Research

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Larry  Benowitz, PhD

Larry benowitz
Research Center:
F.M. Kirby Neurobiology Center
Program:
Neurobiology Program
Department:
Neurosurgery Research
Hospital Title:
Director, Laboratories for Neuroscience Research in Neurosurgery
Academic Title:
Professor of Neurosurgery and Ophthalmology, Harvard Medical School
Research Focus Area:
Brain rewiring after injury
Contact:
617-355-6008

Research Overview

Under normal circumstances, neurons in the mature central nervous system (CNS: brain, spinal cord, eye) cannot re-establish their connections after injury, nor can intact cells grow new connections to compensate for those that have been lost. As a result of this, victims of traumatic injury, stroke or neurodegenerative diseases can suffer permanent and often devastating losses in movement, sensation, bodily functions, and thinking. The goals of the Benowitz lab are to discover the basic mechanisms that control the growth of nerve connections and to apply insights from this work to promote regeneration and functional recovery after CNS injury.

Current projects focus on:

  • Optic nerve regeneration: research on the molecular signals that enable the projection neurons of the eye (retinal ganglion cells) to regrow their connections through the optic nerve.
  • Stroke and spinal cord injury: methods to enhance the rewiring of brain connections and improve functional outcome after stroke or spinal cord injury.
  • Inosine and cell signaling pathways: the small, naturally occurring molecule, inosine, stimulates certain types of nerve cells to extend nerve fibers in cell culture and in vivo. Inosine appears to stimulate a cell signaling pathway that controls the expression of a group of genes required for axon growth.

About Larry Benowitz

Larry Benowitz received his PhD in Biology from CalTech and completed fellowships at CalTech, MIT, and Harvard Medical School. He joined the faculty of Harvard Medical School in 1979, where he is currently a Professor of Surgery and Director of the Laboratories for Neuroscience Research in Neurosurgery at Boston Children's Hospital.

At Boston Children's, he serves on the Research Faculty Council, the Surgical Research Council, and chairs the Steering Committee for Animal Resources (ARCH). At Harvard Med School, he is the Co-chair of the Committee on Awards and Honors and has taught in a number of courses. Extramurally, he serves on the review boards of the Journal of Neuroscience and the Journal of Neurosurgery and has served on review committees for the NIH and private foundations.

He has been invited to speak at many research centers and symposia, including most recently the University of Southern California/UCLA/UC Irvine workshop on Plasticity and Repair in Neurodegenerative Disorders, Williams College, The Wadsworth Center/SUNY Albany, the University of Massachusetts Medical Center, Northwestern Univ. Med. Ctr., an NIH Roadmap Workshop on Transforming Regenerative Medicine, the American Academy of Neurology Symposium on the "Future of Neuroscience", the Wings for Life Spinal Cord Research Foundation Symposium (Salzburg, Austria), the Symposium on Development and Plasticity of the Nervous System at the University of Rio de Janeiro (Brazil), the Lasker/IRRF Initiative for Innovation in Vision Research, and at the Burke Institute/Cornell Medical Center. His research has been reported in the international media and has received television coverage on CBS, CNN and the BBC.

