Research

LIke ThisLIke ThisLIke This

Kyle Copps, PhD

Kyle Copps PhD
Department:
Medicine Research
Division
Endocrinology Research
Hospital Title:
Research Associate
Academic Title:
Instructor of Pediatrics, Harvard Medical School

Publications

Publications powered by Harvard Catalyst Profiles
  1. Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser³°7 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun. 2014 Jan 10; 443(2):689-93.
  2. Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia. 2012 Oct; 55(10):2565-82.
  3. Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler PC. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 2012 Sep; 61(9):2269-79.
  4. Long YC, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol. 2011 Feb; 31(3):430-41.
  5. Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab. 2010 Jan; 11(1):84-92.
  6. Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K, White MF. Human IL6 enhances leptin action in mice. Diabetologia. 2010 Mar; 53(3):525-35.
  7. Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol. 2009 Sep; 29(18):5070-83.
  8. Copps KD, White MF. Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance. Diabetes. 2009 Jan; 58(1):26-7.
  9. Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol. 2007 Sep; 21(9):2294-302.
  10. Dong X, Park S, Lin X, Copps K, Yi X, White MF. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest. 2006 Jan; 116(1):101-14.
  11. Show all
  12. Copps K, Richman R, Lyman LM, Chang KA, Rampersad-Ammons J, Kuroda MI. Complex formation by the Drosophila MSL proteins: role of the MSL2 RING finger in protein complex assembly. EMBO J. 1998 Sep 15; 17(18):5409-17.
  13. Lyman LM, Copps K, Rastelli L, Kelley RL, Kuroda MI. Drosophila male-specific lethal-2 protein: structure/function analysis and dependence on MSL-1 for chromosome association. Genetics. 1997 Dec; 147(4):1743-53.
  14. Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008 Jul; 8(1):65-76.
  15. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11.
  16. Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem. 2014 May 02; 289(18):12467-84.
  17. Copps KD, Hançer NJ, Qiu W, White MF. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. J Biol Chem. 2016 Apr 15; 291(16):8602-17.
LIke ThisLIke ThisLIke This
Close