Research

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Jay  Berry, MD, MPH

Jay Berry
Department:
Medicine Research
Division
General Pediatrics Research
Hospital Title:
Physician in Medicine
Academic Title:
Assistant Professor of Pediatrics, Harvard Medical School
Research Focus Area:
Children with special health care needsQuality of carepersonal hand-held electronic medical records

Research Overview

Jay G. Berry, MD, MPH, is a general pediatrician and hospitalist who specializes in the care of children with medical complexity.  Much of his research examines care delivery, clinical outcomes, and health resource utilization of this important population of children.  Dr. Berry’s current NIH and foundation-funded research on children with medical complexity includes the development and use of contingency plans, the use of machine learning methods to assess the impact of co-morbid conditions on health and utilization, and the development and use of standards of hospital discharge care.

About Jay Berry, MD, MPH

Dr. Berry received his MD from the University of Alabama School of Medicine in 2001.  He completed pediatrics residency at Primary Children’s Medical Center at the University of Utah in 2004.  Dr. Berry completed the Harvard Pediatric Health Services Research Fellowship and the Harvard School of Public Health Clinical Effectiveness Program in 2006.  He founded the Complex Care Quality Improvement Research Collaborative through the Children’s Hospital Association.  He is co-chair of the Academic Pediatrics Association Complex Care Special Interest Group.  Dr. Berry is the recipient of the Agency for Healthcare Research and Quality’s Outstanding Achievement for Scientific Contribution Using HCUP Award, the Young Clinician Research Award from the Center for Integration of Medicine and Innovative Technology, and the AcademyHealth Nemours Child Health Services Research Award.  His research has been featured in U.S News, WBUR (Massachusetts Public Radio), and the Wall Street Journal.

Key Publications

  • Berry JG, Graham D, Graham R, O’Brien J, Hall M, Roberson D, Goldmann D. Predictors of clinical outcomes and hospital resource for children following tracheotomy: A five-year multi-institutional analysis. Pediatrics. 2009;124(2):563-72.
  • Srivastava R, Berry JG, Hall M, Downey J, O’Gorman M, Dean, M, Barnhart D. Reflux related hospital admissions after fundoplication in children with neurological impairment: Retrospective Cohort Study. BMJ. 2009;339:b4411. PMCID: PMC2779335.
  • Simon T, Berry JG, Feudtner C, Stone B, Sheng X, Bratton S, Dean JM, Srivastava R. Children with complex chronic conditions in inpatient hospital settings in the U.S. Pediatrics. 2010;126(4):647-655. PMCID: PMC2962571.
  • Berry JG, Graham R, Roberson D, Graham D, Zhou J, Putney H, O’brien J, Goldmann D. Patient characteristics associated with in-hospital mortality in children following tracheotomy. Arch Dis Child. 2010;95(9):703-710. PMCID: PMC3118570.
  • Berry JG, Hall D, Cohen A, Kuo D, Agrawal D, Kueser J, Feudtner C, Hall M, Neff J. Hospital utilization and characteristics of patients experiencing recurrent readmissions within children's hospitals. JAMA. 2011;305(7):682-690. PMCID: PMC3118568.
  • Berry JG, Agrawal R, Kuo DZ, Cohen E, Risko W, Hall M, Casey P, Gordon J, Srivastava R. Characteristics of hospitalizations for patients who use a structured clinical care program for children with medical complexity. J Pediatr. 2011;159(2):284-290. PMCID: PMC3138997.
  • Berry JG, Poduri A, Bonkowsky JL, Zhou J, Graham DA, Welch C, Putney H, Srivastava R. Trends in resource utilization by children with neurological impairment in the United States inpatient health care system: a repeat cross-sectional study. PLoS Med. 2012;9(1):e1001158. PMCID: PMC3260313.
  • Cohen E, Berry JG, Camacho X, Anderson G, Wodchis W, Guttmann A. Patterns and costs of health care use of children with medical complexity. Pediatrics. 2012;130(6):e1463-1470.
  • Berry JG, Hall M, Hall DE, Kuo DZ, Cohen E, Agrawal R, Mandl KD, Clifton H, Neff J. Inpatient growth and resource use in 28 children's hospitals: A longitudinal, multi-institutional study. JAMA Pediatr. 2013;167(2):170-177. PMCID: PMC3663043.
  • Berry JG, Toomey SL, Zaslavsky AM, Jha AK, Nakamura MM, Klein DJ, Feng JY, Shulman S, Chiang VW, Kaplan W, Hall M, Schuster MA. Pediatric readmission prevalence and variability across hospitals. JAMA. 2013;309(4):372-380. PMCID: PMC3640861.

