Research

LIke ThisLIke ThisLIke This

Martha  Murray, MD

Martha Murray
Lab:
Sports Medicine Research Laboratory
Department:
Orthopedic Surgery Research
Hospital Title:
Orthopedic Surgeon
Academic Title:
Associate Professor in Orthopedic Surgery
Research Focus Area:
Orthopedics: sports medicine
Contact:
617-355-7132
Contact Via Email
Send an email to SendYour Name*Your Email Address*Subject*Comments*

Research Overview

ACL injuries occur at a high frequency in the US with approximately 400,000 ACL reconstructions being performed each year in the US. The anterior cruciate ligament is a major stabilizer of the knee joint and courses through the middle of the joint. Injuries of the ACL do not heal spontaneously, and suture repair of these injuries has been shown to have a high failure rate (over 90%). Thus, suture repair has been abandoned in favor of ACL reconstruction, where the injured ACL is removed and replaced with a tendon graft. While ACL reconstruction is a good operation for restoring gross knee stability, it does not restore joint motion, or prevent the premature development of osteoarthritis in many patients.Current data suggests that 76% of patients with an ACL tear will develop osteoarthritis at only 14 years from injury -- whether they have an ACL reconstruction or not. Thus, new treatments for an ACL injury, which are less invasive and have the potential to minimize patient morbidity, are highly desirable. Bio-enhanced ACL repair, using a tissue engineered approach to stimulate healing, is one such strategy.

Our work has focused on new ways to treat ACL injury to try to improve patient outcomes. We wondered if outcomes would be better if we encouraged the ACL to heal, rather than replacing it. To make this work, we would need to find out why it doesn’t heal naturally. Through a series of studies, we compared ligaments that do heal (like the medial collateral ligament of the knee) with ligaments that don’t (like the ACL) to find out where the differences lie. We found that when the MCL tears, a blood clot forms between the torn tissue ends and serves as a bridge for the tissue to heal back into. However, for the ACL, the joint fluid prevented the blood from forming a solid clot, so there was no structure rejoining the two ends of the ligament, and no structure for the torn ends to heal into. 

We hypothesized that this was the major reason the ACL wouldn’t heal on its own. We worked on developing a scaffold that we could place between the two torn ends of the tissue to use as a substitute bridge. After trying multiple materials, we found a protein-based scaffold that would work. We tried adding different growth factors to the scaffold and found that in the end, the blood that forms the scaffold in other tissues is actually the best biologic agent for stimulating ACL healing as well. The new technique involved taking the protein scaffold and loading it with a few cc's of blood and placing it in between the torn ends of the ACL. The scaffold would make the blood clot and hold it in place long enough for the ACL to heal. 

When we tried this in a preclinical model, we found that the strength of the healing ligament was similar in the knees treated with repair and those treated with reconstruction. When we then looked at what happened at one year after surgery, we found that the strengths of the two techniques were not statistically different, and the knees treated with a bioenhanced repair had less arthritis than those treated with a reconstruction. 

If these same results hold up in human trials, we will have developed a less-invasive and improved method for treating patients with ACL tears. Functional healing of the torn ACL using a bio-enhanced repair technique could significantly impact treatment of hundreds of thousands of patients each year in the US alone. The immediate benefits for the patient would be a far less invasive surgical procedure that ACL reconstruction as no graft harvest is required. The long-term benefits for patients are potentially even greater, as retention of the proprioceptive nerve fibers in the ACL, complex anatomy of the insertion sites and fan shape of the ligament will more closely restore the normal dynamic biomechanics of the knee and thus is likely to decrease the premature osteoarthritis seen in the knees of patients after an ACL tear. The less invasive alternative to conventional ACL reconstruction uses a bio-engineered sponge as a bridge between the ends of the torn ACL to stimulate healing.
 
We have successfully tested this new technique in animal models and with 10 patients in the first BEAR study and are currently enrolling patients in the BEAR II study. The goal of the current trial is the study the BEAR procedure in more patients to determine if the new technique is as good as ACL reconstruction for a larger number of patients. To learn more about the BEAR II trial or to schedule an appointment with a BEAR trial physician, please call 617-355-3501 or email bear.trial@childrens.harvard.edu.

