Research

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Kush Kapur

Hospital Title:
Senior Biostatistician, Biostatistics and Research Design Core, Clinical and Translational Research; Associate Director of Biostatistics, Harvard Catalyst, The Harvard Clinical and Translational Science Center
Academic Title:
Assistant Professor of Neurology, Harvard Medical School
Research Focus Area:
Neurology

Research Overview

My area of excellence is Investigation and I am primarily focused on developing statistical methods in order to improve understanding of neurological and psychiatric diseases. My collaborative research effort is in the areas of design and analysis of randomized clinical trials (RCTs) and observational studies in the Neurology department. Besides supporting Department of Neurology statistical requirements and working on statistical methodology problems, I spend 20% of my time with Harvard Catalyst on providing statistical consultations to the Harvard faculty and research fellows undertaking clinical and translational research.

My overall contributions to the fields of neurology and biostatistics include 40 peer-reviewed publications and various software applications to assist investigators in their research efforts. As a part of statistical methodology development, I have published in the field of sample size determination problems for binary longitudinal data, hypothesis testing of skewed data with small sample sizes, analysis techniques for intensive longitudinal data within a Bayesian framework using mixed-effects location and scale models, and novel modeling techniques based on random-effects models for high dimensional dataset such as Functional Magnetic Resonance Imaging (fMRI). My methodological work has appeared in notable statistical journals such as Technometrics and Statistics in Medicine.