Publications

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  1. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 2; 89(5):956-70.
  2. Chung YG, Seth A, Doyle C, Franck D, Kim D, Cristofaro V, Benowitz LI, Tu DD, Estrada CR, Mauney JR, Sullivan MP, Adam RM. Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury. PLoS One. 2015; 10(11):e0141492.
  3. Li S, Nie EH, Yin Y, Benowitz LI, Tung S, Vinters HV, Bahjat FR, Stenzel-Poore MP, Kawaguchi R, Coppola G, Carmichael ST. GDF10 is a signal for axonal sprouting and functional recovery after stroke. Nat Neurosci. 2015 Dec; 18(12):1737-45.
  4. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 3; 86(5):1215-27.
  5. Xiong W, MacColl Garfinkel AE, Li Y, Benowitz LI, Cepko CL. NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest. 2015 Apr; 125(4):1433-45.
  6. Koriyama Y, Kurimoto T, de Lima S, Benowitz L. [Reinnervation of central visual areas and recovery of visual functions following optic nerve regeneration in adult mice]. Brain Nerve. 2014 Mar; 66(3):265-72.
  7. Dachir S, Shabashov D, Trembovler V, Alexandrovich AG, Benowitz LI, Shohami E. Inosine improves functional recovery after experimental traumatic brain injury. Brain Res. 2014 Mar 25; 1555:78-88.
  8. Kim D, Zai L, Liang P, Schaffling C, Ahlborn D, Benowitz LI. Inosine enhances axon sprouting and motor recovery after spinal cord injury. PLoS One. 2013; 8(12):e81948.
  9. Kurimoto T, Yin Y, Habboub G, Gilbert HY, Li Y, Nakao S, Hafezi-Moghadam A, Benowitz LI. Neutrophils express oncomodulin and promote optic nerve regeneration. J Neurosci. 2013 Sep 11; 33(37):14816-24.
  10. Seth A, Chung YG, Kim D, Ramachandran A, Cristofaro V, Gomez P, Tu D, Huang L, Benowitz LI, Di Vizio D, Sullivan MP, Adam RM. The impact of discrete modes of spinal cord injury on bladder muscle contractility. BMC Urol. 2013; 13:24.
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  12. Roh M, Zhang Y, Murakami Y, Thanos A, Lee SC, Vavvas DG, Benowitz LI, Miller JW. Etanercept, a widely used inhibitor of tumor necrosis factor-a (TNF-a), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS One. 2012; 7(7):e40065.
  13. Wang X, Hasan O, Arzeno A, Benowitz LI, Cafferty WB, Strittmatter SM. Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways. Exp Neurol. 2012 Sep; 237(1):55-69.
  14. de Lima S, Koriyama Y, Kurimoto T, Oliveira JT, Yin Y, Li Y, Gilbert HY, Fagiolini M, Martinez AM, Benowitz L. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc Natl Acad Sci U S A. 2012 Jun 5; 109(23):9149-54.
  15. Dickendesher TL, Baldwin KT, Mironova YA, Koriyama Y, Raiker SJ, Askew KL, Wood A, Geoffroy CG, Zheng B, Liepmann CD, Katagiri Y, Benowitz LI, Geller HM, Giger RJ. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci. 2012 May; 15(5):703-12.
  16. de Lima S, Habboub G, Benowitz LI. Combinatorial therapy stimulates long-distance regeneration, target reinnervation, and partial recovery of vision after optic nerve injury in mice. Int Rev Neurobiol. 2012; 106:153-72.
  17. Benowitz LI, Popovich PG. Inflammation and axon regeneration. Curr Opin Neurol. 2011 Dec; 24(6):577-83.
  18. Wang X, Duffy P, McGee AW, Hasan O, Gould G, Tu N, Harel NY, Huang Y, Carson RE, Weinzimmer D, Ropchan J, Benowitz LI, Cafferty WB, Strittmatter SM. Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 2011 Nov; 70(5):805-21.
  19. Benowitz L. Author's response to Steward et al., "A re-assessment of the effects of intra-cortical delivery of inosine….". Exp Neurol. 2012 Feb; 233(2):674-6.
  20. Zai L, Ferrari C, Dice C, Subbaiah S, Havton LA, Coppola G, Geschwind D, Irwin N, Huebner E, Strittmatter SM, Benowitz LI. Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke. J Neurosci. 2011 Apr 20; 31(16):5977-88.
  21. Kurimoto T, Yin Y, Omura K, Gilbert HY, Kim D, Cen LP, Moko L, Kügler S, Benowitz LI. Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. J Neurosci. 2010 Nov 17; 30(46):15654-63.
