Research

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Kenneth  Mandl, MD, MPH

Kenneth Mandl
Program:
Computational Health Informatics Program (CHIP)
Department:
Medicine Research
Hospital Title:
Senior Associate in Medicine
Academic Title:
Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Biomedical informatics
Contact:
617-355-4145

Email: Kenneth Mandl, MD, MPH


Research Overview

Through scholarship intersecting epidemiology and informatics, Mandl pioneered use of IT and big data for population health, discovery, patient engagement and care redesign.

Mandl leads the transformative SMART Platforms initiative to design the “app store for health" and is principal investigator of the Scalable Collaborative Infrastructure for a Learning Health System across Boston hospitals and nationally.

Recognized for research and teaching, Mandl received the Presidential Early Career Award for Scientists and Engineers and the Clifford A. Barger Award for top mentors at Harvard Medical School.

He was advisor to two Directors of the CDC and chairs the Board of Scientific Counselors of the NIH’s National Library of Medicine. His clinical training and experience is in pediatrics and pediatric emergency medicine.

Dr. Mandl has been elected to multiple honor societies including the American Society for Clinical Investigation, Society for Pediatric Research, American College of Medical Informatics and American Pediatric Society. 

About Kenneth Mandl

Kenneth D. Mandl, MD, MPH is board certified in pediatrics and pediatric emergency physician and received his doctorate in medicine from Harvard Medical School in 1989, and his Master of Public Health degree from the Harvard School of Public Health in 1995. He completed graduate work in medical informatics at the Massachusetts Institute of Technology.

 

Publications

Publications powered by Harvard Catalyst Profiles
  1. Ong MS, Grand RJ, Mandl KD. Trends in Pharmacologic Interventions for Preventing Recurrence of Crohn's Disease After Ileocolonic Surgery. Inflamm Bowel Dis. 2016 Oct; 22(10):2432-41.
  2. Homer ML, Palmer NP, Bodenreider O, Cami A, Chadwick L, Mandl KD. The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight. AMIA Jt Summits Transl Sci Proc. 2016; 2016:105-11.
  3. Lindgren C, Neuman MI, Monuteaux MC, Mandl KD, Fine AM. Patient and Parent-Reported Signs and Symptoms for Group A Streptococcal Pharyngitis. Pediatrics. 2016 Jul; 138(1).
  4. Bourgeois FT, Olson KL, Tse T, Ioannidis JP, Mandl KD. Prevalence and Characteristics of Interventional Trials Conducted Exclusively in Elderly Persons: A Cross-Sectional Analysis of Registered Clinical Trials. PLoS One. 2016; 11(5):e0155948.
  5. Ong MS, Olson KL, Cami A, Liu C, Tian F, Selvam N, Mandl KD. Erratum to: Provider patient-sharing networks and multiple-provider prescribing of benzodiazepines. J Gen Intern Med. 2016 May; 31(5):588.
  6. Pfiffner PB, Pinyol I, Natter MD, Mandl KD. C3-PRO: Connecting ResearchKit to the Health System Using i2b2 and FHIR. PLoS One. 2016; 11(3):e0152722.
  7. Warner JL, Rioth MJ, Mandl KD, Mandel JC, Kreda DA, Kohane IS, Carbone D, Oreto R, Wang L, Zhu S, Yao H, Alterovitz G. SMART precision cancer medicine: a FHIR-based app to provide genomic information at the point of care. J Am Med Inform Assoc. 2016 Jul; 23(4):701-10.
  8. Ong MS, Mandl K. Mammography Risks: The Authors Reply. Health Aff (Millwood). 2016 Mar; 35(3):552.
  9. Mandel JC, Kreda DA, Mandl KD, Kohane IS, Ramoni RB. SMART on FHIR: a standards-based, interoperable apps platform for electronic health records. J Am Med Inform Assoc. 2016 Sep; 23(5):899-908.
  10. Klann JG, Abend A, Raghavan VA, Mandl KD, Murphy SN. Data interchange using i2b2. J Am Med Inform Assoc. 2016 Sep; 23(5):909-15.
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  12. Mandl KD, Kohane IS. Time for a Patient-Driven Health Information Economy? N Engl J Med. 2016 Jan 21; 374(3):205-8.
  13. Peltz A, Hall M, Rubin DM, Mandl KD, Neff J, Brittan M, Cohen E, Hall DE, Kuo DZ, Agrawal R, Berry JG. Hospital Utilization Among Children With the Highest Annual Inpatient Cost. Pediatrics. 2016 Feb; 137(2):e20151829.
  14. Ong MS, Mandl KD. New Guidelines For Breast Cancer Screening. Health Aff (Millwood). 2016 Jan; 35(1):180.
  15. Klann JG, Phillips LC, Turchin A, Weiler S, Mandl KD, Murphy SN. A numerical similarity approach for using retired Current Procedural Terminology (CPT) codes for electronic phenotyping in the Scalable Collaborative Infrastructure for a Learning Health System (SCILHS). BMC Med Inform Decis Mak. 2015 Dec 11; 15:104.
  16. Klann JG, Pfiffner PB, Natter MD, Conner E, Blazejewski P, Murphy SN, Mandl KD. Supporting Multi-sourced Medication Information in i2b2. AMIA Annu Symp Proc. 2015; 2015:747-55.
  17. Bourgeois FT, Olson KL, Poduri A, Mandl KD. Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients. Paediatr Drugs. 2015 Oct; 17(5):401-10.
  18. Tseng YJ, Cami A, Goldmann DA, DeMaria A, Mandl KD. Using Nation-Wide Health Insurance Claims Data to Augment Lyme Disease Surveillance. Vector Borne Zoonotic Dis. 2015 Oct; 15(10):591-6.