Learn more about this safety study by visiting our BEAR trial page or Vector - Boston Children's Hospital's science and innovation clinical blog.

About Martha Murray

Martha Murray received her master's degree in materials science and engineering from Stanford University and her medical degree from the University of Pennsylvania. She completed a residency in orthopedic surgery at Harvard Medical School and fellowships in pediatric orthopedics and sports medicine at Boston Children's Hospital.

Dr. Murray also specializes in the clinical care and surgical treatment of patients with knee injuries, including injuries of the ACL, meniscus, and cartilage.  If you would like to schedule an appointment, please call 617-355-3501.

Dr. Murray's Curriculum vitae

 

Publications

Publications powered by Harvard Catalyst Profiles
  1. Chin KE, Karamchedu NP, Patel TK, Badger GJ, Akelman MR, Moore DC, Proffen BL, Murray MM, Fleming BC. Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model. J Biomech. 2016 Oct 3; 49(14):3559-3563.
  2. Sieker JT, Ayturk UM, Proffen BL, Weissenberger MH, Kiapour AM, Murray MM. Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. Arthritis Rheumatol. 2016 Jul; 68(7):1637-47.
  3. Proffen BL, Sieker JT, Murray MM, Akelman MR, Chin KE, Perrone GS, Patel TK, Fleming BC. Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. J Orthop Res. 2016 Jun; 34(6):995-1003.
  4. Kelly BA, Proffen BL, Haslauer CM, Murray MM. Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold. J Orthop Res. 2016 Apr; 34(4):623-9.
  5. Kiapour AM, Fleming BC, Murray MM. Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model. Clin Orthop Relat Res. 2015 Aug; 473(8):2599-608.
  6. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Badger GJ, Murray MM. Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing. J Orthop Res. 2015 Jul; 33(7):1015-23.
  7. Biercevicz AM, Proffen BL, Murray MM, Walsh EG, Fleming BC. T2* relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model. J Orthop Res. 2015 Aug; 33(8):1180-7.
  8. Proffen BL, Sieker JT, Murray MM. Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy. 2015 May; 31(5):990-7.
  9. Proffen BL, Vavken P, Haslauer CM, Fleming BC, Harris CE, Machan JT, Murray MM. Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model. Am J Sports Med. 2015 Feb; 43(2):320-30.
  10. Haslauer CM, Proffen BL, Johnson VM, Hill A, Murray MM. Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model. J Inflamm (Lond). 2014; 11(1):34.
  11. Show all
  12. Bennike T, Ayturk U, Haslauer CM, Froehlich JW, Proffen BL, Barnaby O, Birkelund S, Murray MM, Warman ML, Stensballe A, Steen H. A normative study of the synovial fluid proteome from healthy porcine knee joints. J Proteome Res. 2014 Oct 3; 13(10):4377-87.
  13. Proffen BL, Nielson JH, Zurakowski D, Micheli LJ, Curtis C, Murray MM. The Effect of Perioperative Ketorolac on the Clinical Failure Rate of Meniscal Repair. Orthop J Sports Med. 2014 May 1; 2(5).
  14. Biercevicz AM, Walsh EG, Murray MM, Akelman MR, Fleming BC. Improving the clinical efficiency of T2(*) mapping of ligament integrity. J Biomech. 2014 Jul 18; 47(10):2522-5.
  15. Fleming BC, Proffen BL, Vavken P, Shalvoy MR, Machan JT, Murray MM. Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2015 Apr; 23(4):1161-70.
  16. Kiapour AM, Murray MM. Basic science of anterior cruciate ligament injury and repair. Bone Joint Res. 2014; 3(2):20-31.
  17. Proffen BL, Fleming BC, Murray MM. Histologic Predictors of Maximum Failure Loads Differ between the Healing ACL and ACL Grafts after 6 and 12 Months In Vivo. Orthop J Sports Med. 2013 Nov; 1(6).
  18. Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM. Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury. Osteoarthritis Cartilage. 2013 Dec; 21(12):1950-7.