  22. Benowitz LI, Yin Y. Optic nerve regeneration. Arch Ophthalmol. 2010 Aug; 128(8):1059-64.
  23. Benowitz LI, Carmichael ST. Promoting axonal rewiring to improve outcome after stroke. Neurobiol Dis. 2010 Feb; 37(2):259-66.
  24. Yin Y, Cui Q, Gilbert HY, Yang Y, Yang Z, Berlinicke C, Li Z, Zaverucha-do-Valle C, He H, Petkova V, Zack DJ, Benowitz LI. Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19587-92.
  25. Lorber B, Howe ML, Benowitz LI, Irwin N. Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways. Nat Neurosci. 2009 Nov; 12(11):1407-14.
  26. Zai L, Ferrari C, Subbaiah S, Havton LA, Coppola G, Strittmatter S, Irwin N, Geschwind D, Benowitz LI. Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb. J Neurosci. 2009 Jun 24; 29(25):8187-97.
  27. Cui Q, Yin Y, Benowitz LI. The role of macrophages in optic nerve regeneration. Neuroscience. 2009 Feb 6; 158(3):1039-48.
  28. Cui Q, Benowitz L, Yin Y. Does CNTF mediate the effect of intraocular inflammation on optic nerve regeneration? Brain. 2008 Jun; 131(Pt 6):e96; author reply e97.
  29. Benowitz LI, Yin Y. Combinatorial treatments for promoting axon regeneration in the CNS: strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state. Dev Neurobiol. 2007 Aug; 67(9):1148-65.
  30. Benowitz L, Yin Y. Rewiring the injured CNS: lessons from the optic nerve. Exp Neurol. 2008 Feb; 209(2):389-98.
  31. Nakazawa T, Hisatomi T, Nakazawa C, Noda K, Maruyama K, She H, Matsubara A, Miyahara S, Nakao S, Yin Y, Benowitz L, Hafezi-Moghadam A, Miller JW. Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2425-30.
  32. Nakazawa T, Nakazawa C, Matsubara A, Noda K, Hisatomi T, She H, Michaud N, Hafezi-Moghadam A, Miller JW, Benowitz LI. Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J Neurosci. 2006 Dec 6; 26(49):12633-41.
  33. Irwin N, Li YM, O'Toole JE, Benowitz LI. Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18320-5.
  34. Piantino J, Burdick JA, Goldberg D, Langer R, Benowitz LI. An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury. Exp Neurol. 2006 Oct; 201(2):359-67.
  35. Yin Y, Henzl MT, Lorber B, Nakazawa T, Thomas TT, Jiang F, Langer R, Benowitz LI. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci. 2006 Jun; 9(6):843-52.
  36. Fischer D, Petkova V, Thanos S, Benowitz LI. Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. J Neurosci. 2004 Oct 6; 24(40):8726-40.
  37. Fischer D, He Z, Benowitz LI. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci. 2004 Feb 18; 24(7):1646-51.
  38. Li Y, Irwin N, Yin Y, Lanser M, Benowitz LI. Axon regeneration in goldfish and rat retinal ganglion cells: differential responsiveness to carbohydrates and cAMP. J Neurosci. 2003 Aug 27; 23(21):7830-8.
  39. Yin Y, Cui Q, Li Y, Irwin N, Fischer D, Harvey AR, Benowitz LI. Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci. 2003 Mar 15; 23(6):2284-93.
  40. Irwin N, Chao S, Goritchenko L, Horiuchi A, Greengard P, Nairn AC, Benowitz LI. Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12427-31.
  41. Chen P, Goldberg DE, Kolb B, Lanser M, Benowitz LI. Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):9031-6.
  42. Benowitz LI, Goldberg DE, Irwin N. Inosine stimulates axon growth in vitro and in the adult CNS. Prog Brain Res. 2002; 137:389-99.
  43. Benowitz LI, Goldberg DE, Irwin N. A purine-sensitive mechanism regulates the molecular program for axon growth. Restor Neurol Neurosci. 2001; 19(1-2):41-9.
  44. Petrausch B, Tabibiazar R, Roser T, Jing Y, Goldman D, Stuermer CA, Irwin N, Benowitz LI. A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells. J Neurosci. 2000 Nov 1; 20(21):8031-41.
  45. Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI. Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci. 2000 Jun 15; 20(12):4615-26.
  46. Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron. 2000 May; 26(2):405-16.