  19. Tseng YJ, Cami A, Goldmann DA, DeMaria A, Mandl KD. Incidence and Patterns of Extended-Course Antibiotic Therapy in Patients Evaluated for Lyme Disease. Clin Infect Dis. 2015 Nov 15; 61(10):1536-42.
  20. Ong MS, Olson KL, Cami A, Liu C, Tian F, Selvam N, Mandl KD. Provider Patient-Sharing Networks and Multiple-Provider Prescribing of Benzodiazepines. J Gen Intern Med. 2016 Feb; 31(2):164-71.
  21. Ong MS, Mandl KD. Breast Cancer Diagnoses: The Authors Reply. Health Aff (Millwood). 2015 Jul; 34(7):1253.
  22. Mandl KD, Mandel JC, Kohane IS. Driving Innovation in Health Systems through an Apps-Based Information Economy. Cell Syst. 2015 Jul; 1(1):8-13.
  23. Dunn AG, Leask J, Zhou X, Mandl KD, Coiera E. Associations Between Exposure to and Expression of Negative Opinions About Human Papillomavirus Vaccines on Social Media: An Observational Study. J Med Internet Res. 2015; 17(6):e144.
  24. Murthy S, Mandl KD, Bourgeois FT. Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013. Health Res Policy Syst. 2015 Jun 05; 13:28.
  25. Mandl KD, Kohane IS. Federalist principles for healthcare data networks. Nat Biotechnol. 2015 Apr; 33(4):360-3.
  26. Ong MS, Mandl KD. National expenditure for false-positive mammograms and breast cancer overdiagnoses estimated at $4 billion a year. Health Aff (Millwood). 2015 Apr; 34(4):576-83.
  27. Taylor PL, Mandl KD. Leaping the Data Chasm: Structuring Donation of Clinical Data for Healthcare Innovation and Modeling. Harvard Health Policy Rev. 2015; 14(2):18-21.
  28. Mandl KD. Ebola in the United States: EHRs as a public health tool at the point of care. JAMA. 2014 Dec 17; 312(23):2499-500.
  29. Pfiffner PB, Oh J, Miller TA, Mandl KD. ClinicalTrials.gov as a data source for semi-automated point-of-care trial eligibility screening. PLoS One. 2014; 9(10):e111055.
  30. Sunyaev A, Dehling T, Taylor PL, Mandl KD. Availability and quality of mobile health app privacy policies. J Am Med Inform Assoc. 2015 Apr; 22(e1):e28-33.
  31. Mandl KD, Olson KL, Mines D, Liu C, Tian F. Provider collaboration: cohesion, constellations, and shared patients. J Gen Intern Med. 2014 Nov; 29(11):1499-505.
  32. Bourgeois FT, Kim JM, Mandl KD. Premarket safety and efficacy studies for ADHD medications in children. PLoS One. 2014; 9(7):e102249.
  33. D'Amore JD, Mandel JC, Kreda DA, Swain A, Koromia GA, Sundareswaran S, Alschuler L, Dolin RH, Mandl KD, Kohane IS, Ramoni RB. Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative. J Am Med Inform Assoc. 2014 Nov-Dec; 21(6):1060-8.
  34. Weber GM, Mandl KD, Kohane IS. Finding the missing link for big biomedical data. JAMA. 2014 Jun 25; 311(24):2479-80.
  35. Mandl KD, Kohane IS, McFadden D, Weber GM, Natter M, Mandel J, Schneeweiss S, Weiler S, Klann JG, Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, Murphy SN. Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):615-20.
  36. Ong MS, Kohane IS, Cai T, Gorman MP, Mandl KD. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol. 2014 May; 71(5):569-74.
  37. Dunn AG, Coiera E, Mandl KD. Is Biblioleaks inevitable? J Med Internet Res. 2014; 16(4):e112.
  38. Ong MS, Umetsu DT, Mandl KD. Consequences of antibiotics and infections in infancy: bugs, drugs, and wheezing. Ann Allergy Asthma Immunol. 2014 May; 112(5):441-445.e1.
  39. Natter MD, Ong MS, Ilowite NT, Mandl KD, Mieszkalski KL, Sandborg CI, Wallace C, Schanberg LE. A167: variations in patterns of care across pediatric rheumatic diseases in the childhood arthritis & rheumatology alliance network registry. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S215-6.
  40. Fine AM, Nizet V, Mandl KD. Participatory medicine: a home score for streptococcal pharyngitis. Ann Intern Med. 2014 Feb 18; 160(4):289.
  41. Dunn AG, Mandl KD, Coiera E, Bourgeois FT. The effects of industry sponsorship on comparator selection in trial registrations for neuropsychiatric conditions in children. PLoS One. 2013; 8(12):e84951.
  42. Mandl KD, McNabb M, Marks N, Weitzman ER, Kelemen S, Eggleston EM, Quinn M. Participatory surveillance of diabetes device safety: a social media-based complement to traditional FDA reporting. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):687-91.
  43. Bourgeois FT, Olson KL, Ioannidis JP, Mandl KD. Association between pediatric clinical trials and global burden of disease. Pediatrics. 2014 Jan; 133(1):78-87.
  44. Fine AM, Nizet V, Mandl KD. Participatory medicine: A home score for streptococcal pharyngitis enabled by real-time biosurveillance: a cohort study. Ann Intern Med. 2013 Nov 5; 159(9):577-83.
  45. Zimolzak AJ, Spettell CM, Fernandes J, Fusaro VA, Palmer NP, Saria S, Kohane IS, Jonikas MA, Mandl KD. Early detection of poor adherers to statins: applying individualized surveillance to pay for performance. PLoS One. 2013; 8(11):e79611.