  19. Rodeo SA, Boden SD, Murray MM, Einhorn TA. 2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues. J Bone Joint Surg Am. 2013 Aug 7; 95(15):e109.
  20. Biercevicz AM, Miranda DL, Machan JT, Murray MM, Fleming BC. In Situ, noninvasive, T2*-weighted MRI-derived parameters predict ex vivo structural properties of an anterior cruciate ligament reconstruction or bioenhanced primary repair in a porcine model. Am J Sports Med. 2013 Mar; 41(3):560-6.
  21. Proffen BL, Haslauer CM, Harris CE, Murray MM. Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation, and collagen gene expression. Connect Tissue Res. 2013; 54(1):14-21.
  22. Magarian EM, Vavken P, Connolly SA, Mastrangelo AN, Murray MM. Safety of intra-articular use of atelocollagen for enhanced tissue repair. Open Orthop J. 2012; 6:231-8.
  23. Yoshida R, Vavken P, Murray MM. Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells. Knee. 2012 Oct; 19(5):672-5.
  24. Proffen BL, McElfresh M, Fleming BC, Murray MM. A comparative anatomical study of the human knee and six animal species. Knee. 2012 Aug; 19(4):493-9.
  25. Harrison SL, Vavken P, Murray MM. Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold. J Orthop Res. 2011 Sep; 29(9):1361-6.
  26. Haddad-Weber M, Prager P, Kunz M, Seefried L, Jakob F, Murray MM, Evans CH, Nöth U, Steinert AF. BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. Cytotherapy. 2010 Jul; 12(4):505-13.
  27. Cheng M, Wang H, Yoshida R, Murray MM. Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. Tissue Eng Part A. 2010 May; 16(5):1479-89.
  28. Vavken P, Murray MM. Translational studies in anterior cruciate ligament repair. Tissue Eng Part B Rev. 2010 Feb; 16(1):5-11.
  29. Vavken P, Joshi SM, Murray MM. Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis. Knee. 2011 Jan; 18(1):42-6.
  30. Vavken P, Joshi S, Murray MM. TRITON-X is most effective among three decellularization agents for ACL tissue engineering. J Orthop Res. 2009 Dec; 27(12):1612-8.
  31. Kritsaneepaiboon S, Shah R, Murray MM, Kleinman PK. Posterior periosteal disruption in Salter-Harris Type II fractures of the distal femur: evidence for a hyperextension mechanism. AJR Am J Roentgenol. 2009 Dec; 193(6):W540-5.
  32. Joshi SM, Mastrangelo AN, Magarian EM, Fleming BC, Murray MM. Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament. Am J Sports Med. 2009 Dec; 37(12):2401-10.
  33. Abreu EL, Palmer MP, Murray MM. Storage conditions do not have detrimental effect on allograft collagen or scaffold performance. Cell Tissue Bank. 2009 Nov; 10(4):333-40.
  34. Jacobson M, Fufa D, Abreu EL, Kevy S, Murray MM. Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold model. Wound Repair Regen. 2008 May-Jun; 16(3):370-8.
  35. Steiner ME, Murray MM, Rodeo SA. Strategies to improve anterior cruciate ligament healing and graft placement. Am J Sports Med. 2008 Jan; 36(1):176-89.
  36. Murray, M. M., Mankin, H. J., Glowacki, J. The Musculoskeletal System. O’Leary, JP editor. The Physiologic Basis of Surgery. 2007.
  37. Kocher MS, Kasser JR, Waters PM, Bae D, Snyder BD, Hresko MT, Hedequist D, Karlin L, Kim YJ, Murray MM, Millis MB, Emans JB, Dichtel L, Matheney T, Lee BM. Lateral entry compared with medial and lateral entry pin fixation for completely displaced supracondylar humeral fractures in children. A randomized clinical trial. J Bone Joint Surg Am. 2007 Apr; 89(4):706-12.
  38. Murray MM., Spindler KP., Ballard P., Welch T., Nanney LB. Enhanced Histologic Repair in a Central Defect in the Anterior Cruciate Ligament with a Collagen-Platelet Rich Plasma Scaffold. 2007.
  39. Fufa D., Shealy B., Jacobson M., Kevy S., Murray MM. Type I Collagen as a Platelet Activator in Platelet-Rich Plasma Hydrogels. 2007.
