Research

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Jonathan Mansbach, MD, MPH

Jonathan Mansbach
Department:
Medicine Research
Division
General Pediatrics Research
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Bronchiolitis care

Research Overview

Dr. Mansbach has been performing multicenter bronchiolitis and respiratory virus research with the Emergency Medicine Network (www.emnet-usa.org) over the past decade.  He has been Principal Investigator, Co-Investigator, or site Principal Investigator of multiple industry, foundation, and NIH grants. Currently, Dr. Mansbach is Co-Investigator and on the Steering Committee for a NIH-funded multicenter study following 1,000 children hospitalized with bronchiolitis for the development of recurrent wheezing and eventual asthma. He is also actively investigating the influence of the nasopharyngeal microbiome and 25-hydroxyvitamin D levels on the severity of a child’s bronchiolitis illness.

About Jonathan Mansbach, MD, MPH

Dr. Mansbach graduated from Haverford College and Duke University School of Medicine before coming to Boston Children’s Hospital as an intern. He has been at Boston Children’s Hospital ever since. He completed a hospitalist and adolescent medicine fellowship, and now spends the majority of his time investigating bronchiolitis and respiratory viruses. He obtained a Masters of Public Health from the Harvard School of Public Health.

Active Projects

2009-2014 Vitamin D deficiency and the severity of bronchiolitis

K23 AI077801
Principal Investigator

This study examines the vitamin D level of the children enrolled for the U01 study at Boston Children’s Hospital.