  46. Bosl W, Mandel J, Jonikas M, Ramoni RB, Kohane IS, Mandl KD. Scalable decision support at the point of care: a substitutable electronic health record app for monitoring medication adherence. Interact J Med Res. 2013 Jul 22; 2(2):e13.
  47. Cassa CA, Chunara R, Mandl K, Brownstein JS. Twitter as a sentinel in emergency situations: lessons from the Boston marathon explosions. PLoS Curr. 2013 Jul 02; 5.
  48. Murthy S, Mandl KD, Bourgeois F. Analysis of pediatric clinical drug trials for neuropsychiatric conditions. Pediatrics. 2013 Jun; 131(6):1125-31.
  49. Fusaro VA, Brownstein C, Wolf W, Clinton C, Savage S, Mandl KD, Margulies D, Manzi S. Development of a scalable pharmacogenomic clinical decision support service. AMIA Jt Summits Transl Sci Proc. 2013; 2013:60.
  50. Pfiffner PB, Mandl KD. An iOS Framework for the Indivo X Personally Controlled Health Record. AMIA Jt Summits Transl Sci Proc. 2013; 2013:196-200.
  51. Mandl KD, Edge S, Malone C, Marsolo K, Natter MD. Next-generation registries: fusion of data for care, and research. AMIA Jt Summits Transl Sci Proc. 2013; 2013:164-7.
  52. Franckle T, Haas D, Mandl KD. App Store for EHRs and Patients Both. AMIA Jt Summits Transl Sci Proc. 2013; 2013:73.
  53. Weitzman ER, Kelemen S, Quinn M, Eggleston EM, Mandl KD. Participatory surveillance of hypoglycemia and harms in an online social network. JAMA Intern Med. 2013 Mar 11; 173(5):345-51.
  54. Berry JG, Hall M, Hall DE, Kuo DZ, Cohen E, Agrawal R, Mandl KD, Clifton H, Neff J. Inpatient growth and resource use in 28 children's hospitals: a longitudinal, multi-institutional study. JAMA Pediatr. 2013 Feb; 167(2):170-7.
  55. Wattanasin N, Porter A, Ubaha S, Mendis M, Phillips L, Mandel J, Ramoni R, Mandl K, Kohane I, Murphy SN. Apps to display patient data, making SMART available in the i2b2 platform. AMIA Annu Symp Proc. 2012; 2012:960-9.
  56. Cassa CA, Miller RA, Mandl KD. A novel, privacy-preserving cryptographic approach for sharing sequencing data. J Am Med Inform Assoc. 2013 Jan 1; 20(1):69-76.
  57. Bourgeois FT, Murthy S, Pinto C, Olson KL, Ioannidis JP, Mandl KD. Pediatric versus adult drug trials for conditions with high pediatric disease burden. Pediatrics. 2012 Aug; 130(2):285-92.
  58. Olson KL, Mandl KD. Temporal patterns of medications dispensed to children and adolescents in a national insured population. PLoS One. 2012; 7(7):e40991.
  59. Natter MD, Quan J, Ortiz DM, Bousvaros A, Ilowite NT, Inman CJ, Marsolo K, McMurry AJ, Sandborg CI, Schanberg LE, Wallace CA, Warren RW, Weber GM, Mandl KD. An i2b2-based, generalizable, open source, self-scaling chronic disease registry. J Am Med Inform Assoc. 2013 Jan 1; 20(1):172-9.
  60. Mandl KD, Kohane IS. Escaping the EHR trap--the future of health IT. N Engl J Med. 2012 Jun 14; 366(24):2240-2.
  61. Fine AM, Nizet V, Mandl KD. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med. 2012 Jun 11; 172(11):847-52.
  62. Mandl KD, Khorasani R, Kohane IS. Meaningful use of electronic health records. Health Aff (Millwood). 2012 Jun; 31(6):1365; author reply 1366.
  63. Weitzman ER, Kelemen S, Kaci L, Mandl KD. Willingness to share personal health record data for care improvement and public health: a survey of experienced personal health record users. BMC Med Inform Decis Mak. 2012 May 22; 12:39.
  64. Dunn AG, Day RO, Mandl KD, Coiera E. Learning from hackers: open-source clinical trials. Sci Transl Med. 2012 May 2; 4(132):132cm5.
  65. Reis BY, Olson KL, Tian L, Bohn RL, Brownstein JS, Park PJ, Cziraky MJ, Wilson MD, Mandl KD. A pharmacoepidemiological network model for drug safety surveillance: statins and rhabdomyolysis. Drug Saf. 2012 May 1; 35(5):395-406.
  66. Mandl KD, Mandel JC, Murphy SN, Bernstam EV, Ramoni RL, Kreda DA, McCoy JM, Adida B, Kohane IS. The SMART Platform: early experience enabling substitutable applications for electronic health records. J Am Med Inform Assoc. 2012 Jul-Aug; 19(4):597-603.
  67. Dunn AG, Bourgeois FT, Murthy S, Mandl KD, Day RO, Coiera E. The role and impact of research agendas on the comparative-effectiveness research among antihyperlipidemics. Clin Pharmacol Ther. 2012 Apr; 91(4):685-91.
  68. Bourgeois FT, Murthy S, Mandl KD. Comparative effectiveness research: an empirical study of trials registered in ClinicalTrials.gov. PLoS One. 2012; 7(1):e28820.
  69. Cassa CA, Savage SK, Taylor PL, Green RC, McGuire AL, Mandl KD. Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility. Genome Res. 2012 Mar; 22(3):421-8.