  47. Benowitz LI, Goldberg DE, Madsen JR, Soni D, Irwin N. Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proc Natl Acad Sci U S A. 1999 Nov 9; 96(23):13486-90.
  48. Jo SA, Wang E, Benowitz LI. Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells. Neuroscience. 1999 Mar; 89(2):579-91.
  49. Madsen JR, MacDonald P, Irwin N, Goldberg DE, Yao GL, Meiri KF, Rimm IJ, Stieg PE, Benowitz LI. Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. Exp Neurol. 1998 Dec; 154(2):673-83.
  50. Benowitz LI, Jing Y, Tabibiazar R, Jo SA, Petrausch B, Stuermer CA, Rosenberg PA, Irwin N. Axon outgrowth is regulated by an intracellular purine-sensitive mechanism in retinal ganglion cells. J Biol Chem. 1998 Nov 6; 273(45):29626-34.
  51. Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8179-84.
  52. Irwin N, Baekelandt V, Goritchenko L, Benowitz LI. Identification of two proteins that bind to a pyrimidine-rich sequence in the 3'-untranslated region of GAP-43 mRNA. Nucleic Acids Res. 1997 Mar 15; 25(6):1281-8.
  53. Benowitz LI, Routtenberg A. GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci. 1997 Feb; 20(2):84-91.
  54. Perrone-Bizzozero NI, Sower AC, Bird ED, Benowitz LI, Ivins KJ, Neve RL. Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14182-7.
  55. Chao S, Benowitz LI, Krainc D, Irwin N. Use of a two-hybrid system to investigate molecular interactions of GAP-43. Brain Res Mol Brain Res. 1996 Sep 1; 40(2):195-202.
  56. Schwalb JM, Gu MF, Stuermer C, Bastmeyer M, Hu GF, Boulis N, Irwin N, Benowitz LI. Optic nerve glia secrete a low-molecular-weight factor that stimulates retinal ganglion cells to regenerate axons in goldfish. Neuroscience. 1996 Jun; 72(4):901-10.
  57. Lu CR, Meng FT, Benowitz LI, Ju G. Evidence for axonal sprouting in the anterior pituitary following adrenalectomy in the rat. J Endocrinol. 1995 Oct; 147(1):161-6.
  58. Schwalb JM, Boulis NM, Gu MF, Winickoff J, Jackson PS, Irwin N, Benowitz LI. Two factors secreted by the goldfish optic nerve induce retinal ganglion cells to regenerate axons in culture. J Neurosci. 1995 Aug; 15(8):5514-25.
  59. Shea TB, Benowitz LI. Inhibition of neurite outgrowth following intracellular delivery of anti-GAP-43 antibodies depends upon culture conditions and method of neurite induction. J Neurosci Res. 1995 Jun 15; 41(3):347-54.
  60. Meyer RL, Miotke JA, Benowitz LI. Injury induced expression of growth-associated protein-43 in adult mouse retinal ganglion cells in vitro. Neuroscience. 1994 Nov; 63(2):591-602.
  61. Chong MS, Reynolds ML, Irwin N, Coggeshall RE, Emson PC, Benowitz LI, Woolf CJ. GAP-43 expression in primary sensory neurons following central axotomy. J Neurosci. 1994 Jul; 14(7):4375-84.
  62. Moya KL, Benowitz LI, Schneider GE, Allinquant B. The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. Dev Biol. 1994 Feb; 161(2):597-603.
  63. Paden CM, Moffett CW, Benowitz LI. Innervation of the rat anterior and neurointermediate pituitary visualized by immunocytochemistry for the growth-associated protein GAP-43. Endocrinology. 1994 Jan; 134(1):503-6.
  64. Schaechter JD, Benowitz LI. Activation of protein kinase C by arachidonic acid selectively enhances the phosphorylation of GAP-43 in nerve terminal membranes. J Neurosci. 1993 Oct; 13(10):4361-71.
  65. Kinney HC, Rava LA, Benowitz LI. Anatomic distribution of the growth-associated protein GAP-43 in the developing human brainstem. J Neuropathol Exp Neurol. 1993 Jan; 52(1):39-54.
  66. Winter J, Evison CJ, O'Brien C, Benowitz L, Lindsay RM, Mulderry P, Woolf C. Neurotoxic damage evokes regenerative responses from adult rat sensory neurones. Neurosci Lett. 1992 Oct 26; 146(1):48-52.
  67. Woolf CJ, Reynolds ML, Chong MS, Emson P, Irwin N, Benowitz LI. Denervation of the motor endplate results in the rapid expression by terminal Schwann cells of the growth-associated protein GAP-43. J Neurosci. 1992 Oct; 12(10):3999-4010.