About the Researcher

Kush Kapur is an Assistant Professor of Neurology at Harvard Medical School, an Associate Director of Biostatistics with Harvard Catalyst, the Harvard Clinical and Translational Science Center and a Senior Biostatistician with the Institutional Centers for Clinical and Translational Research (ICCTR) at Boston Children's Hospital. He received his Ph.D. degree in Biostatistics and Master’s degree in Electrical Engineering from the University of Illinois at Chicago.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Pigula AJ, Wu JS, Kapur K, Darras BT, Rutkove SB, Anthony BW. Muscle compression improves reliability of ultrasound echo intensity. Muscle Nerve. 2017 Aug 18.
  2. Lee JJ, Kapur K, Rodrigues EG, Ibne Hasan MOS, Quamruzzaman Q, Wright RO, Bellinger DC, Christiani DC, Mazumdar M. Anthropometric measures at birth and early childhood are associated with neurodevelopmental outcomes among Bangladeshi children aged 2-3years. Sci Total Environ. 2017 Dec 31; 607-608:475-482.
  3. Singh N, Moody AR, Zhang B, Kaminski I, Kapur K, Chiu S, Tyrrell PN. Age-Specific Sex Differences in Magnetic Resonance Imaging-Depicted Carotid Intraplaque Hemorrhage. Stroke. 2017 Aug; 48(8):2129-2135.
  4. Lehman LL, Beaute J, Kapur K, Danehy AR, Bernson-Leung ME, Malkin H, Rivkin MJ, Trenor CC. Workup for Perinatal Stroke Does Not Predict Recurrence. Stroke. 2017 Aug; 48(8):2078-2083.
  5. Jackson MC, Jafarpour S, Klehm J, Thome-Souza S, Coughlin F, Kapur K, Loddenkemper T. Effect of vigabatrin on seizure control and safety profile in different subgroups of children with epilepsy. Epilepsia. 2017 Sep; 58(9):1575-1585.
  6. Buraniqi E, Sansevere AJ, Kapur K, Bergin AM, Pearl PL, Loddenkemper T. Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit. J Child Neurol. 2017 Sep; 32(10):880-885.
  7. Dy ME, Waugh JL, Sharma N, O'Leary H, Kapur K, D'Gama AM, Sahin M, Urion DK, Kaufmann WE. Defining Hand Stereotypies in Rett Syndrome: A Movement Disorders Perspective. Pediatr Neurol. 2017 Jun 02.
  8. LaRovere KL, Vonberg FW, Prabhu SP, Kapur K, Harini C, Garcia-Jacques R, Chao JH, Akhondi-Asl A, Thiagarajan R, Tasker RC. Patterns of Head Computed Tomography Abnormalities During Pediatric Extracorporeal Membrane Oxygenation and Association With Outcomes. Pediatr Neurol. 2017 Aug; 73:64-70.
  9. Rutkove SB, Kapur K, Zaidman CM, Wu JS, Pasternak A, Madabusi L, Yim S, Pacheck A, Szelag H, Harrington T, Darras BT. Electrical impedance myography for assessment of Duchenne muscular dystrophy. Ann Neurol. 2017 May; 81(5):622-632.
  10. Zaidman CM, Wu JS, Kapur K, Pasternak A, Madabusi L, Yim S, Pacheck A, Szelag H, Harrington T, Darras BT, Rutkove SB. Quantitative muscle ultrasound detects disease progression in Duchenne muscular dystrophy. Ann Neurol. 2017 May; 81(5):633-640.
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  12. LaRovere KL, Kapur K, McElhinney DB, Razumovsky A, Kussman BD. Cerebral High-Intensity Transient Signals during Pediatric Cardiac Catheterization: A Pilot Study Using Transcranial Doppler Ultrasonography. J Neuroimaging. 2017 Jul; 27(4):381-387.
  13. Sanchez B, Iyer SR, Li J, Kapur K, Xu S, Rutkove SB, Lovering RM. Non-invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography. Muscle Nerve. 2017 Jan 05.
  14. Sánchez Fernández I, Jackson MC, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Helseth A, Kapur K, McDonough TL, Mikati MA, Peariso K, Riviello J, Tasker RC, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T. Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology. 2017 Jan 24; 88(4):386-394.
  15. Kapur K. Clinical and Translational Science - Principles of Human Research, Editors: David Robertson and Gordon Williams. Chapter: 14: Principles of Biostatistics. 2016; 243-260.