  70. Weitzman ER, Kelemen S, Mandl KD. Surveillance of an Online Social Network to Assess Population-level Diabetes Health Status and Healthcare Quality. Online J Public Health Inform. 2011; 3(3).
  71. Jonikas MA, Mandl KD. Surveillance of medication use: early identification of poor adherence. J Am Med Inform Assoc. 2012 Jul-Aug; 19(4):649-54.
  72. Fine AM, Nizet V, Mandl KD. Improved diagnostic accuracy of group A streptococcal pharyngitis with use of real-time biosurveillance. Ann Intern Med. 2011 Sep 20; 155(6):345-52.
  73. Hoen AG, Buckeridge DL, Charland KM, Mandl KD, Quach C, Brownstein JS. Effect of expanded US recommendations for seasonal influenza vaccination: comparison of two pediatric emergency departments in the United States and Canada. CMAJ. 2011 Sep 20; 183(13):E1025-32.
  74. Berry JG, Goldmann DA, Mandl KD, Putney H, Helm D, O'Brien J, Antonelli R, Weinick RM. Health information management and perceptions of the quality of care for children with tracheotomy: a qualitative study. BMC Health Serv Res. 2011 May 23; 11:117.
  75. Weitzman ER, Adida B, Kelemen S, Mandl KD. Sharing data for public health research by members of an international online diabetes social network. PLoS One. 2011 Apr 27; 6(4):e19256.
  76. Weitzman ER, Cole E, Kaci L, Mandl KD. Social but safe? Quality and safety of diabetes-related online social networks. J Am Med Inform Assoc. 2011 May 1; 18(3):292-7.
  77. Weitzman ER, Kaci L, Quinn M, Mandl KD. Helping high-risk youth move through high-risk periods: personally controlled health records for improving social and health care transitions. J Diabetes Sci Technol. 2011 Jan 01; 5(1):47-54.
  78. Fine AM, Brownstein JS, Nigrovic LE, Kimia AA, Olson KL, Thompson AD, Mandl KD. Integrating spatial epidemiology into a decision model for evaluation of facial palsy in children. Arch Pediatr Adolesc Med. 2011 Jan; 165(1):61-7.
  79. Bourgeois FC, Olson KL, Mandl KD. Patients treated at multiple acute health care facilities: quantifying information fragmentation. Arch Intern Med. 2010 Dec 13; 170(22):1989-95.
  80. Adida B, Sanyal A, Zabak S, Kohane IS, Mandl KD. Indivo x: developing a fully substitutable personally controlled health record platform. AMIA Annu Symp Proc. 2010 Nov 13; 2010:6-10.
  81. Bourgeois FT, Shannon MW, Valim C, Mandl KD. Adverse drug events in the outpatient setting: an 11-year national analysis. Pharmacoepidemiol Drug Saf. 2010 Sep; 19(9):901-10.
  82. Sox CM, Gribbons WM, Loring BA, Mandl KD, Batista R, Porter SC. Patient-centered design of an information management module for a personally controlled health record. J Med Internet Res. 2010 Aug 30; 12(3):e36.
  83. Bourgeois FT, Murthy S, Mandl KD. Outcome reporting among drug trials registered in ClinicalTrials.gov. Ann Intern Med. 2010 Aug 3; 153(3):158-66.
  84. Weitzman ER, Kaci L, Mandl KD. Sharing medical data for health research: the early personal health record experience. J Med Internet Res. 2010 May 25; 12(2):e14.
  85. Fine AM, Reis BY, Nigrovic LE, Goldmann DA, Laporte TN, Olson KL, Mandl KD. Use of population health data to refine diagnostic decision-making for pertussis. J Am Med Inform Assoc. 2010 Jan-Feb; 17(1):85-90.
  86. Bourgeois FT, Valim C, McAdam AJ, Mandl KD. Relative impact of influenza and respiratory syncytial virus in young children. Pediatrics. 2009 Dec; 124(6):e1072-80.
  87. Dasgupta N, Mandl KD, Brownstein JS. Breaking the news or fueling the epidemic? Temporal association between news media report volume and opioid-related mortality. PLoS One. 2009 Nov 18; 4(11):e7758.
  88. Bourgeois FC, Mandl KD, Shaw D, Flemming D, Nigrin DJ. Mychildren's: integration of a personally controlled health record with a tethered patient portal for a pediatric and adolescent population. AMIA Annu Symp Proc. 2009 Nov 14; 2009:65-9.
  89. Boguski MS, Mandl KD, Sukhatme VP. Drug discovery. Repurposing with a difference. Science. 2009 Jun 12; 324(5933):1394-5.
  90. Fine AM, Kalish LA, Forbes P, Goldmann D, Mandl KD, Porter SC. Parent-driven technology for decision support in pediatric emergency care. Jt Comm J Qual Patient Saf. 2009 Jun; 35(6):307-15.
  91. Keller M, Blench M, Tolentino H, Freifeld CC, Mandl KD, Mawudeku A, Eysenbach G, Brownstein JS. Use of unstructured event-based reports for global infectious disease surveillance. Emerg Infect Dis. 2009 May; 15(5):689-95.
  92. Weitzman ER, Kaci L, Mandl KD. Acceptability of a personally controlled health record in a community-based setting: implications for policy and design. J Med Internet Res. 2009 Apr 29; 11(2):e14.
  93. Mandl KD, Kohane IS. No small change for the health information economy. N Engl J Med. 2009 Mar 26; 360(13):1278-81.
  94. Charland KM, Buckeridge DL, Sturtevant JL, Melton F, Reis BY, Mandl KD, Brownstein JS. Effect of environmental factors on the spatio-temporal patterns of influenza spread. Epidemiol Infect. 2009 Oct; 137(10):1377-87.