  68. Gossels JM, Lewis SE, Perrone-Bizzozero NI, Benowitz LI. Changes in chromatin proteins during optic nerve regeneration in the goldfish. J Neurosci Res. 1992 Sep; 33(1):112-21.
  69. Moya KL, Benowitz LI, Sabel BA, Schneider GE. Changes in rapidly transported proteins associated with development of abnormal projections in the diencephalon. Brain Res. 1992 Jul 24; 586(2):265-72.
  70. Dunn-Meynell AA, Benowitz LI, Levin BE. Vibrissectomy induced changes in GAP-43 immunoreactivity in the adult rat barrel cortex. J Comp Neurol. 1992 Jan 8; 315(2):160-70.
  71. Perrone-Bizzozero NI, Neve RL, Irwin N, Lewis S, Fischer I, Benowitz LI. Post-transcriptional regulation of GAP-43 rnRNA levels during neuronal differentiation and nerve regeneration. Mol Cell Neurosci. 1991 Oct; 2(5):402-9.
  72. Shea TB, Perrone-Bizzozero NI, Beermann ML, Benowitz LI. Phospholipid-mediated delivery of anti-GAP-43 antibodies into neuroblastoma cells prevents neuritogenesis. J Neurosci. 1991 Jun; 11(6):1685-90.
  73. Reynolds ML, Fitzgerald M, Benowitz LI. GAP-43 expression in developing cutaneous and muscle nerves in the rat hindlimb. Neuroscience. 1991; 41(1):201-11.
  74. Fitzgerald M, Reynolds ML, Benowitz LI. GAP-43 expression in the developing rat lumbar spinal cord. Neuroscience. 1991; 41(1):187-99.
  75. Benowitz LI, Perrone-Bizzozero NI. The expression of GAP-43 in relation to neuronal growth and plasticity: when, where, how, and why? Prog Brain Res. 1991; 89:69-87.
  76. Dani JW, Armstrong DM, Benowitz LI. Mapping the development of the rat brain by GAP-43 immunocytochemistry. Neuroscience. 1991; 40(1):277-87.
  77. Benowitz LI, Perrone-Bizzozero NI. The relationship of GAP-43 to the development and plasticity of synaptic connections. Ann N Y Acad Sci. 1991; 627:58-74.
  78. Neve RL, Ivins KJ, Benowitz LI, During MJ, Geller AI. Molecular analysis of the function of the neuronal growth-associated protein GAP-43 by genetic intervention. Mol Neurobiol. 1991; 5(2-4):131-41.
  79. DiFiglia M, Roberts RC, Benowitz LI. Immunoreactive GAP-43 in the neuropil of adult rat neostriatum: localization in unmyelinated fibers, axon terminals, and dendritic spines. J Comp Neurol. 1990 Dec 22; 302(4):992-1001.
  80. Moya KL, Benowitz LI, Schneider GE. Abnormal retinal projections alter GAP-43 patterns in the diencephalon. Brain Res. 1990 Sep 17; 527(2):259-65.
  81. Benowitz LI, Rodriguez WR, Neve RL. The pattern of GAP-43 immunostaining changes in the rat hippocampal formation during reactive synaptogenesis. Brain Res Mol Brain Res. 1990 Jun; 8(1):17-23.
  82. Erzurumlu RS, Jhaveri S, Benowitz LI. Transient patterns of GAP-43 expression during the formation of barrels in the rat somatosensory cortex. J Comp Neurol. 1990 Feb 15; 292(3):443-56.
  83. Yankner BA, Benowitz LI, Villa-Komaroff L, Neve RL. Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration. Brain Res Mol Brain Res. 1990 Jan; 7(1):39-44.
  84. Woolf CJ, Reynolds ML, Molander C, O'Brien C, Lindsay RM, Benowitz LI. The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury. Neuroscience. 1990; 34(2):465-78.
  85. Neve RL, Dawes LR, Yankner BA, Benowitz LI, Rodriguez W, Higgins GA. Genetics and biology of the Alzheimer amyloid precursor. Prog Brain Res. 1990; 86:257-67.
  86. Benowitz LI, Moya KL, Levine DN. Impaired verbal reasoning and constructional apraxia in subjects with right hemisphere damage. Neuropsychologia. 1990; 28(3):231-41.
  87. Benowitz LI, Perrone-Bizzozero NI, Neve RL, Rodriguez W. GAP-43 as a marker for structural plasticity in the mature CNS. Prog Brain Res. 1990; 86:309-20.
  88. Benowitz LI, Rodriguez W, Paskevich P, Mufson EJ, Schenk D, Neve RL. The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp Neurol. 1989 Dec; 106(3):237-50.
  89. Moya KL, Jhaveri S, Schneider GE, Benowitz LI. Immunohistochemical localization of GAP-43 in the developing hamster retinofugal pathway. J Comp Neurol. 1989 Oct 1; 288(1):51-8.