Active Projects

2009-2014 Improving Healthcare Integration for Children with Tracheostomy

NICHD K23 HD058092-01A1
Principal Investigator

The goal of this project is to improve healthcare integration and decrease re-hospitalizations for medically-complex children using an innovative information technology application (personally-controlled health record).

2012-2014 Hospital Discharge Planning for Children

Principal Investigator

The goal of this project is to develop national standards of discharge care for hospitalized children.

2014-2015 Innovative Research Methods to Study Children with Multiple Chronic Conditions

Agency for Healthcare Research and Quality (R21; approved for funding by Council)
Principal Investigator

The goals of this project are:
1) To adapt for children a publicly available, comprehensive diagnosis classification scheme to describe identify and describe the clinical diagnoses of children with multiple chronic conditions (CMCC);
2) to employ an innovative, machine learning method to systematically identify the most consequential interactions of coexisting chronic conditions in CMCC and to predict high resource utilization in these children.

Publications

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  1. Branowicki PM, Vessey JA, Graham DA, McCabe MA, Clapp AL, Blaine K, O'Neill MR, Gouthro JA, Snydeman CK, Kline NE, Chiang VW, Cannon C, Berry JG. Meta-Analysis of Clinical Trials That Evaluate the Effectiveness of Hospital-Initiated Postdischarge Interventions on Hospital Readmission. J Healthc Qual. 2016 Oct 18.
  2. Brittan M, Richardson T, Kenyon C, Sills M, Fieldston E, Hall M, Fox D, Shah S, Berry J. Association between Postdischarge Oral Corticosteroid Prescription Fills and Readmission in Children with Asthma. J Pediatr. 2016 Oct 18.
  3. Agrawal R, Hall M, Cohen E, Goodman DM, Kuo DZ, Neff JM, O'Neill M, Thomson J, Berry JG. Trends in Health Care Spending for Children in Medicaid With High Resource Use. Pediatrics. 2016 Sep 15.
  4. Berry JG. This Is My Hospital's Performance on Quality of Care-No Excuses. JAMA Pediatr. 2016 Sep 1; 170(9):837-8.
  5. Thomson J, Hall M, Berry JG, Stone B, Ambroggio L, Srivastava R, Shah SS. Diagnostic Testing and Hospital Outcomes of Children with Neurologic Impairment and Bacterial Pneumonia. J Pediatr. 2016 Nov; 178:156-163.e1.
  6. Gold JM, Hall M, Shah SS, Thomson J, Subramony A, Mahant S, Mittal V, Wilson KM, Morse R, Mussman GM, Hametz P, Montalbano A, Parikh K, Ishman S, O'Neill M, Berry JG. Long length of hospital stay in children with medical complexity. J Hosp Med. 2016 Nov; 11(11):750-756.
  7. Peltz A, Wu CL, White ML, Wilson KM, Lorch SA, Thurm C, Hall M, Berry JG. Characteristics of Rural Children Admitted to Pediatric Hospitals. Pediatrics. 2016 May; 137(5).
  8. Stephens JR, Steiner MJ, DeJong N, Rodean J, Hall M, Richardson T, Berry JG. Healthcare Utilization and Spending for Constipation in Children with Versus Without Complex Chronic Conditions. J Pediatr Gastroenterol Nutr. 2016 Apr 8.
  9. Watters K, O'Neill M, Zhu H, Graham RJ, Hall M, Berry J. Two-year mortality, complications, and healthcare use in children with medicaid following tracheostomy. Laryngoscope. 2016 Nov; 126(11):2611-2617.