  16. Rutkove SB, Wu JS, Zaidman C, Kapur K, Yim S, Pasternak A, Madabusi L, Szelag H, Harrington T, Li J, Pacheck A, Darras BT. Loss of electrical anisotropy is an unrecognized feature of dystrophic muscle that may serve as a convenient index of disease status. Clin Neurophysiol. 2016 Dec; 127(12):3546-3551.
  17. Tasker RC, Goodkin HP, Sánchez Fernández I, Chapman KE, Abend NS, Arya R, Brenton JN, Carpenter JL, Gaillard WD, Glauser TA, Goldstein J, Helseth AR, Jackson MC, Kapur K, Mikati MA, Peariso K, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T. Refractory Status Epilepticus in Children: Intention to Treat With Continuous Infusions of Midazolam and Pentobarbital. Pediatr Crit Care Med. 2016 Oct; 17(10):968-975.
  18. Haller CS, Bosma CM, Kapur K, Zafonte R, Langer EJ. Mindful creativity matters: trajectories of reported functioning after severe traumatic brain injury as a function of mindful creativity in patients' relatives: a multilevel analysis. Qual Life Res. 2017 Apr; 26(4):893-902.
  19. Mohammadpour Touserkani F, Gaínza-Lein M, Jafarpour S, Brinegar K, Kapur K, Loddenkemper T. HHV-6 and seizure: A systematic review and meta-analysis. J Med Virol. 2017 Jan; 89(1):161-169.
  20. Monson BB, Anderson PJ, Matthews LG, Neil JJ, Kapur K, Cheong JL, Doyle LW, Thompson DK, Inder TE. Examination of the Pattern of Growth of Cerebral Tissue Volumes From Hospital Discharge to Early Childhood in Very Preterm Infants. JAMA Pediatr. 2016 Aug 01; 170(8):772-9.
  21. Crall C, Valle M, Kapur K, Dies KA, Liang MG, Sahin M, Huang JT. Effect of Angiofibromas on Quality of Life and Access to Care in Tuberous Sclerosis Patients and Their Caregivers. Pediatr Dermatol. 2016 Sep; 33(5):518-25.
  22. Patel AA, Ciccone O, Njau A, Shanungu S, Grollnek AK, Fredrick F, Hodgeman R, Sideridis GD, Kapur K, Harini C, Kija E, Peters JM. A pediatric epilepsy diagnostic tool for use in resource-limited settings: A pilot study. Epilepsy Behav. 2016 Jun; 59:57-61.
  23. Hodgeman RM, Kapur K, Paris A, Marti C, Can A, Kimia A, Loddenkemper T, Bergin A, Poduri A, Libenson M, Lamb N, Jafarpour S, Harini C. Effectiveness of once-daily high-dose ACTH for infantile spasms. Epilepsy Behav. 2016 Jun; 59:4-8.
  24. Pier DB, Gholipour A, Afacan O, Velasco-Annis C, Clancy S, Kapur K, Estroff JA, Warfield SK. 3D Super-Resolution Motion-Corrected MRI: Validation of Fetal Posterior Fossa Measurements. J Neuroimaging. 2016 Sep; 26(5):539-44.
  25. Maski K, Holbrook H, Manoach D, Hanson E, Kapur K, Stickgold R. Sleep Dependent Memory Consolidation in Children with Autism Spectrum Disorder. Sleep. 2015 Dec 01; 38(12):1955-63.
  26. Datta SK, Warshaw EM, Edison KE, Kapur K, Thottapurathu L, Moritz TE, Reda DJ, Whited JD. Cost and Utility Analysis of a Store-and-Forward Teledermatology Referral System: A Randomized Clinical Trial. JAMA Dermatol. 2015 Dec 01; 151(12):1323-1329.
  27. Lehman LL, Watson CG, Kapur K, Danehy AR, Rivkin MJ. Predictors of Stroke After Transient Ischemic Attack in Children. Stroke. 2016 Jan; 47(1):88-93.
  28. Ullrich NJ, Pomeroy SL, Kapur K, Manley PE, Goumnerova LC, Loddenkemper T. Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia. 2015 Oct; 56(10):1599-604.
  29. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 03; 86(5):1215-27.
  30. Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goodkin HP, Kapur K, Mikati MA, Peariso K, Ream M, Riviello J, Tasker RC, Loddenkemper T. Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology. 2015 Jun 09; 84(23):2304-11.
  31. Mazumdar M, Christiani DC, Biswas SK, Ibne-Hasan OS, Kapur K, Hug C. Elevated sweat chloride levels due to arsenic toxicity. N Engl J Med. 2015 Feb 05; 372(6):582-4.
  32. Bhaumik DK, Kapur K, Balakrishnan, N, Gibbons RD, Keating JP. Small sample tests for shape parameter of a gamma distribution. Commun Stat Sim Comp. 2015; 44(5):1339-1363.
  33. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24.
  34. Kapur K, Li X, Blood EA, Hedeker D. Bayesian mixed-effects location and scale models for multivariate longitudinal outcomes: an application to ecological momentary assessment data. Stat Med. 2015 Feb 20; 34(4):630-51.