  40. Murray MM., Spindler KP., Ballard P., Welch T., Nanney LB. Histologic Differences in Healing of Intra-Articular and Extra-Articular Ligament Wounds. 2007.
  41. Murray, MM., Spindler, K.P., Ballard, P., Welch, T., Nanney, LB. Enhanced Histologic Repair in a Central Defect in the ACL with a Collagen-PRP Scaffold. J Orthop Res. 2007; 25(8):1007-1017.
  42. Duretti Fufa, MD; Blake Shealy; May Jacobson, PhD; Sherwin Kevy, MD; Martha Meaney Murray, MD. Activation of Platelet-Rich Plasma Using Soluble Type I Collagen. Journal of Oral and Maxillofacial Surgery, accepted for publication. 2007.
  43. Murray MM., Spindler KP., Abreu E., Muller J., Nedder A., Kelly M., Frino J., Zurakowski D., Valenza M., Snyder BD., Palmer M., Connolly S. Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament. 2007.
  44. Yeh J., Shealy B., Jacobson M., Sherwin K., Hootnik J., Murray MM. . Effect of Collagen Source on Human ACL Cell Proliferation and Platelet Activation. 2007.
  45. Abreu E., Marler J., Murray MM. The Effect of Collagen Concentration on Platelet-Rich Plasma Hydrogels. 2007.
  46. Murray MM, Spindler KP, Devin C, Snyder BS, Muller J, Takahashi M, Ballard P, Nanney LB, Zurakowski D. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res. 2006 Apr; 24(4):820-30.
  47. Murray MM, Forsythe B, Chen F, Lee SJ, Yoo JJ, Atala A, Steinert A. The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res. 2006 Mar; 24(3):508-15.
  48. Murray, M. M., Murray, MF. Biology and Gene-Based Therapy. The Pediatric and Adolescent Knee, Micheli, LJ and Kocher, MS, eds. 2006.
  49. Murray, MM, Spindler, KP, Zurakowski, DA, Connolly, SA. Enhancement of suture repair of the ACL using a collagen-PRP hydrogel. 2006.
  50. Murrat, MM inventor. Methods and Procedures for Ligament Repair,. 2006.
  51. Steinert A., Karl N., Pilapil C., Noth U., Evans CH., Murray, M.M. Multilineage Mesenchymal Differentiation Potential of Cells Migrating out of the Anterior Cruciate Ligament. 2006.
  52. Murray MM., Murray MF., Marler JM., Spindler KP., Sawyer AJ., inventors. Biologic Replacement for Fibrin Clot. 2005.
  53. Murray MM., Slocum A., Want YC., Walker D., Carvey M., Salameni A., inventors. Delivery Device for Tissue Repair. 2005.
  54. Murray, MM, Spindler, KP. Anterior Cruciate Ligament Healing and Primary Repair. Sports Medicine and Arthroscopy Review. 2005; 13(3):151-155.
  55. Fufa, D., Chen, F. and Murray, M.M. . The Effect of Insoluble Collagen Morphology on Fibroblast Migration, Proliferation and Collagen Production. 2005.
  56. Murray, M.M., Steinert, A., Evans, C., Pilapil, C., Palmer, G., Betz, O. In Situ IGF-1 Gene Transfer Enhances Healing Response in the Anterior Cruciate Ligament. 2005.
  57. Murray, MM., Spindler, KP. Anterior Cruciate Ligament Healing and Primary Repair. 2005; 13(3):151-156.
  58. Murray MM, Weiler A, Spindler KP. Interspecies variation in the fibroblast distribution of the anterior cruciate ligament. Am J Sports Med. 2004 Sep; 32(6):1484-91.
  59. Murray MM, Zurakowski D, Vrahas MS. The death of articular chondrocytes after intra-articular fracture in humans. J Trauma. 2004 Jan; 56(1):128-31.
  60. Steinert, A., Palmer, G., Betz, O., Gouze, I., Gouze, JM., Pilapil, C., Ghivizzani, S., Evans, C., Murray, M.M. In Situ IGF-1 Gene Transfer for Enhancing Healing of the ACL – Evaluation in an in vitro model. Basic Science Poster Prize. 2004.
  61. Steinert, AF., Chen, F., Evans, CH., Murray, MM. Novel Biological Approaches to Enhance Primary Repair of the Anterior Cruciate Ligament. 2004; 81-83.
  62. Murray MM., Murray MF., Marler JM., Spindler KP., Sawyer AJ., inventors. Biologic Replacement for Fibrin Clot. 2003.
  63. Spindler KP, Murray MM, Detwiler KB, Tarter JT, Dawson JM, Nanney LB, Davidson JM. The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J Orthop Res. 2003 Mar; 21(2):245-9.