Publications

Publications powered by Harvard Catalyst Profiles
  1. Hasegawa K, Linnemann RW, Mansbach JM, Ajami NJ, Espinola JA, Fiechtner LG, Petrosino JF, Camargo CA. Association of household siblings with nasal and fecal microbiota in infants. Pediatr Int. 2016 Sep 16.
  2. Hasegawa K, Linnemann RW, Mansbach JM, Ajami NJ, Espinola JA, Petrosino JF, Piedra PA, Stevenson MD, Sullivan AF, Thompson AD, Camargo CA. The Fecal Microbiota Profile and Bronchiolitis in Infants. Pediatrics. 2016 Jul; 138(1).
  3. Dumas O, Mansbach JM, Jartti T, Hasegawa K, Sullivan AF, Piedra PA, Camargo CA. A clustering approach to identify severe bronchiolitis profiles in children. Thorax. 2016 Aug; 71(8):712-8.
  4. Goto T, Tsugawa Y, Mansbach JM, Camargo CA, Hasegawa K. Trends in Infectious Disease Hospitalizations in US Children, 2000 to 2012. Pediatr Infect Dis J. 2016 Jun; 35(6):e158-63.
  5. Mansbach JM, Hasegawa K, Henke DM, Ajami NJ, Petrosino JF, Shaw CA, Piedra PA, Sullivan AF, Espinola JA, Camargo CA. Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota. J Allergy Clin Immunol. 2016 Jun; 137(6):1909-1913.e4.
  6. Mansbach JM, Clark S, Teach SJ, Gern JE, Piedra PA, Sullivan AF, Espinola JA, Camargo CA. Children Hospitalized with Rhinovirus Bronchiolitis Have Asthma-Like Characteristics. J Pediatr. 2016 May; 172:202-204.e1.
  7. Hasegawa K, Linnemann RW, Avadhanula V, Mansbach JM, Piedra PA, Gern JE, Camargo CA. Detection of respiratory syncytial virus and rhinovirus in healthy infants. BMC Res Notes. 2015 Nov 25; 8:718.
  8. Stevenson MD, Mansbach JM, Mowad E, Dunn M, Clark S, Piedra PA, Sullivan AF, Camargo CA. Prenatal Versus Postnatal Tobacco Smoke Exposure and Intensive Care Use in Children Hospitalized With Bronchiolitis. Acad Pediatr. 2016 Jul; 16(5):446-52.
  9. Simões EA, Carbonell-Estrany X, Guilbert T, Mansbach JM, Piedra PA, Ramilo O, Welliver R. Clinical Endpoints for Respiratory Syncytial Virus Prophylaxis Trials in Infants and Children in High-income and Middle-income Countries. Pediatr Infect Dis J. 2015 Oct; 34(10):1086-92.
  10. Hasegawa K, Mansbach JM, Piedra PA, Dunn MB, Clark S, Sullivan AF, Camargo CA. Eligibility for palivizumab prophylaxis in a cohort of children with severe bronchiolitis. Pediatr Int. 2015 Oct; 57(5):1031-4.
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  12. Hasegawa K, Stevenson MD, Mansbach JM, Schroeder AR, Sullivan AF, Espinola JA, Piedra PA, Camargo CA. Association Between Hyponatremia and Higher Bronchiolitis Severity Among Children in the ICU With Bronchiolitis. Hosp Pediatr. 2015 Jul; 5(7):385-9.
  13. Piedra PA, Mansbach JM, Jewell AM, Thakar SD, Grant CC, Sullivan AF, Espinola JA, Camargo CA. Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season. Pediatr Infect Dis J. 2015 Jun; 34(6):566-70.
  14. O'Donnell K, Mansbach JM, LoVecchio F, Cheng J, Piedra PA, Clark S, Sullivan AF, Camargo CA. Use of Cough and Cold Medications in Severe Bronchiolitis before and after a Health Advisory Warning against Their Use. J Pediatr. 2015 Jul; 167(1):196-8.e1-2.
  15. Pierce HC, Mansbach JM, Fisher ES, Macias CG, Pate BM, Piedra PA, Sullivan AF, Espinola JA, Camargo CA. Variability of intensive care management for children with bronchiolitis. Hosp Pediatr. 2015 Apr; 5(4):175-84.
  16. Jartti T, Hasegawa K, Mansbach JM, Piedra PA, Camargo CA. Rhinovirus-induced bronchiolitis: Lack of association between virus genomic load and short-term outcomes. J Allergy Clin Immunol. 2015 Aug; 136(2):509-12.e11.
  17. Mansbach JM, Clark S, Piedra PA, Macias CG, Schroeder AR, Pate BM, Sullivan AF, Espinola JA, Camargo CA. Hospital course and discharge criteria for children hospitalized with bronchiolitis. J Hosp Med. 2015 Apr; 10(4):205-11.
  18. Hasegawa K, Jartti T, Mansbach JM, Laham FR, Jewell AM, Espinola JA, Piedra PA, Camargo CA. Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland. J Infect Dis. 2015 May 15; 211(10):1550-9.
  19. Hasegawa K, Mansbach JM, Teach SJ, Fisher ES, Hershey D, Koh JY, Clark S, Piedra PA, Sullivan AF, Camargo CA. Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis. Pediatr Infect Dis J. 2014 Aug; 33(8):809-13.
  20. Jartti T, Aakula M, Mansbach JM, Piedra PA, Bergroth E, Koponen P, Kivistö JE, Sullivan AF, Espinola JA, Remes S, Korppi M, Camargo CA. Hospital length-of-stay is associated with rhinovirus etiology of bronchiolitis. Pediatr Infect Dis J. 2014 Aug; 33(8):829-34.
  21. Schroeder AR, Mansbach JM. Recent evidence on the management of bronchiolitis. Curr Opin Pediatr. 2014 Jun; 26(3):328-33.
  22. Hasegawa K, Mansbach JM, Camargo CA. Infectious pathogens and bronchiolitis outcomes. Expert Rev Anti Infect Ther. 2014 Jul; 12(7):817-28.