  35. Shklyar I, Pasternak A, Kapur K, Darras BT, Rutkove SB. Composite biomarkers for assessing Duchenne muscular dystrophy: an initial assessment. Pediatr Neurol. 2015 Feb; 52(2):202-5.
  36. Thome-Souza S, Kadish NE, Ramgopal S, Sánchez Fernández I, Bergin AM, Bolton J, Harini C, Libenson M, Olson H, Peters J, Poduri A, Rotenberg A, Takeoka M, Kothare SV, Kapur K, Bourgeois BF, Loddenkemper T. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44.
  37. Sánchez Fernández I, Vendrame M, Kapur K, Klehm J, Uysal S, Gedik M, An S, Jillella D, Zelener J, Syed S, Gooty V, Rotenberg A, Loddenkemper T. Comparison of pediatric patients with status epilepticus lasting 5-29 min versus =30 min. Epilepsy Behav. 2014 Aug; 37:1-6.
  38. Sánchez Fernández I, Klehm J, An S, Jillella D, Kapur K, Zelener J, Rotenberg A, Loddenkemper T. Comparison of risk factors for pediatric convulsive status epilepticus when defined as seizures = 5 min versus seizures = 30 min. Seizure. 2014 Oct; 23(9):692-8.
  39. Kapur K, Bhaumik R, Tang XC, Hur K, Reda DJ, Bhaumik DK. Sample size determination for longitudinal designs with binary response. Stat Med. 2014 Sep 28; 33(22):3781-800.
  40. Khwaja OS, Ho E, Barnes KV, O'Leary HM, Pereira LM, Finkelstein Y, Nelson CA, Vogel-Farley V, DeGregorio G, Holm IA, Khatwa U, Kapur K, Alexander ME, Finnegan DM, Cantwell NG, Walco AC, Rappaport L, Gregas M, Fichorova RN, Shannon MW, Sur M, Kaufmann WE. Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4596-601.
  41. Whited JD, Warshaw EM, Kapur K, Edison KE, Thottapurathu L, Raju S, Cook B, Engasser H, Pullen S, Moritz TE, Datta SK, Marty L, Foman NA, Suwattee P, Ward DS, Reda DJ. Clinical course outcomes for store and forward teledermatology versus conventional consultation: a randomized trial. J Telemed Telecare. 2013 Jun; 19(4):197-204.
  42. Whited JD, Warshaw EM, Edison KE, Kapur K, Thottapurathu L, Raju S, Cook B, Engasser H, Pullen S, Parks P, Sindowski T, Motyka D, Brown R, Moritz TE, Datta SK, Chren MM, Marty L, Reda DJ. Effect of store and forward teledermatology on quality of life: a randomized controlled trial. JAMA Dermatol. 2013 May; 149(5):584-91.
  43. Bhaumik DK, Kapur K, Bhaumik R, Reda D. Sample size determination and hypothesis testing for the mean of a lognormal distribution. J Environ Stats. 2013; 1(5):1-19.
  44. Bhaumik DK, Aryal S, Amatya AK, Kapur K, Gibbons RD. Sample size determination for between group comparisons in mixed-effects logistic regression models for analysis of longitudinal data. J Appl Stat Sci. 2011; 1(19):11-22.
  45. Mosconi MW, Kay M, D'Cruz AM, Guter S, Kapur K, Macmillan C, Stanford LD, Sweeney JA. Neurobehavioral abnormalities in first-degree relatives of individuals with autism. Arch Gen Psychiatry. 2010 Aug; 67(8):830-40.
  46. Bhaumik DK, Roy A, Lazar NA, Kapur K, Aryal S, Sweeney JA, Patterson D, Gibbons RD. Hypothesis testing, power and sample size determination for between group comparisons in fMRI experiments. Stat Methodol. 2009 Mar; 6(2):133-146.
  47. Kapur K, Roy A, Bhaumik DK, Gibbons RD, Lazar NA, Sweeney JA, Aryal S, Patterson D. Estimation and Classification of BOLD Responses Over Multiple Trials. Commun Stat Theory Methods. 2009; 38(16-17):3099-3113.
  48. Bhaumik DK, Kapur K, Gibbons RD. Testing parameters of a gamma distribution for small samples. Technometrics. 2009; 3(51):326-334.
  49. Demirtas H, Hedeker D, Kapur K. A comparative study on most commonly used correlated binary data generation methods. Adv Appl Stat Sci. 2009; 1(1):45-55.
  50. Gibbons RD, Segawa E, Karabatsos G, Amatya AK, Bhaumik DK, Brown CH, Kapur K, Marcus SM, Hur K, Mann JJ. Mixed-effects Poisson regression analysis of adverse event reports: the relationship between antidepressants and suicide. Stat Med. 2008 May 20; 27(11):1814-33.
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