Research

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Melody G. Duvall, MD, PhD

Melody Duvall MD, PhD
Department:
Department of Anesthesiology, Perioperative and Pain Medicine Research
Division
Critical Care Medicine Research
Hospital Title:
Assistant in Critical Care Medicine
Academic Title:
Instructor in Anaesthesia, Harvard Medical School
Research Focus Area:
Viral lung diseaseLung inflammationInflammation resolution
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Research Overview

Dr. Duvall received her PhD in Immunology from Oxford University, United Kingdom, in 2006 through the NIH-Oxford Graduate Partnership Program and her MD from Washington University in St. Louis School of Medicine in 2008. She completed her pediatrics residency at Boston Children’s Hospital in 2012 and her pediatric critical care medicine fellowship at Boston Children’s Hospital in 2015.

Dr. Duvall works in the laboratory of Dr. Bruce Levy at Brigham and Women’s Hospital (http://levylab.bwh.edu). Research in the Levy laboratory focuses on endogenous mechanisms for resolution of lung inflammation and injury. The lab’s overall mission is to identify novel pathways and cellular targets that promote resolution of pulmonary inflammation or injury and to determine roles for naturally-derived, specialized pro-resolving mediators in lung health and disease as well as their potential as templates for rational new drug design.

Dr. Duvall is investigating the phenotype and function of innate and adaptive cellular mediators of immunity in children with viral lung infection and respiratory failure.

Publications

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  1. Duvall MG, Levy BD. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. Eur J Pharmacol. 2016 Aug 15; 785:144-55.
  2. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, Sectish TC, Mullen MP. Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics. 2013 Dec; 132(6):e1699-703.
  3. Speirs C, van Nimwegen E, Bolton D, Zavolan M, Duvall M, Angleman S, Siegel R, Perelson AS, Lenardo MJ. Analysis of human immunodeficiency virus cytopathicity by using a new method for quantitating viral dynamics in cell culture. J Virol. 2005 Apr; 79(7):4025-32.
  4. Lenardo MJ, Angleman SB, Bounkeua V, Dimas J, Duvall MG, Graubard MB, Hornung F, Selkirk MC, Speirs CK, Trageser C, Orenstein JO, Bolton DL. Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env. J Virol. 2002 May; 76(10):5082-93.
  5. Duvall MG, Precopio ML, Ambrozak DA, Jaye A, McMichael AJ, Whittle HC, Roederer M, Rowland-Jones SL, Koup RA. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol. 2008 Feb; 38(2):350-63.
  6. Duvall MG, Jaye A, Dong T, Brenchley JM, Alabi AS, Jeffries DJ, van der Sande M, Togun TO, McConkey SJ, Douek DC, McMichael AJ, Whittle HC, Koup RA, Rowland-Jones SL. Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection. J Immunol. 2006 Jun 1; 176(11):6973-81.
  7. Duvall MG, Loré K, Blaak H, Ambrozak DA, Adams WC, Santos K, Geldmacher C, Mascola JR, McMichael AJ, Jaye A, Whittle HC, Rowland-Jones SL, Koup RA. Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection. J Virol. 2007 Dec; 81(24):13486-98.
  8. Seale AC, de Jong BC, Zaidi I, Duvall M, Whittle H, Rowland-Jones S, Jaye A. Effects of cryopreservation on CD4+ CD25+ T cells of HIV-1 infected individuals. J Clin Lab Anal. 2008; 22(3):153-8.
  9. Patel KR, Aven L, Shao F, Krishnamoorthy N, Duvall MG, Levy BD, Ai X. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life. Mucosal Immunol. 2016 Nov; 9(6):1466-1476.
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