  10. Berry JG, Hall M, Dumas H, Simpser E, Whitford K, Wilson KM, O'Neill M, Mittal V, Agrawal R, Dribbon M, Haines CJ, Traul C, Marks M, O'Brien J. Pediatric Hospital Discharges to Home Health and Postacute Facility Care: A National Study. JAMA Pediatr. 2016 Apr; 170(4):326-33.
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  12. Berry JG, Chien AT. To Risk Adjust or Not to Risk Adjust: Should That Be the Question? JAMA Pediatr. 2016 Apr; 170(4):319-20.
  13. Thomson J, Hall M, Ambroggio L, Stone B, Srivastava R, Shah SS, Berry JG. Aspiration and Non-Aspiration Pneumonia in Hospitalized Children With Neurologic Impairment. Pediatrics. 2016 Feb; 137(2):e20151612.
  14. Peltz A, Hall M, Rubin DM, Mandl KD, Neff J, Brittan M, Cohen E, Hall DE, Kuo DZ, Agrawal R, Berry JG. Hospital Utilization Among Children With the Highest Annual Inpatient Cost. Pediatrics. 2016 Feb; 137(2):e20151829.
  15. Kuo DZ, Hall M, Agrawal R, Cohen E, Feudtner C, Goodman DM, Neff JM, Berry JG. Comparison of Health Care Spending and Utilization Among Children With Medicaid Insurance. Pediatrics. 2015 Dec; 136(6):e1521-9.
  16. Berry JG, Gay JC. Preventing Readmissions in Children: How Do We Do That? Hosp Pediatr. 2015 Nov; 5(11):602-4.
  17. Kuo DZ, Berry JG, Glader L, Morin MJ, Johaningsmeir S, Gordon J. Health Services and Health Care Needs Fulfilled by Structured Clinical Programs for Children with Medical Complexity. J Pediatr. 2016 Feb; 169:291-6.e1.
  18. Gray SH, Trudell EK, Emans SJ, Woods ER, Berry JG, Vernacchio L. Total Direct Medical Expenses and Characteristics of Privately Insured Adolescents Who Incur High Costs. JAMA Pediatr. 2015 Oct; 169(10):e152682.
  19. Ananth P, Melvin P, Feudtner C, Wolfe J, Berry JG. Hospital Use in the Last Year of Life for Children With Life-Threatening Complex Chronic Conditions. Pediatrics. 2015 Nov; 136(5):938-46.
  20. O'Brien JE, Berry J, Dumas H. Pediatric Post-Acute Hospital Care: Striving for Identity and Value. Hosp Pediatr. 2015 Oct; 5(10):548-51.
  21. Khan A, Nakamura MM, Zaslavsky AM, Jang J, Berry JG, Feng JY, Schuster MA. Same-Hospital Readmission Rates as a Measure of Pediatric Quality of Care. JAMA Pediatr. 2015 Oct; 169(10):905-12.
  22. Berry JG, Zaslavsky AM, Toomey SL, Chien AT, Jang J, Bryant MC, Klein DJ, Kaplan WJ, Schuster MA. Recognizing Differences in Hospital Quality Performance for Pediatric Inpatient Care. Pediatrics. 2015 Aug; 136(2):251-62.
  23. Berry JG, Hall M, Cohen E, O'Neill M, Feudtner C. Ways to Identify Children with Medical Complexity and the Importance of Why. J Pediatr. 2015 Aug; 167(2):229-37.
  24. Auger KA, Simon TD, Cooperberg D, Gay J, Kuo DZ, Saysana M, Stille CJ, Fisher ES, Wallace S, Berry J, Coghlin D, Jhaveri V, Kairys S, Logsdon T, Shaikh U, Srivastava R, Starmer AJ, Wilkins V, Shen MW. Summary of STARNet: Seamless Transitions and (Re)admissions Network. Pediatrics. 2015 Jan; 135(1):164-75.
  25. Berry JG, Blaine K, Rogers J, McBride S, Schor E, Birmingham J, Schuster MA, Feudtner C. A framework of pediatric hospital discharge care informed by legislation, research, and practice. JAMA Pediatr. 2014 Oct; 168(10):955-62; quiz 965-6.