  23. Hasegawa K, Tsugawa Y, Brown DF, Mansbach JM, Camargo CA. Temporal trends in emergency department visits for bronchiolitis in the United States, 2006 to 2010. Pediatr Infect Dis J. 2014 Jan; 33(1):11-8.
  24. Hyde ER, Petrosino JF, Piedra PA, Camargo CA, Espinola JA, Mansbach JM. Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis. J Allergy Clin Immunol. 2014 Apr; 133(4):1220-2.
  25. Schroeder AR, Mansbach JM, Stevenson M, Macias CG, Fisher ES, Barcega B, Sullivan AF, Espinola JA, Piedra PA, Camargo CA. Apnea in children hospitalized with bronchiolitis. Pediatrics. 2013 Nov; 132(5):e1194-201.
  26. Hasegawa K, Tsugawa Y, Brown DF, Mansbach JM, Camargo CA. Trends in bronchiolitis hospitalizations in the United States, 2000-2009. Pediatrics. 2013 Jul; 132(1):28-36.
  27. Wang VJ, Cavagnaro CS, Clark S, Camargo CA, Mansbach JM. Altitude and environmental climate effects on bronchiolitis severity among children presenting to the emergency department. J Environ Health. 2012 Oct; 75(3):8-15; quiz 54.
  28. Mansbach JM, Piedra PA, Borregaard N, Martineau AR, Neuman MI, Espinola JA, Camargo CA. Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis. J Allergy Clin Immunol. 2012 Oct; 130(4):1007-8.e1.
  29. Mansbach JM, Piedra PA, Stevenson MD, Sullivan AF, Forgey TF, Clark S, Espinola JA, Camargo CA. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation. Pediatrics. 2012 Sep; 130(3):e492-500.
  30. Mansbach JM, Piedra PA, Teach SJ, Sullivan AF, Forgey T, Clark S, Espinola JA, Camargo CA. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med. 2012 Aug; 166(8):700-6.
  31. Mansbach JM, Piedra PA, Laham FR, McAdam AJ, Clark S, Sullivan AF, Camargo CA. Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study. Pediatr Infect Dis J. 2012 Jul; 31(7):767-9.
  32. Neuman MI, Ting SA, Meydani A, Mansbach JM, Camargo CA. National study of antibiotic use in emergency department visits for pneumonia, 1993 through 2008. Acad Emerg Med. 2012 May; 19(5):562-8.
  33. Growdon AS, Camargo CA, Clark S, Hannon M, Mansbach JM. Serum 25-hydroxyvitamin D levels among Boston trainee doctors in winter. Nutrients. 2012 Mar; 4(3):197-207.
  34. Mansbach JM. Clinical features can help predict which infants with bronchiolitis will need hospital admission. J Pediatr. 2012 Jan; 160(1):174-5.
  35. Jartti T, Ruuskanen O, Mansbach JM, Vuorinen T, Camargo CA. Low serum 25-hydroxyvitamin D levels are associated with increased risk of viral coinfections in wheezing children. J Allergy Clin Immunol. 2010 Nov; 126(5):1074-6, 1076.e1-4.
  36. Damore D, Mansbach JM, Clark S, Ramundo M, Camargo CA. Insurance status and the variable management of children presenting to the emergency department with bronchiolitis. Pediatr Emerg Care. 2010 Oct; 26(10):716-21.
  37. Norwood A, Mansbach JM, Clark S, Waseem M, Camargo CA. Prospective multicenter study of bronchiolitis: predictors of an unscheduled visit after discharge from the emergency department. Acad Emerg Med. 2010 Apr; 17(4):376-82.
  38. Ginde AA, Sullivan AF, Mansbach JM, Camargo CA. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol. 2010 May; 202(5):436.e1-8.
  39. Mansbach JM, Ginde AA, Camargo CA. Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D? Pediatrics. 2009 Nov; 124(5):1404-10.
  40. Mansbach JM, Clark S, Barcega BR, Haddad H, Camargo CA. Factors associated with longer emergency department length of stay for children with bronchiolitis : a prospective multicenter study. Pediatr Emerg Care. 2009 Oct; 25(10):636-41.
  41. Mansbach JM, Espinola JA, Macias CG, Ruhlen ME, Sullivan AF, Camargo CA. Variability in the diagnostic labeling of nonbacterial lower respiratory tract infections: a multicenter study of children who presented to the emergency department. Pediatrics. 2009 Apr; 123(4):e573-81.
  42. Ginde AA, Mansbach JM, Camargo CA. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009 Feb 23; 169(4):384-90.
  43. Ginde AA, Mansbach JM, Camargo CA. Vitamin D, respiratory infections, and asthma. Curr Allergy Asthma Rep. 2009 Jan; 9(1):81-7.
  44. Damore D, Mansbach JM, Clark S, Ramundo M, Camargo CA. Prospective multicenter bronchiolitis study: predicting intensive care unit admissions. Acad Emerg Med. 2008 Oct; 15(10):887-94.
  45. Mansbach JM, Camargo CA. Bronchiolitis: lingering questions about its definition and the potential role of vitamin D. Pediatrics. 2008 Jul; 122(1):177-9.
  46. Schwartz BI, Mansbach JM, Marion JG, Katzman DK, Forman SF. Variations in admission practices for adolescents with anorexia nervosa: a North American sample. J Adolesc Health. 2008 Nov; 43(5):425-31.
  47. Mansbach JM, Clark S, Christopher NC, LoVecchio F, Kunz S, Acholonu U, Camargo CA. Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department. Pediatrics. 2008 Apr; 121(4):680-8.