  90. Erzurumlu RS, Jhaveri S, Moya KL, Benowitz LI. Peripheral nerve regeneration induces elevated expression of GAP-43 in the brainstem trigeminal complex of adult hamsters. Brain Res. 1989 Sep 25; 498(1):135-9.
  91. Perrone-Bizzozero NI, Benowitz LI, Apostolides PJ, Franck ER, Finklestein SP, Bizzozero OA. Protein fatty acid acylation in developing cortical neurons. J Neurochem. 1989 Apr; 52(4):1149-55.
  92. Benowitz LI, Perrone-Bizzozero NI, Finklestein SP, Bird ED. Localization of the growth-associated phosphoprotein GAP-43 (B-50, F1) in the human cerebral cortex. J Neurosci. 1989 Mar; 9(3):990-5.
  93. Caday CG, Apostolides PJ, Benowitz LI, Perrone-Bizzozero NI, Finklestein SP. Partial purification and characterization of a neurite-promoting factor from the injured goldfish optic nerve. Brain Res Mol Brain Res. 1989 Jan; 5(1):45-50.
  94. Moya KL, Benowitz LI, Jhaveri S, Schneider GE. Changes in rapidly transported proteins in developing hamster retinofugal axons. J Neurosci. 1988 Dec; 8(12):4445-54.
  95. Daniels EK, Shenton ME, Holzman PS, Benowitz LI, Coleman M, Levin S, Levine D. Patterns of thought disorder associated with right cortical damage, schizophrenia, and mania. Am J Psychiatry. 1988 Aug; 145(8):944-9.
  96. Perrone-Bizzozero NI, Weiner D, Hauser G, Benowitz LI. Extraction of major acidic Ca2+ dependent phosphoproteins from synaptic membranes. J Neurosci Res. 1988 Jul; 20(3):346-50.
  97. Finklestein SP, Apostolides PJ, Caday CG, Philips MF, Perrone-Bizzozero NI, Benowitz LI. A factor from the injured lower vertebrate CNS promotes outgrowth from human fetal brain neurons. Brain Res. 1988 May 17; 448(2):346-50.
  98. Neve RL, Finch EA, Bird ED, Benowitz LI. Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain. Proc Natl Acad Sci U S A. 1988 May; 85(10):3638-42.
  99. Kosik KS, Orecchio LD, Bruns GA, Benowitz LI, MacDonald GP, Cox DR, Neve RL. Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. Neuron. 1988 Apr; 1(2):127-32.
  100. Benowitz LI, Apostolides PJ, Perrone-Bizzozero N, Finklestein SP, Zwiers H. Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain. J Neurosci. 1988 Jan; 8(1):339-52.
  101. Haber S, Finklestein SD, Benowitz LI, Collier TJ. Matrigel enhances survival and integration of grafted dopamine neurons into the striatum. Prog Brain Res. 1988; 78:427-33.
  102. Benowitz LI, Schmidt JT. Activity-dependent sharpening of the regenerating retinotectal projection in goldfish: relationship to the expression of growth-associated proteins. Brain Res. 1987 Aug 4; 417(1):118-26.
  103. Neve RL, Perrone-Bizzozero NI, Finklestein S, Zwiers H, Bird E, Kurnit DM, Benowitz LI. The neuronal growth-associated protein GAP-43 (B-50, F1): neuronal specificity, developmental regulation and regional distribution of the human and rat mRNAs. Brain Res. 1987 Jul; 388(2):177-83.
  104. Finklestein SP, Benowitz LI, Olson AJ, Perrone-Bizzozero NI, Majocha RE, Apostolides PJ. Conditioned media from the injured lower vertebrate CNS promote neurite outgrowth from mammalian brain neurons in vitro. Brain Res. 1987 Jun 16; 413(2):267-74.
  105. Katz DL, Frankenburg FR, Benowitz LI, Gilbert JM. Psychosis and prenatal exposure to diethylstilbestrol. J Nerv Ment Dis. 1987 May; 175(5):306-8.
  106. Benowitz LI, Perrone-Bizzozero NI, Finklestein SP. Molecular properties of the growth-associated protein GAP-43 (B-50). J Neurochem. 1987 May; 48(5):1640-7.
  107. Moya KL, Benowitz LI, Jhaveri S, Schneider GE. Enhanced visualization of axonally transported proteins in the immature CNS by suppression of systemic labeling. Brain Res. 1987 Feb; 428(2):183-91.
  108. Perrone-Bizzozero NI, Benowitz LI. Expression of a 48-kilodalton growth-associated protein in the goldfish retina. J Neurochem. 1987 Feb; 48(2):644-52.
