Research

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Kristin Moffitt, MD

Kristin Moffitt
Department:
Medicine Research
Division
Infectious Diseases Research
Hospital Title:
Associate Physician in Medicine
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Host bacterial pathogen interactionsBacterial vaccine development
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Research Overview

Dr. Moffitt’s research focuses on bacterial pathogenesis and host interactions with common human pathogens such as Streptococcus pneumoniae and Staphylococcus aureus. Her work has identified several novel pneumococcal proteins that confer protection against colonization of the nasopharynx and may be candidate components of a pneumococcal protein subunit vaccine. To study these proteins, she is investigating their interaction with the host immune system. Dr. Moffitt’s work specifically explores the role of activation of the innate immune system in acquisition of protective immune responses. Her work also investigates bacterial RNA expression profiles in human infection. The overall goal of her research is to identify factors employed by bacteria to cause disease and to understand the mechanisms of immunity to infection and to use these findings to guide the development of alternative bacterial vaccine strategies.

About Kristin Moffitt

Dr. Moffitt received her undergraduate degree at Wellesley College and her medical degree from University of Vermont College of Medicine. She completed her internship and residency training in pediatrics at Hasbro Children’s Hospital of Brown Medical School followed by fellowship in pediatric infectious diseases at Boston Children’s Hospital. She joined the faculty of the Division of Infectious Diseases at Boston Children’s Hospital in 2010.

Publications

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  1. Koegel AK, Hofmann I, Moffitt K, Degar B, Duncan C, Tubman VN. Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency. Pediatr Blood Cancer. 2016 Oct; 63(10):1844-7.
  2. Moffitt K, Malley R. Rationale and prospects for novel pneumococcal vaccines. Hum Vaccin Immunother. 2016; 12(2):383-92.
  3. Moffitt K, Howard A, Martin S, Cheung E, Herd M, Basset A, Malley R. T(H)17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins. Clin Vaccine Immunol. 2015 Aug; 22(8):909-16.
  4. Moffitt K, Skoberne M, Howard A, Gavrilescu LC, Gierahn T, Munzer S, Dixit B, Giannasca P, Flechtner JB, Malley R. Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins. Infect Immun. 2014 May; 82(5):2079-86.
  5. Schwenk HT, Vo P, Moffitt K, Kehoe E, Blume E, Sharma T, Khatwa U. Allograft-Transmitted Histoplasma capsulatum Infection in a Solid Organ Transplant Recipient. J Pediatric Infect Dis Soc. 2013 Sep; 2(3):270-3.
  6. Moffitt KL, Malley R, Lu YJ. Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine. PLoS One. 2012; 7(8):e43445.
  7. Moffitt KL, Yadav P, Weinberger DM, Anderson PW, Malley R. Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine. Vaccine. 2012 Jun 19; 30(29):4316-22.
  8. Moffitt KL, Gierahn TM, Lu Y, Gouveia P, Alderson M, Flechtner JB, Higgins DE, Malley R . Cell Host and Microbe. TH17-based vaccine design for prevention of Streptococcus pneumoniae colonization. 2011; 9(2):158-65.
  9. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28.
  10. Moffitt KL, Malley R. Next generation pneumococcal vaccines. Curr Opin Immunol. 2011 Jun; 23(3):407-13.
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