  64. Murray, MM., Berstein, J. Meniscus. Musculoskeletal Medicine, Bernstein J, editor. 2003.
  65. Murray, M.M., section editor for Basic Science. Musculoskeletal Medicine. Bernstein, J. Senior Editor. 2003.
  66. Murray, MM, Rice, K, Wright, RJ, Spector, M. The Effect of selected growth factors on human anterior cruciate ligament cell interactions with a three dimensional collagen-GAG scaffold. J Orthop Res. 2003; 21:238-244.
  67. Murray, MM., Bernstein, J. Ligaments. Musculoskeletal Medicine, Berstein J, editor. 2003.
  68. Murray MM, Bennett R, Zhang X, Spector M. Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1. J Orthop Res. 2002 Jul; 20(4):875-80.
  69. Murray, M. M., Martin, S. D., Spector, M. . Changes in cell number density and smooth muscle actin expression after rupture of the human rotator cuff tendon. 2002.
  70. Murray, M. M., Rice, K. R., Spector, M. S.,. The effects of selected crosslinking protocols on human ACL cell interactions with 3-D collagen-GAG scaffolds. 2002.
  71. Murray, MM., Mankin, HJ., Glowacki, J. The Musculoskeletal System. The Physiologic Basis of Surgery, O'Leary JP, editor. 2002.
  72. Murray, M. M., Sawyer, A., Zurakowski, D., Gerbino, P., Micheli, L. . The effect of age on the response to injury in the human ACL. 2002.
  73. Murray MM, Spector M. The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials. 2001 Sep; 22(17):2393-402.
  74. Murray, MM., Murray, MF., Marler JM., inventors. Biologic Replacement for Fibrin Clot. 2001.
  75. Ahluwalia S, Fehm M, Murray MM, Martin SD, Spector M. Distribution of smooth muscle actin-containing cells in the human meniscus. J Orthop Res. 2001 Jul; 19(4):659-64.
  76. Murray, M. M., Dawson, C., Kocolas, I., Spector, M. . Gender differences in the histology of the human anterior cruciate ligament. 2001.
  77. Murray, MM., invited editorial. Effect of the intra-articular environment on healing of the ruptured anterior cruciate ligament. 2001.
  78. Qiu W, Murray MM, Shortkroff S, Lee CR, Martin SD, Spector M. Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Wound Repair Regen. 2000 Sep-Oct; 8(5):383-91.
  79. Murray MM, Martin SD, Spector M. Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds. J Orthop Res. 2000 Jul; 18(4):557-64.
  80. Murray, MM., inventor. Biologic Replacement for Fibrin Clot for Intra-articular Use. 2000.
  81. Qiu, W, Murray, MM, Shortkroff, S, Lee, CR, Martin, SD, Spector, M. Outgrowth of Chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Would Repair and Regeneration. 2000; 18:383-391.
  82. Murray, MM., inventor. Biologic Replacement for Fibrin Clot for Intra-articular Use, Provisional application. 1999.
  83. Murray MM, Spector M. Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. J Orthop Res. 1999 Jan; 17(1):18-27.
  84. Murray, M.M. Guided Tissue Regeneration of the ACL: Preliminary Studies. 1999.
  85. Murray, M.M. E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program. 1999.
  86. Murray, M.M. E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program. 1998.
  87. Kolker D, Murray M, Wilson M. Osteochondral defects of the talus treated with autologous bone grafting. J Bone Joint Surg Br. 2004 May; 86(4):521-6.
  88. Vavken P, Saad FA, Fleming BC, Murray MM. VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL. Knee Surg Sports Traumatol Arthrosc. 2011 Oct; 19(10):1675-82.
  89. Fleming BC, Vajapeyam S, Connolly SA, Magarian EM, Murray MM. The use of magnetic resonance imaging to predict ACL graft structural properties. J Biomech. 2011 Nov 10; 44(16):2843-6.
  90. Pearse RV, Esshaki D, Tabin CJ, Murray MM. Genome-wide expression analysis of intra- and extraarticular connective tissue. J Orthop Res. 2009 Apr; 27(4):427-34.
