Research

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Jennifer Yeh, PhD

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Hospital Title:
Associate Scientific Researcher
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Decision ScienceComparative and Cost-Effectiveness AnalysisCancer PreventionCancer SurvivorshipHealth Disparities
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Research Overview

Jennifer M. Yeh, PhD, is a decision scientist whose research focuses on improving health outcomes at the population level. She has extensive experience applying decision-analytic modeling and cost-effectiveness analysis methods to evaluate clinical guidelines and health policy. Her research focuses primarily on cancer control and spans across the cancer continuum, ranging from gastric cancer prevention to childhood cancer survivorship. Dr. Yeh has developed and applied methods of decision analysis, simulation modeling and economic evaluation to identify opportunities to enhance cancer screening and surveillance programs. In particular, she has developed novel approaches that incorporate the effects of early life exposures on long-term health outcomes. Her work on childhood cancer survivorship focuses on how treatment-related risks for secondary cancers, cardiac events and other late effects impact long-term health and quality of life. She was recently awarded a grant from the American Cancer Society to evaluate secondary cancer screening guidelines for childhood cancer survivors.

About the Researcher

Dr. Yeh is an Assistant Professor of Pediatrics at Harvard Medical School and Associate Scientific Researcher in the Division of General Pediatrics at Boston Children's Hospital. She graduated from the University of Colorado at Boulder with a B.A. in Biology, received an M.S. in Health Policy and Management from the Harvard T.H. Chan School of Public Health, and completed her doctorate from the Health Policy PhD program at Harvard University, concentrating in Decision Sciences. Upon completing a NCI-sponsored post-doctoral fellowship at the Harvard T.H. Chan School of Public Health and Dana Farber/Harvard Cancer Center, she was awarded a NCI K07 Career Development Award. She is a current recipient of an American Cancer Society Research Scholar Grant.

Publications

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  1. Tramontano AC, Sheehan DF, Yeh JM, Kong CY, Dowling EC, Rubenstein JH, Abrams JA, Inadomi JM, Schrag D, Hur C. The Impact of a Prior Diagnosis of Barrett's Esophagus on Esophageal Adenocarcinoma Survival. Am J Gastroenterol. 2017 Apr 04.
  2. Yeh JM, Tramontano AC, Hur C, Schrag D. Comparative effectiveness of adjuvant chemoradiotherapy after gastrectomy among older patients with gastric adenocarcinoma: a SEER-Medicare study. Gastric Cancer. 2017 Feb 15.
  3. Yeh JM, Hanmer J, Ward ZJ, Leisenring WM, Armstrong GT, Hudson MM, Stovall M, Robison LL, Oeffinger KC, Diller L. Chronic Conditions and Utility-Based Health-Related Quality of Life in Adult Childhood Cancer Survivors. J Natl Cancer Inst. 2016 Sep; 108(9).
  4. Yeh JM, Hur C, Ward Z, Schrag D, Goldie SJ. Gastric adenocarcinoma screening and prevention in the era of new biomarker and endoscopic technologies: a cost-effectiveness analysis. Gut. 2016 Apr; 65(4):563-74.
  5. Yeh JM, Nohria A, Diller L. Routine echocardiography screening for asymptomatic left ventricular dysfunction in childhood cancer survivors: a model-based estimation of the clinical and economic effects. Ann Intern Med. 2014 May 20; 160(10):661-71.
  6. Yeh JM, Hur C, Schrag D, Kuntz KM, Ezzati M, Stout N, Ward Z, Goldie SJ. Contribution of H. pylori and smoking trends to US incidence of intestinal-type noncardia gastric adenocarcinoma: a microsimulation model. PLoS Med. 2013; 10(5):e1001451.
  7. Chen SC, Toy M, Yeh JM, Wang JD, Resch S. Cost-effectiveness of augmenting universal hepatitis B vaccination with immunoglobin treatment. Pediatrics. 2013 Apr; 131(4):e1135-43.
  8. Yeh JM, Diller L. Pediatric Hodgkin lymphoma: trade-offs between short- and long-term mortality risks. Blood. 2012 Sep 13; 120(11):2195-202.
  9. Yeh JM, Hur C, Kuntz KM, Ezzati M, Goldie SJ. Cost-effectiveness of treatment and endoscopic surveillance of precancerous lesions to prevent gastric cancer. Cancer. 2010 Jun 15; 116(12):2941-53.
  10. Yeh JM, Ho W, Hur C. Cost-effectiveness of endoscopic surveillance of gastric ulcers to improve survival. Gastrointest Endosc. 2010 Jul; 72(1):33-43.
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  12. Yeh JM, Nekhlyudov L, Goldie SJ, Mertens AC, Diller L. A model-based estimate of cumulative excess mortality in survivors of childhood cancer. Ann Intern Med. 2010 Apr 06; 152(7):409-17, W131-8.
  13. Hur C, Hayeck TJ, Yeh JM, Richards EM, Richards EB, Spechler SJ, Gazelle GS, Kong CY. Development, calibration, and validation of a U.S. white male population-based simulation model of esophageal adenocarcinoma. PLoS One. 2010 Mar 01; 5(3):e9483.
  14. Yeh JM, Goldie SJ, Kuntz KM, Ezzati M. Effects of Helicobacter pylori infection and smoking on gastric cancer incidence in China: a population-level analysis of trends and projections. Cancer Causes Control. 2009 Dec; 20(10):2021-9.
  15. Yeh JM, Kuntz KM, Ezzati M, Goldie SJ. Exploring the cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer in China in anticipation of clinical trial results. Int J Cancer. 2009 Jan 01; 124(1):157-66.
  16. Yeh JM, Kuntz KM, Ezzati M, Hur C, Kong CY, Goldie SJ. Development of an empirically calibrated model of gastric cancer in two high-risk countries. Cancer Epidemiol Biomarkers Prev. 2008 May; 17(5):1179-87.
  17. Yeh JM, Hook EW, Goldie SJ. A refined estimate of the average lifetime cost of pelvic inflammatory disease. Sex Transm Dis. 2003 May; 30(5):369-78.
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