  26. Neuman MI, Alpern ER, Hall M, Kharbanda AB, Shah SS, Freedman SB, Aronson PL, Florin TA, Mistry RD, Berry JG. Characteristics of recurrent utilization in pediatric emergency departments. Pediatrics. 2014 Oct; 134(4):e1025-31.
  27. Nakamura MM, Toomey SL, Zaslavsky AM, Berry JG, Lorch SA, Jha AK, Bryant MC, Geanacopoulos AT, Loren SS, Pain D, Schuster MA. Measuring pediatric hospital readmission rates to drive quality improvement. Acad Pediatr. 2014 Sep-Oct; 14(5 Suppl):S39-46.
  28. Bogetz JF, Ullrich CK, Berry JG. Pediatric hospital care for children with life-threatening illness and the role of palliative care. Pediatr Clin North Am. 2014 Aug; 61(4):719-33.
  29. Zhu H, Das P, Roberson DW, Jang J, Skinner ML, Paine M, Yuan J, Berry J. Hospitalizations in children with preexisting tracheostomy: a national perspective. Laryngoscope. 2015 Feb; 125(2):462-8.
  30. Liu C, Heffernan C, Saluja S, Yuan J, Paine M, Oyemwense N, Berry J, Roberson D. Indications, Hospital Course, and Complexity of Patients Undergoing Tracheostomy at a Tertiary Care Pediatric Hospital. Otolaryngol Head Neck Surg. 2014 Aug; 151(2):232-9.
  31. Barnhart DC, Berry JG, Srivastava R. Does Nissen fundoplication decrease reflux-related problems including respiratory illness in children with neurological impairment?--reply. JAMA Pediatr. 2014 Feb; 168(2):188-9.
  32. Jernigan SC, Berry JG, Graham DA, Goumnerova L. The comparative effectiveness of ventricular shunt placement versus endoscopic third ventriculostomy for initial treatment of hydrocephalus in infants. J Neurosurg Pediatr. 2014 Mar; 13(3):295-300.
  33. Kenyon CC, Melvin PR, Chiang VW, Elliott MN, Schuster MA, Berry JG. Rehospitalization for childhood asthma: timing, variation, and opportunities for intervention. J Pediatr. 2014 Feb; 164(2):300-5.
  34. Barnhart DC, Hall M, Mahant S, Goldin AB, Berry JG, Faix RG, Dean JM, Srivastava R. Effectiveness of fundoplication at the time of gastrostomy in infants with neurological impairment. JAMA Pediatr. 2013 Oct; 167(10):911-8.
  35. Berry JG, Ziniel SI, Freeman L, Kaplan W, Antonelli R, Gay J, Coleman EA, Porter S, Goldmann D. Hospital readmission and parent perceptions of their child's hospital discharge. Int J Qual Health Care. 2013 Oct; 25(5):573-81.
  36. Morse RB, Hall M, Fieldston ES, Goodman DM, Berry JG, Gay JC, Sills MR, Srivastava R, Frank G, Hain PD, Shah SS. Children's hospitals with shorter lengths of stay do not have higher readmission rates. J Pediatr. 2013 Oct; 163(4):1034-8.e1.
  37. Berry JG, Hall M, Hall DE, Kuo DZ, Cohen E, Agrawal R, Mandl KD, Clifton H, Neff J. Inpatient growth and resource use in 28 children's hospitals: a longitudinal, multi-institutional study. JAMA Pediatr. 2013 Feb; 167(2):170-7.
  38. Berry JG, Toomey SL, Zaslavsky AM, Jha AK, Nakamura MM, Klein DJ, Feng JY, Shulman S, Chiang VW, Chiang VK, Kaplan W, Hall M, Schuster MA. Pediatric readmission prevalence and variability across hospitals. JAMA. 2013 Jan 23; 309(4):372-80.
  39. Cohen E, Berry JG, Camacho X, Anderson G, Wodchis W, Guttmann A. Patterns and costs of health care use of children with medical complexity. Pediatrics. 2012 Dec; 130(6):e1463-70.