  91. Premdas J, Tang JB, Warner JP, Murray MM, Spector M. The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res. 2001 Mar; 19(2):221-8.
  92. Vavken P, Murray MM. The potential for primary repair of the ACL. Sports Med Arthrosc. 2011 Mar; 19(1):44-9.
  93. Mastrangelo AN, Vavken P, Fleming BC, Harrison SL, Murray MM. Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model. J Orthop Res. 2011 Jul; 29(7):1002-7.
  94. Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, Nanney LB. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res. 2007 Aug; 25(8):1007-17.
  95. Mahan ST, Murray MM, Woolf AD, Kasser JR. Increased blood lead levels in an adolescent girl from a retained bullet. A case report. J Bone Joint Surg Am. 2006 Dec; 88(12):2726-9.
  96. Fleming BC, Carey JL, Spindler KP, Murray MM. Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study. J Orthop Res. 2008 Nov; 26(11):1500-5.
  97. Vavken P, Sadoghi P, Murray MM. The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials. Arthroscopy. 2011 Nov; 27(11):1573-83.
  98. Spindler KP, Murray MM, Devin C, Nanney LB, Davidson JM. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res. 2006 Mar; 24(3):401-6.
  99. Steinert AF, Weber M, Kunz M, Palmer GD, Nöth U, Evans CH, Murray MM. In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. Biomaterials. 2008 Mar; 29(7):904-16.
  100. Haus BM, Mastrangelo AN, Murray MM. Effect of anterior cruciate healing on the uninjured ligament insertion site. J Orthop Res. 2012 Jan; 30(1):86-94.
  101. Mastrangelo AN, Haus BM, Vavken P, Palmer MP, Machan JT, Murray MM. Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res. 2010 Aug; 28(8):1100-6.
  102. Mastrangelo AN, Magarian EM, Palmer MP, Vavken P, Murray MM. The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res. 2010 May; 28(5):644-51.
  103. Murray MM. Current status and potential of primary ACL repair. Clin Sports Med. 2009 Jan; 28(1):51-61.
  104. Murray MM, Palmer M, Abreu E, Spindler KP, Zurakowski D, Fleming BC. Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. J Orthop Res. 2009 May; 27(5):639-45.
  105. Vavken P, Proffen B, Peterson C, Fleming BC, Machan JT, Murray MM. Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study. Arthroscopy. 2013 Jan; 29(1):122-32.
  106. Murray MM, Magarian E, Zurakowski D, Fleming BC. Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite. Arthroscopy. 2010 Sep; 26(9 Suppl):S49-57.
  107. Steinert AF, Kunz M, Prager P, Barthel T, Jakob F, Nöth U, Murray MM, Evans CH, Porter RM. Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A. 2011 May; 17(9-10):1375-88.
  108. Murray MM, Martin SD, Martin TL, Spector M. Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am. 2000 Oct; 82-A(10):1387-97.
  109. Vavken P, Murray MM. Treating anterior cruciate ligament tears in skeletally immature patients. Arthroscopy. 2011 May; 27(5):704-16.
  110. Fleming BC, Magarian EM, Harrison SL, Paller DJ, Murray MM. Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. J Orthop Res. 2010 Jun; 28(6):703-9.
  111. Murray MM, Magarian EM, Harrison SL, Mastrangelo AN, Zurakowski D, Fleming BC. The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am. 2010 Sep 1; 92(11):2039-49.
  112. Abreu EL, Palmer MP, Murray MM. Collagen density significantly affects the functional properties of an engineered provisional scaffold. J Biomed Mater Res A. 2010 Apr; 93(1):150-7.
  113. Harrison S, Vavken P, Kevy S, Jacobson M, Zurakowski D, Murray MM. Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med. 2011 Apr; 39(4):729-34.
  114. Cheng M, Johnson VM, Murray MM. Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression. J Orthop Res. 2012 Jan; 30(1):79-85.