  95. Wieland SC, Cassa CA, Mandl KD, Berger B. Revealing the spatial distribution of a disease while preserving privacy. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17608-13.
  96. Cassa CA, Kenfield S, Daniel J, Mandl KD. The Massachusetts Health and Homeland Alert Network: a scalable and secure public health knowledge management and notification system. AMIA Annu Symp Proc. 2008 Nov 06; 893.
  97. Bourgeois FC, Taylor PL, Emans SJ, Nigrin DJ, Mandl KD. Whose personal control? Creating private, personally controlled health records for pediatric and adolescent patients. J Am Med Inform Assoc. 2008 Nov-Dec; 15(6):737-43.
  98. Cassa CA, Wieland SC, Mandl KD. Re-identification of home addresses from spatial locations anonymized by Gaussian skew. Int J Health Geogr. 2008 Aug 12; 7:45.
  99. Cassa CA, Schmidt B, Kohane IS, Mandl KD. My sister's keeper?: genomic research and the identifiability of siblings. BMC Med Genomics. 2008 Jul 25; 1:32.
  100. Brownstein JS, Freifeld CC, Reis BY, Mandl KD. Surveillance Sans Frontières: Internet-based emerging infectious disease intelligence and the HealthMap project. PLoS Med. 2008 Jul 8; 5(7):e151.
  101. Mandl KD, Kohane IS. Tectonic shifts in the health information economy. N Engl J Med. 2008 Apr 17; 358(16):1732-7.
  102. Bourgeois FT, Simons WW, Olson K, Brownstein JS, Mandl KD. Evaluation of influenza prevention in the workplace using a personally controlled health record: randomized controlled trial. J Med Internet Res. 2008 Mar 14; 10(1):e5.
  103. Freifeld CC, Mandl KD, Reis BY, Brownstein JS. HealthMap: global infectious disease monitoring through automated classification and visualization of Internet media reports. J Am Med Inform Assoc. 2008 Mar-Apr; 15(2):150-7.
  104. Levine M, Adida B, Mandl K, Kohane I, Halamka J. What are the benefits and risks of fitting patients with radiofrequency identification devices. PLoS Med. 2007 Nov 27; 4(11):e322.
  105. Halamka JD, Mandl KD, Tang PC. Early experiences with personal health records. J Am Med Inform Assoc. 2008 Jan-Feb; 15(1):1-7.
  106. Nakamura MM, Simons WW, Samuels R, Daniel J, Mandl KD. Service-oriented architecture for pediatric immunization decision support. AMIA Annu Symp Proc. 2007 Oct 11; 1056.
  107. Taylor P, Bourgeois FC, Mandl KD. Access controls for a pediatric personally controlled health record. AMIA Annu Symp Proc. 2007 Oct 11; 1131.
  108. Cassa CA, Mandl KD. Multi-factor authentication using contents from disparate EHRs. AMIA Annu Symp Proc. 2007 Oct 11; 891.
  109. Bourgeois F, Olson K, Mandl KD. Patients treated across multiple sites of care: a case for personally controlled health records. AMIA Annu Symp Proc. 2007 Oct 11; 881.
  110. Mandl KD, Simons WW, Crawford WC, Abbett JM. Indivo: a personally controlled health record for health information exchange and communication. BMC Med Inform Decis Mak. 2007 Sep 12; 7:25.
  111. Brownstein JS, Sordo M, Kohane IS, Mandl KD. The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction. PLoS One. 2007 Sep 05; 2(9):e840.
  112. Bourgeois FT, Porter SC, Valim C, Jackson T, Cook EF, Mandl KD. The value of patient self-report for disease surveillance. J Am Med Inform Assoc. 2007 Nov-Dec; 14(6):765-71.
  113. Reis BY, Kirby C, Hadden LE, Olson K, McMurry AJ, Daniel JB, Mandl KD. AEGIS: a robust and scalable real-time public health surveillance system. J Am Med Inform Assoc. 2007 Sep-Oct; 14(5):581-8.
  114. Wieland SC, Brownstein JS, Berger B, Mandl KD. Automated real time constant-specificity surveillance for disease outbreaks. BMC Med Inform Decis Mak. 2007 Jun 13; 7:15.
  115. Reis BY, Kohane IS, Mandl KD. An epidemiological network model for disease outbreak detection. PLoS Med. 2007 Jun; 4(6):e210.
  116. Wieland SC, Brownstein JS, Berger B, Mandl KD. Density-equalizing Euclidean minimum spanning trees for the detection of all disease cluster shapes. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9404-9.
  117. Kohane IS, Mandl KD, Taylor PL, Holm IA, Nigrin DJ, Kunkel LM. Medicine. Reestablishing the researcher-patient compact. Science. 2007 May 11; 316(5826):836-7.
  118. McMurry AJ, Gilbert CA, Reis BY, Chueh HC, Kohane IS, Mandl KD. A self-scaling, distributed information architecture for public health, research, and clinical care. J Am Med Inform Assoc. 2007 Jul-Aug; 14(4):527-33.
  119. Fine AM, Nigrovic LE, Reis BY, Cook EF, Mandl KD. Linking surveillance to action: incorporation of real-time regional data into a medical decision rule. J Am Med Inform Assoc. 2007 Mar-Apr; 14(2):206-11.
  120. Brownstein JS, Cassa CA, Kohane IS, Mandl KD. An unsupervised classification method for inferring original case locations from low-resolution disease maps. Int J Health Geogr. 2006 Dec 08; 5:56.
  121. Brownstein JS, Cassa CA, Mandl KD. No place to hide--reverse identification of patients from published maps. N Engl J Med. 2006 Oct 19; 355(16):1741-2.