  40. Charland KM, Buckeridge DL, Hoen AG, Berry JG, Elixhauser A, Melton F, Brownstein JS. Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza Other Respir Viruses. 2013 Sep; 7(5):718-28.
  41. Zhang X, Elliott MN, Saaddine JB, Berry JG, Cuccaro P, Tortolero S, Franklin F, Barker LE, Schuster MA. Unmet eye care needs among U.S. 5th-grade students. Am J Prev Med. 2012 Jul; 43(1):55-8.
  42. Jernigan SC, Berry JG, Graham DA, Bauer SB, Karlin LI, Hobbs NM, Scott RM, Warf BC. Risk factors of sudden death in young adult patients with myelomeningocele. J Neurosurg Pediatr. 2012 Feb; 9(2):149-55.
  43. Berry JG, Poduri A, Bonkowsky JL, Zhou J, Graham DA, Welch C, Putney H, Srivastava R. Trends in resource utilization by children with neurological impairment in the United States inpatient health care system: a repeat cross-sectional study. PLoS Med. 2012 Jan; 9(1):e1001158.
  44. Das P, Zhu H, Shah RK, Roberson DW, Berry J, Skinner ML. Tracheotomy-related catastrophic events: results of a national survey. Laryngoscope. 2012 Jan; 122(1):30-7.
  45. Shah RK, Lander L, Berry JG, Nussenbaum B, Merati A, Roberson DW. Tracheotomy outcomes and complications: a national perspective. Laryngoscope. 2012 Jan; 122(1):25-9.
  46. Kuo DZ, Cohen E, Agrawal R, Berry JG, Casey PH. A national profile of caregiver challenges among more medically complex children with special health care needs. Arch Pediatr Adolesc Med. 2011 Nov; 165(11):1020-6.
  47. Feudtner C, Berry JG, Parry G, Hain P, Morse RB, Slonim AD, Shah SS, Hall M. Statistical uncertainty of mortality rates and rankings for children's hospitals. Pediatrics. 2011 Oct; 128(4):e966-72.
  48. Berry JG, Goldmann DA, Mandl KD, Putney H, Helm D, O'Brien J, Antonelli R, Weinick RM. Health information management and perceptions of the quality of care for children with tracheotomy: a qualitative study. BMC Health Serv Res. 2011 May 23; 11:117.
  49. Cohen E, Kuo DZ, Agrawal R, Berry JG, Bhagat SK, Simon TD, Srivastava R. Children with medical complexity: an emerging population for clinical and research initiatives. Pediatrics. 2011 Mar; 127(3):529-38.
  50. Berry JG, Bloom S, Foley S, Palfrey JS. Health inequity in children and youth with chronic health conditions. Pediatrics. 2010 Dec; 126 Suppl 3:S111-9.
  51. Mahmood A, Berry J, Wenger DA, Escolar M, Sobeih M, Raymond G, Eichler FS. Metachromatic leukodystrophy: a case of triplets with the late infantile variant and a systematic review of the literature. J Child Neurol. 2010 May; 25(5):572-80.
  52. Srivastava R, Berry JG, Hall M, Downey EC, O'Gorman M, Dean JM, Barnhart DC. Reflux related hospital admissions after fundoplication in children with neurological impairment: retrospective cohort study. BMJ. 2009 Nov 18; 339:b4411.
  53. Berry JG, Graham DA, Graham RJ, Zhou J, Putney HL, O'Brien JE, Roberson DW, Goldmann DA. Predictors of clinical outcomes and hospital resource use of children after tracheotomy. Pediatrics. 2009 Aug; 124(2):563-72.
  54. Shah SS, Hall M, Slonim AD, Hornig GW, Berry JG, Sharma V. A multicenter study of factors influencing cerebrospinal fluid shunt survival in infants and children. Neurosurgery. 2008 May; 62(5):1095-102; discussion 1102-3.