  115. Fleming BC, Spindler KP, Palmer MP, Magarian EM, Murray MM. Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model. Am J Sports Med. 2009 Aug; 37(8):1554-63.
  116. Vavken P, Fleming BC, Mastrangelo AN, Machan JT, Murray MM. Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model. Arthroscopy. 2012 May; 28(5):672-80.
  117. Murray MM, Spindler KP, Abreu E, Muller JA, Nedder A, Kelly M, Frino J, Zurakowski D, Valenza M, Snyder BD, Connolly SA. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res. 2007 Jan; 25(1):81-91.
  118. Pascher A, Steinert AF, Palmer GD, Betz O, Gouze JN, Gouze E, Pilapil C, Ghivizzani SC, Evans CH, Murray MM. Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Mol Ther. 2004 Aug; 10(2):327-36.
  119. Magarian EM, Fleming BC, Harrison SL, Mastrangelo AN, Badger GJ, Murray MM. Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament. Am J Sports Med. 2010 Dec; 38(12):2528-34.
  120. Mesiha M, Zurakowski D, Soriano J, Nielson JH, Zarins B, Murray MM. Pathologic characteristics of the torn human meniscus. Am J Sports Med. 2007 Jan; 35(1):103-12.
  121. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008 Apr; 66(4):684-90.
  122. Magarian EM, Vavken P, Murray MM. Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals. Knee. 2011 Aug; 18(4):247-51.
  123. Vavken P, Saad FA, Murray MM. Age dependence of expression of growth factor receptors in porcine ACL fibroblasts. J Orthop Res. 2010 Aug; 28(8):1107-12.
  124. Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC. The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res. 2009 May; 27(5):631-8.
  125. Yoshida R, Murray MM. Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. J Orthop Res. 2013 Jan; 31(1):29-34.
  126. Palmer MP, Abreu EL, Mastrangelo A, Murray MM. Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffolds. J Orthop Res. 2009 Jul; 27(7):964-71.
  127. Murray MM, Fleming BC. Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery. Am J Sports Med. 2013 Aug; 41(8):1762-70.
  128. Murray MM, Fleming BC. Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013. J Orthop Res. 2013 Oct; 31(10):1501-6.
  129. Haslauer CM, Proffen BL, Johnson VM, Murray MM. Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury. Wound Repair Regen. 2014 Jan-Feb; 22(1):103-10.
  130. Yoshida R, Cheng M, Murray MM. Increasing platelet concentration in platelet-rich plasma inhibits anterior cruciate ligament cell function in three-dimensional culture. J Orthop Res. 2014 Feb; 32(2):291-5.
  131. Biercevicz AM, Murray MM, Walsh EG, Miranda DL, Machan JT, Fleming BC. T2 * MR relaxometry and ligament volume are associated with the structural properties of the healing ACL. J Orthop Res. 2014 Apr; 32(4):492-9.
  132. Kiapour AM, Shalvoy MR, Murray MM, Fleming BC. Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. Clin Orthop Relat Res. 2015 Feb; 473(2):639-50.
  133. Hutchinson ID, Rodeo SA, Perrone GS, Murray MM. Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair? J Knee Surg. 2015 Feb; 28(1):19-28.
  134. Kiapour AM, Fleming BC, Proffen BL, Murray MM. Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model. Am J Sports Med. 2015 Jul; 43(7):1623-31.
  135. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Murray MM. Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds. J Biomater Appl. 2015 Oct; 30(4):435-49.
  136. Proffen BL, Perrone GS, Roberts G, Murray MM. Bridge-enhanced ACL repair: A review of the science and the pathway through FDA investigational device approval. Ann Biomed Eng. 2015 Mar; 43(3):805-18.
  137. Palmer M, Stanford E, Murray MM. The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots. Materials (Basel). 2011 Aug 20; 4(8):1469-1482.
LIke ThisLIke ThisLIke This

Related Laboratory

Sports Medicine Research Laboratory

Learn more
Close