  109. Perrone-Bizzozero NI, Finklestein SP, Benowitz LI. Synthesis of a growth-associated protein by embryonic rat cerebrocortical neurons in vitro. J Neurosci. 1986 Dec; 6(12):3721-30.
  110. Yoon MG, Benowitz LI, Baker FA. The optic tectum regulates the transport of specific proteins in regenerating optic fibers of goldfish. Brain Res. 1986 Sep 24; 382(2):339-51.
  111. Moya KL, Benowitz LI, Levine DN, Finklestein S. Covariant defects in visuospatial abilities and recall of verbal narrative after right hemisphere stroke. Cortex. 1986 Sep; 22(3):381-97.
  112. Levine DN, Warach JD, Benowitz L, Calvanio R. Left spatial neglect: effects of lesion size and premorbid brain atrophy on severity and recovery following right cerebral infarction. Neurology. 1986 Mar; 36(3):362-6.
  113. Strocchi P, Gilbert JM, Benowitz LI, Dahl D, Lewis ER. Cellular origin and biosynthesis of rat optic nerve proteins: a two-dimensional gel analysis. J Neurochem. 1984 Aug; 43(2):349-57.
  114. Benowitz LI, Lewis ER. Increased transport of 44,000- to 49,000-dalton acidic proteins during regeneration of the goldfish optic nerve: a two-dimensional gel analysis. J Neurosci. 1983 Nov; 3(11):2153-63.
  115. Benowitz LI, Yoon MG, Lewis ER. Transported proteins in the regenerating optic nerve: regulation by interactions with the optic tectum. Science. 1983 Oct 14; 222(4620):185-8.
  116. Benowitz LI, Bear DM, Rosenthal R, Mesulam MM, Zaidel E, Sperry RW. Hemispheric specialization in nonverbal communication. Cortex. 1983 Apr; 19(1):5-11.
  117. Finklestein S, Benowitz LI, Baldessarini RJ, Arana GW, Levine D, Woo E, Bear D, Moya K, Stoll AL. Mood, vegetative disturbance, and dexamethasone suppression test after stroke. Ann Neurol. 1982 Nov; 12(5):463-8.
  118. Benowitz LI, Shashoua VE, Yoon MG. Specific changes in rapidly transported proteins during regeneration of the goldfish optic nerve. J Neurosci. 1981 Mar; 1(3):300-7.
  119. Benowitz LI, Shashoua VE. Immunoreactive sites for nerve growth factor (NGF) in the goldfish brain. Brain Res. 1979 Aug 31; 172(3):561-5.
  120. Benowitz LI, Shashoua VE. Rapidly labeled and secreted proteins of the chick brain. J Neurochem. 1979 Mar; 32(3):797-809.
  121. Benowitz LI, Greene LA. Nerve growth factor in the goldfish brain: biological assay studies using pheochromocytoma cells. Brain Res. 1979 Feb 16; 162(1):164-8.
  122. Benowitz LI, Shashoua VE. Localization of a brain protein metabolically linked with behavioral plasticity in the goldfish. Brain Res. 1977 Nov 11; 136(2):227-42.
  123. Benowitz LI, Karten HJ. Organization of the tectofugal visual pathway in the pigeon: a retrograde transport study. J Comp Neurol. 1976 Jun 15; 167(4):503-20.
  124. Benowitz LI, Karten HJ. The tractus infundibuli and other afferents to the parahippocampal region of the pigeon. Brain Res. 1976 Jan 30; 102(1):174-80.
  125. Benowitz L. Conditions for the bilateral transfer of monocular learning in chicks. Brain Res. 1974 Jan 11; 65(2):203-13.
  126. Benowitz LI, Sperry RW. Amnesic effects of lithium chloride in chicks. Exp Neurol. 1973 Aug; 40(2):540-6.
  127. Benowitz L, Teng EL. Contrasting effects of three forebrain ablations on discrimination learning and reversal in chicks. J Comp Physiol Psychol. 1973 Aug; 84(2):391-7.
  128. Benowitz L, Magnus JG. Memory storage processes following one-trial aversive conditioning in the chick. Behav Biol. 1973 Mar; 8(3):367-80.
  129. Benowitz L. Effects of forebrain ablations on avoidance learning in chicks. Physiol Behav. 1972 Oct; 9(4):601-8.
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The F.M. Kirby Neurobiology Center, together with the Neurobiology Program at Boston Children’s Hospital, is the largest basic neuroscience research enterprise at a U.S. hospital. It incorporates basic and translational neuroscience research, focusing primarily on developmental neurobiology.

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