. 1990 Dec; 117(6):993-5.
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