  122. Olson KL, Grannis SJ, Mandl KD. Privacy protection versus cluster detection in spatial epidemiology. Am J Public Health. 2006 Nov; 96(11):2002-8.
  123. Fine AM, Goldmann DA, Forbes PW, Harris SK, Mandl KD. Incorporating vaccine-preventable disease surveillance into the National Health Information Network: leveraging children's hospitals. Pediatrics. 2006 Oct; 118(4):1431-8.
  124. Brownstein JS, Wolfe CJ, Mandl KD. Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States. PLoS Med. 2006 Sep; 3(10):e401.
  125. Bourgeois FT, Valim C, Wei JC, McAdam AJ, Mandl KD. Influenza and other respiratory virus-related emergency department visits among young children. Pediatrics. 2006 Jul; 118(1):e1-8.
  126. Sebastiani P, Mandl KD, Szolovits P, Kohane IS, Ramoni MF. A Bayesian dynamic model for influenza surveillance. Stat Med. 2006 Jun 15; 25(11):1803-16; discussion 1817-25.
  127. Kimia A, Brownstein JS, Olson KL, Zak V, Bourgeois FT, Mandl KD. Lumbar puncture ordering and results in the pediatric population: a promising data source for surveillance systems. Acad Emerg Med. 2006 Jul; 13(7):767-73.
  128. Mohtashemi M, Szolovits P, Dunyak J, Mandl KD. A susceptible-infected model of early detection of respiratory infection outbreaks on a background of influenza. J Theor Biol. 2006 Aug 21; 241(4):954-63.
  129. Bourgeois FT, Olson KL, Brownstein JS, McAdam AJ, Mandl KD. Validation of syndromic surveillance for respiratory infections. Ann Emerg Med. 2006 Mar; 47(3):265.e1.
  130. Bourgeois F, Taylor P, Mandl K. A proposed legal framework for addressing privacy for patient controlled health records in pediatrics. AMIA Annu Symp Proc. 2006; 861.
  131. Brownstein JS, Mandl KD. Reengineering real time outbreak detection systems for influenza epidemic monitoring. AMIA Annu Symp Proc. 2006; 866.
  132. Simons WW, Halamka JD, Kohane IS, Nigrin D, Finstein N, Mandl KD. Integration of the personally controlled electronic medical record into regional inter-regional data exchanges: a national demonstration. AMIA Annu Symp Proc. 2006; 1099.
  133. Cassa CA, Grannis SJ, Overhage JM, Mandl KD. A context-sensitive approach to anonymizing spatial surveillance data: impact on outbreak detection. J Am Med Inform Assoc. 2006 Mar-Apr; 13(2):160-5.
  134. Reis BY, Brownstein JS, Mandl KD. Running outside the baseline: impact of the 2004 Major League Baseball postseason on emergency department use. Ann Emerg Med. 2005 Oct; 46(4):386-7.
  135. Kleinman KP, Abrams A, Mandl K, Platt R. Simulation for assessing statistical methods of biologic terrorism surveillance. MMWR Suppl. 2005 Aug 26; 54:101-8.
  136. Ma H, Rolka H, Mandl K, Buckeridge D, Fleischauer A, Pavlin J. Implementation of laboratory order data in BioSense Early Event Detection and Situation Awareness System. MMWR Suppl. 2005 Aug 26; 54:27-30.
  137. Daniel JB, Heisey-Grove D, Gadam P, Yih W, Mandl K, Demaria A, Platt R. Connecting health departments and providers: syndromic surveillance's last mile. MMWR Suppl. 2005 Aug 26; 54:147-50.
  138. Brownstein JS, Kleinman KP, Mandl KD. Identifying pediatric age groups for influenza vaccination using a real-time regional surveillance system. Am J Epidemiol. 2005 Oct 1; 162(7):686-93.
  139. Cassa CA, Iancu K, Olson KL, Mandl KD. A software tool for creating simulated outbreaks to benchmark surveillance systems. BMC Med Inform Decis Mak. 2005 Jul 14; 5:22.
  140. Wang L, Ramoni MF, Mandl KD, Sebastiani P. Factors affecting automated syndromic surveillance. Artif Intell Med. 2005 Jul; 34(3):269-78.
  141. Olson KL, Bonetti M, Pagano M, Mandl KD. Real time spatial cluster detection using interpoint distances among precise patient locations. BMC Med Inform Decis Mak. 2005 Jun 21; 5:19.
  142. Sax U, Kohane I, Mandl KD. Wireless technology infrastructures for authentication of patients: PKI that rings. J Am Med Inform Assoc. 2005 May-Jun; 12(3):263-8.
  143. Fine AM, Forbes P, Osganian S, Goldmann DA, Mandl KD. Feasibility of leveraging electronic data from pediatric hospitals for national surveillance: a survey of chief information officers. AMIA Annu Symp Proc. 2005; 954.
  144. Brownstein JS, Cassa CA, Kohane IS, Mandl KD. Reverse geocoding: concerns about patient confidentiality in the display of geospatial health data. AMIA Annu Symp Proc. 2005; 905.
  145. Simons WW, Mandl KD, Kohane IS. The PING personally controlled electronic medical record system: technical architecture. J Am Med Inform Assoc. 2005 Jan-Feb; 12(1):47-54.
  146. Mandl KD, Reis B, Cassa C. Measuring outbreak-detection performance by using controlled feature set simulations. MMWR Suppl. 2004 Sep 24; 53:130-6.
  147. Reis BY, Mandl KD. Syndromic surveillance: the effects of syndrome grouping on model accuracy and outbreak detection. Ann Emerg Med. 2004 Sep; 44(3):235-41.