  55. Berry JG, Hall MA, Sharma V, Goumnerova L, Slonim AD, Shah SS. A multi-institutional, 5-year analysis of initial and multiple ventricular shunt revisions in children. Neurosurgery. 2008 Feb; 62(2):445-53; discussion 453-4.
  56. Berry JG, Askovich B, Shaddy RE, Hawkins JA, Cowley CG. Prognostic value of B-type natriuretic peptide in surgical palliation of children with single-ventricle congenital heart disease. Pediatr Cardiol. 2008 Jan; 29(1):70-5.
  57. Berry JG, Lieu TA, Forbes PW, Goldmann DA. Hospital volumes for common pediatric specialty operations. Arch Pediatr Adolesc Med. 2007 Jan; 161(1):38-43.
  58. Berry JG, Cowley CG, Hoff CJ, Srivastava R. In-hospital mortality for children with hypoplastic left heart syndrome after stage I surgical palliation: teaching versus nonteaching hospitals. Pediatrics. 2006 Apr; 117(4):1307-13.
  59. Berry JG, Hall DE, Kuo DZ, Cohen E, Agrawal R, Feudtner C, Hall M, Kueser J, Kaplan W, Neff J. Hospital utilization and characteristics of patients experiencing recurrent readmissions within children's hospitals. JAMA. 2011 Feb 16; 305(7):682-90.
  60. Berry JG, Agrawal R, Kuo DZ, Cohen E, Risko W, Hall M, Casey P, Gordon J, Srivastava R. Characteristics of hospitalizations for patients who use a structured clinical care program for children with medical complexity. J Pediatr. 2011 Aug; 159(2):284-90.
  61. Berry JG, Graham RJ, Roberson DW, Rhein L, Graham DA, Zhou J, O'Brien J, Putney H, Goldmann DA. Patient characteristics associated with in-hospital mortality in children following tracheotomy. Arch Dis Child. 2010 Sep; 95(9):703-10.
  62. Simon TD, Berry J, Feudtner C, Stone BL, Sheng X, Bratton SL, Dean JM, Srivastava R. Children with complex chronic conditions in inpatient hospital settings in the United States. Pediatrics. 2010 Oct; 126(4):647-55.
  63. Berry JG, Hall M, Neff J, Goodman D, Cohen E, Agrawal R, Kuo D, Feudtner C. Children with medical complexity and Medicaid: spending and cost savings. Health Aff (Millwood). 2014 Dec; 33(12):2199-206.
  64. Florin TA, Aronson PL, Hall M, Kharbanda AB, Shah SS, Freedman SB, Alpern ER, Mistry RD, Simon HK, Berry J, Coley BD, Neuman MI. Emergency Department Use of Computed Tomography for Children with Ventricular Shunts. J Pediatr. 2015 Dec; 167(6):1382-8.e2.
  65. Colvin JD, Hall M, Gottlieb L, Bettenhausen JL, Shah SS, Berry JG, Chung PJ. Hospitalizations of Low-Income Children and Children With Severe Health Conditions: Implications of the Patient Protection and Affordable Care Act. JAMA Pediatr. 2016 Feb; 170(2):176-8.
  66. Colvin JD, Hall M, Berry JG, Gottlieb LM, Bettenhausen JL, Shah SS, Fieldston ES, Conway PH, Chung PJ. Financial Loss for Inpatient Care of Medicaid-Insured Children. JAMA Pediatr. 2016 Nov 1; 170(11):1055-1062.
  67. Brenner M, Connolly M, Cawley D, Howlin F, Berry J, Quinn C. Family and healthcare professionals' perceptions of a pilot hospice at home programme for children: a qualitative study. BMC Palliat Care. 2016 Oct 28; 15(1):89.
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