  48. Mansbach JM, McAdam AJ, Clark S, Hain PD, Flood RG, Acholonu U, Camargo CA. Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. Acad Emerg Med. 2008 Feb; 15(2):111-8.
  49. Mansbach JM, Pelletier AJ, Camargo CA. US outpatient office visits for bronchiolitis, 1993-2004. Ambul Pediatr. 2007 Jul-Aug; 7(4):304-7.
  50. Mansbach J, Kunz S, Acholonu U, Clark S, Camargo CA. Evaluation of compliance with palivizumab recommendations in a multicenter study of young children presenting to the emergency department with bronchiolitis. Pediatr Emerg Care. 2007 Jun; 23(6):362-7.
  51. Mansbach JM, Acholonu U, Clark S, Camargo CA. Variation in IRB responses to a standard, observational pediatric research protocol. Academic Emergency Medicine. 2007; 14(4):377-380.
  52. Mansbach J, Acholonu U, Clark S, Camargo CA. Variation in institutional review board responses to a standard, observational, pediatric research protocol. Acad Emerg Med. 2007 Apr; 14(4):377-80.
  53. Mansbach, JM. Evidence Based Medicine. Comprehensive Pediatric Hospital Medicine. Zauoutis LB, Chiang VW, editors. 2007; 32-35.
  54. Mansbach JM, Pelletier AJ, Camargo CA. U.S. Outpatient office visits for bronchiolitis, 1993-2004. Ambulatory Pediatrics. 2007; 7(4):304-307.
  55. Pelletier AJ, Mansbach JM, Camargo CA. Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics. 2006 Dec; 118(6):2418-23.
  56. Mansbach JM, Acholonu U, Clark S, Camargo CA. . Multicenter Study of Bronchiolitis in the Emergency Department. Oral Presentation. American Academy of Pediatrics National Convention and Exhibition. 2006.
  57. Mansbach JM, Forbes P, Peters C. Testicular torsion and risk factors for orchiectomy. Arch Pediatr Adolesc Med. 2005 Dec; 159(12):1167-71.
  58. Mansbach JM, Schwartz B, Gordon J, Katzman D, Forman S. . Variation in Admission for Adolescents with Anorexia Nervosa: A North American Sample. Poster. Society for Adolescent Medicine Annual Conference. 2005.
  59. Moses JM, Riseberg RS, Mansbach JM. . Two children with Lyme disease presenting with persistent headache. Pediatrics. 2003; 112: e477-e479. Reprinted in Review Series Neurology. 2004; 2:10-12.
  60. Moses JM, Riseberg RS, Mansbach JM. Lyme disease presenting with persistent headache. Pediatrics. 2003 Dec; 112(6 Pt 1):e477-9.
  61. Mansbach JM, Wharff E, Austin SB, Ginnis K, Woods ER. Which psychiatric patients board on the medical service? Pediatrics. 2003 Jun; 111(6 Pt 1):e693-8.
  62. Mansbach JM, Emans SJ. . A practical guide to prescribing oral contraceptives. Contemporary Pediatrics. 2001; 18(10):111-126. Reprinted in Contemporary OB/GYN. 2001; 46(11):87-104 and Patient Care [serial online] June. 2003.
  63. Mansbach JM, Austin SB, Schwartz B, Woods ER. Optimizing the care of hospitalized youth. Poster. Society for Adolescent Medicine Annual Conference. 2002.
  64. Mansbach JM, Gordon C. . Demystifying delayed puberty. Contemporary Pediatrics. 2001; 18(4): 43-60. Reprinted in Contemporary OB/GYN. 2001; 46(8):39-54.
  65. Pizzo C, Mansbach J, Koh A., Tunnessen W. . New seizures in a 6 year-old: Expanding Horizons. Contemporary Pediatrics. 1999; 16(8):25-33.
  66. Mansbach JM, Mills JJ, Boyer IJ, De Souza AT, Hankins GR, Jirtle RL. Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels. Carcinogenesis. 1996 Jan; 17(1):171-4.
  67. Mansbach JM, Camargo CA. Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma. Clin Lab Med. 2009 Dec; 29(4):741-55.
  68. Mansbach JM, Emond JA, Camargo CA. Bronchiolitis in US emergency departments 1992 to 2000: epidemiology and practice variation. Pediatr Emerg Care. 2005 Apr; 21(4):242-7.
  69. Santiago J, Mansbach JM, Chou SC, Delgado C, Piedra PA, Sullivan AF, Espinola JA, Camargo CA. Racial/ethnic differences in the presentation and management of severe bronchiolitis. J Hosp Med. 2014 Sep; 9(9):565-72.
  70. Macias CG, Mansbach JM, Fisher ES, Riederer M, Piedra PA, Sullivan AF, Espinola JA, Camargo CA. Variability in inpatient management of children hospitalized with bronchiolitis. Acad Pediatr. 2015 Jan-Feb; 15(1):69-76.
  71. Hasegawa K, Pate BM, Mansbach JM, Macias CG, Fisher ES, Piedra PA, Espinola JA, Sullivan AF, Camargo CA. Risk factors for requiring intensive care among children admitted to ward with bronchiolitis. Acad Pediatr. 2015 Jan-Feb; 15(1):77-81.
  72. Hasegawa K, Mansbach JM, Ajami NJ, Espinola JA, Henke DM, Petrosino JF, Piedra PA, Shaw CA, Sullivan AF, Camargo CA. Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis. Eur Respir J. 2016 Nov; 48(5):1329-1339.
  73. Hasegawa K, Mansbach JM, Ajami NJ, Petrosino JF, Freishtat RJ, Teach SJ, Piedra PA, Camargo CA. Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis. J Allergy Clin Immunol. 2016 Nov 11.
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