  148. Beitel AJ, Olson KL, Reis BY, Mandl KD. Use of emergency department chief complaint and diagnostic codes for identifying respiratory illness in a pediatric population. Pediatr Emerg Care. 2004 Jun; 20(6):355-60.
  149. Fine AM, Wong JB, Fraser HS, Fleisher GR, Mandl KD. Is it influenza or anthrax? A decision analytic approach to the treatment of patients with influenza-like illnesses. Ann Emerg Med. 2004 Mar; 43(3):318-28.
  150. Chung S, Mandl KD, Shannon M, Fleisher GR. Efficacy of an educational Web site for educating physicians about bioterrorism. Acad Emerg Med. 2004 Feb; 11(2):143-8.
  151. Madden JM, Soumerai SB, Lieu TA, Mandl KD, Zhang F, Ross-Degnan D. Length-of-stay policies and ascertainment of postdischarge problems in newborns. Pediatrics. 2004 Jan; 113(1 Pt 1):42-9.
  152. Mandl KD, Overhage JM, Wagner MM, Lober WB, Sebastiani P, Mostashari F, Pavlin JA, Gesteland PH, Treadwell T, Koski E, Hutwagner L, Buckeridge DL, Aller RD, Grannis S. Implementing syndromic surveillance: a practical guide informed by the early experience. J Am Med Inform Assoc. 2004 Mar-Apr; 11(2):141-50.
  153. Keren R, Muret-Wagstaff S, Goldmann DA, Mandl KD. Notifying emergency department patients of negative test results: pitfalls of passive communication. Pediatr Emerg Care. 2003 Aug; 19(4):226-30.
  154. Willwerth BM, Harper MB, Mandl KD. Prolonged partial thromboplastin times in children with fever and petechiae without bacteremia or sepsis. Pediatr Emerg Care. 2003 Aug; 19(4):244-7.
  155. Madden JM, Soumerai SB, Lieu TA, Mandl KD, Zhang F, Ross-Degnan D. Effects on breastfeeding of changes in maternity length-of-stay policy in a large health maintenance organization. Pediatrics. 2003 Mar; 111(3):519-24.
  156. Reis BY, Pagano M, Mandl KD. Using temporal context to improve biosurveillance. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1961-5.
  157. Porter SC, Fleisher GR, Kohane IS, Mandl KD. The value of parental report for diagnosis and management of dehydration in the emergency department. Ann Emerg Med. 2003 Feb; 41(2):196-205.
  158. Reis BY, Mandl KD. Time series modeling for syndromic surveillance. BMC Med Inform Decis Mak. 2003 Jan 23; 3:2.
  159. Reis BY, Mandl KD. Integrating syndromic surveillance data across multiple locations: effects on outbreak detection performance. AMIA Annu Symp Proc. 2003; 549-53.
  160. Madden JM, Soumerai SB, Lieu TA, Mandl KD, Zhang F, Ross-Degnan D. Effects of a law against early postpartum discharge on newborn follow-up, adverse events, and HMO expenditures. N Engl J Med. 2002 Dec 19; 347(25):2031-8.
  161. Shannon M, Burstein J, Mandl K, Fleisher G. Usage of a web-based decision support tool for bioterrorism detection. Am J Emerg Med. 2002 Jul; 20(4):384-5.
  162. Lober WB, Karras BT, Wagner MM, Overhage JM, Davidson AJ, Fraser H, Trigg LJ, Mandl KD, Espino JU, Tsui FC. Roundtable on bioterrorism detection: information system-based surveillance. J Am Med Inform Assoc. 2002 Mar-Apr; 9(2):105-15.
  163. Mandl KD, Lee TH. Integrating medical informatics and health services research: the need for dual training at the clinical health systems and policy levels. J Am Med Inform Assoc. 2002 Mar-Apr; 9(2):127-32.
  164. Mandl KD, Feit S, Larson C, Kohane IS. Newborn screening program practices in the United States: notification, research, and consent. Pediatrics. 2002 Feb; 109(2):269-73.
  165. Riva A, Mandl KD, Oh DH, Nigrin DJ, Butte A, Szolovits P, Kohane IS. The personal internetworked notary and guardian. Int J Med Inform. 2001 Jun; 62(1):27-40.
  166. Mandl KD, Szolovits P, Kohane IS. Public standards and patients' control: how to keep electronic medical records accessible but private. BMJ. 2001 Feb 3; 322(7281):283-7.
  167. Kaplan RL, Harper MB, Baskin MN, Macone AB, Mandl KD. Time to detection of positive cultures in 28- to 90-day-old febrile infants. Pediatrics. 2000 Dec; 106(6):E74.
  168. Mandl KD, Homer CJ, Harary O, Finkelstein JA. Effect of a reduced postpartum length of stay program on primary care services use by mothers and infants. Pediatrics. 2000 Oct; 106(4 Suppl):937-41.
  169. Mandl KD, Feit S, Peña BM, Kohane IS. Growth and determinants of access in patient e-mail and Internet use. Arch Pediatr Adolesc Med. 2000 May; 154(5):508-11.
  170. Porter SC, Silvia MT, Fleisher GR, Kohane IS, Homer CJ, Mandl KD. Parents as direct contributors to the medical record: validation of their electronic input. Ann Emerg Med. 2000 Apr; 35(4):346-52.
  171. Soprano JV, Mandl KD. Four strategies for the management of esophageal coins in children. Pediatrics. 2000 Jan; 105(1):e5.
  172. Mandl KD, Tronick EZ, Brennan TA, Alpert HR, Homer CJ. Infant health care use and maternal depression. Arch Pediatr Adolesc Med. 1999 Aug; 153(8):808-13.
  173. Mandl KD, Kohane IS. Healthconnect: clinical grade patient-physician communication. Proc AMIA Symp. 1999; 849-53.
  174. Sun Y, van Wingerde FJ, Kohane IS, Harary O, Mandl KD, Salem-Schatz SR, Homer CJ. The challenges of automating a real-time clinical practice guideline. Clin Perform Qual Health Care. 1999 Jan-Mar; 7(1):28-35.
  175. Porter SC, Mandl KD. Data quality and the electronic medical record: a role for direct parental data entry. Proc AMIA Symp. 1999; 354-8.
  176. Mandl KD, Kohane IS, Brandt AM. Electronic patient-physician communication: problems and promise. Ann Intern Med. 1998 Sep 15; 129(6):495-500.
  177. Mandl KD, Katz SB, Kohane IS. Social equity and access to the World Wide Web and E-mail: implications for design and implementation of medical applications. Proc AMIA Symp. 1998; 215-9.
  178. van Wingerde FJ, Sun Y, Harary O, Mandl KD, Salem-Schatz S, Homer CJ, Kohane IS. Linking multiple heterogeneous data sources to practice guidelines. Proc AMIA Symp. 1998; 391-5.
  179. Mandl KD, Brennan TA, Wise PH, Tronick EZ, Homer CJ. Maternal and infant health: effects of moderate reductions in postpartum length of stay. Arch Pediatr Adolesc Med. 1997 Sep; 151(9):915-21.
  180. Mandl KD, Stack AM, Fleisher GR. Incidence of bacteremia in infants and children with fever and petechiae. J Pediatr. 1997 Sep; 131(3):398-404.
  181. Mandl KD, Lovejoy FH. Common poisonings. Pediatr Rev. 1994 Apr; 15(4):151-9.
  182. Dowton SB, Waggoner DJ, Mandl KD. Developmental regulation of expression of C-reactive protein and serum amyloid A in Syrian hamsters. Pediatr Res. 1991 Nov; 30(5):444-9.
  183. MANDL K. [Principles in mirion therapy of chronic rheumatic diseases]. Wien Med Wochenschr. 1951 Aug 11-18; 101(32-33):624-6.
  184. MANDL K. [Treatment of diarrhea with tryptagon]. Prakt Arzt. 1951 Apr 15; 5(47):914-22.
  185. MANDL K. [Treatment of prostate cancer with retarded-action estrogen]. Wien Med Wochenschr. 1950 Jun 21; 100(23-24):438-9.
  186. BLUMENCRON W, MANDL K. [Experience with intravenous salicyl therapy]. Prakt Arzt. 1950 Jun 15; 4(37):292-7.
  187. MANDL K. [Treatment results with Polyval]. Wien Med Wochenschr. 1949 Dec 3; 99(47-48):574.
  188. Bourgeois FT, Mandl KD, Valim C, Shannon MW. Pediatric adverse drug events in the outpatient setting: an 11-year national analysis. Pediatrics. 2009 Oct; 124(4):e744-50.
  189. Brownstein JS, Mandl KD. Pediatric population size is associated with geographic patterns of acute respiratory infections among adults. Ann Emerg Med. 2008 Jul; 52(1):63-8.
  190. Soprano JV, Fleisher GR, Mandl KD. The spontaneous passage of esophageal coins in children. Arch Pediatr Adolesc Med. 1999 Oct; 153(10):1073-6.
  191. Garcia Peña BM, Mandl KD, Kraus SJ, Fischer AC, Fleisher GR, Lund DP, Taylor GA. Ultrasonography and limited computed tomography in the diagnosis and management of appendicitis in children. JAMA. 1999 Sep 15; 282(11):1041-6.
  192. Peña BM, Taylor GA, Fishman SJ, Mandl KD. Costs and effectiveness of ultrasonography and limited computed tomography for diagnosing appendicitis in children. Pediatrics. 2000 Oct; 106(4):672-6.
  193. Peña BM, Taylor GA, Lund DP, Mandl KD. Effect of computed tomography on patient management and costs in children with suspected appendicitis. Pediatrics. 1999 Sep; 104(3 Pt 1):440-6.
  194. Boutis K, Komar L, Jaramillo D, Babyn P, Alman B, Snyder B, Mandl KD, Schuh S. Sensitivity of a clinical examination to predict need for radiography in children with ankle injuries: a prospective study. Lancet. 2001 Dec 22-29; 358(9299):2118-21.
  195. Peña BM, Taylor GA, Fishman SJ, Mandl KD. Effect of an imaging protocol on clinical outcomes among pediatric patients with appendicitis. Pediatrics. 2002 Dec; 110(6):1088-93.
  196. Reis BY, Kohane IS, Mandl KD. Longitudinal histories as predictors of future diagnoses of domestic abuse: modelling study. BMJ. 2009 Sep 29; 339:b3677.
  197. Garcia Peña BM, Cook EF, Mandl KD. Selective imaging strategies for the diagnosis of appendicitis in children. Pediatrics. 2004 Jan; 113(1 Pt 1):24-8.
  198. Dunn AG, Coiera E, Mandl KD, Bourgeois FT. Conflict of interest disclosure in biomedical research: A review of current practices, biases, and the role of public registries in improving transparency. Res Integr Peer Rev. 2016; 1.
  199. Tseng YJ, DeMaria A, Goldmann DA, Mandl KD. Claims-Based Diagnostic Patterns of Patients Evaluated for Lyme Disease and Given Extended Antibiotic Therapy. Vector Borne Zoonotic Dis. 2016 Nov 17.
  200. Wagholikar KB, Mandel JC, Klann JG, Wattanasin N, Mendis M, Chute CG, Mandl KD, Murphy SN. SMART-on-FHIR implemented over i2b2. J Am Med Inform Assoc. 2016 Jun 6.
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